Digital Commons Network^™

A Peptide Mimetic Of Tyrosine Phosphatase Step: A Potential Therapeutic Agent For Treatment Of Stroke Under Hypertensive Condition, Seong Won Choi, Sathyanarayanan Rajagopal, Prabu Paramasivam, Ranjana Poddar, Surojit Paul

Brain & Behavioral Health Research Day

Background: Hypertension is a complex multifactorial disease that is influenced by both genetic and environmental factors. Although hypertension can develop at any age, the prevalence of hypertension is particularly evident in the aging population. It is also the most common comorbid condition in ischemic stroke patients and accounts for ~54% of all strokes. Despite advances in understanding the pathophysiology of stroke, current pharmacologic therapies are still limited to rapid reperfusion using thrombolytic agents, and neuroprotective approaches that can reduce the consequences of ischemic and reperfusion injury are still not available. To bridge this gap, we have evaluated the long-term efficacy …

Impact Of Two Different Rodent Diets On Maternal Ethanol Consumption, Serum Ethanol Concentration And Pregnancy Outcome Measures, Suzy Davies, Danika E. Nelson, Daniel D. Savage

Brain & Behavioral Health Research Day

Recent studies have reported that varying levels of ethanol consumption by rodents maintained on different commercially available laboratory diets, may impact offspring outcome measures. Here, we compared ethanol consumption by rats maintained on the Envigo 2920 diet used in our lab, with an isocalorically equivalent PicoLab 5L0D diet, used in some alcohol consumption studies.

Compared to the 5L0D diet, female rats maintained on the 2920 diet consumed 14% less ethanol during the daily four-hour drinking sessions prior to pregnancy and 28% less ethanol during gestation. While this difference did not affect litter size, maternal weight gain during pregnancy by 5L0D …

Slc7a5 (Lat1) Inhibition Alleviates Chemotherapy-Induced Neuropathic Pain, Sachin Goyal, Ian M. Adams, Sascha Ra Alles

Brain & Behavioral Health Research Day

Background: Chemotherapy-induced neuropathic pain (CINP) is a debilitating and difficult-to-treat side effect of chemotherapeutic drugs. Effective, non-addictive, non-opioid therapeutics are urgently needed for the treatment of chemotherapy associated chronic pain. Slc7a5 (Lat1), also known as system L-neutral amino acid transporter, is involved in a number of physiological processes related to inflammation. Transcriptomics studies have shown that Slc7a5 and its binding partner Slc3a2 are expressed in neurons of the dorsal root ganglia (DRG) and spinal dorsal horn, which are critical to the initiation and maintenance of nociception and pathophysiology of chronic pain. Here, we investigate the role of Slc7a5 in the …

Validation Of The Substance Use Protective Strategies Scale (Supss) Among U.S. College Students, Jakub Greń, Matthew R. Pearson, Dylan K. Richards, Addictions Research Team

Brain & Behavioral Health Research Day

Protective Behavioral Strategies (PBS) are behaviors that effectively reduce the likelihood of experiencing substance-related harms. Despite the fact that most individuals use more than one substance, previous research on PBS has been limited to substance-specific measurement, i.e. alcohol-specific (e.g., PBSS) and cannabis-specific (e.g., PBSM). We developed the Substance Use Protective Strategies Scale (SUPSS) to measure more general substance use PBS, which was preliminary validated among Polish young adults (aged 18-30) using various substances (Greń et al., 2023), sand sought to its further examination. Participants (N=1856) took part in a multisite research of substance use among college students recruited from 10 …

Rodent Models Of Subconcussive Brain Injury, Colin M. Wilson, Russell Morton, Afshin A. Divani, Kimberly Byrnes, Reed Selwyn

Brain & Behavioral Health Research Day

Subconcussion has been defined as a cranial impact or rapid acceleration-deceleration that does not result in clinically observable neurological signs or symptoms that would typically indicate a diagnosis of mild traumatic brain injury (mTBI) or concussion.¹ Low-level subconcussive impacts due to soccer ball heading have been reported to cause an acute, transient dysfunction in vestibular processing, which returns to baseline levels within 24 hours.² Although one or even several subconcussive impacts may have no lasting effects, there is increasing evidence that repeated subconcussive exposure over an extended period has the potential to cause significant neurological deficits. Among former …

Neurodevelopmental Transcription Factors Promote Proliferation, Regulate Cell Type, And Play Opposing Roles In Cellular Migration In Glioblastoma, Bianca L. Myers, Kathryn J. Brayer, Luis E. Paez-Beltran, Tou Yia Vue

