Digital Commons Network^™

Development And Validation Of A Novel Decision Aid For Walant Hand Surgeries: Investigating Patient Preferences, Majd Faraj Bs, Alex Lindahl Bs, Shreya Balusu Bs, Rachel Feldstein Ba, Charles S. Day Md, Mba, Elizabeth King Md, Andrew Baron Md

Medical Student Research Symposium

INTRODUCTION: This study aims to develop a novel decision aid packet (DAP) for hand surgery patients deciding between Wide-Awake-Local-Anesthesia-No-Tourniquet (WALANT) and traditional anesthesia.

METHODS:

Development:

The DAP was developed following International Patient Decision Aid Standards.

Validation:

Alpha Testing

Seven hand surgeons experienced in WALANT and traditional surgeries belonging to the WALANT Research Consortium in the U.S. commented on the DAP through three rounds of editing utilizing the Delphi method. Seven patient advocates provided readability feedback.

Beta Testing

Orthopedic hand surgery patients were assigned to the control or experimental group. The experimental group was given the DAP pre-surgery. Both groups completed …

Understanding Asthma Care And Management Challenges In Pediatric Patients, Alexander Wind, Priya Spencer, Amy Delaroche

Medical Student Research Symposium

Background:

Asthma is a common pediatric health condition with highly variable manifestations. It may require daily management with medications and lifestyle adjustments throughout childhood. Due to the varied severity of the disease, effective management of asthma can place undue demands and challenges on asthmatic children and their families.

Objective:

To understand the challenges families face in managing their child’s asthma.

Methods:

Currently ongoing since November 18, 2021, this study enrolls 5-11 years old presenting with an acute asthma exacerbation to the emergency room of a tertiary care children’s hospital. We use structured questionnaires to collect information on …

Assessment Of The Nanodropper Eye Drop Adaptor For Glaucoma Medications, Nicholas Pryde, Parker J. Williams, Faisal Ridha Al-Timimi, John Michael Guest

Medical Student Research Symposium

Assessment of the Nanodropper Eye Drop Adaptor for Glaucoma Medications

Nicholas Pryde, BS¹; Parker J. Williams, DO ¹; John-Michael Guest, MD¹; Bret A. Hughes, MD¹; Faisal Ridha MD¹

¹Kresge Eye Institute and Wayne State University Department of Ophthalmology, Detroit, MI, USA

Purpose: To determine the dispensed volume change for seven medications with and without the Nanodropper adaptor.

Methods: Sequentially, 100 µL of each medication was dispensed by micropipette into a 1.5 mL Eppendorf tube, and mass without the tube was determined with a precision balance (Practum, Germany). The mean mass was …

Gender Disparities In The Diagnosis Of Sleep Disordered Breathing, Kenna Haile, Nesrine Ibrahim, Safwan Badr, Apala Vaishnav

Medical Student Research Symposium

Introduction: Current diagnostic guidelines for sleep disordered breathing (SDB) require that apneas and hypopneas be accompanied by a 4% desaturation for it to constitute a respiratory event (AHI-Accepted). However, the American Academy of Sleep Medicine recommends expanding the diagnostic criteria to include apneas and hypopneas accompanied by a 3% desaturation or a cortical arousal for diagnosis (AHI-Recommended). We hypothesized that a clinical sample of both men and women would demonstrate that women are more likely to be misdiagnosed using the accepted criteria compared to the recommended criteria.

Methods: The clinical sample consisted of all patients receiving a PSG at the …

Residential Racial Segregation And Neighborhood Adversity: Associations With Hemoglobin A1c In Adolescents With Type 1 Diabetes, Zechariah Jean, April Carcone, Deborah Ellis

Medical Student Research Symposium

Black adolescents with Type 1 Diabetes (T1D) are at increased risk for disparities in health outcomes. More research is necessary on the effects of neighborhood characteristics such as residential racial segregation (RRS) and neighborhood adversity on health.

149 Black youth with T1D were recruited from seven pediatric diabetes clinics in Detroit and Chicago to participate in a clinical trial to improve diabetes management. RRS was calculated at the census block group level based on US census data using Location Quotients. LQs represented the ratio of patients to total population in the block group compared to the same ratio in the …

High Output Heart Failure, A Lethal And Forgotten Cause Of Heart Failure, Neiberg A. Lima Md, Ian Detroyer Bs, Saman Razzaq Md, Oluwale Adegbala Md, Preeti Ramappa Md

Medical Student Research Symposium

Introduction

Cardiac output (CO) is usually low or normal in patients with heart failure. However, some patients have a high CO deemed high-output heart failure (HOHF). HOHF is not well characterized and continues to be under-recognized clinically. At the Detroit VA, we conducted a quality improvement project to define the characteristics of this unique patient population, identify predictors and increase awareness of this entity.

