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Uptake And Localization Of Poly(2-Vinyl-4,4-Dimethyl Azlactone) Modified With Rhodamine- And Coumarin-Based Molecules In Human Embryonic Kidney (Hek293) Cells, Garrett Tassin

Honors Theses

Fluorescence microscopy is a bioimaging technology that utilizes the excitation and emission of fluorophores to identify cellular structures, processes, and interactive events. Natural and synthetic organic dyes are frequently used in fluorescence microscopy techniques for imaging, therapeutic, and biomedical applications. It is also employed in the development of novel organic dyes for innovative methods of drug delivery and labelling. In this study, we investigate the behavior of an organic dye consisting of the post-polymerization modification of poly(2-vinyl-4,4-dimethyl azlactone) (PVDMA) with tetramethyl rhodamine cadaverine (TMR) and a coumarin-based molecule (DBAC). Using cultured HEK293 cells and fluorescence confocal microscopy, we show the …

Dissolved Copper Distributions In The Western Mississippi Sound: Characterizing An Unrecognized Endmember, Megan Hansen

Honors Theses

This study examined the distribution of dissolved copper (Cu) in the western Mississippi Sound, as the element can be beneficial or harmful to organisms depending on its concentration and its chemical form. A mixing experiment eliminated flocculation as a control on Cu distributions during estuarine mixing in both dissolved and colloidal fractions. Field sampling of the western Mississippi Sound occurred during a low river discharge period, and distributions of Cu indicated conservative mixing between fresh ([Cu] ≈ 17 nM) and saline ([Cu] ≈ 2 nM) sources in mid-to-high salinities. Storm outfalls were sampled after rain events to evaluate the impact …

Breaking The Cycle Of Stigma: The Role Of Majority Group Stigmatization In Contributing To Internalized Stigma Among Racial Minorities, Camryn Harris

Honors Theses

This study investigates whether individuals hold more stigma against minority group members with mental health issues based on race. Individuals are more susceptible to the negligence of treatment and further assistance due to increased stigmatization associated with mental health. Internalized stigma is more prominent within marginalized communities due to various co-existing factors such as socioeconomic status, inadequate resources, aversive health experiences, and low education levels infiltrated by systemic discrimination and structural inequality. In addition, minority group members are also more at risk for mental health disorders due to these factors. Past research has shown that stigmatization against individuals with mental …

Lighting And Furniture In Higher Education: The Impact Of Classroom Environmental Features On Student Learning Perceptions, Robert Mcdonald

Honors Theses

Universities worldwide are undertaking extensive renovations and new construction projects to enhance their facilities. These efforts include upgrading flooring, repainting walls, purchasing new furniture, and updating lighting. With many outdated classrooms, institutions redesign older spaces and invest in more modern facilities to create comfortable and collaborative environments. Researchers and commercial manufacturers have studied the significant impact of classroom environments on students' mental well-being, perceptions, and learning performance. However, while research shows the effects of school environments on Pre-K - 12 students, limited studies have focused on the impact of classroom environments in higher education. This research aims to fill this …

Impact Of Training Volume On Female Athlete Triad Risk For Female Collegiate D1 Track And Field Athletes, Sarah Parnell

Honors Theses

iv ABSTRACT The Female Athlete Triad is the joint-presentation of three intertwined conditions (i.e., low energy availability (LEA), low bone mineral density (BMD), and menstrual dysfunction) that range in severity across affected individuals and have been known to affect the mental, emotional, and physical health of female athletes in a number of sports, especially those that are leanness-orientated and feature a high prevalence of disordered eating. The purpose of this study is to assess the potential relationship between increasing amounts of training volume and individual Triad risk factors in women’s collegiate track and field. Online Qualtrics surveys were administered to …

Morphological And Functional Classification Of The Amblyomma Americanum (Lone Star Tick) Hemocytes, Julia Hanson

