Digital Commons Network^™

Severe, Non-Apneic Respiratory Dysfunction And Hypoxia Following Generalized Convulsive Seizures, Haley E Pysick, Rup K Sainju, Roshni Nair, Deidre N Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D Lhatoo, George B Richerson, Brian K Gehlbach

Faculty, Staff and Student Publications

Objective: Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non-apneic ventilation or identifying other dysfunctional breathing patterns. We hypothesized that GCS frequently induce immediate, severe, non-apneic respiratory dysfunction that can induce critical hypoxia and bradycardia and sought to characterize breathing patterns after GCS.

Methods: Adult patients admitted to an epilepsy monitoring unit were studied. The effects of GCS on breathing and heart rate were analyzed using nasal pressure transducers, chest and abdominal …

Donor Sex And Platelet Storage Change The Therapeutic Effects Of Platelet-Derived Extracellular Vesicles On Endothelium, Mandeep Kaur, Malvika Gupta, Sowmya Shree Gopal, Charles E Wade, Jessica C Cardenas, Amit K Srivastava

Faculty, Staff and Student Publications

Platelet-derived extracellular vesicles (PEVs) play an active role in vascular protection and repair and are being explored as a viable alternative to platelet therapy. Because platelet function and stability are shaped by donor sex and storage conditions, these same factors are likely to influence the PEVs they release. Understanding these influences is key to developing PEVs into a safe and dependable therapeutic option. In this study, we investigated how donor sex and platelet storage affect the therapeutic properties of PEVs. To address this, PEVs were isolated from platelets of healthy male and female donors. Platelets were either processed immediately after …

Plasma Constituents Promote Endothelial Thromboinflammatory Dysfunction After Hemorrhagic Shock, Kelly E Sanders, Marissa D Pokharel, Baron K Osborn, Yao-Wei Wang, Charles E Wade, Lucy Z Kornblith, Mitchell J Cohen, Jessica C Cardenas

Faculty, Staff and Student Publications

Background: Hemorrhagic shock (HS) following traumatic injury is hallmarked by innate immune activation, hypercoagulability, and thromboinflammatory complications. To date, the direct link between HS, injury severity, and endothelial cell (EC) contributions to thromboinflammation remains poorly understood. The goals of this study were to determine the impact of injury severity and HS on endothelial-mediated thromboinflammation and examine whether these changes increase the propensity for thrombosis.

Methods: Plasma from 89 male trauma patients, stratified by HS and injury severity, and 10 healthy subjects were assessed for inflammatory mediators by BioPlex. Human lung microvascular endothelial cells were exposed to patient plasma for 4 …

Surgical Timing After Acromioclavicular Joint Separation: Association With Clinical Outcomes, Mallory B Lane, Jacob Siahaan, James M Gregory

Faculty, Staff and Student Publications

Background: Treatment of acromioclavicular joint (ACJ) separations continually lacks consensus between providers, and while low-grade injuries generally respond well to conservative management, high-grade injury management is more complex. For patients requiring surgery, the effect of the timing of surgery with respect to the original injury on clinical outcomes remains unclear.

Hypothesis: Clinical outcome measures would worsen as the time between ACJ dislocation injury and surgery increased.

Study design: Cohort study; Level of evidence, 3.

Methods: A large nationwide insurance claims database was queried for patients who had an ACJ dislocation injury using International Classification of Diseases, Ninth and Tenth Revision …

Multidisciplinary Approach To Complex Lower Extremity Limb Salvage In Pyogenic Arthritis, Pyoderma Gangrenosum, And Acne (Papa) Syndrome: A Case Report, Michael M Talanker, Anthony V Basta, Tien Do, Robert Tung, Addison Allen, Morgan Martin, Bryan L Ruygrok, Patrick J Kellam, Jeffrey G Trost, Mohin A Bhadkamkar

Faculty, Staff and Student Publications

Limb salvage using free tissue transfer in patients with rare autoinflammatory syndromes is poorly described, and the safety of microvascular reconstruction in this population remains uncertain. Hereditary pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome is characterized by dysregulated inflammation, pathergy, and impaired wound healing, raising concern for flap compromise and postoperative complications. We report a rare case of lower extremity free tissue transfer in a patient with PAPA syndrome. A 66-year-old woman with rheumatoid arthritis and PAPA syndrome presented with rapid wound breakdown, violaceous ulceration, exposed hardware, and periprosthetic joint infection following left total knee arthroplasty (TKA). Examination revealed …

A Rare Case Of Gastric Ascariasis, Sharon Pan, Kevin Yu, Blaine A Mathison, Yan Gao, Marc Roger Couturier, Salem Muayad, Violeta Chávez, Ranya Selim

Faculty, Staff and Student Publications

Background: Ascariasis, caused by the parasitic roundworm Ascaris lumbricoides, is one of the most common helminthic infections globally. Spread by contaminated soil through the fecal-oral route, A. lumbricoides typically infects the small intestine and has rarely been reported to infect the stomach.

