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Sex-Aware Genome-Wide Assessment Of De Novo Variants In Autism Across Coding And Noncoding Regions, Tychele N Turner Apr 2026

Sex-Aware Genome-Wide Assessment Of De Novo Variants In Autism Across Coding And Noncoding Regions, Tychele N Turner

2020-Current year OA Pubs

BACKGROUND: Autism spectrum disorder (ASD) shows a consistent sex bias, yet how sex shapes de novo variant (DNV) risk across coding and noncoding sequence remains unclear. I analyzed DNVs in > 41,000 parent–child sequenced trios from three ASD family-based cohorts and compared DNV characteristics and enrichment patterns in males and females. Notably, these trios included individuals with ASD as well as those without ASD. I developed a new sex-aware DNV caller (HAT-FLEX) and thoroughly evaluated each candidate DNV using an additional tool introduced in this study, SNOW, to generate a high-confidence callset. RESULTS: I identified enrichment of missense and loss-of-function (LOF) …

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Assessing Usability Gaps And Implementing User-Centered Practices In Nonprofit Web Applications, Mackenzie R. Swain Apr 2026

Assessing Usability Gaps And Implementing User-Centered Practices In Nonprofit Web Applications, Mackenzie R. Swain

Departmental Honors & Graduate Capstone Projects

Nonprofit organizations increasingly rely on web applications to coordinate volunteers, yet many such systems lack the usability necessary to support diverse user populations. This study evaluates and redesigns the Gwyneth’s Gift Volunteer Management System using established human–computer interaction principles and user-centered design methodologies. A systematic assessment identified four major usability gaps—menu navigation, form structure, breadcrumb trails, and selection‑bar behavior—each contributing to user confusion, inefficiency, or error. High‑fidelity prototypes were developed to address these issues, emphasizing consistency, reduced cognitive load, transparent navigation, and improved interaction flow. These prototypes informed the implementation of redesigned interface components, including streamlined menus, multi‑step registration forms …

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Impacts On Knee And Ankle Joint Stiffness During Walk And Stair Negotiation For Individuals With Acl-R And Oa, Genavieve J. Golightly, Nicholas L. Hunt, Tyler N. Brown Apr 2026

Impacts On Knee And Ankle Joint Stiffness During Walk And Stair Negotiation For Individuals With Acl-R And Oa, Genavieve J. Golightly, Nicholas L. Hunt, Tyler N. Brown

2026 Undergraduate Research Showcase

Knee injuries, including those requiring anterior cruciate ligament reconstruction (ACLR), are associated with numerous degenerative outcomes, including the progression of osteoarthritis (OA). Although reconstructive surgery and physical therapy are available treatment options, OA progression following knee joint injury continues to leave many individuals facing premature joint degeneration. Increased joint stiffness is a common consequence of knee joint injury and is seen in many patients who have undergone ACLR, and may be a contributing factor in the acceleration of OA by creating an environment of concentrated stress on knee cartilage, thereby promoting joint degeneration. It is unclear whether knee injuries alter …

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The Impact Of Glyphosate On Parkinson’S Pathology In A Mouse Model, Katie Hettel, Kaitlyn Carver, Sabrina Wilson, Trevor Walker, Tyra Naymik, Sydney Boutros Apr 2026

The Impact Of Glyphosate On Parkinson’S Pathology In A Mouse Model, Katie Hettel, Kaitlyn Carver, Sabrina Wilson, Trevor Walker, Tyra Naymik, Sydney Boutros

2026 Undergraduate Research Showcase

Parkinson’s Disease (PD) is characterized by a progressive loss of dopamine neurons in the brain, leading to symptoms such as tremors, poor balance and bradykinesia. PD has a unique pathology: Lewy bodies, which are primarily comprised of phosphorylated alpha-synuclein (p-Syn), spread through synaptic connections. Yet, it is unclear how the first Lewy body starts. Recently, evidence suggests that environmental influences such as pesticides and herbicides might initiate PD pathology. The most widely-used herbicide is glyphosate, the main chemical in products such as RoundUp. Thus, we tested if glyphosate in water could lead to PD-like pathology in a mouse model. A …

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Marker-Less Motion Capture Underestimates Foot Strike Angle During Walk And Run Tasks, Mikala A. Hicks, Aidan M. Thayer, Tyler N. Brown Apr 2026