Methods

Patients with HOHF were compared to patients with heart failure with preserved ejection fraction (HFpEF) and normal CO. HOHF was defined as CO >8 L/minute on right heart catheterization performed between 2008-2021. Retrospective data regarding …

Dueling Active Surveillance: Does Utilization Of Active Surveillance For Low Risk Prostate Cancer Correspond With Utilization Of Active Surveillance For Small Renal Masses?, Sophie Wittenberg, Kevin Ginsburg Md, Michael Wang Md

Medical Student Research Symposium

Background: Active surveillance (AS) is the recommended management strategy for low-risk prostate cancer (LR CaP) and has also been shown to be safe for management of small renal masses <4cm (SRM). We assessed surgeon-level practice patterns for the use of AS in two different genitourinary malignancies: LR CaP and SRM.

Methods: We retrospectively reviewed the Michigan Urological Surgery Improvement Collaborative’s (MUSIC) prospectively maintained prostate and kidney registries to identify surgeons that managed at least 10 patients with SRMs and 10 patients with LR CaP from 2017-2021. The outcome was to assess for an association between AS for LR CaP with AS for SRMs among MUSIC surgeons.

Results: 27 urologists met inclusion criteria. 82% of men with LR CaP …

Signaling The Signaler: What Do Radiology Directors Advise Radiology Applicants About The Supplemental Application?, Harika K. Bollineni, Nathan Sim, Unie Háng, Ahmed Ayantayo, Arif Musa Md, Ali Harb Md

Medical Student Research Symposium

No abstract provided.

Glutamate, And Its Relationship To Task-Induced Functional Connectivity In The Human Brain: A Focus On Schizophrenia, Kathleen Liu Young, John Kopchick, Jeffrey Stanley, Vaibhav Diwadkar

Medical Student Research Symposium

Glutamate is the brain’s major excitatory neurotransmitter mediating both neuroplasticity and network function (Zhou & Danbolt, 2014). Basal glutamate (Glu) measured using proton magnetic resonance spectroscopy (1H-MRS) provides insight into a region’s density of neuropil related to the glutamatergic system. Moreover, given the role of glutamate in mediating brain network function, Glu levels may play a role in the brain’s functional connectivity (FC), which is typically estimated from functional magnetic resonance imaging (fMRI) time series data. These questions converge when considering the clinical syndrome of schizophrenia (SCZ). Patients with SCZ show abnormalities in basal Glu in the hippocampus and prefrontal …

Preoperative Promis Depression Scores Can Predict Failure To Improve After Trapeziectomy And Lrti, Shreya Balusu, Hardy Evans Md, Eric Jiang Md, Matthew Myhand, Noopur Ranganathan, Charles Day Md

Medical Student Research Symposium

INTRODUCTION: Patient-Reported Outcomes Measurement Information System (PROMIS) scores have been utilized in setting realistic post-intervention expectations. Having a model to stratify likelihood of improvement based on pre-operative variables may allow for better decision making and patient counseling. We hypothesized that preoperative PROMIS scores correlate with patients’ subjective level of improvement after trapeziectomy and ligament reconstruction with tendon interposition (LRTI)

METHODS: Retrospective chart review was performed to identify patients who underwent trapeziectomy and LRTI. Demographic data along with preoperative PROMIS Upper Extremity (UE), Pain Interference (PI), Depression (DP), and QuickDASH (QD) scores were collected. At their follow-up appointment, patients were asked …

The Effects Of Different Antihypertensives, Steroids, And Beta Blockers On Covid-19 Outcomes In A Ckd And Non-Ckd Cohort In Detroit, Michigan, Vidhya Nadarajan, Maham Ahmed, Katerina Furman, Zoya Gurm, Priyanka Kale, Zaina Khoury, Paul Kim, Sara Koussa, Dana Labuda, Margo Mekjian, Pooja Polamarasetti, Charlotte Thill, Sophie Wittenberg, Sorabh Dhar, Dragana Komnenov

