Digital Commons Network^™

The Comorbidity Of Depression And Neurocognitive Disorder In Persons With Hiv Infection: Call For Investigation And Treatment, Karl Goodkin, Teresa H. Evering, Albert M. Anderson, Ann Ragin, Cynthia L. Monaco, Christina Gavegnano, Ryan J. Avery, Sean B. Rourke, Lucette A. Cysique, Bruce J. Brew

School of Medicine Publications

Depression and neurocognitive disorder continue to be the major neuropsychiatric disorders affecting persons with HIV (PWH). The prevalence of major depressive disorder is two to fourfold higher among PWH than the general population (∼6.7%). Prevalence estimates of neurocognitive disorder among PWH range from 25 to over 47% – depending upon the definition used (which is currently evolving), the size of the test battery employed, and the demographic and HIV disease characteristics of the participants included, such as age range and sex distribution. Both major depressive disorder and neurocognitive disorder also result in substantial morbidity and premature mortality. However, though anticipated …

Alternative Splicing Of Gsdmb Modulates Killer Lymphocyte-Triggered Pyroptosis, Qing Kong, Shiyu Xia, Xingxin Pan, Kaixiong Ye, Zhouyihan Li, Xiaoqiang Tang, S Stephen Yi, Xing Liu, Hao Wu, Michael B Elowitz, Judy Lieberman, Zhibin Zhang

Faculty, Staff and Student Publications

Granzyme A from killer lymphocytes cleaves gasdermin B (GSDMB) and triggers pyroptosis in targeted human tumor cells, eliciting antitumor immunity. However, GSDMB has a controversial role in pyroptosis and has been linked to both anti- and protumor functions. Here, we found that GSDMB splicing variants are functionally distinct. Cleaved N-terminal (NT) fragments of GSDMB isoforms 3 and 4 caused pyroptosis, but isoforms 1, 2, and 5 did not. The nonfunctional isoforms have a deleted or modified exon 6 and therefore lack a stable belt motif. The belt likely contributes to the insertion of oligomeric GSDMB-NTs into the membrane. Consistently, noncytotoxic …

Heartworm Adulticide Treatment: A Tropical Perspective, Gad Baneth, Tawin Inpankaew, Pablo Borrás, Sangaran Arumugam, Barend Louis Penzhorn, Adrian Patalinghug Ybañez, Peter Irwin, Rebecca J Traub

Faculty, Staff and Student Publications

Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and …

The Dental Workforce Recruitment And Retention Crisis In The Uk, Deborah Evans, Ian Mills, Lorna Burns, Marie Bryce, Sally Hanks

Peninsula Dental School

The precarious state of NHS dentistry is widely acknowledged, yet there is limited progress in addressing the underlying issues. Further delays will undoubtedly impact patient care, leading to oral health deterioration and unnecessary suffering. This will predominantly affect the most vulnerable in society, resulting in greater oral health inequalities. The underlying issues contributing to the current NHS dental crisis are many, and they include: prolonged delays in contract reform; long-term underinvestment; private sector growth; and fewer dentists working full-time and/or in the NHS. In England, an NHS dental contract that fails to promote prevention or equality of access continues to …

The Genomic Landscape Of Familial Glioma, Dong-Joo Choi, Georgina Armstrong, Brittney Lozzi, Prashanth Vijayaraghavan, Sharon E Plon, Eric Boerwinkle, Hsiao-Chi Chen, Richard A Gibbs, Quinn T Ostrom, Beatrice Melin, Benjamin Deneen, Melissa L Bondy, Gliogene Consortium, Genomics England Research Consortium, Matthew N Bainbridge, Christopher I Amos, Jill S Barnholtz-Sloan, Jonine L Bernstein, Elizabeth B Claus, Richard S Houlston, Dora Il'yasova, Robert B Jenkins, Christoffer Johansen, Daniel Lachance, Rose Lai, Beatrice S Melin, Ryan T Merrell, Sara H Olson, Siegal Sadetzki, Joellen Schildkraut, Sanjay Shete, J C Ambrose, P Arumugam, R Bevers, M Bleda, F Boardman-Pretty, C R Boustred, H Brittain, M A Brown, M J Caulfield, G C Chan, A Giess, J N Griffin, A Hamblin, S Henderson, T J P Hubbard, R Jackson, L J Jones, D Kasperaviciute, M Kayikci, A Kousathanas, L Lahnstein, A Lakey, S E A Leigh, I U S Leong, F J Lopez, F Maleady-Crowe, M Mcentagart, F Minneci, J Mitchell, L Moutsianas, M Mueller, N Murugaesu, A C Need, P O'Donovan, C A Odhams, C Patch, D Perez-Gil, M B Pereira, J Pullinger, T Rahim, A Rendon, T Rogers, K Savage, K Sawant, R H Scott, A Siddiq, A Sieghart, S C Smith, A Sosinsky, A Stuckey, M Tanguy, A L Taylor Tavares, E R A Thomas, S R Thompson, A Tucci, M J Welland, E Williams, K Witkowska, S M Wood, M Zarowiecki