Case summary: We describe an unusual case of a male in his 30s with a history of neuroendocrine tumor (NET) who immigrated from Colombia and who underwent esophagogastroduodenoscopy (EGD) and colonoscopy for further evaluation of abdominal pain. He was incidentally found to have a female Ascaris worm in his stomach that was retrieved during the EGD.

Conclusion: …

Antidepressant-Like Effects Of Extinction Learning As An Animal Model Of Behavioral Therapy, Jing Liu, Sarah E Bulin, David A Morilak

Faculty, Staff and Student Publications

Exposure-based behavioral therapy, the most effective treatment for posttraumatic stress disorder (PTSD), also reduces depressive symptoms. However, neurobiological mechanisms underlying the beneficial effects of exposure-based behavioral therapy on depression remain unknown. Our lab has established fear extinction as a rat model of exposure therapy to investigate the mechanisms underlying its therapeutic behavioral effects in chronically stressed rats. In this study, we demonstrated that extinction learning reduced immobility in the forced-swim test and reversed chronic stress-induced reduction in sucrose preference. Chemogenetic inactivation of pyramidal neurons in the ventral medial prefrontal cortex (vmPFC) prevented these antidepressant-like effects of extinction. Extinction learning enhanced …

Minimal Change Disease Following B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T-Cell Therapy, Kiran Shivaraj, Omar Mamlouk, Amanda Tchakarov, Krina Patel, Ala Abudayyeh

Faculty, Staff and Student Publications

Acute kidney injury (AKI) is a well-recognized complication of chimeric antigen receptor (CAR) T-cell therapy, typically attributed to cytokine release syndrome and acute tubular injury. However, glomerular disease post CAR-T cell is rare. We report a case of minimal change disease presenting with AKI and nephrotic-range proteinuria 3 weeks after B-cell maturation antigen-directed CAR-T cell therapy, ciltacabtagene autoleucel, in a patient with relapsed refractory multiple myeloma. The kidney biopsy revealed diffuse podocyte foot process effacement and a predominance of CD4+ T cells with potential on-target, off-tumor effect of B-cell maturation antigen-directed CAR-T cell therapy, leading to podocyte injury. The patient …

Effects Of Tourist Feeding On The Gut Microbiome And Ecophysiology Of Endangered Northern Bahamian Rock Iguana (Cyclura Cychlura), Erin Lucy Lewis

All Graduate Theses and Dissertations, Fall 2023 to Present

The lifespan and reproduction of an animal depends on maintaining a healthy physiology. The proportion of individuals that survive to an age at which procreation can occur is important to long-term stability of populations and contributes to species survival. Health in an animal is measured in a variety of ways, including through monitoring of the body’s physiological systems, as well as its ability to respond to invading pathogens, and through the different types of bacteria present in the gut. Relationships among those different health metrics have been discovered in recent years and have been found to play important roles in …

A Low Power Fpga Compute Array For Machine Learning And Artificial Intelligence Applications, Todd Wilson

All Graduate Theses and Dissertations, Fall 2023 to Present

Modern small satellites often lack the ability to analyze their data in real time, relying instead on downlinking raw measurements to Earth before any scientific interpretation can occur. This delay restricts missions that require rapid awareness of environmental or space-weather events. This thesis presents the Low-power Array for Cubesat Edge Computing Architecture, Algorithms, and Applications (LACE-C3A), a hardware platform designed to enable in-orbit data processing within the power and volume limits of CubeSat-class spacecraft. 

LACE-C3A uses a modular cluster of flash-based FPGAs, which offer low power consumption, radiation resilience, and in-flight reconfigurability. The system consists of a Controller board responsible …

Adversarial Heterogeneous Agent Learning For Robotic Systems: A Framework For Coordinated Competitive Behaviors, Christopher T. Allred

All Graduate Theses and Dissertations, Fall 2023 to Present

Autonomous robot teams must move reliably, explain their actions, and work together—even in changing or adversarial settings. We present a structured, three-stage pathway that builds coordinated team behavior from strong single-robot skills. First, we develop robust legged-robot locomotion and interpretability using only internal actuator signals. From these proprioceptive cues, robots learn to classify terrain and predict short-term power use, enabling energy-aware movement without external sensors. We further analyze learned behaviors with motif discovery to reveal recurring sensor–action patterns, which clarify how agility emerges and guide reward design. Second, we compose these skills into heterogeneous teamwork using centralized training with decentralized …