Honors Theses

Ticks are a diverse group of obligate blood-feeding (hematophagous) arthropods that transmit a wide array of human and animal pathogens. These pathogens have caused an increase in tick-borne diseases that pose a significant threat to public health without preventative measures. These pathogens interact with the tick immune system upon uptake, which is primarily divided into humoral and cellular components. Cellular immunity in ticks encompasses several pathogen-eliminating mechanisms including phagocytosis. These mechanisms are mediated by the action of immune cells, commonly referred to as hemocytes, which are analogous to mammalian white blood cells. This study utilized a combination of morphological, functional, …

Developing A Continuous Cell Line Derived From The Gulf-Coast Tick (Amblyomma Maculatum) Embryos, Sabrina Walia

Honors Theses

Tick cell lines provide an affordable, reproducible, and efficient in vitro experimental system to study tick-pathogen interactions at the cellular level. Before the first tick cell lines were developed, there was no established method to perform in vitro studies with ticks. Tick research at the organismal level is full of difficulties and challenges. An increase in tick-borne infections and the availability of cutting-edge molecular tools have stimulated the research community's interest in using tick cell lines to answer important biological questions related to new and emerging tick-borne diseases. Unfortunately, not all medically relevant tick species have a cell line available. …

Law And Leadership Series | Cornerstones Of Democracy: Civics, Civility, And Collaboration, Center For New York City Law, Law And Leadership Institute

Center for New York City Law

2023 Law Day Program

May 1, 2023

Reconstruction's Lessons, Susan D. Carle

Scholarly Articles in Law Reviews & Journals

In the current moment in the legal struggle for racial justice in the United States, the Nation appears at risk of repeating its history. The country stands at a time of some hope but more cause for pessimism. The current United States Supreme Court has exhibited hostility towards key legal priorities of the racial justice movement, and all indications point to this trend continuing or getting even worse. Leading commentators on race issues have suggested that the United States is headed back to the post Reconstruction era, sometimes referred to as “Redemption” in reference to southern states’ reassertion of white …

Pedestal Foods Ends Contract With Lindenwood Aftermany Years, Sofiya Melnychuk

Lindenlink (2012- )

No abstract provided.

Advancement Of Detection And Treatment For Triple-Negative Breast Cancer And Infectious Disease, Austin Smothers

All Dissertations

Triple-negative breast cancer (TNBC) continues to be one of the leading causes of death in women, making up 7% of all cancer deaths. Tumor-treating electric fields (TTFields) are low-energy, low-frequency oscillating electric fields (OEF) that have been shown to induce an anti-proliferative effect on mitotic cells in glioblastoma multiforme (GBM), non-small cell lung cancer (NSCLC), and ovarian cancer. Currently, tumor-treating field (TTField) therapy utilizes “optimal” frequencies of electric fields to achieve maximal cell death by cell line. However, because of differences in cell size, shape, and ploidy during mitosis, optimal electric field characteristics for maximal cell death may not exist. …

Understanding The Factors Affecing Expatriate Teacher Retention In A Cross-Cultural Setting: A Case Study Of An American International Sschool In Panama, Roberto Flores

All Dissertations

The purpose of this study was to investigate the factors that affect expatriate teacher retention. The research aimed to identify the factors that contribute to expatriate teacher adaptation and retention in cross-cultural settings. As the demand for expatriate teachers has increased with the growth of international schools, retaining them has become a persistent challenge. The scarcity of literature on expatriate teacher retention, combined with high turnover rates and an expanding demand for such teachers, highlights the need for further research in this area. Therefore, this study aimed to fill this gap by exploring the factors that impact expatriate teacher retention …

Explaining Spatio-Temporal Evolution Of Extreme Hydro-Climatic Events Using A Complex Network Framework, Somnath Mondal

All Dissertations

Severe hydroclimatic extreme events, such as droughts, heatwaves, and heavy rainfall, are occurring with increasing frequency and causing significant impacts on both people and the environment. These events also compound in space and time, leading to even more significant consequences. Therefore, it is essential to comprehend these phenomena' concurrent and time-delayed progression across different temporal and spatial scales to address adaptation and mitigation effectively. To accurately understand and map the co-evolution of extreme events, it's necessary to have a thorough grasp of their spatiotemporal patterns, how they propagate and interact with one another, and the underlying mechanisms driving their occurrence. …