Faculty, Staff and Student Publications

Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisposition that accounts for approximately 5% of glioma cases. We performed whole-genome sequencing on an exploratory cohort of 203 individuals from 189 families with a history of familial glioma and an additional validation cohort of 122 individuals from 115 families. We found significant enrichment of rare deleterious variants of seven genes in both cohorts, and the most significantly enriched gene was HERC2 (P = 0.0006). Furthermore, we identified rare noncoding variants in both cohorts that were predicted to …

Enhancing Cancer Diagnosis With Real-Time Feedback: Tumor Metabolism Through Hyperpolarized 1-13c Pyruvate Mrsi, Gaurav Sharma, José S Enriquez, Ryan Armijo, Muxin Wang, Pratip Bhattacharya

Faculty, Staff and Student Publications

This review article discusses the potential of hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) as a noninvasive technique for identifying altered metabolism in various cancer types. Hyperpolarization significantly improves the signal-to-noise ratio for the identification of 13C-labeled metabolites, enabling dynamic and real-time imaging of the conversion of [1-13C] pyruvate to [1-13C] lactate and/or [1-13C] alanine. The technique has shown promise in identifying upregulated glycolysis in most cancers, as compared to normal cells, and detecting successful treatment responses at an earlier stage than multiparametric MRI in breast and prostate cancer patients. The review provides a concise overview of the applications …

Managing Epilepsy In People With Intellectual Disabilities – Creating Capable Communities, R Shankar

Peninsula Medical School

Almost a quarter of people with intellectual disabilities have epilepsy. This life-long condition adversely affects their health, safety and well-being and carries an increased risk of sudden unexpected death in epilepsy (SUDEP) in this population. This commentary considers what not only health and social services but also communities and people with intellectual disabilities themselves can do to improve outcomes.

Cvam: Cna Profile Inference Of The Spatial Transcriptome Based On The Vgae And Hmm, Xiaobo Zhou

Faculty, Staff and Student Publications

Tumors are often polyclonal due to copy number alteration (CNA) events. Through the CNA profile, we can understand the tumor heterogeneity and consistency. CNA information is usually obtained through DNA sequencing. However, many existing studies have shown a positive correlation between the gene expression and gene copy number identified from DNA sequencing. With the development of spatial transcriptome technologies, it is urgent to develop new tools to identify genomic variation from the spatial transcriptome. Therefore, in this study, we developed CVAM, a tool to infer the CNA profile from spatial transcriptome data. Compared with existing tools, CVAM integrates the spatial …

Author Spotlight, Ren-Jie Chen, Jia-Jia Chen, Zhong Jin

Journal of Electrochemistry

No abstract provided.