Marker-Less Motion Capture Underestimates Foot Strike Angle During Walk And Run Tasks, Mikala A. Hicks, Aidan M. Thayer, Tyler N. Brown

2026 Undergraduate Research Showcase

A larger foot strike angle (FSA, shift towards rearfoot strike) during locomotion may increase risk of lower-limb musculoskeletal injury risk by resulting in larger, faster vertical ground reaction forces. Recent advances in low-cost, portable marker-less motion capture have shown promise for accurate kinematic analysis of locomotion. Yet it is unknown if marker-less motion capture can accurately quantify FSA during common walk and run tasks. This study sought to be the first to quantify FSA with marker-less motion capture, and compare accuracy of marker-less derived FSA with FSA derived with marker based motion capture (gold standard) during a battery of walk …

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Identifying Mosquito Species From Gyrfalcon Nests In Nome, Alaska, Zosha Kocemba, Annastasia Waters, Michael Henderson, Kara Beer, Travis Booms, Carly L. Tolle, Anna Grimstein, Stephanie J. Galla Apr 2026

Identifying Mosquito Species From Gyrfalcon Nests In Nome, Alaska, Zosha Kocemba, Annastasia Waters, Michael Henderson, Kara Beer, Travis Booms, Carly L. Tolle, Anna Grimstein, Stephanie J. Galla

2026 Undergraduate Research Showcase

Climate change in the Arctic is accelerating much faster than the rest of the globe, changing the disease ecology of Arctic environments. A prime example of this are disease carrying mosquitoes (Family: Culicidae) expanding their realized habitats and interacting with new animal hosts. To understand this changing disease ecology in the new Arctic, methods to identify disease vectors- like mosquitoes- are needed. This study aims to identify mosquitoes that may carry avian malaria (Plasmodium spp.) taken from nests of immunologically naive Arctic Gyrfalcons (Falco rusticolus). This ongoing study focuses on characterizing mosquito species found in Gyrfalcon nests …

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Usa V. Jacob Montague Apr 2026

Usa V. Jacob Montague

2026 Decisions

USDC for the Eastern District of Pennsylvania

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The Scarlet - Volume Civ, No. 11 (April 24, 2026), Scarlet Staff Apr 2026

The Scarlet - Volume Civ, No. 11 (April 24, 2026), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The April 24, 2026 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

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The Pam-1 Aminopeptidase Does Not Protect Against Ptl-1 Mediated Neurodegeneration In C. Elegans., Ethan E. Schuff Apr 2026

The Pam-1 Aminopeptidase Does Not Protect Against Ptl-1 Mediated Neurodegeneration In C. Elegans., Ethan E. Schuff

Honors College Theses

Debilitating neurodegenerative conditions are increasingly prevalent in our aging population, yet treatment options remain limited. Though neurodegenerative diseases vary in pathophysiology and clinical manifestations, these diseases are related to one another in that many involve misfolded proteins. Tau is a member of the microtubule-stabilizing MAPT/MAP2/MAP4 family, and misfolded tau proteins form the neurotoxic aggregates called neurofibrillary tangles (NFTs) found in the brains of patients with Alzheimer's disease and other neurodegenerative diseases. Designing a study to elucidate the neurotoxic role of tau is difficult because other MAPs may have compensatory mechanisms which confound study data. Caenorhabditis elegans (C. elegans) …

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A Pentadic Rhetorical Analysis Of Malala Yousafzai’S Address To The United Nations’ Youth Assembly, Alexis Rehm Apr 2026

A Pentadic Rhetorical Analysis Of Malala Yousafzai’S Address To The United Nations’ Youth Assembly, Alexis Rehm

Pepperdine Journal of Communication Research

This paper is a rhetorical criticism of Malala Yousafzai’s 2013 address to the United Nations Youth Assembly using Kenneth Burke’s pentad. Malala Yousafzai’s address was delivered less than one year after surviving an assassination attempt by the Taliban. The address reframes access to education as a shared moral responsibility rather than a personal or political issue. By analyzing the scene, act, agent, agency, and purpose, this analysis shows how Malala constructs rhetorical authority through personal narrative, forgiveness, and moral appeal. Her speech positions education as a universal human right and challenges global audiences to move from sympathy to accountability.

