Digital Commons Network^™

Cocktail-Party Listening And Cognitive Abilities Show Strong Pleiotropy, Samuel R. Mathias, Emma M. Knowles, Josephine Mollon, Peter T. Fox, Rene L. Olvera, Juan M. Peralta, Satish Kumar, Harald H. H. Goring, Ravi Duggirala, Joanne E. Curran, John Blangero, David C. Glahn

School of Medicine Publications

Introduction: The cocktail-party problem refers to the difficulty listeners face when trying to attend to relevant sounds that are mixed with irrelevant ones. Previous studies have shown that solving these problems relies on perceptual as well as cognitive processes. Previously, we showed that speech-reception thresholds (SRTs) on a cocktail-party listening task were influenced by genetic factors. Here, we estimated the degree to which these genetic factors overlapped with those influencing cognitive abilities.

Methods: We measured SRTs and hearing thresholds (HTs) in 493 listeners, who ranged in age from 18 to 91 years old. The same individuals completed a cognitive test …

Take Back Your Power: 10 New Rules For Women At Work Book Review, Tomi Daniel

Journal of Social, Behavioral, and Health Sciences

Deb Liu wrote Take Back Your Power to contribute her insights to the reckoning around the power imbalance that continues to disadvantage women in the workforce. The author reiterated that women must take back their power—whether they ceded it, had it taken from them, or never had it given them in the first place. Take Back Your Power is 240 pages of the author’s personal anecdotes and case studies of other women who experienced different nuances of power imbalance at work and how they overcame them. Written by a respected female leader who inched her way to the top in …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

Youth Mental Health Issues on the Rise: National Youth Advocacy and Resilience Research Center Awards Seed Grants for Faculty Research in Support of Local Youth Advocacy and Resiliency

Business Innovation Group Announces Patrick Woock as New Director of Business Incubation

School Of Nursing News, Georgia Southern University

Nursing: News & Publications (2013-2023)

• Milano Awarded First Place

Pedicle Screw-Associated Violation Of The Adjacent Unfused Facet Joint: Clinical Outcomes And Fusion Rates, Nathan J. Sinz, David Hanwuk Kim, Raymond W. Hwang, Gyu-Ho Lee, Kevin Charles Baker, Rick C. Sasso, Daniel K. Park, Jeffrey S. Fischgrund, Ruijia Niu

Conference Presentation Abstracts

INTRODUCTION: Lumbar spine pedicle screws are the most commonly utilized implants for providing immediate spinal stability during fusion surgery. Ideal pedicle screw positioning includes avoiding violation of any adjacent unfused facet joints. Nevertheless, inadvertent screw malposition and screw-associated violation of adjacent facet joints (FJV) remains a potential complication of the procedure regardless of whether surgery is performed in open fashion or with minimally invasive techniques and despite the use of intraoperative imaging or surgical navigation. Given the proximity of the lumbar vertebral pedicle to the proximal facet joint, FJV occurs almost exclusively at the level of the proximal as opposed …

Health And Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Graduate Sport Management Program Receives Two Rankings

College Of Engineering News, Georgia Southern University

College of Engineering & Computing: News & Publications (2010-2023)

• Local high schoolers explore engineering on Georgia Southern’s Armstrong Campus

Role Of Klotho And Age/Rage-Wnt/Β-Catenin Signalling Pathway On The Development Of Cardiac And Renal Fibrosis In Diabetes, Beatriz Martín-Carro, Julia Martín-Vírgala, Sara Fernández-Villabrille, Alejandra Fernández-Fernández, Marcos Pérez-Basterrechea, Juan F Navarro-González, Javier Donate-Correa, Carmen Mora-Fernández, Adriana S Dusso, Natalia Carrillo-López, Sara Panizo, Manuel Naves-Díaz, José L Fernández-Martín, Jorge B Cannata-Andía, Cristina Alonso-Montes