Metals And Alloys As Catalytic Hosts Of Sulfur Cathode For Lithium-Sulfur Batteries, Zhen-Yu Wang, Xue-Ping Gao

Journal of Electrochemistry

Lithium-sulfur batteries are recognized as one of the most promising next-generation energy storage devices, owing to the high theoretical energy density of 2600 Wh·kg^–1. However, their application has been seriously hindered by the sluggish electrochemical reaction kinetics of elemental sulfur and discharged products (Li₂S₂/Li₂S), and the notorious “shuttle effect” of soluble intermediate lithium polysulfide species, leading to poor cycle stability, low sulfur utilization and inferior coulombic efficiency. Introducing catalytic hosts into sulfur cathode is an efficient path to propel the conversion of sulfur-contained species, thus preventing the dissolution and loss of active-sulfur …

Using Emotion Regulation To Support Informed Literacy, Rachael A. Vandonkelaar

Journal of Educational Research and Practice

When it comes to fake news, no medium circulates and reaches more youth than social media. Social media can provide an opportunity for students to create and post with an authentic audience; however, social media can also perpetuate the danger of fake news. Youth across the globe emotionally engage with content several hours a day and can become vulnerable to the clickbait style of news. Therefore, although research has studied how critical literacy instruction supports informed reading, literacy instruction must also address students’ emotional regulation needs. This research-to-practice article describes the dangers of fake news on youth interactions and provides …

Behind The Scenes Of Controversial International Commercial Arbitration: Case Study Of Heirs To The Sultanate Of Sulu V. Malaysia, Tze Chin Ong, James Ding Tse Wen

Indonesian Journal of International Law

Recently, an ad hoc arbitration final award of US$14.92 billion (approximately RM62.59 billion) in favour of the heirs of the 19^th-century sultanate, the late Sultan of Sulu, Sultan Jamalul Kiram II against Malaysia (the “Award”) that was handed down by a sole arbitrator had created much discussion in the international public and private law arena. Following the issuance of the n Award, Malaysia challenged the Award in the Paris Court of Appeal and successfully stayed the Award’s enforcement in France on July 12. During the same time, on July 11, two Luxembourg-registered subsidiaries of the Malaysian …

Two Roads Diverged In A Yellow Wood And I Have Taken Them Both: Tales From A New Ir Librarian, Allison Boswell

Southern Miss Institutional Repository Conference

The first road:

When Houston Cole Library started an Institutional Repository (IR) at Jacksonville State University, reading all of the journal articles and literature and watching all of the webinars on how to make an IR work was a must. One of the top recommendations was to cultivate buy-in. The standard recommended process for getting buy-in did not work for me and my faculty. Everything I tried did not work. It was a ton of work, a lot of hope, and even more disappointment. I had to come up with a new plan if the IR was going to succeed. …

Bollywood As A Site Of Resistance: Women And Agency In Indian Popular Culture, Sheetal Yadav, Smita Jha

Journal of International Women's Studies

This article evaluates the contemporary Indian redefinition of gender norms, subjectivity, and practices by analyzing Bollywood films as a major influence upon its global audiences. This study explores how Indian cinema redefines women’s status and promotes gender-neutral entertainment by harnessing the powerful energies of current movements such as #MeToo. The article closely examines the textual and conceptual features of current women-focused movies like Ek Ladki Ko Dekha To Aisa Laga (2019), Thappad (2020), and Paglait (2021). This examination focuses on key insights from popular Bollywood actresses’ critical feminist roles to understand their assertions of women’s power, agency, and equality. Additionally, …

Women And The Precarity Of War: Reading Women Militants And Activists In Sharmila Seyyid’S Ummath, Aparna Nandha

Journal of International Women's Studies

Ummath, written by Sharmila Seyyid, navigates the sensitive topic of the precarious lives of three separate women amid the chaos of war-torn Sri Lanka. The stories of main characters Yoga and Theivanai demonstrate women’s challenges in and out of militancy. Their struggles led them to Thawakkul, a Muslim social worker devoted to the cause of rehabilitating disabled and widowed women who once served the LTTE (Liberation Tigers of Tamil Elam). Ummath provides a powerful social critique of the conditions that aggravated the separatist conflict, the stigmatization of women who become part of the LTTE, the inexorable violence perpetrated by …

Impact Of Rural Financial Institutions Building Program (Rufin) On The Productivity Of Women-Owned Farms And Non-Farm Enterprises In Northern Nigeria, Ayodele Abiodun Olaleye, Abigail John Jirgi, Kpotun Mohammed Baba, Usman Shabba Mohammed