Studying Pedestrian’S Unmarked Midblock Crossing Behavior On A Multilane Road When Interacting With Autonomous Vehicles Using Virtual Reality, Fengjiao Zou

All Dissertations

This dissertation focuses on the challenge of pedestrian interaction with autonomous vehicles (AVs) at unmarked midblock locations where the right-of-way is unspecified. A virtual reality (VR) simulation was developed to replicate an urban unmarked midblock environment where pedestrians cross a four-lane arterial roadway and interact with AVs. One research goal is to investigate the impact of roadway centerline features (undivided, two-way left-turn lane, and median) and AV operational schemes portrayed through on-vehicle signals (no signal, yellow negotiating indication, and yellow/blue negotiating/no-yield indications) on pedestrian crossing behavior. Results demonstrate that both roadway centerline design features and AV operations and signaling show …

Understanding Job Satisfaction In The National Park Service, The Needs Of Black Employees, And The Decision-Making Of Managers, Akiebia Hicks

All Dissertations

According to the 2020 U.S. Office of Personnel Management’s Federal Employee Viewpoint Survey, the National Park Service (NPS) was ranked the 353rd best place to work out of the 411 government agencies surveyed, with an engagement score of 61.3%, which was lower than the 69.0% average amongst government agencies. This survey is performed annually and asks employees to score their employer in the following categories: leadership, empowerment, pay, teamwork, innovation, recognition, response to COVID-19, and work-life balance. The scores are divided by a quartile key. In every category except “innovation,” the NPS landed in the lower quartile, causing the need …

Explainable Physics-Informed Deep Learning For Rainfall-Runoff Modeling And Uncertainty Assessment Across The Continental United States, Sadegh Sadeghi Tabas

All Dissertations

Hydrologic models provide a comprehensive tool to calibrate streamflow response to environmental variables. Various hydrologic modeling approaches, ranging from physically based to conceptual to entirely data-driven models, have been widely used for hydrologic simulation. During the recent years, however, Deep Learning (DL), a new generation of Machine Learning (ML), has transformed hydrologic simulation research to a new direction. DL methods have recently proposed for rainfall-runoff modeling that complement both distributed and conceptual hydrologic models, particularly in a catchment where data to support a process-based model is scared and limited.

This dissertation investigated the applicability of two advanced probabilistic physics-informed DL …

Essays In Urban Economics, Terrence Jewell

All Dissertations

My dissertation focuses on the impact of housing demand shocks on neighborhood change and internal migration. My first chapter uses house prices to measure the amenity value households place on new stadium construction in a hosting city. The second chapter studies the impact of two amendments to California’s Proposition 13. Namely, Proposition 60 and Proposition 90 allowed individuals over age 55 to transfer the assessed value of their homes to a replacement dwelling of equal or lesser value in the same county or different county, respectively, without a change of ownership reassessment. In this chapter, I study the removal of …

Planting Date, Seed Size, And Maturity Effects On Cotton And Soybean Growth And Yield In South Carolina, Sarah Holladay

All Dissertations

Seed size, seeding rates, pre-emergence (PRE) herbicides, planting dates, and maturity groups are all important factors that growers must consider before planting cotton or soybean. Previous research has suggested that seed size and seedling vigor are positively correlated and having greater seeding vigor may compensate for adverse planting conditions, pest and disease pressure, and potentially injury from PRE herbicides. Seeding rates and planting dates for cotton are dependent on the variety, environmental conditions, and grower goals. Planting date and maturity group selection are also important considerations for soybean growers in SC as in many cases soybean is planted in rotation …

Studies Of The Ionosphere-Thermosphere Responses To Multi-Scale Energy Deposition Processes, Haonan Wu

All Dissertations

The Ionosphere-Thermosphere (I-T) system is greatly affected by the magnetospheric energy deposition from above and subjected to forcing from the lower atmosphere simultaneously. A central problem in studying the coupled I-T system is to analyze the multi-scale processes naturally embedded in both ways. Magnetospheric energy input such as auroral precipitation and electric field demonstrates multi-scale structures during magnetic storms, resulting in multi-scale I-T responses when deposited into the I-T system. To better quantify the multi-scale aurora and electric field, we developed a new data assimilation model based on a multi-resolution Gaussian process model to synthesize empirical models and observational data …

