Digital Commons Network^™

More Synapses, More Problems: The Underdiagnosis Of Depression In Patients With Temporal Lobe Epilepsy, Daisy Delgado

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Artificial Intelligence In Continuous Kidney Replacement Therapy, Lucas J. Liu, Tomonori Takeuchi, Jin Chen, Javier A. Neyra

Markey Cancer Center Faculty Publications

Over the past decade, artificial intelligence (AI) through machine learning (ML) has been increasingly used in health care applications. The use of AI/ML to enhance the provision of continuous kidney replacement therapy (CKRT) is an area of active investigation because of the growing clinical needs of critically ill patients and the abundance of multimodal data from the electronic health records (EHRs) and the CKRT machine itself. Importantly, best clinical practices of CKRT have not been sufficiently standardized, so there is considerable heterogeneity in utilization and deliverables. In this context, AI/ML-based tools could facilitate informed decisions to enhance CKRT goal-oriented deliver- …

Development And Characterization Of Nanobodies That Specifically Target The Oncogenic Phosphatase Of Regenerating Liver-3 (Prl-3) And Impact Its Interaction With A Known Binding Partner, Cnnm3, Caroline N. Smith, Kyle Kihn, Zachary A. Williamson, K. Martin Chow, Louis B. Hersh, Konstantin V. Korotkov, Daniel Deredge, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and metastasis. The mechanisms that drive PRL-3’s oncogenic functions are not well under- stood, partly due to a lack of research tools available to study this protein. We have begun to address these issues by developing alpaca-derived single domain antibodies, or nanobo- dies, targeting PRL-3 with a KD of 30–300 nM and no activity towards highly homologous family members PRL-1 and PRL-2. We found that longer and charged N-terminal tags on PRL-3, such as GFP and FLAG, changed PRL-3 localization compared to untagged protein, indicating that the nanobodies may provide …

Icam-1-Supar-Cd11b Axis Is A Novel Therapeutic Target For Metastatic Triple-Negative Breast Cancer, Dong Li, Hami Hemati, Younhee Park, Rokana Taftaf, Youbin Zhang, Jinpeng Liu, Massimo Cristofanilli, Xia Liu

Markey Cancer Center Faculty Publications

Accumulating evidence demonstrates that circulating tumor cell (CTC) clusters have higher metastatic ability than single CTCs and negatively correlate with cancer patient outcomes. Along with homotypic CTC clusters, heterotypic CTC clusters (such as neutrophil–CTC clusters), which have been identified in both cancer mouse models and cancer patients, lead to more efficient metastasis formation and worse patient outcomes. However, the mechanism by which neutrophils bind to CTCs remains elusive. In this study, we found that intercellular adhesion molecule-1 (ICAM-1) on triple- negative breast cancer (TNBC) cells and CD11b on neutrophils mediate tumor cell–neutrophil binding. Consequently, CD11b deficiency inhibited tumor cell–neutrophil binding …

Life Stressors And Immune Aging: Protective Effects Of Cognitive Reappraisal, Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz, Suzanne C. Segerstrom

Markey Cancer Center Faculty Publications

Stressful life events may accelerate aspects of immune aging, but habitual use of an adaptive emotion regulation strategy, cognitive reappraisal, may attenuate these effects. This study examined whether cognitive reappraisal moderates the associations between life stressor frequency and stressor desirability on aspects of immune aging, including late-differentiated CD8+ T and natural killer (NK) cells and inflammatory markers (IL-6, TNF-α, and CRP), both between and within people in a longitudinal sample of 149 older adults (mean age = 77.8, range: 64–92 years). Participants reported stressful life events, use of cognitive reappraisal, and provided blood semiannually for up to 5 years to …

Single Fraction And Hypofractionated Radiation Cause Cochlear Damage, Hearing Loss, And Reduced Viability Of Merlin-Deficient Schwann Cells, Christine T. Dinh, Si Chen, Aida Nourbakhsh, Kyle Padgett, Perry Johnson, Stefania Goncalves, Olena Bracho, Esperanza Bas, Jorge Bohorquez, Paula V. Monje, Cristina Fernandez-Valle, Nagy Elsayyad, Xuezhong Liu, Scott M. Welford, Fred Telischi