Journal of International Women's Studies

This study was undertaken to determine the impact of the Rural Financial Institution Building Program (RUFIN) on the productivity of women-owned farms and non-farm enterprises in Northern Nigeria. The study utilized primary data collected through a questionnaire administered to 390 beneficiaries and an equal number of non-beneficiaries selected through a multi-stage sampling procedure. The productivity of women-owned enterprises was determined using Total Factor Productivity (TFP), which was measured as a ratio of the total annual output of the enterprise to the product of capital input, labor input, and total material input. The propensity score matching approach was used to analyze …

Changing Ideologies Of Marriage In Contemporary Indian Women’S Novels, Bhushan Sharma

Journal of International Women's Studies

Marriage in Hinduism is sacramental in nature and considered a divine religious bond. As per Shastras, man alone is incomplete until or unless he marries. The wife is called Ardhangini (half of man) or dharmapatni, who shares religious duties with her husband. This paper views matrimony from a feminist lens and explores the changing ideology of marriage by drawing upon feminist theory. The study uses two novels by contemporary Indian women writers, Shashi Deshpande's A Matter of Time (1996) and Shobhaa De's Second Thoughts (1996), to explore the world of married women. These novels by Indian women express women’s …

Beautiful, Sexy, And Happy Celebrities: Perfect Mothers Or Instamoms, Ebru Güzel

Journal of International Women's Studies

The development of information technologies and the Internet has created an enormous economy. In line with this digital transformation, cultural change has come about. Global companies create new trends focused on vanity and pleasure in social media that follow the patriarchal capitalist ideology. Motherhood has also been included in this process, and “perfect motherhood,” as an extension to new generation motherhood, has been popularized on social media. Perfect motherhood requires mothers who are responsible for looking after children and the home to also be successful in their professional and personal lives while looking beautiful, young, chic, sexy, and fit. Recently …

Women Caregivers Of Palliative Care Patients: The Arogyakeralam Project In Kerala, India, Florence Jose

Journal of International Women's Studies

Palliative care is primarily holistic care given to the patient and their family where the caregiver plays a significant role in the patient’s health and wellbeing. This research studies the perception of the caregivers on the functioning of the Arogyakeralam palliative care project in Kerala, India, in order to understand the challenges faced by women caregivers of this type of patient. In this descriptive and analytical study, the researcher used the multi-stage random sampling methodology. A structured interview schedule was used to obtain data from 54 primary caregivers of palliative care patients who were randomly and proportionately selected from two …

Child Sexual Abuse And Exploitation Through Livestreaming In Indonesia: Unequal Power Relations At The Root Of Child Victimization, Ni Luh Tasya Prathisthita Tanaya, Ni Made Martini Puteri

Journal of International Women's Studies

Child sexual abuse and exploitation through livestreaming is a rising phenomenon of online child sexual abuse and exploitation in Indonesia. This phenomenon takes place in both offline and online spaces. Moreover, due to the active involvement of the viewers, these content viewers can also be considered as offenders. Thus, it is necessary to recognize this phenomenon as a crime against children, instead of merely a sexual act. By using a criminology perspective, this research explores the roots of this phenomenon, the impact on survivors, and the child protection system’s actions against it. This qualitative study used secondary data analysis, derived …

Masculinist Constructions Of Nationalism In India: Gender, Body Politics, And Hindi Cinema, Nupur Ray

Journal of International Women's Studies

Nationalism is an evocative concept with multiple philosophies around its meanings, purposes and contentions. Symbols, imagery, and spectacle play an important role in cultural expressions of nationalism that sustain an emotional response. The paper argues that imaginative constructs of nationalism in India are primarily constructed around women’s bodily metaphors, sexual norms, and their maternal roles in families. Popular culture, particularly cinema, tends to reinforce power hierarchies in which women symbolizing the nation are in need of protection by men or the state as a masculine authority. Hindi cinema has been an integral part of the socio-cultural lives of people in …

Who Is To Blame? African Feminism, Human Rights, And Sexual Violence Against Izintombi (Virgins) In South Africa, Goodness Thandi Ntuli