Reconfigurable Antennas Using Varactors On A Planar Parasitic Layer And Pin Diodes On A Dome Parasitic Layer, Andrew J. Hendricks

All Graduate Theses and Dissertations, Fall 2023 to Present

This research explores two types of reconfigurable, steerable antennas. These antennas change their beam direction based on electric input signals. The antennas have a layer that overlays the main antenna circuit board. The layer has small copper rectangles (pixels) that may be connected using either varactor diodes (which behave as voltage-controlled capacitors) or PIN diodes (electronic switches). The first antenna can steer in the xz-plane in any direction within about 23° from boresight (straight up from the antenna) and in the yz-plane to about 29° from boresight. The antenna uses varactor diodes on a planar layer. The second …

Evaluating The Feasibility, Acceptability, And Preliminary Efficacy Of An Online Acceptance And Commitment Therapy Program To Improve Dietary Quality In Highly Stressed Adults, Francesca M. Knudsen

All Graduate Theses and Dissertations, Fall 2023 to Present

Stress can negatively affect both mental and physical health, which can increase the risk for chronic illness. When people feel stressed, they may also find it harder to make healthy food choices, which can further impact their health. Despite this, there are limited treatments designed to help people improve their dietary quality while managing stress. Acceptance and commitment therapy (ACT) is an evidence-based psychological approach that helps people respond more effectively to difficult thoughts and emotions while behaving in ways that are aligned with their personal values. This study tested whether a brief, online ACT-based program, combined with coaching phone …

Cultural Adaptation Of A Single Session Acceptance And Commitment Therapy Guide For College Students In Uganda, Miriam Mukasa Kasozi

All Graduate Theses and Dissertations, Fall 2023 to Present

Mental health problems such as depression, anxiety, and stress are common among Ugandan university students and can make it difficult for them to succeed in school or maintain well-being. However, many students do not have access to professional mental health care. Digital self-help programs can make support more available, especially when they are designed to fit the local culture and context. This project examined how an online program called ACT Guide Lite, which teaches skills from Acceptance and Commitment Therapy (ACT), could be adapted for use with Ugandan college students. Students and other university community members first completed the program …

Using Picturebooks In Elementary School To Support Discussion, Connection, And Community Action, Polly Parkinson

All Graduate Theses and Dissertations, Fall 2023 to Present

Children are in school to acquire knowledge, so the books they read are a significant influence on how they see themselves and others. School curricula often lack diverse voices, which may limit students’ views of themselves and how they relate to their communities. The research objective of this study was to examine the potential for fostering empathy in students, to encourage societal benefits of positive community behaviors, deepen understanding of history, and future contributions to an engaged democratic society.

The problem identified was that although much research exists discussing children’s literature and empathy, little explores whether that empathy leads to …

Two Applications Of Lifting-Line Theory For The Design Of Efficient Aircraft, Amanda K. Olsen

All Graduate Theses and Dissertations, Fall 2023 to Present

Numerical lifting-line is a tool that can be used to evaluate the forces and moments of an aircraft wing. This method has limitations but it is beneficial in obtaining a large set of results with relatively little computational power. This research seeks to analyze two different flight scenarios through the use of two numerical lifting-line tools developed at the Utah State University AeroLab. The first scenario involves an aircraft in ground effect flight. When an aircraft flies close to the ground, a phenomenon called ground effect occurs where the lift is increased and the induced drag is decreased. Therefore, flying …

Assessing Young Children's Computational Thinking: Validation Of Items And Item Design Features, And Diagnostic Approaches, Chungsoo Na

All Graduate Theses and Dissertations, Fall 2023 to Present

The goals of this multiple-paper dissertation are to evaluate the psychometric evidence of the Computational and Spatial Thinking Assessment (CaST), designed and developed by the Coding in Kindergarten (CiK) research team (supported by NSF #1842116). In Chapter 2 (Paper 1), I evaluate the psychometric quality of the CaST assessment at the item level. The CaST has moderate item difficulty and high item discrimination, on average, with high reliability and no gender- or age-related item bias. In Chapter 3 (Paper 2), I identify seven item design features from the CaST assessment and examine their impact on item difficulty. All item design …

Drought-Tolerant Plants Of Great Salt Lake: Determining Dormancy Break, Germination, And Seeding Timing Requirements To Improve Restoration Under Hydrologically Extreme Conditions, Montana Horchler