Medical Student Research Symposium

Initial studies during the COVID-19 pandemic reported angiotensin converting enzyme 2 inhibitors (ACE2i) could be associated with worse disease course due to potential increase in ACE2 receptors which SARS-CoV2 virus uses for cellular entry. Subsequent studies refuted such concerns, reporting that continued use of ACEis and angiotensin receptor blockers (ARBs) in hypertensive individuals is protective. However, there remains a paucity of data evaluating effects of various antihypertensive medications, steroids, and beta blockers in chronic kidney disease (CKD) populations and in individuals with normal kidney function. This study was designed to evaluate the potential risks associated with antihypertensive medications and COVID-19 …

Preoperative Promis Depression Scores Can Predict Failure To Improve After Trapeziectomy And Lrti, Shreya Balusu, Hardy Evans Md, Eric Jiang Md, Matthew Myhand, Noopur Ranganathan, Charles Day Md

Medical Student Research Symposium

Introduction

Patient-Reported Outcomes Measurement Information System (PROMIS) scores have been utilized in setting realistic post-intervention expectations. Predicting likelihood of improvement based on pre-operative variables may allow for better decision-making and patient counseling. We hypothesized that preoperative PROMIS scores correlate with patients’ subjective level of improvement after trapeziectomy and ligament reconstruction with tendon interposition (LRTI)

Methods

Retrospective chart review was performed to identify patients who underwent trapeziectomy and LRTI. Preoperative PROMIS Upper Extremity (UE), Pain Interference (PI), Depression (DP), and QuickDASH (QD) scores were collected. At follow-up appointments, patients were asked an anchor question: “Since your treatment, how would you rate …

High Variability Exists In Reporting Clinical And Patient-Reported Outcome Measures Following Meniscal Surgery, Leah Shephard, Varag Abed, Michael Nichols, Andrew Kennedy, Camille Khalily, Caitlin Conley, Cale Jacobs, Austin V. Stone

Medical Student Research Symposium

Purpose: To evaluate the variability in outcomes following surgical meniscal repair and compare responsiveness between patient reported outcome measures (PROMs).

Methods: A systematic search of the PubMed/MEDLINE and Web of Science databases was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A total of 257 unique studies met inclusion criteria. Patient and study attributes were extracted, including pre- and postoperative means for PROMs. Of the studies that met inclusion criteria for responsiveness analysis (2+ PROMs reported, 1-year minimum follow-up; n=172), we compared the responsiveness between PROM instruments using effect size and relative efficiency (RE) if …

Assessing Accessibility And Equity Of Autism Spectrum Disorder Screening Tools, Kiernan S. Bloye, Joseph Aderemi Md, Roman Grossi, Tessa Hampton, Melissa Maye Phd

Medical Student Research Symposium

Introduction: Disparities to accessing autism spectrum disorder (ASD) screening tools have been demonstrated across race, ethnicity, socioeconomic status, and language. Additionally, there are concerns that existing screening tools are not as accurate for minoritized individuals. Thus, it is likely that level 1 screening tools must be adapted and developed for, and with, marginalized populations in the United States to promote increased levels of universal screening access and accuracy among minoritized populations.

Methods: Using the PRISMA scoping review checklist, an initial search produced 1880 unique records. Following title and abstract review, 35 articles met criteria for full manuscript review. Finally, 7 …

Assessing Peer Mentor Skill Development In Participating In A Novel Medical Student Mentoring Initiative, Chelsea Yu, Dhruvil Patel, Jack Considine, Madison Graifman, Kyla Kosidowski, Megan Seyerle, Elise Turke, Kathleen Young, Sahar Elmenini, Nicole White, Latoya Sherman, Eric Ayers Md

Medical Student Research Symposium

Background
Learning communities in medical schools create a bridge for senior students to engage with junior peers, providing advice and support as mentors. In this process, mentors are likely to gain skills in communication, empathy, and leadership - well received traits for residency.

Methods
We aim to elucidate an objective measure of mentor growth and development during the mentorship program. We will evaluate opinions on the program's ability to foster professional attributes including leadership, communication, and empathy; determining features that benefit them while assessing for paradigms of improvement. We will survey 24 M2-students through self-rated queries on a Likert scale. …

Determining Access Of In-Person Vs Virtual Clinic Visits In Orthopedic Medicine, Mithil Gudi, Nevil Khurana, Nicholas Livingston, Ahmad Chouman, Jack T. Mcconnell, Charles S. Day Md, Mba

Medical Student Research Symposium

INTRODUCTION: Virtual visits in orthopedics provide added benefits compared to in-person visits. We hypothesize that virtual visits will offer patients greater same-day and future access to orthopedic physicians.