Revision, Description, And Diagnosis Of Adult And Larval Pycnopsyche Spp. (Trichoptera: Limnephilidae) Using Morphological And Molecular Methods, Matthew Green

All Dissertations

The genus Pycnopsyche Banks, 1905 (Trichoptera: Limnephilidae) is the 2nd most species-rich genus of Nearctic Limnephilidae. Larvae and adults are ecologically diverse and widespread throughout eastern North America. Larvae construct cases from mineral or plant material and are frequently used by biomonitoring professionals at the species level to monitor trends in water quality. However, only two species of Pycnopsyche are currently separable as larvae, with diagnosis limited by the number of unknown larvae associated with known adults. Using morphological and molecular data, the phylogenetic relationships among Pycnopsyche species and species groups were inferred with Bayesian and Maximum Likelihood analyses to …

Annotations Of Awareness: A Framework For Externalizing Thinking To Promote Metacognitive Discourse In High School English And Social Studies Classrooms, Todd Howard

All Dissertations

Teachers find it challenging to integrate metacognition into the classroom to promote critical thinking, but such rigorous instruction is one way to improve access to quality education for all students, no matter their access to outside-of-school resources. To help teachers find more comfort and confidence in designing for increased critical thinking and metacognitive discourse and to help close the theory-practice gap in metacognition research, I conducted a mixed-methods case study focusing on assessment-design interventions. Using the Metacognitive Framework for Assessment Design and Annotations of Awareness, both designed in response to my literature review, my 90-day action research included three Plan-Do-Study-Act …

Supramolecular Pi-Donor/Acceptor Arrays Based On Redox-Active Metal-Organic Coordination Assemblies, Paola Benavides

All Dissertations

Coordination-driven self-assembly is an attractive strategy for constructing thermodynamically stable supramolecular coordination complexes, ranging from discrete metallacycles and cages to infinite coordination polymers and metal-organic frameworks for a variety of applications.

Chapter 1 discusses strategies for preparing supramolecular charge-transfer π-donor/acceptor assemblies and their potential applications.

Chapter 2 demonstrates that tricomponent self-assembly method, which was believed to yield 3D-cages, based on tetrapyridyl porphyrin (M’TPP, M’ = Zn or H₂), dicarboxylate ligands (XDC), and caped cis-Pt(II) corners, actually yields 2D-bowties featuring an M’TPP core and two parallel XDC linkers held together by four heteroligated PtII(N,O) corners. The 2D-bowties showed …

Methyltransferase, Glucose Adaptation, And Import Complex In Trypanosoma Brucei, Emily Knight

All Dissertations

Trypanosoma brucei is a kinetoplastid parasite responsible for human African trypanosomiasis (HAT) and nagana, a livestock wasting disease, which both endemic to sub-Saharan Africa. Unique to kinetoplastids are the specialized peroxisomes, named glycosomes, which compartmentalize the first several steps of glycolysis and gluconeogenesis, nucleotide sugar biosynthesis, and many other metabolic processes. Kinetoplastids are unique in that they have a single mitochondrion. In this work, I present the first study into SET domain proteins in any kinetoplastid parasites. We have characterized a predicted SET domain protein, TbSETD3, that localizes to the mitochondrion and a depletion of the protein results in growth …

Essays On Labor Market Size And Job Match Quality, Lan Lan

All Dissertations

This dissertation is comprised of two essays that delve into the construction of a major-related labor market and its correlation with college graduates’ job match quality. Investigating the job match quality of college graduates for different majors in large cities is crucial, as it provides evidence on which majors tend to yield better job matches. This contributes to the study of the return on major while also shedding light on how city size impacts individuals’ ability to find jobs that align with their educational level and major, thereby enriching the study of the benefits of agglomeration.

