Digital Commons Network^™

Understanding The Behavior Of Upper Subcritical Limit Calculations, Bobbi Riedel

Nuclear Engineering ETDs

This research consists of two comparison studies: the first study employed standard practices to characterize Upper Subcritical Limit (USL) estimation methods. A series of 33 neutronic systems that used standardized nuclear data and benchmark libraries were studied to compare the Whisper, TSURFER, and USLSTATS methods relative to a stochastic USL. USLs were also estimated for these 20 systems using the Whisper 1.1 code. Sensitivity data files were produced using MCNP6.2 and then used with the ORNL TSURFER and USLSTATS methods to estimate USLs for a cross-method USL comparison. The results show that USLs for each of the loosely coupled system …

Single-Cell Discovery And Multiomic Characterization Of Therapeutic Targets In Multiple Myeloma, Lijun Yao, Julia T Wang, Reyka G Jayasinghe, Julie O'Neal, Chia-Feng Tsai, Michael P Rettig, Yizhe Song, Ruiyang Liu, Yanyan Zhao, Omar M Ibrahim, Mark A Fiala, Julie M Fortier, Siqi Chen, Leah Gehrs, Fernanda Martins Rodrigues, Michael C Wendl, Daniel Kohnen, Andrew Shinkle, Song Cao, Steven M Foltz, Daniel Cui Zhou, Erik Storrs, Matthew A Wyczalkowski, Smrithi Mani, Scott R Goldsmith, Feng Chen, Ravi Vij, Li Ding, John F Dipersio, Et Al.

2020-Current year OA Pubs

UNLABELLED: Multiple myeloma (MM) is a highly refractory hematologic cancer. Targeted immunotherapy has shown promise in MM but remains hindered by the challenge of identifying specific yet broadly representative tumor markers. We analyzed 53 bone marrow (BM) aspirates from 41 MM patients using an unbiased, high-throughput pipeline for therapeutic target discovery via single-cell transcriptomic profiling, yielding 38 MM marker genes encoding cell-surface proteins and 15 encoding intracellular proteins. Of these, 20 candidate genes were highlighted that are not yet under clinical study, 11 of which were previously uncharacterized as therapeutic targets. The findings were cross-validated using bulk RNA sequencing, flow …

A Systematic Review Of Multimodal Brain Age Studies: Uncovering A Divergence Between Model Accuracy And Utility, Robert J Jirsaraie, Aaron J Gorelik, Martins M Gatavins, Denis A Engemann, Ryan Bogdan, Deanna M Barch, Aristeidis Sotiras

2020-Current year OA Pubs

Brain aging is a complex, multifaceted process that can be challenging to model in ways that are accurate and clinically useful. One of the most common approaches has been to apply machine learning to neuroimaging data with the goal of predicting age in a data-driven manner. Building on initial brain age studies that were derived solely from T1-weighted scans (i.e., unimodal), recent studies have incorporated features across multiple imaging modalities (i.e., "multimodal"). In this systematic review, we show that unimodal and multimodal models have distinct advantages. Multimodal models are the most accurate and sensitive to differences in chronic brain disorders. …

A Predator-Prey Biological Model With Combined Birth Rates, Self-Limitation And Competition Terms, Joon Hyuk Kang, Lucinda Ford

Faculty Publications

The purpose of this paper is to give sufficient conditions for the existence and uniqueness of positive solutions to a rather general type of elliptic system of the Dirichlet problem on a bounded domain Ω in Rⁿ. Also considered are the effects of perturbations on the coexistence state and uniqueness. The techniques used in this paper are super-sub solutions method, eigenvalues of operators, maximum principles, spectrum estimates, inverse function theory, and general elliptic theory. The arguments also rely on some detailed properties for the solution of logistic equations. These results yield an algebraically computable criterion for the positive …

Pertuzumab, Trastuzumab, And An Aromatase Inhibitor For Her2-Positive And Hormone Receptor-Positive Metastatic Or Locally Advanced Breast Cancer: Pertain Final Analysis, Grazia Arpino, Juan De La Haba Rodríguez, Jean-Marc Ferrero, Sabino De Placido, C Kent Osborne, Dirk Klingbiel, Valentine Revelant, Christine Wohlfarth, Raf Poppe, Mothaffar F Rimawi

Faculty, Staff and Students Publications

PURPOSE: In PERTAIN's primary analysis (31 months' median follow-up), adding pertuzumab to trastuzumab and an aromatase inhibitor (AI) with/without chemotherapy significantly improved progression-free survival (PFS) in patients with previously untreated HER2-positive and hormone receptor-positive metastatic or locally advanced breast cancer (M/LABC). A potentially enhanced treatment effect was observed in patients with no induction chemotherapy. We present the final analysis (>6 years' median follow-up).

