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In This Issuesystematic Revieworiginal Articles

Saudi Medical Journal

No abstract provided.

Cellular Resistance Mechanisms In Cancer And The New Approaches To Overcome Resistance Mechanisms Chemotherapy, Ali A. Rabaan

Saudi Medical Journal

Despite major advancements in cancer healing approaches over the last few decades, chemotherapy remains the most popular malignancy treatment. Chemotherapeutic drugs are classified into many kinds based on their mechanism of action. Multidrug resistance (MDR) is responsible for approximately 90% of fatalities in malignancy cases treated with standard chemotherapeutics or innovative targeted medicines. Many innovative prospective anti-cancer medicines displayed high anti-cancer efficacy in a single application. However, combining them with other medications improves cancer treatment efficacy. This supports the belief that a combination of drugs is significantly more effective than a single medicine. Due to the intricacy of MDR processes …

Systematic Review And Pooled Analysis Of Randomized Controlled Trials In Countries Of The Gulf Cooperation Council (Gcc): Methods And Quality Assessment, Khalid S. Alraddadi, Fayzah H. Al-Adwani, Rajaa M. Al-Raddadi, Sultan H. Alamri, Iman K. Ramadan, Ahmad A. Mirza

Saudi Medical Journal

Objectives: To describe variations in characteristics of randomized controlled trials conducted in the Gulf Cooperation Council (GCC) countries, and critically appraising the quality of design, conduct and analysis of the trials. Methods: We carried out a systematically comprehensive electronic search of articles published between 1990 and 2018 and indexed in several databases: i) MEDLINE/PubMed, ii) EMBASE, iii) Cochrane Central Register of Controlled Trials (CENTRAL), iv) ClinicalTrials.gov, and v) World Health Organization International Clinical Trials Registry Platform. We summarized the overall risk of bias present in all analyzed studies using the Cochrane Collaboration risk of bias tool (CCRBT). Results: A remarkable …

The Histopathological Effects Of Sleep Disorders On Striated Muscle In Rats, İlkay Çinar, Muhammed Bozoğlan, Kürşad Aytekin, Deniz Esenyel, Cem Zeki Esenyel

Saudi Medical Journal

Objectives: To histopathologically examine the change in gastrocnemius muscle created by sleep disorder in rats. Methods: This study was carried out at Giresun University, Turkey from December 2018 to January 2021. A total of 30 Wistar rats were separated into 3 groups as the control group (CG), absence of rapid eye movement (REM) sleep (ARS) group, chronic absence of sleep (CAS) group. The lack of sleep was created in all rats. At the end of 21 days, all the rats were euthanized. Degeneration and regeneration findings, and expressions of muscle RING finger 1 (MuRF1), muscle atrophy F-box (MAFbx), tumor necrosis …

Frequency Of The Rs2015 (T>G) And Rs2241703 (G>A) Polymorphisms In The Mirna-Sirt2 Gene In Type 2 Diabetes Mellitus In Saudi Arabia, Nahla A. Alshaikh, Siddig I. Abdelwahab, Mahmoud M. Habibullah, Ahmed A. Jerah, Mohammed A. Bakri, Yahia A. Kaabi

Saudi Medical Journal

Objectives: To investigate the prevalence of rs2015 (T>G) and rs2241703 (G>A) polymorphisms in the miRNA-SIRT2 gene in Saudi Arabia and their possible associations with type 2 diabetes mellitus (T2DM). Methods: Blood samples were collected from 428 participants from Jazan University Hospital, Jazan, Saudi Arabia between September 2021 and June 2022 and subjected to TaqMan single-nucleotide polymorphisms (SNP) genotyping assay for rs241703 (G>A) and rs2015 (G>T). Genotype frequencies were determined in control (n=217). Results: The A allele of rs2241703 was undetected in our population, and all samples carried the GG genotype. The rs2015 SNP frequency was 29.4% …