2020-Current year OA Pubs

Fibrosis plays an important role in the pathogenesis of long-term diabetic complications and contributes to the development of cardiac and renal dysfunction. The aim of this experimental study, performed in a long-term rat model, which resembles type 1 diabetes mellitus, was to investigate the role of soluble Klotho (sKlotho), advanced glycation end products (AGEs)/receptor for AGEs (RAGE), fibrotic Wnt/β-catenin pathway, and pro-fibrotic pathways in kidney and heart. Diabetes was induced by streptozotocin. Glycaemia was maintained by insulin administration for 24 weeks. Serum and urine sKlotho, AGEs, soluble RAGE (sRAGE) and biochemical markers were studied. The levels of Klotho, RAGEs, ADAM10, …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Assessing General Vs. Spinal Anesthesia As A Risk Factor For 90-Day Emergency Department Visits Status-Post Index Total Knee Arthroplasty: A Retrospective Case Control Study, Ian Penvose, Helen E. Huetteman, James Feng, Robert Runner, Drew Douglas Moore, Mark S. Karadsheh

Conference Presentation Abstracts

INTRODUCTION: As bundle payment care initiatives become ever prevalent in total knee arthroplasty (TKA), institutions have increasingly focused on cost-saving measures which maintain or improve upon the standard of care. One area of interest is identifying potential modifiable and non-modifiable risk factors. Here we evaluate the correlations of general versus spinal anesthesia in TKAs in perioperative outcomes. METHODS: All primary TKAs between 7/1/2013 to 12/31/2017 were obtained retrospectively from a prospective institutional database utilized for contribution to a state-wide joint arthroplasty database. Prospective data includes baseline demographics, select medical comorbidities, intraoperative variables and postoperative course/complications. Patients were separated into two …

Analysis Of The Effects Of Intraoperative Neurophysiological Monitoring On Anterior Cervical Surgery: A Michigan Spine Surgery Improvement Collaborative (Mssic) Study, Conner D. Ahlgren, Philip Zakko, Andrew Zachary Blankenship, Daniel K. Park

Conference Presentation Abstracts

INTRODUCTION: The utility of intraoperative neurophysiological monitoring (IOM) for anterior cervical surgery remains controversial. Despite insufficient evidence demonstrating a clear benefit, IOM continues to be utilized and in some areas is considered standard of care. The aim of this study was to evaluate the effects of IOM on anterior cervical surgery outcomes by utilizing data from the Michigan Spine Surgery Improvement collaborative. METHODS: Anterior cervical surgeries from February 2014 to November 2019 were included for analysis. IOM (EMG, MMG, SSEPs, or MEP) was the primary variable examined. Primary outcome measures were: new weakness after surgery, new radicular symptoms, return to …

Antonio Marquail Stevens

African American Funeral Programs

No abstract provided.

Engineering T Cells To Suppress Acute Gvhd And Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation, Feiyan Mo, Norihiro Watanabe, Kayleigh I Omdahl, Phillip M Burkhardt, Xiaoyun Ding, Eiko Hayase, Angela Panoskaltsis-Mortari, Robert R Jenq, Helen E Heslop, Leslie S Kean, Malcolm K Brenner, Victor Tkachev, Maksim Mamonkin

Faculty, Staff and Student Publications

Acute graft-versus-host disease (aGVHD) limits the therapeutic benefit of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and requires immunosuppressive prophylaxis that compromises antitumor and antipathogen immunity. OX40 is a costimulatory receptor upregulated on circulating T cells in aGVHD and plays a central role in driving the expansion of alloreactive T cells. Here, we show that OX40 is also upregulated on T cells infiltrating GVHD target organs in a rhesus macaque model, supporting the hypothesis that targeted ablation of OX40+ T cells will mitigate GVHD pathogenesis. We thus created an OX40-specific cytotoxic receptor that, when expressed on human T cells, enables selective …

Neurofibromatosis Type 1-Dependent Alterations In Mouse Microglia Function Are Not Cell-Intrinsic, Francesca Logiacco, Laura Cathleen Grzegorzek, Elizabeth C Cordell, Oliver Popp, Philipp Mertins, David H Gutmann, Helmut Kettenmann, Marcus Semtner