METHODS: Two previously established methodologies were used to measure orthopedic surgeons: same-day and third-next-available. Same-day access is analyzed using a ratio of unfilled to filled virtual return and in-person return appointments for every clinic day of each physician. Third-next-available is measured as the number of total non-clinic days and clinic days until each physician’s third next-available-virtual and in-person appointments.

RESULTS: For same-day access, the ratio of unfilled virtual to filled virtual appointments …

Outcomes Of Dupilumab Treatment In Patients Presenting With Severe Asthma Or Chronic Rhinosinusitis With Nasal Polyps, Over The Age Of 65, Keisha Arielle Best, Samiat Awosanya, Chandala Chitguppi, Marc Rosen, Mindy Rabinowitz, Elina Toskala, Gurston Nyquist, Jessica Most

Medical Student Research Symposium

Introduction:

Dupilumab is an IL-4/13 inhibitor that has been successfully implemented in the treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). The safety and efficacy of Dupilumab has not been reported for these indications in patients over the age of 65. This study aims to determine the long-term benefits of dupilumab while detailing adverse effects.

Methods:

This study is a single institution retrospective review of patients receiving dupilumab for severe asthma and/or CRSwNP from 2018 to present. Charts were reviewed for patient demographics, Sino-nasal Outcome Test (SNOT-22) scores, asthma control test (ACT) scores, polyp scores, and adverse …

Intravital Imaging Of Cellular Response Due To Traumatic Brain Injury Using Confocal Microscopy, Enoch G. Kim, Jeffrey Horbatiuk, Carolyn Harris

Medical Student Research Symposium

Introduction: Cellular reaction to traumatic brain injury is complex and involves considerable interactions between cells and reactivity to foreign bodies. Our objective was to assess neurons, microglia, astrocytes, and intracellular Ca²⁺ signaling by creating a novel confocal microscopy technique involving an air immersed lens that does not sacrifice resolution and limits signal attenuation. This study aimed to create a consistent dynamic methodology to observe the cortical cellular response using real-time intravital imaging as trauma is being induced.

Methods: Once surgical plane was achieved, rodent cortices were exposed via craniotomy and blunt insertion with a silicone shunt catheter into the …

Gender And Financial Implications Of Parental Leave Utilization At A Major Us Academic Institution, Maurgan Lee, Lucki Word, Mayra Shafique, Julie Crego, Leah Robinson Phd, Anil Aranha Phd, Beena Sood

Medical Student Research Symposium

Background and Purpose: In the United States, women on average are paid $0.83 for every dollar earned by male counterparts. Creating a family can promote heightened obligations for both parents, however, women tend to take on amplified responsibility associated with childrearing. Studies show females are more likely to utilize parental leave (PL) compared to men. Our study aims to evaluate the impact of PL usage on financial and earning potential based on gender.

Methods: Analysis of retrospective human resources data of WSU employees was conducted. Data parameters included: demographics, length, usage, and number of parental leaves. Data was analyzed using …

Sun Protection Intervention For Urban Youth, Erika Polanco, Jordan Tall, Erin Caris, Arjun Muralidharan, Michael Escobar, Sofia Howson, Jason Liu, Alyssa Goodwin, Steven Daveluy

Medical Student Research Symposium

Introduction:

Skin cancer is less prevalent in persons with darker skin color compared to those with light skin, but contrarily is associated with greater mortality rates. Experts agree this is primarily due to late detection. Challenges in early detection include low public awareness, uncommon presentation, lower index of suspicion among health care providers, and decreased access to specialty care. To address some of these barriers, we designed a survey-based study to discover current beliefs, perceptions, and attitudes of urban youth towards sun protection before and after an educational intervention.