Brain & Behavioral Health Research Day

Glioblastomas (GBM) make up ~50% of primary brain tumors and prognosis has not improved over the last 30 years. Despite the inherently high inter- and intratumoral heterogeneity of GBMs, basic-helix-loop-helix (bHLH) transcription factors, ASCL1 and OLIG2, are present in the majority of tumors. Previously, we showed in patient-derived GBM xenograft (PDX-GBM) that ASCL1 binds to promoter and enhancer regions of cell cycle genes, as well as neurodevelopmental transcription factors including OLIG2. Similarly, we showed that OLIG2 binding overlaps with the majority (~90%) of ASCL1 binding sites, including at promoter and/or enhancer regions of ASCL1 and OLIG1/2 loci, illustrating their …

Alcohol Consumption During Early Adulthood In A Preclinical Mouse Model Of Alzheimer’S Disease Leads To Gait Impairments, Dysregulated Circadian Rhythm, Alterations In Tauopathy And Brain-Region-Specific Transcriptional Alterations, N M. Maphis, D Furlano, S A. David, D N. Linsebardt

Brain & Behavioral Health Research Day

Alzheimer’s disease (AD) is a leading cause of cognitive dysfunction and death in the US attributable in part to the accumulation and spread of pathologically modified tau (pTau). Recently, excessive alcohol use, particularly binge drinking, has emerged as a risk factor for the development of AD. However, the neurobiological consequences underlying how excessive alcohol exposure might lead to the accumulation and/or progression of pTau and associated neurobehavioral deficits has not been fully explored. We used the binge-alcohol drinking paradigm, ‘drinking-in-the-dark’ (DID), in the P301S mouse model of tauopathy to test the hypothesis that excessive voluntary alcohol consumption during young adulthood …

Compensatory Functional Activation During Motion Discrimination In Parkinson’S Disease, Stetphanie Nitschke, Kayla Julio, Nicholas Shaff, Chris Wertz, David Stone, Andrei Vakhtin, Andrew Mayer, Elena K. Festa, William C. Heindel, David P. Salmon, Gerson Suarez Cedeno, Amandaa Deligtisch, Sarah Pirio Richardson, Sephira Ryman

Brain & Behavioral Health Research Day

Objective

PD patients commonly exhibit cognitive dysfunction early in the disease course which may or may not predict further cognitive decline. In contrast, early emergence of visuospatial and memory impairments are more consistent predictors of an evolving dementia syndrome. Prior studies using fMRI have demonstrated that PD patients exhibit hyperactivation dependent on the degree of cognitive impairment, suggestive of compensatory strategies. No study has evaluated whether PD patients with normal cognition (PD-NC) and PD patients with Mild Cognitive Impairment (PD-MCI) exhibit compensatory activation patterns during visuospatial task performance.

Participants and Methods

10 PD-NC, 12 PD-MCI, and 14 age and sex-matched …

Ksrp Reduces The Migration And Invasion Of Glioblastoma Cells And Restricts Angiogenesis Of Human Brain Microvascular Endothelial Cells, Pearl Huynh, Robert Oliver, Gabriela Perales, Amy S. Gardiner

Brain & Behavioral Health Research Day

Glioblastoma multiforme (GBM) is a highly aggressive and invasive brain tumor that has been continuously challenging to treat. Combined treatment strategies, including surgical resection, radiotherapy, and chemotherapy, have improved patient outcomes, however, median survival time is less than 15 months. Thus, there is a critical need for new therapeutic targets and approaches. KSRP is a multi-functional RNA-binding protein that acts post-transcriptionally to regulate mRNA stability, splicing, and transport, as well as the biogenesis and function of microRNAs and other non-coding RNAs. Several studies have shown that KSRP expression is significantly associated with prolonged survival of glioblastoma patients. We recently identified …

Alzheimer’S Disease-Associated Circhomer1 Can Inhibit The Expression Of Long App And Mapt Mrna Isoforms In The Frontal Cortex Via Competing For Binding To Hud, Madison Otero, Grigorios Papageorgiou, Sophie E. Eckel, Marissa R. Westenskow, Ibrahim El-Sharkawy, Niko Nykänen, Bruno A. Benitez, Carlos Cruchaga, Nikolaos Mellios

Brain & Behavioral Health Research Day

Circular RNAs (circRNAs) are a novel category of non-coding RNAs derived from the back-splicing and covalent joining of exons or introns. Recent studies have suggested that circRNAs are preferentially generated from synaptic plasticity-related genes and are particularly enriched in the brain. Although some circRNAs have been found to sequester microRNAs and others to associate with RNA-binding proteins (RBPs), the mechanism of action of most circRNAs remains poorly understood. Moreover, little is known about the potential involvement of circRNAs in Alzheimer’s disease (AD). Using circRNA-specific quantification, we had previously found that circHomer1, a neuronal-enriched circRNA derived from Homer protein homolog …