The first chapter examines …

Credit Constraints And Innovation, Jun Li

All Dissertations

This paper examines the effects of credit constraints on aggregate innovation when firms face heterogeneous innovation costs and have differential access to credit. Better credit access affects aggregate innovation through (i) a direct effect by facilitating firms to innovate, (ii) a market share effect by encouraging low-cost firms to expand, and (iii) a value effect that increases competition and deteriorates high-cost firms’ innovation. We first develop a structural model featuring the above three channels. We then contrast this theory with the Chinese firm-level data documenting that Chinese state-owned enterprises are less constrained but face higher innovation costs than their private …

Characterization Of Lignin And Cellulose Biopolymers Structure – Function Relationships, Zachariah Pittman

All Dissertations

Biomass is vital to ongoing efforts to secure a sustainable future. While many of our efforts focus on finding alternative forms of energy, biomass among them, only biomass has the potential to serve as a sustainable materials feedstock. However, biomass is heterogenous, complicating the upgrading processes needed to manufacture commodity and performance products. For example, plant biomass consists largely of cellulose, a crystalline polysaccharide, and lignin, a highly stable polyaromatic. The specific properties of cellulose and lignin depend greatly on the plant, harvesting conditions, and isolation procedures. Thus, accurate and reliable determination of the fundamental properties of biomass is crucial …

Classification Of Electrical Current Used In Electroplastic Forming, Tyler Grimm

All Dissertations

Electrically assisted manufacturing (EAM) is the direct application of an electric current to a workpiece during manufacturing. This advanced manufacturing process has been shown to produce anomalous effects which extend beyond the current state of modeling of thermal influences. These purported non-thermal effects have collectively been termed electroplastic effects (EPEs).

While there is a distinct difference in results between steady-state (ideal DC) testing and pulsed current testing, the very definition of these two EAM methods has not been well established. A "long" pulse may be considered DC current; a "short" pulse may produce electroplastic effects; and even "steady-state" current shapes …

Designing Noncentrosymmetric Multifunctional Materials, Ebube Oyeka

All Dissertations

Noncentrosymmetric (NCS) materials with crystal lattices lacking spatial inversion symmetry display a wide range of exciting functionalities. This dissertation covers two classes of functional NCS materials: magnetic skyrmion-host compounds and multifunctional materials. Magnetic skyrmion and multifunctional materials combining optical and magnetic responses are providing avenues for developing and optimizing the performance of electronic devices that can have uses in memory storage, laser technology, medicine, sensors, etc. The formation of skyrmions is driven by asymmetric Dzyaloshinskii–Moriya (DM) interaction facilitated by broken spatial inversion symmetry and large spin-orbit coupling (SOC), while multiple functionalities arise when spin carriers and optical chromophores are optimally …

Top Down Effects And Resource Selection By Coyotes In South Carolina, Alex Jensen

All Dissertations

Top predators play important roles in functioning ecosystems, including regulating the populations of prey species and competing with other predators. However, in the face of global change, many top terrestrial predators have declined in both range and abundance, making room for some smaller predators to expand into new niches. Coyotes (Canis latrans) in North America are a prime example of this – they have rapidly expanded their range in the last 120 years, raising concerns about their impacts on both domestic and wild species. In eastern North America, research has centered around their effects on white-tailed deer ( …

New Dna Repair And Demethylation Functions In Uracil Dna Glycosylase Superfamily, Chenyan Chang

All Dissertations

Uracil-DNA glycosylase (UDG) superfamily, which consists of several groups of enzymes that recognize the damaged DNA bases and initiate the base excision repair (BER) pathway, is most important in dealing with DNA deamination and other base modifications. Thymine DNA glycosylase (TDG), which belongs to family 2 in the UDG superfamily, is able to specifically recognize and cleave the 5-methylcytosine (mC) oxidative derivatives including 5-formylcytosine (fC), 5-carboxylcytosine (caC), 5-hydromethyluracil (hmU) caused by active demethylation or DNA damage. My dissertation work is mainly focused on the fC and caC glycosylase activity within UDG superfamily. Chapter 1 is a general introduction to the …