PATIENTS AND METHODS: Patients (N = 258) were randomized 1:1 to pertuzumab (loading/maintenance: 840/420 mg) plus trastuzumab (loading/maintenance: 8/6 mg/kg) every 3 weeks and an AI (1 mg anastrozole or 2.5 mg letrozole daily; Arm A), …

Graduate Recital: Katherine Shindledecker, Trumpet; Lu Witzig, Piano; Seth Marshall, Trumpet; Daniel G. Castillon Iii, Horn; Brett Harris, Trombone; April 14, 2023, Katherine Shindledecker, Lu Witzig, Seth Marshall, Daniel G. Castillon Iii, Brett Harris

School of Music Programs

Kemp Recital Hall
April 14, 2023
Friday Evening
8:00 p.m.

A Peptide-Centric Quantitative Proteomics Dataset For The Phenotypic Assessment Of Alzheimer's Disease, Gennifer E Merrihew, Randall Bateman, Richard J Perrin, Et Al.

2020-Current year OA Pubs

Alzheimer's disease (AD) is a looming public health disaster with limited interventions. Alzheimer's is a complex disease that can present with or without causative mutations and can be accompanied by a range of age-related comorbidities. This diverse presentation makes it difficult to study molecular changes specific to AD. To better understand the molecular signatures of disease we constructed a unique human brain sample cohort inclusive of autosomal dominant AD dementia (ADD), sporadic ADD, and those without dementia but with high AD histopathologic burden, and cognitively normal individuals with no/minimal AD histopathologic burden. All samples are clinically well characterized, and brain …

Mek Inhibition Synergizes With Tyk2 Inhibitors In Nf1-Associated Malignant Peripheral Nerve Sheath Tumors, Dana C Borcherding, Neha V Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A Pratilas, Kai Pollard, Taylor Sundby, Brigitte C Widemann, Angela C Hirbe

2020-Current year OA Pubs

PURPOSE: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome. Overexpression of TYK2 occurs in the majority of MPNST, implicating TYK2 as a therapeutic target.

EXPERIMENTAL DESIGN: The effects of pharmacologic TYK2 inhibition on MPNST cell proliferation and survival were examined using IncuCyte live cell assays in vitro, and downstream actions were analyzed using RNA-sequencing (RNA-seq), qPCR arrays, and validation of protein changes with the WES automated Western system. Inhibition of TYK2 alone and in combination …

Investigating The Effects Of Work-Family Conflict On Turnover Intention Of Ict Employees In Malaysia, Lai Meng Lee, Su Wan Gan, Yong Sheng Chia

Makara Human Behavior Studies in Asia

With the intensified focus on information and communication technology (ICT) as a driver of the Malaysian economy, pressure will increase on the recruitment and retention of ICT employees. However, work overload and conflict with family roles may lead to a higher level of turnover intention among ICT employees. The objective of this study is to investigate the predicting effects of all forms of work-family conflict (time-based, strain-based and behavior-based) on turnover intentions. This quantitative cross-sectional study utilizes primary data collected from 200 employees from ICT companies in the Klang valley using purposive sampling. Various statistical analyses such as correlation and …

Figures Du Père Et Parenté Littéraire Dans La Vie De Saint Alexis Et Le Livre De La Cité Des Dames, Marie Bellec

Vernacular: New Connections in Language, Literature, & Culture

Cet article examine la figure paternelle dans trois récits de la vie des saints, La Vie de Saint Alexis, « Sainte Marine » et « Sainte Euphrosine » dans Le Livre de la Cité des Dames, de Christine de Pizan. Les pères respectifs des saints incarnent certaines attentes sociales et familiales, ils exercent notamment sur leurs enfants une pression pour qu’ils se marient. Les contraintes ne sont pas les mêmes selon le genre des saints : alors que la piété d’Alexis l’empêche de convoler, l’oppression sociale se déplace vers celle du genre pour nos hagiographies au féminin. Par …

Chilean Cinema In The 21st Century World (Review), James L. Richie Iv

Vernacular: New Connections in Language, Literature, & Culture

No abstract provided.