Markey Cancer Center Faculty Publications

Background: Vestibular schwannomas (VS) are benign intracranial tumors caused by loss of function of the merlin tumor suppressor. We tested three hypotheses related to radiation, hearing loss (HL), and VS cell survival: (1) radiation causes HL by injuring auditory hair cells (AHC), (2) fractionation reduces radiation-induced HL, and (3) single fraction and equivalent appropriately dosed multi-fractions are equally effective at controlling VS growth. We investigated the effects of single fraction and hypofractionated radiation on hearing thresholds in rats, cell death pathways in rat cochleae, and viability of human merlin-deficient Schwann cells (MD-SC). Methods: Adult rats received cochlear irradiation with single …

The Plod2/Succinate Axis Regulates The Epithelial–Mesenchymal Plasticity And Cancer Cell Stemness, Yuxin Tong, Yifei Qi, Gaofeng Xiong, Junyan Li, Timothy L. Scott, Jie Chen, Daheng He, Linzhang Li, Chi Wang, Andrew N. Lane, Ren Xu

Markey Cancer Center Faculty Publications

Aberrant accumulation of succinate has been detected in many cancers. However, the cellular function and regulation of succinate in cancer progression is not completely understood. Using stable isotope-resolved metabolomics analysis, we showed that the epithelial mesenchymal transition (EMT) was associated with profound changes in metabolites, including elevation of cytoplasmic succinate levels. The treatment with cell-permeable succinate induced mesenchymal phenotypes in mammary epithelial cells and enhanced cancer cell stemness. Chromatin immunoprecipitation and sequence analysis showed that elevated cytoplasmic succinate levels were sufficient to reduce global 5-hydroxymethylcytosinene (5hmC) accumulation and induce transcriptional repression of EMT-related genes. We showed that expression of procollagen-lysine,2-oxoglutarate …

Dysfunctions Associated With The Intraparietal Sulcus And A Distributed Network In Individuals With Math Learning Difficulties: An Ale Meta-Analysis, Jonathan Tablante, Lani Krossa, Tannaz Azimi, Lang Chen

Psychology

Math learning difficulty (MLD) is a learning disorder characterized by persistent impairments in the understanding and application of numbers independent of intelligence or schooling. The current study aims to review existing neuroimaging studies to characterize the neurobiological basis in MLD for their quantity and arithmetic dysfunctions. We identified a total of 24 studies with 728 participants through the literature. Using the activation likelihood estimate (ALE) method, we found that the most consistent neurobiological dysfunction in MLD was observed in the right intraparietal sulcus (IPS) with distinct patterns of the anterior and posterior aspects. Meanwhile, neurobiological dysfunctions were also observed in …

The People And The Experts: Alternative Views On Economic Affairs, William D. Nordhaus, Douglas Rivers

Cowles Foundation Discussion Papers

Are speculators driving up oil prices? Should we raise energy prices to slow global warming? The present study takes a small number of such questions and compares the views of economic experts with those of the public. This comparison uses a panel of 2000+ respondents from YouGov with the views of the panel of experts from the IGM at the Chicago Booth School. We found that most of the US population is at best modestly informed about major economic questions and policies. The low level of knowledge is generally associated with the intrusion of ideological, political, and religious views that …

The Safe And Effective Clinical Deployment Of Artificial Intelligence To Ols, Kelly Nealon

Dissertations and Theses (Open Access)

18 million new cancer cases are diagnosed each year. Roughly half of these patients will be treated with radiation therapy, a complex technique that requires an interdisciplinary team of clinical staff and expensive equipment to be delivered safely. Cancer centers in Low- and Middle-Income Countries (LMIC) have an especially difficult time meeting the demands of radiation therapy as the complexity of treatment techniques increase, with only 37% of patients in these regions having access to the care they need. Artificial Intelligence (AI) based tools are being developed to simplify the treatment planning and quality assurance processes to increase the number …

Who’S My Child’S Main Doctor?​ Caregiver Perceptions Of Teaching Teams, Jonathan Ermer, Shelby Chesbro, Jessica Boerner, Jacqueline M. Walker, Joy L. Solano

Posters

Background: At academic medical centers, children are cared for by large medical teams consisting of multi-level learners including medical students, interns, senior residents and fellows on patient-and family-centered rounds (PFCR). The size and structure of these teaching teams can make it difficult for patients and families to know who is caring for them and establish a trusting relationship. Also, research has shown when residents are perceived as a “team leader,” they learn more. Previous literature in adults has shown that patients often perceive the intern as their “main doctor,” but this has not been studied in pediatrics. Objective: We sought …