All Graduate Theses and Dissertations, Fall 2023 to Present

Wetlands are declining worldwide, and those in arid regions are especially vulnerable to climate change, drought, water diversions, and other human pressures. As a result, land managers increasingly rely on active revegetation to re-establish native plant communities and their associated ecosystem functions. Restoration that utilizes seeds as the propagule source is often the most cost-effective way to revegetate large areas, but in highly variable environments such as exist at Great Salt Lake, Utah, drought and flooding regularly limit plant establishment. Restoration practitioners require science-informed strategies to reach their goal of establishing diverse native plant communities with high native species cover. …

Freshwater Mussel Reintroduction And Recolonization Habitat Modeling Using Hydraulic, Sediment And Geomorphic Parameters, Megan Elizabeth Dinicola

All Graduate Theses and Dissertations, Fall 2023 to Present

Freshwater mussels are an important group of aquatic animals that live within the riverbed, but their populations have been drastically reduced by habitat alteration and other anthropogenic activities. In an effort to bolster populations, river managers and biologists are using mussel reintroductions as part of their restoration efforts but there are gaps in our understanding of where to reintroduce mussels within a river to see them create self-sustaining populations. This research helps shrink this gap by better understanding the physical habitat needs and population expansion potential of subadult freshwater mussels, or the size of mussel that hatcheries grow for reintroduction, …

Evaluation Of Fertilizer Recommendation And Soil Amendment Impacts On Crop Production In The Intermountain West, Megan Baker

All Graduate Theses and Dissertations, Fall 2023 to Present

Fertilizers improve crop yield and quality by supplying crops with essential nutrients, but can also be a significant input cost. Determining what nutrients and rates to apply for optimal crop growth can be difficult, leading many growers to use external sources for these decisions. Land-grant universities are a common source for fertilizer recommendations, but often based on decades-old research and should be evaluated periodically to verify effectiveness and calibrated to current soil analysis methods. Current Utah State University (USU) guidelines for sulfur (S) and zinc (Zn) were tested across Utah in on-farm trials in 2021-2025. Zinc applications of 5 or …

Continuous Symmetry Discovery And Enforcement Using Vector Fields With Application To Time Series And Image Data, Benjamin D. Shaw

All Graduate Theses and Dissertations, Fall 2023 to Present

Machine learning powers many technologies we use every day, from image classification in computer vision to analyzing time series data such as sensor readings or financial trends. One way to make these systems smarter and more reliable is by using symmetry, meaning patterns that remain unchanged under certain transformations, such as rotations for images or uniform changes in signal amplitude for time series. Discovering these patterns can improve understanding of data and help build models that perform well in new situations. 

Current methods for finding symmetry often rely on large neural networks and are limited to simple transformations like stretching …

Social And Institutional Factors Influencing Restoration Decisions In Sagebrush Plant Communities In The Great Basin, Carmen Calzado-Martínez

All Graduate Theses and Dissertations, Fall 2023 to Present

Sagebrush landscapes of the Great Basin in the western United States have changed dramatically over the past century. Invasive grasses, repeated wildfires, and past land-use practices have made it increasingly difficult for native plant communities to recover once they are damaged. Most restoration efforts occur after disturbances such as wildfire, when ecosystems may already be severely degraded. An alternative approach is proactive restoration, which aims to strengthen ecosystems before major damage occurs. 

This dissertation examines whether proactive restoration strategies could realistically be used in sagebrush rangelands and what factors influence their adoption. The research combines three complementary approaches. First, interviews …

Characterizing Metabolic Flux Of Plant Secondary Metabolites From Diverse Animal-Source Foods To Humans, Muhammad Ahsin

All Graduate Theses and Dissertations, Fall 2023 to Present

There is a popular saying: “You are what you eat.” But does this also mean, “You are what your food eats”? This dissertation explores that question by examining how farming practices shape the nutritional quality of meat—and what, if anything, those differences mean for the people who consume it. While modern livestock production and nutrition research often emphasize protein and fat, this work tests the idea that animals function as biological mediators, linking soil and plant conditions to human diets through the chemical composition of meat and milk. To evaluate this hypothesis, we tracked health-relevant plant compounds— phytonutrients—across the soil–plant–animal–human …

Comparing Strategies For Wetland Revegetation In An Uncertain Water Future, Hailey M. Machnikowski