Modification Of Existing Head Circumference Charts For New Mexico Native American Children, Myranda Robinson, Holly Jones, Sahana Ummadi, Julianne Olguin, Jewel Meyer-Hagen, Hengameh Pajer, James Botros, Ariana Barkley, Orrin Myers, Heather Spader

Brain & Behavioral Health Research Day

Background

Current Centers for Disease Control (CDC) and World Health Organization (WHO) growth charts are based on normative data that do not adequately represent the distinct pattern of head growth observed by providers for New Mexican Native American children.¹ Therefore, Native American children with normal but larger head circumferences (HC), can be inaccurately diagnosed with macrocephaly and undergo unnecessary diagnostic workups.² The purpose of this study is to evaluate whether HCs for Native American children in New Mexico distribute differently than established growth charts.

Methods

This is an IRB-approved retrospective chart review of all Native American well-child visits …

The Bronze Age Armenian Artifact Decoded Via Cbb (Discovered In Lake Sevan, Armenia, During The 1950s By Archeologist), April Vihilidal

Brain & Behavioral Health Research Day

Background: Within the research paradigm in the cognition, brain, and behavior (CBB) group includes studies of sensation and perception, learning and memory, attention, mental imagery, and conceptual representation. The Bronze Age Armenian Artifact is an example of humans from the past using (CBB) to communicate with humans of the present. The artifact dates to the 11th-12th centuries BCE.

There are five ancient archeological sites related to the Bronze Age Armenian artifact via the planet's ley lines:

1) Mount Nemrut, Turkey, dates from the 1st century BCE.

2) Lake Sevan, Armenia, where the artifact was discovered.

3) Carahunge dates back 7,500 …

Brief Of Federal Courts Professor Derek T. Muller As Amicus Curiae In Support Of Petitioners, Christopher G. Michel, Rachel G. Frank, Isabel R. Peraza, Katherine Schroeder, Derek T. Muller

Court Briefs

No. 22-824
The Synod of Bishops of the Russian Orthodox Church Outside of Russia v. Alexander Belya

On Petition for a Writ of Certiorari to the United States Court of Appeals for the Second Circuit

From the Introduction and Summary of Argument

This case presents an exceptionally important question at the intersection of civil procedure and constitutional law. Under 28 U.S.C. § 1291, federal courts of appeals have jurisdiction over appeals from “final decisions of the district courts.” That provision, which “descends from the Judiciary Act of 1789,” has long been understood to confer appellate jurisdiction over more than just …

Central Pattern Generator And Control Of Breathing (Ośrodkowy Generator Wzorca I Kontrola Oddychania), Jaroslaw Richard Romaniuk

Faculty Scholarship

Fifty years ago, Clark and Euler published a model of the neural control of respiration that stimulated modern studies on the central generator of the rate and depth of breathing. These studies led to new discoveries concerning both anatomical localization and functional characteristics of respiratory central pattern generator (CPG), and as a result our knowledge has greatly changed. This article describes the history of respiratory CPG research and, more specifically, explains how studies concerning the regulation of breathing parameters affect the creation of new hypotheses and theoretical models of the neural control of respiration. Comparing studies on the generators of …

Neurochemical Effects Of Sepsis On The Brain, Tatiana Barichello, Vijayasree V Giridharan, Carlos Henrique R Catalão, Cristiane Ritter, Felipe Dal-Pizzol

Faculty, Staff and Student Publications

Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host immune response to eliminate an infection. After the host immune response is activated, a complex, dynamic, and time-dependent process is triggered. This process promotes the production of inflammatory mediators, including acute-phase proteins, complement system proteins, cytokines, chemokines, and antimicrobial peptides, which are required to initiate an inflammatory environment for eliminating the invading pathogen. The physiological response of this sepsis-induced systemic inflammation can affect blood-brain barrier (BBB) function; subsequently, endothelial cells produce inflammatory mediators, including cytokines, chemokines, and matrix metalloproteinases (MMPs) that degrade tight junction (TJ) proteins and decrease BBB …

Genetic Correlations Between Alzheimer’S Disease And Gut Microbiome Genera, Davis Cammann, Yimei Lu, Melika J Cummings, Mark L Zhang, Joan Manuel Cue, Jenifer Do, Jeffrey Ebersole, Xiangning Chen, Edwin C Oh, Jeffrey L Cummings, Jingchun Chen

