Digital Commons Network^™

Sex Differences In The Inflammatory Response To Stroke, Muhammad Bilal Tariq, Juneyoung Lee, Louise D Mccullough

Faculty, Staff and Student Publications

Ischemic stroke is a leading cause of morbidity and mortality and disproportionally affects women, in part due to their higher longevity. Older women have poorer outcomes after stroke with high rates of cognitive deficits, depression, and reduced quality of life. Post-stroke inflammatory responses are also sexually dimorphic and drive differences in infarct size and recovery. Factors that influence sex-specific immune responses can be both intrinsic and extrinsic. Differences in gonadal hormone exposure, sex chromosome compliment, and environmental/social factors can drive changes in transcriptional and metabolic profiles. In addition, how these variables interact, changes across the lifespan. After the onset of …

Resilience To Stress Across The Lifespan: Childhood Maltreatment, Heart Rate Variability, And Bereavement, Michelle A Chen, Robert Suchting, Julian F Thayer, Christopher P Fagundes

Faculty, Staff and Student Publications

Following a stressful life event, there is considerable variation in how individuals respond and adapt. Multiple models of risk and resilience show that adverse childhood experiences may be associated with an individual's response to stress later in life. While there is considerable support that early adversity can sensitize the stress response system and lead to adverse outcomes later in life, there is mounting evidence that in adolescence and young adulthood, certain biological predispositions to stress may be associated with resilience in the context of subsequent stressors. In this study, we evaluated how individual differences in vagally mediated heart rate variability …

Updated Analysis To Reject The Laboratory-Engineering Hypothesis Of Sars-Cov-2, Fuqing Wu

Faculty, Staff and Student Publications

A clear understanding of the origin of SARS-CoV-2 is important for future pandemic preparedness. Here, I provided an updated analysis of the type IIS endonuclease maps in genomes of alphacoronavirus, betacoronavirus, and SARS-CoV-2. Scenarios to engineer SARS-CoV-2 in the laboratory and the associated workload was also discussed. The analysis clearly shows that the endonuclease fingerprint does not indicate a synthetic origin of SARS-CoV-2 and engineering a SARS-CoV-2 virus in the laboratory is extremely challenging both scientifically and financially. On the contrary, current scientific evidence does support the animal origin of SARS-CoV-2.

Opioid-Related Mortality: Dynamic Temporal And Spatial Trends By Drug Type And Demographic Subpopulations, Massachusetts, 2005–2021, Thomas J Stopka, Marc R Larochelle, Xiaona Li, Dana Bernson, Wenjun Li, Leland K Ackerson, Ric Bayly, Olaf Dammann, Cici Bauer

Faculty, Staff and Student Publications

BACKGROUND: Fatal opioid-related overdoses (OOD) present significant public health challenges. Intuitive and replicable analytical approaches are needed to inform targeted public health responses.

METHODS: We obtained fatal OOD data for 2005-2021 from the Massachusetts Registry of Vital Records and Statistics. We conducted heatmap analyses to assess trends in fatal OOD rates per 100,000 residents, visualizing rates by death year and decedent age at one-year intervals, stratifying by race/ethnicity, sex, rurality, and involved substances. We calculated Getis-Ord Gi* statistics to identify spatial clusters of OOD rates.

RESULTS: Among 20,774 fatal OODs, rates were higher among males, and highly variable by race/ethnicity, …

Perceived Negative Political Climate Among Hispanic/Latino Adolescents Before And After The 2020 Us Presidential Election: Associations With Internalizing Symptoms And Substance Use, Pablo Montero-Zamora, Saskia R Vos, Jennifer B Unger, Ingrid Zeledon, Ryan Lee, Daniel W Soto, Eric C Brown, Maria Duque, Maria Fernanda Garcia, Carolina Scaramutti, Beyhan Ertanir, Seth J Schwartz

Faculty, Staff and Student Publications

The political climate often changes following the installment of a new president. This volatility presents opportunities for examining how elections might affect vulnerable subgroups such as Hispanic/Latino (HL) adolescents. The present study explored the perception of negative political climate among HL adolescents before and after the 2020 U.S. presidential election and its association with internalizing symptoms and substance use. We conducted the study in Los Angeles and Miami between 2020-2021, with a sample of 304 HL adolescents (Females = 60.8%), aged 15.3 years on average. Participants completed measures of negative political climate (pre- post-election) and measures of depressive symptoms, anxiety, …

One Immune System Plays Many Parts: The Dynamic Role Of The Immune System In Chronic Pain And Opioid Pharmacology, Sanam Mustafa, Juliana E Bajic, Benjamin Barry, Samuel Evans, Kariel R Siemens, Mark R Hutchinson, Peter M Grace

Faculty, Staff and Student Publications

The transition from acute to chronic pain is an ongoing major problem for individuals, society and healthcare systems around the world. It is clear chronic pain is a complex multidimensional biological challenge plagued with difficulties in pain management, specifically opioid use. In recent years the role of the immune system in chronic pain and opioid pharmacology has come to the forefront. As a highly dynamic and versatile network of cells, tissues and organs, the immune system is perfectly positioned at the microscale level to alter nociception and drive structural adaptations that underpin chronic pain and opioid use. In this review, …

Consumer Reaction To The Use Of Artificial Intelligence Chatbot On Distribution Of General Insurance In Singapore, Lai Hing Tan

Dissertations and Theses Collection (Open Access)

As technology rapidly permeates all aspects of our lives, it is not unusual to question and even challenge the rationale on why certain industries are slower to adapt to the new digital age. Insurance is a business that is under scrutiny given its traditional ways of selling and legacy challenges. Why is technology investment in insurance companies lagging others? One emerging technological disruption is artificial intelligence (AI). It is the science of designing and building intelligent systems that can complete tasks traditionally performed by humans. AI is expected to fundamentally transform today’s marketplace, for businesses and consumers alike. However, because …

Directed Trusts And The Conflict Of Laws, Jeffrey Schoenblum

Vanderbilt Law School Faculty Publications

Directed trusts are an extremely important development in trust law, indeed truly transformative, because they challenge what was presumed to be the "irreducible core" of the trust.' That is, the trustee owes certain nonwaivable fiduciary obligations to the beneficiaries with regard to the management of the trust estate and also with respect to distributions.