All Graduate Theses and Dissertations, Fall 2023 to Present

Wetlands worldwide are expected to experience more frequent and intense droughts and floods due to climate change. These shifting water conditions introduce challenges to restoring wetland plants, especially using direct seeding. Seeding is cost and labor-efficient compared to planting, but seeds and seedlings are highly vulnerable to water stress, so restoration efforts often fail when conditions are too wet or dry. Understanding how to improve seed-based revegetation under these conditions is increasingly important. Therefore, we sought to understand the response, measured by percent canopy cover or dry biomass weights, of native plants to different durations of drought in greenhouse experiments, …

An Analysis Of The War On Terror In Textbooks, Kason Kendall

All Graduate Theses and Dissertations, Fall 2023 to Present

This study analyzes how the War on Terror is presented in history textbooks used in the United States and Brazil. Textbooks play an important role in shaping how students understand major global events, including wars, national security, and international relations. However, these materials do not simply present facts, they also reflect specific perspectives and priorities.

The purpose of this study is to analyze how key topics related to the War on Terror, such as the justification for the Iraq War, domestic security policies, treatment of prisoners, and public dissent are portrayed in textbooks from other countries. By comparing these narratives, …

Does Psychosocial Stress Moderate The Association Between Indicators Of Vascular Health And Cognitive Performance: An Examination In Native Hawaiian - Pacific Islander And Non-Nhpi Older Adults, Maddy Mills

All Graduate Theses and Dissertations, Fall 2023 to Present

Late-life cognitive decline and dementia that are unrelated to normal aging are a source of major global health concerns. Vascular risk factors, including high blood pressure, high cholesterol, and diabetes, along with psychosocial stress, are well-established risk factors for cognitive decline. However, no research has explored how these variables interact to influence cognitive performance in older adults. Native Hawaiian-Pacific Islanders (NHPI) face disproportionate rates of vascular risk factors linked to cognitive decline, yet this population has been historically underrepresented in health research. As a result, limited evidence exists regarding how these factors collectively impact cognitive performance in this population. This …

The Role Of Response Time In Math Anxiety, Christine K. Hartmann

All Graduate Theses and Dissertations, Fall 2023 to Present

Math anxiety is characterized by feelings of discomfort or distress that are triggered when an individual is tasked with using numbers. Math anxiety impacts people at all ages, from early elementary school into adulthood (for review see Ramirez et al., 2018). In these studies, we investigated the cognitive impact that math anxiety has on both children and adults by measuring their math anxiety and reaction time on two tasks. The first task was the arithmetic affective priming task (AAPT), which purportedly shows that those with math anxiety tend to complete math tasks more efficiently (faster) when they are primed to …

Impact Of Inhibiting Mitochondrial Calcium Uptake On Calcium Homeostasis And Postmortem Metabolism In Porcine Muscle, Fatema Rahaman Mishu

All Graduate Theses and Dissertations, Fall 2023 to Present

After harvesting the animal, pork muscle continues to undergo changes as it turns from muscle into meat. During this early period, the muscle uses up energy and produces acid, which lowers pH and can affect important quality traits such as color and how well the meat holds water. A key driver of these early changes is calcium, a natural mineral inside muscle cells that helps control contraction and energy use. In this study, we tested whether mitochondria (the cell’s “powerhouse”) help control calcium after harvest and, in turn, influence early postmortem changes in pork. We used a research compound (DS16570511) …

Influence Of Predation Risk On Elk Feeding Behavior In A Multi-Predator Environment, Rosemarie C. Pugh

All Graduate Theses and Dissertations, Fall 2023 to Present

Sometimes predators don’t just affect prey by killing them, they can also change how prey behave. For example, animals may spend more time watching for danger and less time eating, which could affect their health and survival. In Yellowstone National Park, past research has suggested that elk may reduce feeding because they are trying to avoid predators like wolves and cougars. However, most previous studies have only looked at elk behavior during the daytime and have often looked at responses from single predators rather than multiple.

In this study, I used high-resolution tracking collars equipped with motion sensors to directly …

Effects Of Mineral Supplementation On Ovine Performance, Forage Selectivity, And Rangeland Utilization In Southern Utah, Ryan A. Spurling

All Graduate Theses and Dissertations, Fall 2023 to Present

Sheep producers in the Intermountain West region of the US rely on productive rangeland ecosystems that vary widely in forage composition and nutrient availability. As such, supplementation is often necessary to offset dietary deficiencies. Soils and forages grown on rangelands are known to be highly variable in mineral content. Even so, a third to half of the producers in the Intermountain West choose not to provide a complete mineral supplement. Rangeland environments are often characterized by rugged geographical features that make optimal supplement placement difficult. New advances in technology have allowed us to measure individual animal intake on rangelands via …