Methods:

In 2022, 17 children living in metro Detroit …

Utility Of Autophagy In Treating Alzheimer’S Disease, Matthew H. Bautista, Jiani Hu

Medical Student Research Symposium

Alzheimer’s Disease (AD) is the most common cause of dementia in developed countries. The global prevalence is estimated to be as high as 24 million and is expected to continue growing. Despite more than 100 thousand papers on AD encompassing several decades of research, our understanding of the underlying pathogenesis remains limited, consequently contributing to the stagnancy in developing effective therapeutic treatment options. Enormous data in the literature provides opportunities to theoretically evaluate the most likely effective approach for this disease. By digging into the relationship between autophagy and risk factors of AD, we find that autophagy is directly or …

Do Lower Extremity Injuries Of Nfl Players Affect Their Yearly Income?, Abdullah Sahyouni, Robert De La Torre, Gautham Pavar, Kinan Sawar, Yasmeen Alcodray, Bohdan Matsko, Justin Bennie, Nicole Xu, Harika Bollineni

Medical Student Research Symposium

Introduction: Injuries are arguably the most daunting career setbacks professional sports players have to face. To better understand the drawbacks of sports injuries, we decided to examine players’ annual income before and after sports injuries. Income is arguably the most important metric of success for professional athletes. To make the study more relevant for the US, we collected data on one of the most viewed professional sports leagues in the country: the National Football League (NFL).

Methods: We examined the NFL’s weekly injury reports for seasons from 2016 to 2020, and recorded players with lower extremity injuries (LEI) (Hamstring, Calves, …

Radiated Immediate Prepectoral Direct To Implant Reconstruction: A Retrospective Cohort Study, Kinan Sawar, Tala Al-Saghir, Jamie Hall, Michael Diffley, Madeleine Gonte, Donna Tepper, Vigen Darian, Maristella Evangelista, Amy Tang, Dunya Atisha

Medical Student Research Symposium

Purpose: Increasing use of prepectoral plane in post mastectomy implant-based reconstruction has made immediate direct to implant (DTI) reconstruction more achievable. There has been increased incidence of post mastectomy radiation therapy (PMRT) making it important to understand the complication profile of immediate DTI reconstruction in patients who may require adjuvant radiation therapy.

Methods: A retrospective cohort study of consecutive patients undergoing prepectoral DTI reconstruction with and without PMRT was performed. Patient and treatment level factors, operative, and post-operative outcomes were extracted on both the patient and breast level for the prepectoral radiated and nonradiated patients. The presence of at least …

The Effect Of Anesthetic Drugs During Craniotomy On Patient Outcomes, Thomas Vander Woude, Timothy Nold, Katherine Nowak, Donald Penning

Medical Student Research Symposium

Glioblastoma remains an aggressive, highly malignant brain cancer with poor prognosis despite treatment options including surgery, radiotherapy, and chemotherapy. The objective of this retrospective chart review study was to evaluate if there is a correlation between the type and dose of anesthetic drugs administered during craniotomy surgery for glioblastoma and the time to first postoperative tumor progression and mortality. Based on preliminary data in mice, it was hypothesized that the use of propofol during surgery is associated with slower tumor progression and lower mortality, when compared with other anesthetic drugs. In the observed time frame, 133 patients were diagnosed with …

Evaluating The Role Of Lvi As An Indicator For Adverse Outcomes In Patients With Upper Tract Urothelial Carcinoma And Its Histological Subtypes, Ivan Rakic, Matthew Davis, Nicholas Corsi, Alexander Stephens, Chase Morrison, Sohrab Arora, Taylor Malchow, Akshay Sood, Craig Rogers, Firas Abdollah

Medical Student Research Symposium

Lymphvascular invasion (LVI) is recognized as an adverse prognostic factor in many cancers. Our aim is to assess the prognostic ability of LVI in UTUC urothelial carcinoma (UC) and micropapillary urothelial carcinoma (MPUC) subtypes as a predictor of overall survival (OS) using a large North American cohort.

Our cohort included 9750 cM0 UTUC patients who underwent a radical nephroureterectomy (RNU), between 2004 and 2015, within the National Cancer Database (NCDB). The main variable of interest was LVI status, and its interaction with pathological nodal (pN) status. Kaplan-Meier curves were used to estimate the OS. Cox regression analysis tested the impact …

Is Old Really Gold? Examining The Effect Of Playing Experience In Preventing Professional Athletes’ Injuries, Gautham Pavar, Abdullah Sahyouni, Robert De La Torre, Kinan Sawar, Yasmeen Alcodray, Justin Bennie, Nicole Xu, Harika Bollineni, Bohdan Matsko

Medical Student Research Symposium

Introduction: The literature contains research showing that age increases the risk of injury in individuals who live sedentary lives. Looking at injury rates in individuals who are active for a living can better inform the importance of exercise training regimens in an aging population