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Between The Middle Kingdom And The Middle Way: An Analysis Of State Power And Sacred Authority In The Sino-Tibet Conflict, Madison M. Berry, Aimee N. Ebeling, Jayden A. Hanson Apr 2026

Between The Middle Kingdom And The Middle Way: An Analysis Of State Power And Sacred Authority In The Sino-Tibet Conflict, Madison M. Berry, Aimee N. Ebeling, Jayden A. Hanson

Pepperdine Journal of Communication Research

This research paper addresses the growing concerns of the Sino-Tibetan conflict by analyzing the relationship between the People’s Republic of China (PRC) and the Tibetan Autonomous Region (TAR) through an intercultural communication and negotiation lens. By analyzing historical relationships between the two parties and comparing them to similar contemporary situations, this paper examines the sinicization of the Tibetan people. By exploring the “Old Tibet” and “New Tibet” narratives, while acknowledging the centrality of the Dalai Lama to both parties, it also addresses territorial disagreements and the contrasting understandings of sovereignty and modernization, which fuel the conflict. Finally, a policy framework …

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Partnership For Observation, Leadership, And Arctic Resilience (Polar): Strengthening Eu–Us Cooperation Through Technology, Trade, And Arctic Governance, Nikki Quartuccio, Emily White Apr 2026

Partnership For Observation, Leadership, And Arctic Resilience (Polar): Strengthening Eu–Us Cooperation Through Technology, Trade, And Arctic Governance, Nikki Quartuccio, Emily White

Pepperdine Journal of Communication Research

This speech was presented at the EU Delegation to the United States’ 2026 Schuman Challenge. The Schuman Challenge is an academic competition for U.S. undergraduate students to debate transatlantic issues, judged by a panel of stakeholders. The prompt for this speech was to create a policy that analyzes a current issue area in the E.U.-U.S. transatlantic relationship and suggests ways to strengthen it in the years ahead. Our policy, POLAR, the Partnership for Observation, Leadership, and Arctic Resilience, establishes a neutral, AI-enabled early-warning and consultation mechanism hosted within the International Maritime Organization (IMO). By institutionalizing shared situational awareness, structured clarification …

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Analysis Toolkit For Potential Lunar Landing Zones, Jacobo Matallana Apr 2026

Analysis Toolkit For Potential Lunar Landing Zones, Jacobo Matallana

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Science and Engineering Morehead State University in partial fulfillment of the requirements for the Degree Master of Science by Jacobo Matallana on April 24, 2026.

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How Additive Manufacturing Is Changing The Automotive Industry, Gavin B. Schumacher Apr 2026

How Additive Manufacturing Is Changing The Automotive Industry, Gavin B. Schumacher

Honors Theses

No abstract provided.

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Global Comparison Of Radiation Safety And Patient Dose In Chest X-Ray Imaging: Practices In The Usa, Africa, And Asia, Khanh L. Ha, Kevin Tran, Ikhlas Musa Apr 2026

Global Comparison Of Radiation Safety And Patient Dose In Chest X-Ray Imaging: Practices In The Usa, Africa, And Asia, Khanh L. Ha, Kevin Tran, Ikhlas Musa

Research Methods Poster Session 2026

No abstract provided.

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From Burnout To Resilience: Evidence-Based Strategies To Promote Nurse Well-Being, Rachell Nguyen Apr 2026

From Burnout To Resilience: Evidence-Based Strategies To Promote Nurse Well-Being, Rachell Nguyen

Creating Healthy Work Environments (CHWE)

Purpose: To review and translate evidence-based interventions into practical strategies for promoting mental health, preventing burnout, and fostering resilience among nurses.

Background: Nurses are experiencing unprecedented challenges to mental health and well-being, calling for the systematic adoption of research-supported interventions to maintain the workforce and improve patient care outcomes.

Methods: A comprehensive review of evidence-based interventions was conducted across individual, interpersonal, and organizational levels, focusing on promoting nurses' mental health, preventing burnout, and building resilience.

Findings: Mental health promotion has strong empirical backing through mindfulness-based interventions, as shown by systematic reviews that consistently report reductions in stress and anxiety. Peer …

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Caregiving For Older Adults: How The Child And Dependent Care Credit Could Help, Gabrielle Pepin, Yulya Truskinovsky Apr 2026

Caregiving For Older Adults: How The Child And Dependent Care Credit Could Help, Gabrielle Pepin, Yulya Truskinovsky

Upjohn Institute Policy and Research Briefs

No abstract provided.