Surgicel Plug Technique Versus Endoclose Technique For Port-Site Closure Post Minimally Invasive (Robotic And Laparoscopic) Surgeries: Retrospective Cohort Study, Maher S. Moazin, Abdulrahman M. Alsuwailim, Mosab M. Botaiban, Abdulaziz Y. Alabdulrahman, Abdullah Alfakhri, Naif Aldhaam,, Muhammad Abukhater, Arjmand Reyaz, Mohammed Y. Alessa

Saudi Medical Journal

Objectives: To compares the endoclose technique (ET) techniques and surgicel plug technique (SPT) in terms of port-site related complications. Minimally invasive surgeries (MIS) are widely performed nowadays, nonetheless, port-site closure technique plays a role in the prevention of port-site related complications. Methods: This retrospective study was carried out at general surgery and urology departments of King Fahad Medical City, Saudi Arabia. Variables that were collected include age, gender, height, weight, body mass index, co-morbidities, type and date of surgery, intraoperative visceral injury or bleeding, technique cost, and port-site post-operative complications (hernia, infection, bleeding, dehiscence, and hypertrophic scarring). Data was collected …

Clinicopathologic Characteristics And Outcomes Of Patients With Mycosis Fungoides: A Single Tertiary Center Retrospective Analysis In Saudi Arabia, Faisal A. Alghubaywi, Sawsan A. Alharthi, Sarah S. Aldharman, Raneem H. Najjar, Majed Y. Aleissa, Ohoud Z. Aljarbou, Mohammed I. Aljasser, Mohammad A. Almohideb

Saudi Medical Journal

Objectives: To determine the distinctive clinical and pathological characteristics and outcomes of MF in a Saudi population. Methods: We conducted a retrospective analysis of all MF cases diagnosed clinically with pathological confirmation at King Abdulaziz Medical City in Riyadh from January 2016 to July 2022. Variables include demographical, clinical, and pathological MF traits and disease outcomes. Results: A sum of 73 patients were enrolled. The mean age was 44 years. The female-to-male ratio was 1.3:1. The mean duration between cutaneous manifestations and MF diagnosis was 33 months (2.7 years). Classic MF was the most common variant (60.3%), followed by hypopigmented …

Demographic And Clinical Profile Of Patients With Chronic Rhinosinusitis In Saudi Arabia, Rayan Alfallaj, Sultan Bin Obaid, Hisham Almousa, Dawood Ismail, Saleh Mahjoub, Fatma Alanazy, Surayie Al Dousary, Saud Alromaih, Mohammad Aloulah, Abdulaziz Alrasheed, Ahmad S. Alroqi, Saad Alsaleh

Saudi Medical Journal

Objectives: To determine the clinical features of patients with chronic rhinosinusitis at a tertiary hospital in Riyadh, Saudi Arabia. Methods: A cross-sectional study was carried out at King Abdulaziz University Hospital, Riyadh, Saudi Arabia. We enrolled 660 male and female participants with medical records indicating a history of chronic rhinosinusitis between 2021 and 2022. Quantitative and descriptive analyses of age, gender, nationality, presence of polyps, aspirin sensitivity, presence of urticaria, asthma, and allergies were performed. Results: Of the 660 enrolled patients, 60% (n=396) were male and 40% (n=264) were female. Additionally, 67.7% (447) had nasal polyps, 32% had a history …

Potential Barriers To The Daily Use Of Hearing Aids In Children, Medhat F. Yousef, Ziyad I. Dhayan, Tahera Islam, Fahad Z. Alotabi, Eman A Hajr

Saudi Medical Journal

Objectives: To identify factors affecting hearing aid usage in children. Methods: This retrospective study examined 59 hearing-impaired children fitted with hearing aids for at least 6 months. Patients with moderate to profound sensorineural hearing loss with complete data-logging information stored in the hearing aid programming file from January 2020 until June 2021 were included. Children with concomitant disabilities were excluded. Data for audiological assessments included hearing assessment, aided hearing thresholds, and aided speech tests. Results: The children’s age ranged from 6 months to 6 years. Average daily hearing aid usage was 5.5 hour (h) after 3 months, 7 h after …