Understanding Involuntary Illegal Online Gamblers In The U.S.: Framing In Misleading Information By Online Casino Reviews, Sinyong Choi

UNLV Gaming Research & Review Journal

Although there are many illegal online gamblers in the United States who use offshore gambling sites while falsely believing that their activity is legitimate, few studies have focused on the role of online casino reviews (OCR) who facilitate this activity. These reviews, for a variety of reasons, may present misleading information designed to encourage U.S. players to use offshore gambling sites. Using framing theory and neutralization techniques, we conducted a content analysis of multiple OCR to examine how they present information and justifications regarding the use of offshore gambling sites in the U.S. The findings indicate that many OCR positively …

Attributions & Citations: Best Practices For Remixing Oer, Alison Cole

Open Access Conference

No abstract provided.

Facilitating Discussions Of Diversity, Power, And Privilege For Professional Students With Loden's Diversity Wheel, Giacinta Talarico

Open Access Conference

Diversity wheels have been widely used since the 1990s to facilitate reflection and discussion regarding individual diversity and intersectionality in the workplace (Loden & Rosener, 1991). Now widely available online, these tools have been adapted for a variety of community-building exercises in the classroom. This participatory workshop demonstrates how these activities can be adapted to facilitate engaged dialogue among professional students in the interest of developing critical self-awareness that enhances justice, equity, and inclusion as they begin internships and careers in clinical practice.

The Holocaust Experienced By Jewish Women, Ra-Quelle Parker

Undergraduate Research Competition

We have plenty of information on The Holocaust from the male point of view, such as Elie Wiesel, Primo Levi, and Viktor Frankl, but there is barely any information on the female point of view during The Holocaust beyond the point of Anne Frank or Ida Fink. This study shows the horror in the camps that women had to face. Women feared sexual harassment, among other horrible treatment in different camps. The sole purpose of this paper is to find more information on Jewish women’s experience in the ghettos and concentration camps and to understand the female victims of The …

Making Inclusion The End Goal: Redefining Internationalization Through Diversity, Equity, And Inclusion(Dei) At U.S. Higher Education Institutions., Eunice Nkansah, Eunice Nkansah

Open Access Conference

International students in higher education are often categorized under “institutional labels” despite their tremendous diversity. Unfortunately, this label obscures the unique experiences and complexities that characterize international students. As a result, internationalization and Diversity, Equity, and Inclusion(DEI) are considered under separate conversations and offices. Over the years, recruiting international students in higher education institutions has often been viewed as a distinct role of internationalization. However, despite the continuous recruitment, enrollment of international students does not equate to attaining diversity and inclusion in academic communities. Therefore, realigning DEI policies to address internationalization is crucial to creating a meaningful and welcoming experience …

Bear Fruit, Kole Matheson

Virginia Poets Database: Poetry Spotlight

No abstract provided.

The Human Superiority Complex, Peyton Kinavey

Undergraduate Research Competition

For decades humans have possessed a superiority complex regarding nonhuman beings, but this has not always been the case. Through analyzing prehistoric art, such as therianthropic figurines and nonhuman animal motifs in cave paintings, it appears that prehistoric humans practiced respect for fellow animals and even viewed them as equals. These results are comparable with ethnographic data from contemporary hunter-gatherer and small-scale agricultural societies all over the world. Thus, it is suggested that the rise of industrial agriculture and the meat and dairy industries, alongside the philosophical justifications for their continuance, may have contributed to the widespread idea of human …

Non-State Actors And International Crisis Outcomes, 1987-2017, Taylor Schubert

Undergraduate Research Competition

This study examines the way non-state actor involvement affects the outcome of international crises. This was tested by looking at a set of international crises from 1987 through 2017. We find that the involvement of a non-state actor in an international crisis is associated with a greater likelihood of the crisis terminating via agreement or unilateral act, and a reduced likelihood of a crisis fading away. Additionally, we find that non-state actors who engage in direct fighting as a part of the crisis are further associated with negotiated and unilaterally-imposed outcomes, but that non-state actors who control territory are less …

Hispanic Population At Coastal Carolina University: An Analysis Of Challenges And Adversity In Higher Education, Valentina Bermejo

Undergraduate Research Competition

This research pursues the analysis of the Hispanic Population at Coastal Carolina University. It seeks to explain the factors that shaped their journey to secondary education whether it be through intrinsic motivation or generational guilt; while also seeking to understand the hardships that come with being the first generational student to attend an American University. Through previously conducted research by scholars such as Consuelo Arbona, Amaury Nora, Laura Perna, and Claudia Kouyoumdjian, along with a series of interviews amongst self-identifying Hispanic university-goers at Coastal Carolina; the study comes to find the disparities amongst the previously grouped category of "Hispanics at …

Developing Narrative Content For The Virtual Shikoku Pilgrimage Immersive Platform, Theresa Brick