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Are You Lost? Developing A Map (Metadata Application Profile) For Your Institutional Repository, David Advent, Connor Murphy Apr 2026

Are You Lost? Developing A Map (Metadata Application Profile) For Your Institutional Repository, David Advent, Connor Murphy

Library Faculty & Staff Presentations

Developing a MAP (Metadata Application Profile) for your Institutional Repository.

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Supply Chain And Analytics Students Help Business Tackle Ai And Operations Challenges, Aaron Sanborn Apr 2026

Supply Chain And Analytics Students Help Business Tackle Ai And Operations Challenges, Aaron Sanborn

UNH Today Archive

No abstract provided.

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Innovate Springfield's Ben Hage Named Director Of Illinois Wesleyan Petrick Idea Center, Ann Aubry Apr 2026

Innovate Springfield's Ben Hage Named Director Of Illinois Wesleyan Petrick Idea Center, Ann Aubry

Press Releases 2020-2029

No abstract provided.

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Active Coping Is Associated With An Increased Capacity For Resilience, Anna Kief, Patrick J. Cooper Apr 2026

Active Coping Is Associated With An Increased Capacity For Resilience, Anna Kief, Patrick J. Cooper

Student Publications and Presentations

This study investigated the impact of various coping styles on emotional resilience in college students. Coping styles refer to the ways people respond to everyday stress or challenges. This study focused on five major coping styles: wishful thinking (hoping problems will get better on their own), goal-oriented coping (implementing action to overcome challenges), seeking support (asking peers for help), thinking-coping (analyzing situations and developing solutions), and avoidance (ignoring or escaping problems). It was hypothesized that goal-oriented, seeking, and thinking-coping styles would positively correlate with resilience, while wishful and avoidance coping styles would negatively correlate with resilience. Preliminary results show that …

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Florida Tech Botanical Gardens Improvement: Raised Bridged Walkway Design, Peter Abdou, Logan Allen, Severiano Cartagena, Brennan Lackey, Miranda Schwartz Apr 2026

Florida Tech Botanical Gardens Improvement: Raised Bridged Walkway Design, Peter Abdou, Logan Allen, Severiano Cartagena, Brennan Lackey, Miranda Schwartz

Mechanical and Civil Engineering Student Publications

Design a flood-resilient pedestrian system using hydrologic and hydraulic modeling to improve safety, accessibility, and environmental performance within the Botanical Gardens.

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Lockheed Martin & U.S. Navy Air Pallet For Materials Handling, Samantha Ryan, Ryan Zerneke, Joshua Bible, Justin Conner, Brycen Haner, Nevan Juteram, Alexander Lacy, Gavin Lanka, Henry Lewis Apr 2026

Lockheed Martin & U.S. Navy Air Pallet For Materials Handling, Samantha Ryan, Ryan Zerneke, Joshua Bible, Justin Conner, Brycen Haner, Nevan Juteram, Alexander Lacy, Gavin Lanka, Henry Lewis

Mechanical and Civil Engineering Student Publications

The purpose of this project is to design, manufacture, and deliver an Air Pallet capable of lifting heavy loads and positively engaging with the Drive Tractor for movement. This project was developed to address current maintenance hazards and difficulty, structural integrity concerns, and increase system reliability for our customers Lockheed Martin and the United States Navy.

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3d Filament Recycler, Connor Easley, Stephan Jean-Baptiste, Armando Loynaz, Brody Paulk, Meagan Prouty, Tai Roberts, Jack Salcedo, Vanessa Tohorton, Alex Tremblay, Ruhaan Zaveri Apr 2026

3d Filament Recycler, Connor Easley, Stephan Jean-Baptiste, Armando Loynaz, Brody Paulk, Meagan Prouty, Tai Roberts, Jack Salcedo, Vanessa Tohorton, Alex Tremblay, Ruhaan Zaveri

Mechanical and Civil Engineering Student Publications

The purpose of the project is to design and manufacture an integrated system for the L3HSDC that can recycle 3D filament waste by shredding, heating, extruding, and spooling it.