Journal of International Women's Studies

This article highlights the intensifying prevalence of sexual violence in South Africa, which affects women including izintombi (virgins, also known as Zulu maidens). Ubuntombi (virginity) traditionally represented a typical identity marker of young-womanhood in the indigenous lives of Zulus. As an aftermath of colonialism and imperialism, the cultural importance of women’s virginity faded into the past with only sporadic survival in some rural areas of South Africa. For some reasons, it was visibly revived together with virginity-testing as public events in the 1980s and 1990s. The practice of virginity-testing was criticized by some scholars, human rights and gender activists, who …

Converging Crises And The Cost Of Exclusion: Unveiling The Invisible Women Of Sri Lanka’S Economy, Lihini Ratwatte

Journal of International Women's Studies

In Sri Lanka, women’s labor force participation has never exceeded 35% in over three decades. As of 2022, the country was ranked 110 out of 146 countries in the World Economic Forum’s Gender Gap Index. The gaps in women’s participation in the formal economy alongside women’s limited political empowerment are two leading causes for the country to be lagging in such global gender equality indicators. At a large cost to the economy, the existence of archaic gender norms that promulgate women’s unpaid care work often exclude women from the formal labor force. This paper dissects the socio-economic and socio-political factors …

Globalization And Migration: The Great Gender Equalizer?, Akm Ahsan Ullah, Sharifah Nurul Huda Alkaff, Shirley Chin Wei Lee, Diotima Chattoraj, Jannatul Ferdous

Journal of International Women's Studies

Globalization has been extensively debated in a range of contexts, from trade to borders, international relations, and conflict. It appears to be a positive force for women as many scholars contend that it has offered women new opportunities, thus enhancing greater gender equality in many countries where traditional patriarchal structures are firmly entrenched. However, some scholars are more skeptical of the benefits of globalization for women. They note that despite women gaining an increasing share of employment opportunities in a globalized world, the expected redistribution of domestic, household, and childcare responsibilities often did not materialize. They also argue that multinational …

Global Women’S Precarity, Borderlands, Decoloniality, And Transformative Change, Vivienne Tailor, Nupur Ray, Goodness Thandi Ntuli, Lihini Ratwatte

Journal of International Women's Studies

No abstract provided.

How The Communist Party Of China Developed Sustainable Economic Growth, Matthew Zawaski

Academic Festival

“It does not matter whether the cat is black or white so long as it catches the mouse,” stated Deng Xiaoping, who served as the President of the People’s Republic of China (PRC) from 1978 to 1989. What Deng Xiaoping meant by this was that it did not matter what type of economic reform took place in China, so long as it yielded a more prosperous economy for the nation. Additionally, he realized that the communist regime in China would be threatened if there was no corrective action implemented to improve the living standards of Chinese citizens through economic reform. …

The Professional, Psychological, And Physical Effects On Women Who Face Gender Discrimination, Gabriella D'Arienzo

Academic Festival

Gender discrimination in the workplace negatively affects women’s professional lives and consequently affects them psychologically and physically.

The Importance Of Performing Arts In Development, Christopher Devlin

Academic Festival

The importance of creativity in life cannot be overstated, and having a base of performing arts in education allows for a person to become even more creative, confident, and self-assured.

Why President Bidens Relief Plan Should Be Passed But For More Limited Borrowers, Nicholas Labanca

Academic Festival

With the cost of attending college dramatically increasing over the past forty years, the same has happened to the national student loan debt causing American citizens to vocalize their concerns. In response, on August 24, 2022, the Biden administration announced its Student Loan Debt Forgiveness Plan. This announcement was met with immediate backlash and praise thus raising the question; should the Student Loan Debt Forgiveness Plan be passed and who should be eligible? To accurately answer this question, there needs to be an understanding of why it is such a big issue. Based on nontraditional borrower delinquency rates, the number …

Compassion Fatigue In Nursing, Madeline Bragaw

Academic Festival

What started as the reason nurses chose the field has now become the reason many nurses are choosing to leave. Empathy and compassion are two qualities that make nurses so special, but when nurses begin to take on the emotional stress of their patients’ pain and illnesses, they can grow burnt out and fatigued. Compassion fatigue is defined as, “apathy or indifference towards the suffering of others” (Oxford University Press, 2021). As a protective mechanism, nurses can begin to become apathetic to suffering when they are constantly seeing people go through emotional and physical pain. While nurses are protecting themselves, …