Clinical Presentation And Differential Diagnosis Of A 10-Year-Old Presenting With Unerupted Maxillary Central Incisor: A Case Report., Dev Patel, Robin Onikul, Amy Burleson, Brenda S Bohaty, Jenna Sparks, Neena Patel, A Naidu

Posters

Delayed eruption of permanent teeth can be caused by numerous factors including nutritional deficiencies, tooth positioning, presence of supernumerary tooth, or presence of a cyst impeding eruption. The keys to identifying the cause of delayed eruption are good clinical and radiographic exam, along with obtaining a complete and accurate history from the patient and parent. This case report details a 10-year-old female presenting to the Children’s Mercy Kansas City Dental Clinic with chief concern for an unerupted upper anterior tooth. The patient’s medical history is noncontributory, and she has no known allergies. This case report will include the patient’s clinical …

Clinical Course Of A Patient With Agammaglobulinemia Caused By Slc39a7 Defect, Thao Le, Emily Farrow, Alvin Singh, Isabelle Thiffault, Nikita Raje

Posters

Case Report: A 10-year-old unimmunized boy initially presented to the hospital at 18-months of age with pneumonia and failure to thrive. He had multiple infections including Escherichia coli urosepsis, viral croup, chronic otitis media with bilateral ruptured tympanic membranes, and bacterial pneumonia. On physical examination, he was ill appearing and had diffuse crackles. His laboratory work-up showed leukocytosis, normocytic anemia, undetectable immunoglobulin (Ig) G, A, and E, low IgM (28 mg/dL), absent B cell with normal T cell (7800 mm3) and NK cell (527 mm3) counts, and low zinc level (63 mcg/dL). Genetic testing was negative for Bruton tyrosine kinase …

Solitary Median Maxillary Incisor And Holoprosencephaly: A Review Of The Literature, Benjamin Olson, Robin Onikul, Amy Burleson, Brenda S. Bohaty, Jenna Sparks, Neena Patel

Posters

A solitary median maxillary incisor (SMMCI) is a rare anomaly that affects approximately 1:50,000 live births. The presence of an SMMCI tooth may be an isolated finding or may be associated with other anomalies such as Holoprosencephaly (HPE). Early recognition of SMMCIS is important given the possibility of other associated findings that may impact pediatric growth and development. The purpose of this clinical case is to report the clinical findings associated with a nine-month-old patient who presented to our clinics with a primary solitary median maxillary incisor and a diagnosis of HPE. This presentation will review the literature regarding the …

Bone Marrow Transplant For Macrophage Activation Syndrome In Systemic Juvenile Idiopathic Arthritis​, Shailly Gaur, Michael J. Holland, J Allyson Hays, Ibrahim A. Ahmed

Posters

7yo w/ systemic juvenile idiopathic arthritis who developed macrophage activation syndrome and interstitial lung disease non-responsive to steroids, immunosuppression, and directed biologics with significant adverse reactions who required chemotherapy and eventual bone marrow transplant leading to complete resolution of symptoms.

Incarceration Effects On Children And Families, Sharon Rose

Electronic Theses, Projects, and Dissertations

Children of incarcerated parents have been found to experience long-term trauma as an effect of parental incarceration. There is little information regarding resources and programs available to these children to mitigate these issues. This study aims to identify recurring themes experienced by children and families separated by incarceration which cause negative long-term issues. The study will identify these overlaps and identify plans that can be implemented by social service agencies to alleviate and diminish the rates at which children are affected by incarceration. The researcher will conduct individual interviews with participants to complete an exploratory cross-sectional study. Data gathered from …

Don't Say Gay: How Laws Are Tools For Hate, Discrimination, And Violence, Christina Hartman

Electronic Theses, Projects, and Dissertations

American society teaches the narrative that the law is preeminently fair and just. The law is not now and never has been a bulwark for the rights of the marginalized, voiceless, or those who remain powerless. Instead, states effectively wield law to alter the social meaning behind thought patterns and behavior—whether through the writing of new laws, passing of new laws, or the disregarding of current laws—to mobilize a large population to accept a group as different or other. Florida’s 2022 “Don’t Say Gay” law is an example of that method aimed at the LGBTQ+ community and part of a …

Full Court Press: The Influence Of Midnight Basketball, Talk Radio, And Racial Coding On The Violent Crime Control And Law Enforcement Act Of 1994, George “Matt” Patino

Electronic Theses, Projects, and Dissertations

During the latter half of the twentieth century, “dog whistle” rhetoric increasingly entered the common vernacular, normalized by politicians and media personalities. Initially, the terminology was ambiguous, but it became racially charged when the media started broadcasting images of African Americans alongside the “thug” label. This research explores how “dog whistles” were, in part, a neoconservative response to the liberal policies of President Lyndon B. Johnson and his “Great Society.”