Methods: Combing player injury data from thet NFL and player statistics from pro-football-reference.com, we will create a dataset containing variables like seasons played in the NFL and age of player at time of injury. We will include all uninjured players in our dataset for comparison. We will use ANOVA to figure out how much these variables …

Do Lower Extremity Injuries Of Nfl Players Affect Their Contracts?, Shravan Morisetty, Robert De La Torre, Abdullah Sahyouni, Kinan Sawar, Yasmeen Alcodray, Gautham Pavar, Justin Bennie, Nicole Xu, Harika Bollineni, Bohdan Matsko

Medical Student Research Symposium

Introduction: There is likely a correlation between National Football League (NFL) players who endure lower extremity injuries (LEI) and the length and remuneration of subsequent contracts. This kind of data can be useful in training a model to predict how an injury may influence a player’s contracts in the future.

Methods: We examined the NFL’s weekly injury reports for seasons from 2016 to 2020, and recorded players with lower extremity injuries (LEI) (Hamstring, Calves, Groin, or Quadricep). We accessed pro-football-reference.com and spotrac.com to record player identifiers and individual annual salaries 3 years prior to the index injury and up to …

Analysis Of Opioid Prescription Patterns And Postoperative Opioid Use In Opioid-Naïve Patients Undergoing Elective Lumbar Spine Surgery, Tim Nold, Tarek Mansour, Edvin Telemi, Ariel Walker, Nachiket Deshpande

Medical Student Research Symposium

Title: Analysis of Opioid Prescription Patterns and Postoperative Opioid Use in Opioid-Naïve Patients Undergoing Elective Lumbar Spine Surgery

Background: Post-operative opioid prescribing patterns after elective spine surgery is a growing topic of concern, as over-prescribing can lead to potential medication dependence, while under-prescribing can lead to inadequate pain management.

Objective: The primary objective was to develop prescribing guidelines based upon the amount of opioids used in the first 2 weeks after lumbar spine surgery by 80% of patients.

Methods: Utilizing a prospective study design, opioid-naïve patients undergoing elective lumbar spine surgery at our institution were identified each week and preoperatively …

Which Position In American Football Is More Likely To Get You Benched Due To Lei? An Analysis Of Nfl Players Injured In The Years 2016-2020., Robert A. De La Torre, Abdullah Sahyouni, Kinan Sawar, Gautham Pavar, Cristian J. Diaz Alvarenga, Shravan Morisetty, Bohdan Matsko, Justin Bennie, Niyaz Uddin, Olvia Pakula

Medical Student Research Symposium

Title: Which position in American Football is more likely to get you benched due to LEI? An Analysis of NFL Players injured in the years 2016-2020.

Authors: Robert de la Torre, Abdullah Sahyouni, Kinan Sawar, Gautham Pavar, Cris J. Diaz Alvarenga, Shravan Morisetty, Justin Bennie, Bohdan Matsko, Niyaz Uddin, Olivia Pakula

Introduction:

In American Football, there are twenty-four different positional roles that a player may assume. Some positions are unique to offense, such as quarterback and wide receiver. Others are unique to defense, such as cornerback or linebacker. There are also unique positions such as kicker or punter. All of …

Differential Expressed Genes Identified Between African American And European American Keloid Fibroblasts, Bianca Parker Ms, Albert M. Levin Phd, Oghenefejiro Okifo Md, Katherine Buhl Bs, Takahiro Ouchi Bs, Jessica Tan Bs, Xiangguo Dai Phd, Yalei Chen Phd, Nallasivam Palanisamy Phd, Jesse Veenstra Md, Phd, Shannon Carskadon Ms, Jia Li Phd, David Ozog Ozong Md, Christian E. Keller Md, Dhananjay Chitale Md, Mba, Kevin R. Bobbitt Phd, Howard C. Crawford Phd, Nina Steele Phd, Qing-Sheng Mi Md, Phd, Lamont R. Jones Md, Mba

Medical Student Research Symposium

Keloids are benign fibroproliferative tumors due to dysregulation of collagen remodeling and abnormal wound healing. Although worldwide, there is a higher incidence of keloid disease (KD) in skin of color, little is known about this predisposition. In this study, we used one tissue micro array slide comprised of six AA and 6 EA punch biopsies of primary untreated keloid tissue from the head and neck area was created, following the NanoString® DSP Technology Access Program protocol. The GeoMx Human Whole Transcriptome Atlas Assay was performed, using morphology marker FAP. Polygonal region of interests selection strategy for Fibroblast Activation Protein (FAP) …