Faculty, Staff and Student Publications

A growing body of evidence suggests that dysbiosis of the human gut microbiota is associated with neurodegenerative diseases like Alzheimer's disease (AD) via neuroinflammatory processes across the microbiota-gut-brain axis. The gut microbiota affects brain health through the secretion of toxins and short-chain fatty acids, which modulates gut permeability and numerous immune functions. Observational studies indicate that AD patients have reduced microbiome diversity, which could contribute to the pathogenesis of the disease. Uncovering the genetic basis of microbial abundance and its effect on AD could suggest lifestyle changes that may reduce an individual's risk for the disease. Using the largest genome-wide …

Genome-Wide Crispr Screens Reveal Zatt As A Synthetic Lethal Target Of Top2-Poison Etoposide That Can Act In A Tdp2-Independent Pathway, Jeong-Min Park, Huimin Zhang, Litong Nie, Chao Wang, Min Huang, Xu Feng, Mengfan Tang, Zhen Chen, Yun Xiong, Namsoo Lee, Siting Li, Ling Yin, Traver Hart, Junjie Chen

Faculty, Staff and Student Publications

Etoposide (ETO) is an anticancer drug that targets topoisomerase II (TOP2). It stabilizes a normally transient TOP2-DNA covalent complex (TOP2cc), thus leading to DNA double-strand breaks (DSBs). Tyrosyl-DNA phosphodiesterases two (TDP2) is directly involved in the repair of TOP2cc by removing phosphotyrosyl peptides from 5'-termini of DSBs. Recent studies suggest that additional factors are required for TOP2cc repair, which include the proteasome and the zinc finger protein associated with TDP2 and TOP2, named ZATT. ZATT may alter the conformation of TOP2cc in a way that renders the accessibility of TDP2 for TOP2cc removal. In this study, our genome-wide clustered regularly …

U.S. Government Information Resources For Accountability On U.S. Assistance To Ukraine, Bert Chapman

Libraries Faculty and Staff Presentations

Provides detailed coverage of U.S. Government information resources documenting accountability for U.S. civilian and military assistance to Ukraine. Includes U.S. laws, agencies involved in U.S. arms export policy, Defense Department resources and data, Defense Dept. Inspector General reports, Government Accountability Office reports, congressional committee hearings, a letter from a congressional committee to the Secretaries of Defense and State and U.S. Agency for International Development administrator, congressional debate, and congressional recorded votes.

Native American Student Success Program Receives Isan Innovative Practice Award, Communications And Marketing

Campus News Archive

No abstract provided.

Cardozo's 2023 Inspire! Awards!, Benjamin N. Cardozo School Of Law

2022–2023 Flyers

No abstract provided.

Gratitude Journal As An Instrument To Increase The Level Of Gratitude Among Adolescent In Ambon During Covid-19, Theophanny Paula Theresia Rampisela, Yulian Hermanus Wenno

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

COVID-19, which has plagued the world since 2020, has brought changes in the order of human life globally, and ultimately has an impact on the psychological state of individuals, including teenagers. The aim of this study is to find the differences between students’ gratitude score before and after the implementation of writing gratitude journal regularly. Participants on this study was 20 adolescents in Ambon City Maluku Indonesia, consists of 6 boys and 14 girls. The participants age was between 15-16 years old. Quantitative Method with experimental design used in this study. From the results, it was found that the significant …

Strengthening Character Education Based On Ethnic Advantage Through Higher Education Curriculum Integration In The Industrial Revolution Era 4.0, Carolina M. Lasambouw, Neneng Nuryati, Ediana Sutjiredjeki, Ajeng Ayu Milanti, Florida Mathilda

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Strengthening character education in the era of the industrial revolution 4.0 is urgent to anticipate the dehumanization of students. This research using exploratory qualitative methods has found seven superior ethnic characteristics in Indonesia as the most dominant: independent, consistent, hardworking, honest, challenging, assertive, and happy to work together. This paper describes the framework for strengthening character education by integrating prominent ethnic characters in Indonesia with the characters that become learning outcomes in national compulsory courses and skills courses in the higher education curriculum. As a result, student achievement in character aspects asses in an integrated manner at the end of …

Analysis Of The Flat Sided Volume Of Elementary Mathematics Textbook Based On Praxeology, Miranda Abung, Tatang Herman