Vitamin D Status Among Residents Of Molidawa Daur Autonomous Banner, Inner Mongolia, North China, Jingwen Hu, Yunmei Liang, Guiping Wen, Dezhong Chen, Yuanjing Liu, Hongmei Zhang, Xiaosong Qin

Saudi Medical Journal

Objectives: To retrospectively analyze the vitamin D (VD) status of residents in northeastern Inner Mongolia and its relationship with the average monthly sunshine hours. Methods: Serum 25-hydroxyvitamin D[s-25(OH)D] samples from 4982 outpatients (2092 males) in Moli Dawa Daur Autonomous Banner People’s Hospital, Hulunbuir, China from July 2018 to January 2022 were included in this study. Results: The overall median s-25(OH)D was 53.3 nmol/L, VD deficiency (<30 nmol/L), deficiency (30-50 nmol/L), sufficient (>50-250 nmol/L) and excess (>250 nmol/L) were 16% (796/4982), 30% (1495/4982), 53.4% (2658/4982) and 0.7% (33/4982). There were statistically significant differences in median s-25(OH)D by month, age-groups and gender ( p <0.001). Low VD status (LVDS, including VD deficiency and insufficiency) in females was 54.6% and males was 33.9%, and the LVDS composition differed significantly by age-group and month ( p <0.05). The changing trend of the median s-25(OH)D level was similar to the monthly average sunshine hours, with a slight lag. Conclusion: Nearly half of residents live in LVDS. LVDS is affected by month, gender, and age.

Comment On: Prevalence Of Transfusion-Transmitted Infections In Saudi Arabia Blood Donors: A Nationwide, Cross-Sectional Study, Nour Al-Mozain, Maha A. Badawi, Mohammad A. Alfhili

Saudi Medical Journal

No abstract provided.

Can Moderate Dietary Salt Restriction Help Patients With Hypertension?

Saudi Medical Journal

No abstract provided.

Statement On The Update Of Who’S Working Definitions And Tracking System For Sars-Cov-2 Variants Of Concern And Variants Of Interest

Saudi Medical Journal

No abstract provided.

Mexico Consensus Economic Forecast, Volume 26, Number 2, Thomas M. Fullerton Jr., Steven L. Fullerton

Border Region Modeling Project

No abstract provided.

Borderplex Business Barometer, Volume 7, Number 4, Thomas M. Fullerton Jr., Steven L. Fullerton

Border Region Modeling Project

No abstract provided.

“Research Is Not Innocent”: A Review Of Thalia Mulvihill And Raji Swaminathan’S Collaborative Qualitative Research, Daniel P. Wulff

The Qualitative Report

Mulvihill and Swaminathan have written a wide-ranging book that takes a close look at how qualitative research can be collaborative and what implications come from how collaborative practices are taken up. While taking an appreciative stance toward collaborative research practices, they do not shy away from the challenges and unrealized potentials that are involved. This book serves as both an introduction to the basics of collaborative qualitative research and an in-depth look at the issues for the more experienced collaborative researcher.

Research On The Relationship Between Service-Oriented Manufacturing Platforms And Customer Enterprise Innovation — Evidence From The 3d Printing Industry, Donglai Zhao

Dissertations and Theses Collection (Open Access)

Micro, small and medium-sized enterprises (MSMEs) are highly flexible and creative and play a significant role in the national economy and in employment, innovation, and entrepreneurship. However, due to their relatively small size, low technical level, lack of funds and talent, and backward management, they generally face development predicaments, such as the pressure to survive and weak anti-risk abilities. Therefore, in addition to leveraging their initiative to develop their competitive strength, making full use of external public service resources has become one approach MSMEs can take to find a way out of such predicaments. Various service-oriented manufacturing platform enterprises have …

Maximising Effectiveness Of Talent Pools Through Mindfulness: An Empirical Investigation In A Multinational Corporation, Tarmo Raudsepp

Dissertations and Theses Collection (Open Access)

Traditional human resource management is looking to identify and develop talent for maximising human capital in a competitive environment with limited resources and negative demographic trends. Attracting, deploying, motivating, developing and retaining talented employees is a corporate norm for meeting organisational goals. Proper human resource processes through rigorous mapping of employees according to the performance-potential matrix allow the grading of employees against peer groups to establish talent pools for development and internal succession planning.