This study explores how “Great Society” policies aimed to balance the liberal expansion of Civil Rights with neoconservative “law and order” policing strategies. This research also investigates how right-wing talk …

Engaging Online Learners Through A Technological Competencies Training For Student Services Professionals: An Action Research Study On Professional Development, Doungchit Sakoonphong

Electronic Theses, Projects, and Dissertations

The purpose of this study was to understand Student Services professionals’ perceptions of their technological competencies as they engage with students online and what an institution in the California community college system could do to develop technological competencies in Student Services classified professionals. Three questions guided this study and they were: (1) what technological competencies do California community college Student Services professionals indicate they have in order to engage with students online, (2) how does an online professional development training course increase technological competencies in California community college Student Services professionals so that they can engage with students online, (3) …

Investigating The Costs And Economic Impact Of Flight Delays In The Aviation Industry And The Potential Strategies For Reduction, Ashmith Anupkumar

Electronic Theses, Projects, and Dissertations

This study addressed a critical issue in our travel life: flight delays. This study covers all aspects of a flight delay, from its causes and consequences to reduction strategies. The focused research questions were: To determine the outcome of flight delays in the aviation industry, to determine costs associated with flight delays for airlines, airports, and passengers, and to determine strategies for reducing flight delays in the aviation industry for robust findings. The findings for each question were as follows: the primary causes were overscheduling, airport hubbing, late check-ins, technical failure, etc. And the consequences were significant financial loss, the …

Ott Subscriber Churn Prediction Using Machine Learning, Needhi Devan Senthil Kumar

Electronic Theses, Projects, and Dissertations

Subscriber churn is a critical issue for companies that rely on recurring revenue from subscription-based services like the OTT platform. Machine Learning algorithms can be used to predict churn and develop targeted retention strategies to address the specific needs and concerns of at-risk subscribers. The research questions are 1) What Machine Learning algorithms are used to overcome subscriber churn? 2) How to predict subscribers’ churn in the OTT platform using Machine Learning? 3) How to retain subscribers and improve customer targeting? The dataset was collected from the Kaggle repository and implemented it into the various prediction algorithms used in previous …

Relative Reactivity Of Six Amino Acids With Sodium Hypochlorite Measured By Gas Chromatography/ Mass Spectrometry And Methyl Chloroformate Derivatization., Josephine Wangui Gitau

Electronic Theses, Projects, and Dissertations

There are 20 common amino acids that act as building blocks for proteins and each one of them differ from each other due to their chemical structure of the R group. During the process of chlorination of water and wastewaters, amino acids present have been implicated as precursors of disinfection by-products. For the analysis of amino acids Gas Chromatography/Mass Spectrometry (GC/MS) is widely used. In this research six amino acids (glycine, valine, leucine, isoleucine, methionine, and phenylalanine) were derivatized with Methyl Chloroformate and analyzed using Gas Chromatography/Mass Spectrometry without heating. The main aim of this study was to observe the …

Authenticity, Support, And Identity Management In The Workplace For Transgender Employees, Raeven Jones

Electronic Theses, Projects, and Dissertations

Prior research has established the importance of understanding topics such as identity management and authenticity in the workplace for the lesbian, gay, and bisexual communities. However, minimal research has been conducted on the unique experiences of transgender employees. Studying identity management for transgender employees can help researchers understand concealment and disclosure behaviors, which can impact employee work experiences. Efforts can be made to promote authenticity through a supportive environment inside the workplace and by encouraging inclusivity at work. Through interviews with 10 participants, this study identified precursors to authenticity for transgender employees, explored the support factors that influence the work …

A Study Of Various Data Sizes Using Machine Learning, Sochaeta Koeum

Electronic Theses, Projects, and Dissertations

Social media is a great domain for news consumption; however, it is referred to as a double-edged sword. While it is user-friendly and low-cost, social media is the reason why fake news can spread rapidly, which is detrimental to society, businesses, and many consumers. Therefore, fake news detection is an emerging field. However, some challenges have restricted other researchers from developing a universal machine learning model that is fast, efficient, and reliable to stop the proliferation because of the lack of resources available, such as large-sized datasets. The goal of this culminating experience project is to explore how varying datasets …