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Geometry is one of the materials that must be understands by students in mathematics. Even though, students still find difficulties while studying geometric, especially the con-cept of the volume of a cuboid. The difficulties experienced by students can be handled in various ways, one of which is by using books as a source of student learning. This study analyzed the mathematics textbooks for fifth-grade elementary school, which is the Electronic School Book (BSE). The result of this research is an analysis of the presented material on the concept of the volume of the cuboid. The volume of cuboid analyzed consisted …

The Stakeholder's Perception Of The National Education Standard Fulfilment Based On School Accreditation Grade (A Preliminary Study), Marselus Ruben Payong, Hendrikus Midun, Oswaldus Bule

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to explore the opinions of basic education stakeholders regarding the fulfilment of national education standards in terms of school accreditation ratings. For this purpose, 307 stakeholders were involved (school principals, teachers, school committee members, and parents) from 43 elementary schools and 20 junior high schools in two sub-districts in Manggarai Regency, NTT. The method used was a cross-sectional survey. Data collection used a four-option (1-4) Likert scale questionnaire based on eight national education standards. The study results show that of the eight standards that stakeholders have assessed, two of them, namely the standards for teachers and standards …

Impact Of Covid-19: Explosion Of Saturation On Distance Learning In Elementary Schools, Desy Nur Wulandari, Riyadi Riyadi, Sri Marmoah

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Learning independently can decrease for students during the Covid-19 pandemic if students experience saturation in learning so that they are lazy to do the tasks given. This research uses a qualitative approach with a type of case study. The research, placed in Banjar sari Surakarta, used respondents totaling 27 upper-class students from grades 4-6 and 5 interviews with teachers. Data were collected through interviews and direct observation with respondents. Overall, the level of saturation and independence of students is at an alarming level; this is because students often experience fatigue and boredom, so they are reluctant to do learning and …

Modulatory Effect Of Medicinal Plants And Their Active Constituents On Atp-Sensitive Potassium Channels (Katp) In Diabetes, Lina T. Al Kury

All Works

Hyperglycemia, which is a chronic metabolic condition caused by either a defect in insulin secretion or insulin resistance, is a hallmark of diabetes mellitus (DM). Sustained hyperglycemia leads to the onset and development of many health complications. Despite the number of available antidiabetic medications on the market, there is still a need for novel treatment agents with increased efficacy and fewer adverse effects. Many medicinal plants offer a rich supply of bioactive compounds that have remarkable pharmacological effects with less toxicity and side effects. According to published evidence, natural antidiabetic substances influence pancreatic β-cell development and proliferation, inhibit pancreatic β-cell …

Data Set: Themes In Health Sciences Librarianship Literature, 2016-2020: A Keyword And Subject Analysis, Shalu Gillum, Terri Gotschall, Pamela Herring, Deedra Walton, Natasha Williams, Nadine Dexter

Research Data and Datasets

Data set for Themes in Health Sciences Librarianship Literature, 2016-2020: A Keyword and Subject Analysis.

Conference Proceedings - Philippine Physical Therapy Association Convention 2022 Conference Abstracts

Philippine Journal of Physical Therapy

No abstract provided.

Novel Bacterial Proteolytic And Metabolic Activity Associated With Dental Erosion-Induced Oral Dysbiosis, Leanne M. Cleaver, Miguel Carda-Diéguez, Rebeca Moazzez, Guy H. Carpenter

Pacific Faculty Work

Background: Dental erosion is a disease of the oral cavity where acids cause a loss of tooth enamel and is defined as having no bacterial involvement. The tooth surface is protected from acid attack by salivary proteins that make up the acquired enamel pellicle (AEP). Bacteria have been shown to readily degrade salivary proteins, and some of which are present in the AEP. This study aimed to explore the role of bacteria in dental erosion using a multi-omics approach by comparing saliva collected from participants with dental erosion and healthy controls. Results: Salivary proteomics was assessed by liquid-chromatography mass spectrometry …

Intratumoral Bacteria In Uveal Melanoma: A Case Report, Katherine Vega Escobar, Paola Ordonez Armijos, Tatyana Milman, Carol L. Shields, Ralph C. Eagle Jr.

Wills Eye Hospital Papers

Purpose Intratumoral bacteria and their potential application to cancer immunotherapy have been a topic of interest in recent studies. To our knowledge, bacteria in uveal melanoma have not been previously reported.

Observations We describe a patient with a large choroidal melanoma, measuring 18 × 16 mm in basal dimension and 15 mm in ultrasonographic thickness, managed by plaque brachytherapy. At the time of plaque removal, a prophylactic scleral patch graft was placed to protect from anticipated scleral necrosis. Progressive ocular ischemia led to a blind and painful eye. The enucleated eye demonstrated an extensively necrotic and heavily pigmented mushroom-shaped regressed …