Mindfulness originates from 2,500-year-old Buddhist spiritual practices and has a rare combination of spirituality and science. Eastern perspective originates from Asian traditions focusing on the self-regulation …

The Impact Of Subordinates’ Proactive Personality On Empowering Leadership, Xin Zhan

Dissertations and Theses Collection (Open Access)

Research has documented numerous benefits of proactive personality for employees’ job outcomes. However, the success of proactive employees largely depends on their leaders’ empowerment. Extant research has focused on the bright side of proactive personality for inducing empowerment, without considering its risks. We thus have an incomplete understanding of the effects of employees’ proactive personality on empowering leadership. I take a balanced perspective on proactive personality and propose that proactive personality has an inverted U-shaped relationship with empowering leadership, such that empowering leadership is highest when proactive personality is at a moderate level. I argue that leader-member exchange (LMX) mediates …

A Study On The Business Models Of Chinese Video Websites And Its Evolution, Xiaohui Wang

Dissertations and Theses Collection (Open Access)

This dissertation delves into the 20-year developmental history of Chinese video websites, with specific emphasis on major players currently in operation such as iQIYI, Tencent Video, Youku, Bilibili, and Mango TV. It critically analyzes the business model of Chinese video websites from five key dimensions—developmental evolution, market operation, content production, user relationships, and policy relations—providing a comprehensive understanding of the industry’s landscape. Research has shown that the business models of Chinese video websites present not a simple chain relationship but a complex network of relationships. Elements such as capital, market, content, technology, users, and policies dynamically interact and balance each …

The Impact Of Ipo Pricing Model On The Issuing Price: Evidence From China, Shancheng Chen

Dissertations and Theses Collection (Open Access)

IPO pricing effectiveness refers to the deviation between the IPO price in the primary market and the actual trading price in the secondary market at the initial stage of listing. IPO underpricing ratio is the main research index used to investigate the effectiveness of IPO pricing in capital market. The phenomenon of excessive IPO underpricing brings many problems to the development of Chinese capital market. The GEM from the establishment of the initial audit system to the registration system, to the inquiry of the implementation of the new rules, IPO underpricing rate has been gradually controlled. This paper mainly studies …

Customer Value, Product Repositioning And Supply Chain Strategy: A Case Of Supply Chain Design For Lansea Corporation, Lei Zhang

Dissertations and Theses Collection (Open Access)

With continuous development of Chinese economy, the incomes of Chinese citizens are constantly increasing, leading to dramatical changes of consumer demand patterns, especially in household electric appliances. The analysis of income and household wealth shows that the proportion of the middle-class population is about 20%-30% of the total population, and this proportion is still increasing. Consequently, it seems that consumption is constantly upgrading. This means, on one hand, part of the consumers still focuses on quality and cost, while on the other hand, part of consumers pays more attention on performance and styles. Therefore, it is critical for the manufacturers …

The Effect Of Psychological Distance On Online Advertising: A Case Study Of Video Enrollment Advertisement Of Colleges, Xian He

Dissertations and Theses Collection (Open Access)

Advertising for enrolment through the Internet has become an important means of enrolment promotion in Chinese universities. However, there is currently no clear research conclusion on how to conduct effective advertising, especially on the selection of factors such as promotion time, promotion platform, and promotion targets. Based on the construal level theory, this study investigated the effects of different types of college enrolment advertising on different new media platforms, using different dimensions of psychological distance corresponding to factors such as promotional time and promotional area. The empirical results show that different advertising types do have significant effect differences on different …

Regulating By New Technology: The Impacts Of The Sec Data Analytics On The Sec Investigations, Tian Deng

Dissertations and Theses Collection (Open Access)