Undergraduate Research Competition

The Virtual Shikoku Pilgrimage project is a multidisciplinary digital virtual heritage project to replicate the experience of the 88-temple Shingon Buddhist pilgrimage around the island of Shikoku. The project also aims to teach users about the Shikoku pilgrimage, including its historical, cultural, and spiritual significance. Utilizing the Unity 3D engine for 3D immersive virtual applications, this project is centered on developing an immersive videogame-style platform where users can navigate a recreated digital version of the pilgrimage temples and journey using a third-person perspective. Within these virtual landscapes, embedded multimedia popups (such as text, photos, and video) provide users with information …

Imitation Of Life, Tiquasha Hagood

Undergraduate Research Competition

"A Sunday Afternoon on the Island of La Grande Jatte" is an iconic painting by French artist Georges Seurat that features a group of elegantly dressed Parisians spending a leisurely Sunday afternoon on the banks of the Seine. While the painting is widely celebrated for its technical brilliance, it is also notable for the way it reflects the social norms and cultural values of 19th-century France. One such norm was the objectification and exploitation of Black women's bodies, exemplified by the tragic story of Sarah Baartman, a South African woman who was paraded across Europe as a spectacle because of …

Promoting Self-Awareness And Self-Advocacy For Students With Disabilities, Caitlin Conroy

Undergraduate Research Competition

Using the ME! Lessons for Teaching Self-Awareness & Self-Advocacy (Cantley, Little, & Martin, n.d.) as a guideline, I created "bell ringers" to teach transition age students with disabilities about self-awareness and self-advocacy in rewards to their disability and IEP. I taught these skills to a small group of four students. Every day, these four students met for 10 minutes during the start of the day. The research conducted is self-study research (Hauge, 2021). For all students with disabilities, especially at the transition age, self-awareness and self-advocacy is so important. To be able to continue teaching these lessons after this experience, …

Language Objectives For English Language Learners, Jessica Batt

Undergraduate Research Competition

The purpose of this study is to evaluate the quality of language objectives written by various types of teachers for English language learners. This research study examines language objectives in lesson planning for English Language Learners. Participants are a small group of six graduate students enrolled in an ESOL methods course. Data was collected from written assignments that were already part of this online course: application activities and lesson plans. Language objectives were analyzed and categorized as being focused on reading, writing, speaking, and/or listening. Study results and implications of the study will be presented.

Do Attitudes Toward Police Mediate The Relationship Between Judgment Response Times And Judgments Of Police Use Of Force?, Kali Goldman, Alex Fusee

Undergraduate Research Competition

In the current study we examined how people’s attitudes toward police might mediate the relationship between the length of time it takes people to make judgments of an officer’s use of excessive force and their actual judgments of the officer’s use of force. Research on dual-processing theories of decision-making suggests that people might rely on their attitudes toward police when making determinations of police officer behavior (Bornstein & Greene, 2011; Yeong, 1999). Based on this research, we believe that people likely use their attitudes toward police when engaging in the judgment formation process and deciding whether an officer used excessive …

Adopt, Adapt, And Review: The Nj Otc Project In Year 3, Robert Hilliker, Steven Chudnick

Open Access Conference

The Open Textbook Collaborative (OTC), a project funded by the US Department of Education’s Fund for the Improvement of Postsecondary Education (FIPSE), is now in its third year of operation. Having successfully funded and piloted more than a dozen OER projects across a variety of STEM subjects, we will now be focused on promoting the use and adaptation of these OERs at other institutions throughout New Jersey and beyond. We are also soliciting reviews of the completed OER materials as part of these promotional efforts.

A Systematic Review On High Flux And Medium Cut Off Membranes – Benchmarking Using Simulation Models, Ahana Fatima Alex, R Vinoth, Ravishankar Dudhe

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Eben Cabs (Mobility As A Service), Asha Kumari

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Health Status In Gestational Diabetes And Oxidative Dna Damage, Nitu Basumatary, Vaishnavi Singh, Chamma Gupta, Pesona Grace Lucksom, Abhishek Byahut

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.

Spatial Design And Multisensory Stimulation In Therapeutic Clinical Settings, Jesnao Shaji Mnachan, Arushi Malhotra

Manipal Research Colloquium - 2023

Manipal Research Colloquium- 2023 aims to bring students, scholars, and scientists to this forum where discussion on a diverse range of topics from various streams (Health Sciences, Technical Sciences, Basic & Applied Sciences, Humanities & Social Sciences, and Management Sciences) will be taking place.