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Psi Epsilon Station, Ember Clark, Zac Hardin, Jasper Stevens, Cole Capawana, Carter Tomasky Apr 2026

Psi Epsilon Station, Ember Clark, Zac Hardin, Jasper Stevens, Cole Capawana, Carter Tomasky

Mechanical and Civil Engineering Student Publications

Thermodynamics is one of the first classes an engineer will take, where you no longer learn practical ideas; instead, the concepts become theoretical. All of thermodynamics culminates in one of the most important cycles, the Rankine Cycle. This can be very overwhelming for students as everything they've learned throughout the semester is now being put into one cycle. The primary goal is to design and build an operational Rankine cycle to demonstrate to students how it works and what each component does.

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Variable Arm Reach Extender (Vare), Matthew Gorton, Adam Johnson, Kaleem Bocus, Quin Fredrickson, Vaughn Havins, James Koethe, Leira Maynard, David Mierzejewski, James Moore, Joonhyung Si Apr 2026

Variable Arm Reach Extender (Vare), Matthew Gorton, Adam Johnson, Kaleem Bocus, Quin Fredrickson, Vaughn Havins, James Koethe, Leira Maynard, David Mierzejewski, James Moore, Joonhyung Si

Mechanical and Civil Engineering Student Publications

Approximately 6.7% of the US population suffer from physical disabilities, producing the need for assistive devices. Amongst assistive equipment, reach-extenders have a 64% dissatisfaction rate..

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The Matear System, Kylie Strong, Adel Siraeva, Julianna Bartus, Lilly Davies, Cameron Deen, Rayna Doty, Amiana Mata, Jack Minners, Matthew Skwiot Apr 2026

The Matear System, Kylie Strong, Adel Siraeva, Julianna Bartus, Lilly Davies, Cameron Deen, Rayna Doty, Amiana Mata, Jack Minners, Matthew Skwiot

Mechanical and Civil Engineering Student Publications

The MATEAR attachment collects regolith simulant and uses compression and heat to form brick-like building blocks for sustainable infrastructure. It mounts to the Clearpath Robotics Husky A200 rover provided by the team’s faculty advisor.

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Lockheed Martin & U.S. Navy Drive Tractor, Nicolas Czincila, Andrew Pestone, Santiago Florez-Tascon, Kalvin Long, Nick Norman, Joseph Phan, Ashlynn Redding, Brandon Ribeiro, Noah Rodriguez, Diana Viherek, Mckenzie Winder Apr 2026

Lockheed Martin & U.S. Navy Drive Tractor, Nicolas Czincila, Andrew Pestone, Santiago Florez-Tascon, Kalvin Long, Nick Norman, Joseph Phan, Ashlynn Redding, Brandon Ribeiro, Noah Rodriguez, Diana Viherek, Mckenzie Winder

Mechanical and Civil Engineering Student Publications

The purpose of this project is to design and manufacture a manually operated, pneumatic-assisted Drive Tractor system for transporting heavy loads with the Air Pallet. This project was developed to improve maneuverability, reduce operator effort, and increase system reliability within industrial environments for our customers Lockheed Martin and the U.S Navy.

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Sparcc – Solar Panel Augmentation Via Regulated Cooling And Cleaning, Zachary Rodgers, Connor Fromme, Mohammed Al Jahwari, Jack Connor, Nicolas Hubley, Adrian Kingdollar, Iain Leroy, Maria Jesus Munoz, Ashton Stringer Apr 2026

Sparcc – Solar Panel Augmentation Via Regulated Cooling And Cleaning, Zachary Rodgers, Connor Fromme, Mohammed Al Jahwari, Jack Connor, Nicolas Hubley, Adrian Kingdollar, Iain Leroy, Maria Jesus Munoz, Ashton Stringer

Mechanical and Civil Engineering Student Publications

Problem Statement: Solar energy is the fastest-growing source of energy in the world. Solar cells lose efficiency by 0.35-0.7% per degree Celsius and up to 98% from debris build up. The primary objective of SPARCC was to improve cell efficiency through cooling and cleaning. A brush system with water spray was implemented to clean the panels, and a passive cooling system that utilizes a solar chimney, heat sinks, and phase change material to clean and cool.

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College Of Business Relocation Project, Genevieve Spitaletto, Nicky Vreeland, Matthew Loudon, Chris Fox Apr 2026

College Of Business Relocation Project, Genevieve Spitaletto, Nicky Vreeland, Matthew Loudon, Chris Fox

Mechanical and Civil Engineering Student Publications

Construct a modern, six-story College of Business building at Florida Tech that provides functional, accessible, and collaborative learning spaces while meeting all code requirements and supporting long-term campus growth.

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