2020-Current year OA Pubs

We previously discovered a sex-by-genotype defect in microglia function using a heterozygous germline knockout mouse model of Neurofibromatosis type 1 (Nf1 ± mice), in which only microglia from male Nf1 ± mice exhibited defects in purinergic signaling. Herein, we leveraged an unbiased proteomic approach to demonstrate that male, but not female, heterozygous Nf1 ± microglia exhibit differences in protein expression, which largely reflect pathways involved in cytoskeletal organization. In keeping with these predicted defects in cytoskeletal function, only male Nf1 ± microglia had reduced process arborization and surveillance capacity. To determine whether these microglial defects were cell autonomous or reflected …

Prevalence Of Potentially Traumatic Events And Symptoms Of Depression, Anxiety, Hazardous Alcohol Use, And Post-Traumatic Stress Disorder Among People With Hiv Initiating Hiv Care In Cameroon, Angela M Parcesepe, Lindsey M Filiatreau, Peter Vanes Ebasone, Anastase Dzudie, Brian W Pence, Milton Wainberg, Marcel Yotebieng, Kathryn Anastos, Eric Pefura-Yone, Denis Nsame, Rogers Ajeh, Denis Nash

2020-Current year OA Pubs

BACKGROUND: This study explored the relationship between specific types of potentially traumatic events (PTEs) and symptoms of mental health disorders among people with HIV (PWH) in Cameroon.

METHODS: We conducted a cross-sectional study with 426 PWH in Cameroon between 2019-2020. Multivariable log binominal regression was used to estimate the association between exposure (yes/no) to six distinct types of PTE and symptoms of depression (Patient Health Questionnaire-9 score > 9), PTSD (PTSD Checklist for DSM-5 score > 30), anxiety (Generalized Anxiety Disorder-7 scale score > 9), and hazardous alcohol use (Alcohol Use Disorders Identification Test score > 7 for men; > 6 for women).

RESULTS: A …

Nirogacestat, A Γ-Secretase Inhibitor For Desmoid Tumors, Mrinal Gounder, Brian A Van Tine, Et Al.

2020-Current year OA Pubs

BACKGROUND: Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments.

METHODS: We conducted a phase 3, international, double-blind, randomized, placebo-controlled trial of nirogacestat in adults with progressing desmoid tumors according to the Response Evaluation Criteria in Solid Tumors, version 1.1. Patients were assigned in a 1:1 ratio to receive the oral γ-secretase inhibitor nirogacestat (150 mg) or placebo twice daily. The primary end point was progression-free survival.

RESULTS: From May 2019 through August 2020, a total of 70 patients were assigned to receive nirogacestat and 72 to receive placebo. Nirogacestat had a significant progression-free survival benefit …

The Tetraspanin Cd53 Protects Stressed Hematopoietic Stem Cells Via Promotion Of Dream Complex-Mediated Quiescence, Zev J Greenberg, Luana Chiquetto Paracatu, Darlene A Monlish, Qian Dong, Michael Rettig, Nate Roundy, Rofaida Gaballa, Weikai Li, Wei Yang, Cliff J Luke, Laura G Schuettpelz

2020-Current year OA Pubs

The hematopoietic stem cell (HSC) cycle responds to inflammatory and other proliferative stressors; however, these cells must quickly return to quiescence to avoid exhaustion and maintain their functional integrity. The mechanisms that regulate this return to quiescence are not well understood. Here, we show that tetraspanin CD53 is markedly upregulated in HSCs in response to a variety of inflammatory and proliferative stimuli and that the loss of CD53 is associated with prolonged cycling and reduced HSC function in the context of inflammatory stress. Mechanistically, CD53 promotes the activity of the dimerization partner, RB-like, E2F, and multi-vulva class B (DREAM) transcriptional …

Who Cares? A Scoping Review On Intellectual Disability, Epilepsy And Social Care, Hannah Newman, Sonya Rudra, Lisa Burrows, Samuel Tromans, Lance Watkins, Paraskevi Triantafyllopoulou, Angela Hassiotis, Alexandra Gabrielsson, Rohit Shankar