Despite the Securities and Exchange Commission’s (SEC) growing emphasis on data analytics in recent years, there is scant research about whether the investment in data analytics accomplishes its objective of enhancing enforcement efficiency. This study examines the effects of the SEC regional offices’ use of data analytics on their investigation outcomes. The utilization of data analytics reduces information processing costs, thereby streamlining the enforcement process as a whole. I find that the SEC’s use of data analytics is associated with a 12% increase in the SEC’s investigation success rate. Such an improvement is greater for firms whose disclosure are more …

Reading Between The Lines Of The Second-Hand E-Commerce Business In China: A Study Of Consumer Behaviour Xianyu Second-Hand Platform, Bing Sun

Dissertations and Theses Collection (Open Access)

Second-hand transactions are gradually becoming an indispensable and significant form of the sharing economy; however, there is limited research on consumer behaviour in second-hand markets in an online environment. This dissertation aims to enrich the research in this area by analysing the impact of the characteristics of buyers, sellers, and products in second-hand markets on consumer purchasing intentions and behaviours. The study uses transaction data from Xianyu, China’s largest C2C second-hand trading platform, to investigate the factors that influence consumers’ choices between first-hand and second-hand trading platforms. It was found that consumers have a higher willingness to purchase well-known brands …

Covid-19 Is Not All Bad News: Negative And Surprisingly Positive Reports From College Stem Students And Implications For Stem Instruction, Yuchen Jiang, Boyan Ma, Zimo Ma, Pamela M. Propsom, Zaheen Rashed '24, Rudrayani Upadhyay, Zichen Zhao

Student Research

The negative educational consequences of COVID-19 are well documented. Much less investigated have been any potential positive outcomes of the pandemic. We surveyed 392 students at one college querying why they continue studying STEM or leave the STEM disciplines and about the effects of COVID-19 on their education. STEM students may have been especially impacted by pandemic-imposed remote instruction given STEM’s reliance on hands-on laboratory experiences. Because the literature indicates that people of color and those from lower socioeconomic groups were more negatively affected by COVID-19, we hypothesized that students from these groups would report greater adverse educational consequences of …

Ins And Outs Of Rocker Switch Mechanism In Major Facilitator Superfamily Of Transporters, Stephanie Sauve, Joseph Williamson, Adithya Polasa, Mahmoud Moradi

Chemistry & Biochemistry Faculty Publications and Presentations

The major facilitator superfamily (MFS) of transporters consists of three classes of membrane transporters: symporters, uniporters, and antiporters. Despite such diverse functions, MFS transporters are believed to undergo similar conformational changes within their distinct transport cycles, known as the rocker-switch mechanism. While the similarities between conformational changes are noteworthy, the differences are also important since they could potentially explain the distinct functions of symporters, uniporters, and antiporters of the MFS superfamily. We reviewed a variety of experimental and computational structural data on a select number of antiporters, symporters, and uniporters from the MFS family to compare the similarities and differences …

A Basic Model For The Association Of Ligands With Membrane Cholesterol: Application To Cytolysin Binding, Yvonne Lange, S. M. Ali Tabei, Theodore L. Steck

Faculty Publications

Almost all the cholesterol in cellular membranes is associated with phospholipids in simple stoichiometric complexes. This limits the binding of sterol ligands such as filipin and perfringolysin O (PFO) to a small fraction of the total. We offer a simple mathematical model that characterizes this complexity. It posits that the cholesterol accessible to ligands has two forms: active cholesterol, which is that not complexed with phospholipids; and extractable cholesterol, that which ligands can capture competitively from the phospholipid complexes. Simulations based on the model match published data for the association of PFO oligomers with liposomes, plasma membranes, and the isolated …

The Data Services Continuing Professional Education (Dscpe) Program: Creating Communities Of Practice For Data Services Librarianship, Sara Hoover

Himmelfarb Library Faculty Posters and Presentations

No abstract provided.

Correcting Misinformation In The Clinic: A New Course For Medical Students, Rachel Brill, Stacy Brody, Ian Roberts

Himmelfarb Library Faculty Posters and Presentations

No abstract provided.