Identification Of Molecular Markers Associated With Copd In Non-Smokers And Smokers: A Bioinformatics Analysis, Agede O. Ayodele, Isa M. Wasagu, Ademola E. Fawibe, Alakija K. Salami

The University of Louisville Journal of Respiratory Infections

Background

Even though the proportional burden of COPD among never-smokers is significant in both developing and developed nations, accounting for around 30% of all COPD in the community, there is little awareness of the prevalence of COPD in this population. Understanding the molecular processes that underlie COPD in nonsmokers is essential.

Methods

Dataset (GSE146560) was acquired from the Gene Expression Omnibus (GEO). The limma and clusterProfiler software tools were used to identify differentially expressed genes (DEGs) and conduct a functional enrichment analysis respectively.

Results

In all, 10,583 DEGs were found, of which 1,065 were up-regulated and 9,518 were down-regulated. The …

The Role Undocumented Student Resource Centers Play In Supporting Undocumented Students In Higher Education, Cynthia Boyzo

Electronic Theses, Projects, and Dissertations

Undocumented Students face many challenges in their daily lives. Accessing higher education is a challenge alone. Many undocumented students get discouraged to attend higher education due to financial constraints. The students that do attend institutions for higher education encounter different challenges. According to Murillo (2017), 65,000 undocumented students graduate from high school each year nationwide; however, only half (49%) attain a degree or enroll in college. Many institutions have developed Undocumented Student Resource Centers to provide a safe and welcoming environment for undocumented students. The purpose of this study explored how Undocumented Student Resource Centers support undocumented students throughout their …

Healthcare Data Breaches: Analysis And Prevention, Nikita S. Dean

Electronic Theses, Projects, and Dissertations

It is evident that the healthcare sector continues to experience data breaches. This culminating experience project focuses on the need to maintain patient data privacy, minimize financial risks, and address public health concerns. The study examined data collected from U.S. Department of Health and Human Services from 2018 to 2023 to answer the following research questions: Q1. How many individuals are affected due to data breaches in healthcare & which States had the most affected individuals? Q2. What are the most common causes of healthcare data breaches & what measures can be taken to prevent this? and Q4. What are …

How Language, Healthcare Insurance Status, Stigma, Age, And Educational Attainment Influenced The Utilization Of Mental Health Services Among The Latino Male Population, Esmeralda Solis, Annika Coe

Electronic Theses, Projects, and Dissertations

Latinx individuals comprise the largest ethnic minority group in the US but are the least likely to use mental health treatments despite experiencing increased mental health difficulties. This study conducted a secondary data analysis of the 2020 and 2021 California Health Interview Survey (CHIS) by UCLA’s Center for Health Policy Research. This study tested whether mental health service use among Latino males could be predicted based on language, healthcare insurance status, stigma, age, and educational attainment. The logistic regression analysis results explained that of the predictor variables, two, age and healthcare insurance status, were statistically significant. Our research aims to …

The Effects Of Organizational Justice, Anneliese Yuenger

Electronic Theses, Projects, and Dissertations

The aim of the present study was to examine the perceptions of organizational justice on employee outcomes of work engagement, burnout, turnover intentions, and presenteeism. The study used survey data from 329 employees who worked over 30 hours per week in the last six months. Data were analyzed using SPSS 28 and Hayes PROCESS Macro to assess descriptive statistics, correlation, simple linear regression, and mediated path analyses. The results of the study found that perceptions of organizational justice (POJ) positively related to engagement. An inverse relationship was found for POJ, burnout, turnover intention, and presenteeism. Overall, engagement and burnout were …

The Components Of Professional Development Design And Methods That Teachers Perceive As The Most Valuable., Elizabeth Esquivelhofstedt

Electronic Theses, Projects, and Dissertations

The purpose of this study is to determine the key design components of transformational teacher professional development programming using sensemaking theory and adult learning theory. This research study was comprised of five phases: 1) needs assessment pre-survey of participating teachers, 2) follow-up interviews with participating teachers, 3) construction of professional development session using the needs assessment pre-survey and follow-up interviews 4) professional development session presentation to teachers 5) post-survey after the professional development session repeating the needs assessment survey to compare pre to post surveys