Peninsula Medical School

PurposeNearly a quarter of people with Intellectual disability (PwID) have epilepsy. Many have seizures across their lifetime. In the UK supporting their epilepsy linked risks and needs, particularly in professional care settings and in the community, requires significant social care input. Therefore, the interface between social and health care services is important. This study aim is to identify key intersectional areas of social provision for PWID and epilepsy.MethodsA scoping review of the literature was performed in accordance with PRISMA guidance with suitable search terms. The search was completed in CINAHL, Embase, Psych INFO, SCIE, and Cochrane electronic databases by an …

"Please Don't Assess Him To Destruction": The R.A.I.S.E. Assessment Framework For Primary Progressive Aphasia, Jeanne Gallée, Jade Cartwright, Anna Volkmer, Anne Whitworth, Deborah Hersh

Research outputs 2022 to 2026

Purpose: Speech-language pathologists (SLPs) assess people with primary progressive aphasia (PPA) through measurements of speech, language, communication, and well-being, with the aims of identifying challenges and strengths, monitoring change, and informing treatment directions and supports. The purpose of this clinical focus article is to highlight the necessity for person-centered assessment specific to PPA and to conceptualize a framework that acknowledges the multifaceted nature of assessment for this population. In this framework, the unique challenges posed by a diagnosis of PPA are addressed with the aim to provide practical guidance for clinicians and to support reflection on current practices. Method: In …

Factors Impacting Readiness To Perform Secondary Population-Based Triage During The Second Wave Of Covid-19 In Victoria, Australia: Pilot Study, Zachary B. Horn

Research outputs 2022 to 2026

Objective: Pandemics generate such a significant demand for care that traditional triage methods can become saturated. Secondary population-based triage (S-PBT) overcomes this limitation. Although the coronavirus disease (COVID-19) pandemic forced S-PBT into operation internationally during the first year of the pandemic, Australian doctors were spared this responsibility. However, the second wave of COVID-19 provides an opportunity to explore the lived experience of preparing for S-PBT within the Australian context. The aim of this study is to explore the lived experience of preparing to operationalize S-PBT to allocate critical care resources during Australia's second wave of COVID-19 in 2020. Methods: Intensivists …

The Repercussions Of The Corona Pandemic On Zayed University Students In Terms Of Psychological Aspects، Ways Of Thinking And Learning Methods, Sawsan Alskaf

An-Najah University Journal for Research - B (Humanities)

The study aimed at investigating the extent of the Covid-19 pandemic repercussions on the Zayed University student’s mentality by looking at the methods of adaptation with the news regarding it، and their attitudes towards shifting to the use of online platforms to persevere education. The researcher has done a special survey consisting on (25) paragraphs divided into three categories that has addressed results based upon the levels of mental anxiety of students between males and females. This process was conducted following the country and university efforts in facing the pandemic while continuing education using suitable and credible online platforms following …

“I’Ve Got Out At Last”: The Subversion Of Hegemonic Masculinity In Charlotte Perkins Gilman’S “The Yellow Wallpaper”, Ahmad Qabaha, Bilal Hamamra

An-Najah University Journal for Research - B (Humanities)

Drawing on Raewyn Connell’s concept “hegemonic masculinity” and engaging the critical line of feminism, this article argues that Gilman’s “The Yellow Wallpaper” unearths the institutional dynamics that sustain the masculine hegemonic discourse. This article reads this short story as counter-hegemony, the narrator of which critiques what Gramsci called “manufacture of consent”, wherein ideas and beliefs are shaped, and hegemony is reproduced, through culture. We argue that Gilman accounts for the ways in which gender hierarchy is maintained through consent rather than force, and she endorses a struggle over ideas and beliefs to create counter-hegemony that contests socially-constructed dominant ideas and …

Spatial Analysis Of Bank Locations In Irbid As An Indicator Of Urban Development, Qasem Al-Dowikat, Safaa Al-Wedyan

An-Najah University Journal for Research - B (Humanities)

This study aimed to reveal the spatial distribution pattern of Banks in the city of Irbid/Jordan. And analysis of variables that influenced the formation of this pattern. The study applied historical approach to trace the spatial spread of Banks, and how they relate to the stages of the city’s growth. Descriptive analytical approachis also appliedtoreveal the relationship between the distribution of Banks and population densities. Statistical and Cartographic analysis within (GIS) is used as well. Results showed a tremendous variation in the distribution of Banks among the areas, revealing a clear clustered pattern. Population density was not an affecting variable. …

The Effect Of A Proposed Training Program For The Foundation Course On Basic Skills And Body Composition Among Members Of Karate Clubs In The Governorate Of Jenin - Palestine, Ismail Zakarnah, Ghaith Nasief, Ahmad Nassar, Nashat Jabareen

An-Najah University Journal for Research - B (Humanities)

The study aimed to identify the effect of a proposed training program for the foundation course of the basic skills and body composition of the members of karate clubs in the governorate of Jenin – Palestine. The researchers used the experimental approach due to its suitability to the nature and objectives of the study. To achieve this, the study was conducted on a carefully chosen sample of karate clubs (the Talented Academy of Physical Fitness and self Defense, Arrabah Karate Club and Zababdeh Karate Club). The sample consisted of 50 members, 10 of those members were of exploratory sample, and …

Determinants Of Tax Revenues In Jordan, Mosab Bani Hani, Taleb Warrad

An-Najah University Journal for Research - B (Humanities)

This study aims to shed light on the reality of tax revenue and to identify its determinants in Jordan. This is done by analysing the impact of a set of economic and non-economic factors on tax revenue. Economic factors were represented by the real GDP, consumer price index CPI, foreign direct investment FDI, and economic openness, meanwhile, non-economic factors were represented by corruption and amendments to tax laws. In order to achieve its objectives, the study uses a descriptive method in addition to econometric analysis to time-series data for the period (1995-2019) using several models. Three econometric models were constructed: …

The Problematic Linguistics In Building Second Generation Curricula 'Linguistic Approach In The Curriculum Of The Fourth Year Of Primary Education', Nouari Saoudi

An-Najah University Journal for Research - B (Humanities)

The research is an applied linguistic approach, based on the content analysis method .Its topic is how to deal with the problematic linguistics, and its manifestations in the curricula of the second generation in Algeria, taking the Arabic language curriculum for the fourth year of primary school-as it is the last school year that has been reformed (2018) -as a sample for study and analysis .In this study, we will focus on the procedural handling of the curricula in the following points: its dealing with linguistic activities, its view of the functional roles that the Arabic language can advance in, …

Risks Of Dealing With Gold In Islamic Financial Institutions, Omima Al-Refai

An-Najah University Journal for Research - B (Humanities)

The study deals with the issue of gold and the risks of dealing in it Islamic financial institutions. In view of the risks faced by Islamic financial institutions as a result of their dealings with Gold.as the study included the concept of Gold and its importance and factors affecting its prices and rulings in Islamic Fiqh then explaining the risks of dealing with gold in Islamic Finance contracts for participation, trade-offs and authentications, and the risks of dealing with gold in banking services Islamic such as documentary credits letters guarantee and clearing, and finally its risks in the Islamic financial …

Perianth Interior Design, Hilary Unger

Seminar in Textiles and Clothing

Interior design combines art and creativity with running a business. Hilary Unger, a 1987 URI Graduate, gained experience in New York City design firms before launching her own business, Perianth, in 2001. Hilary discussed the concepts of design, communication, and business. She gave an example of the design process using a current client's apartment.

Endnotes, Sdlp

Sustainable Development Law & Policy

No abstract provided.

Toxic Criminals: Prosecuting Individuals For Hazardous Waste Crimes Under The United States Resource Conservation And Recovery Act, Dr. Joshua Ozymy, Dr. Melissa Jarrell Ozymy

Sustainable Development Law & Policy

The U.S. Resource Conservation and Recovery Act (“RCRA”) contains criminal provisions which allow prosecutors to seek substantial penalties when individuals commit hazardous waste crimes involving significant harm or culpable conduct. However, our empirical understanding of enforcement outcomes is limited. We used content analysis of 2,728 criminal prosecutions derived from U.S. EPA criminal investigations from 1983 to 2021 and examined all prosecutions of individual defendants for RCRA violations. Our results show that 222 prosecutions were adjudicated, with over $72.9 million in monetary penalties, 755 years of probation, and 451 years of incarceration levied at sentencing. Seventeen percent of prosecutions centered on …