The directed trust in its radical format, as found to a greater or lesser degree in Tennessee, Nevada, South Dakota, and Delaware, represents a fundamental assault on this irreducible core of trust law because, with respect to investments and distributions, new actors, known as trust advisers …

Characterization Of Neutrophil Extracellular Traps In Naked Mole-Rats: A Step Towards Cancer Resistance, Thomas Abraham Smith

Undergraduate Honors Capstone Projects

Cancer is the second leading cause of death in the United States, exceeded only by heart disease. One of every five deaths in the United States is due to cancer. A growing area of research involves the analysis of cancer resistant traits in other species to understand their biological mechanisms and eventually make translations to human cancer research and clinical treatment. Because of their remarkable cancer resistance, the naked mole-rat (NMR) is a prime subject for this research, and various studies have already suggested that the immune mechanisms of the NMR might be harnessed for human cancer therapies^1-4,7. …

Protein Nutrition And Immunity In Male Bumblebees (Bombus Impatiens), Carson Stoker

Undergraduate Honors Capstone Projects

Male bumble bees play a vital but understudied role in their colonies. They are essential to colony reproduction and success, despite not emerging until the end of the colony's life cycle. Even so, the biology of male bumble bees is not well understood, which leaves our understanding of colony health incomplete. This knowledge gap is important because bumblebee populations are declining, which threatens the ecosystems and industries which rely on them for pollination. This study aimed to understand how two understudied factors of bumble bee health—diet and immunity—are related in males. Pollen, a bee’s main source of protein, has been …

Shifting The Paradigm With Wednesday Addams: Why Nuanced, Intersectional Portrayals Of Autistic People Matter, Camille Alyse Bassett

Undergraduate Honors Capstone Projects

For decades, Autistic people have been portrayed in the media through dehumanizing stereotypes such as the robot, the superhuman savant, and the empty shell. Through these stereotypes, Autistic people are construed as non-human, above-human, and sub-human but never as human beings with complexity, authenticity, and dignity. In addition to being stereotypical, depictions of Autistic people have historically featured white and male characters, a longstanding pattern that erases Autistic women and people of color, among others. In 2022, however, Netflix’s spinoff series of The Addams Family, Wednesday, brought to the screen one of the very first autistic-coded …

Applying The Extended Parallel Process Model To Climate Change Communication, Mikenna Renee Debruin

Undergraduate Honors Capstone Projects

Whereas over 99% of the scientific community believes in the concept of anthropogenic climate change, lay support is still lagging behind. I suggest three key factors to lagging lay support: 1) complexity, 2) manufactured scientific controversy, and 3) doom-and-gloom framing. Because of these factors, individuals are less willing believe in the prevalence of human-induced climate change, nonetheless do something about it. The Extended Parallel Process Model (EPPM), however, presents a model to assuage eco-anxiety and counter psychological distance from the problem. The EPPM, proposed by Kim Witte in the 1990s, combines appeals to threat and appeals to efficacy to contextualize …

Connections For Success: Social Networking In Virtual University, Clara K. Cook

Undergraduate Honors Capstone Projects

Online learning has experienced an unexpected increase in the last two years in response to the demands of the COVID-19 pandemic and its accompanying mitigation efforts. As universities engage in discussions regarding whether to keep offering a wide selection of online courses or transition fully back to traditional course modes, it is important to understand the extent to which students are able to network with their instructors and classmates in their online courses and the ways in which it differs from in-person courses. This paper explores the differences in networking between in-person, synchronous online, and asynchronous online courses. Additionally, it …

Markov Chain Analysis Comparison, Thomas Robert Prouty

Undergraduate Honors Capstone Projects

This Honors Capstone was proposed as a method to develop a greater understanding of modern model-checking tools. To do this the student chose to analyze and compare the results of the tools Prism, Storm, and Stamina. To evaluate the effectiveness of each tool, comparisons were made of the results for running each tool on a simplified communication network.

The simplified communication network model used was a CTMC (Continuous-Time Markov Chain) model that employed correct signal transitions and erroneous bit flipping transitions. This was done in an effort to simulate possible errors and faults that can occur between a provider and …

Level 3 High Powered Rocketry Certification Through Tripoli Rocketry Association, Zachary Foster

Undergraduate Honors Capstone Projects

This paper aims to give an overview of the Level 3 certification process through the TRIPOLI Rocketry Association. This paper will also give an overview of Zachary Foster’s Level 3 Certification submission. The overview of the certification submission will include fin flutter calculations, stability calculations, descent rate calculations, flight simulations, flight results, construction overview, drawing package for the airframe, and pre-flight checklists. The results of fin flutter calculations showed that the minimum flutter speed is 1972 ft/s. The maximum flight velocity is 1309.6 ft/s. The flutter calculation has a total factor of safety of 1.5. The stability calculations show a …

Oppression In Xinjiang: Rhetorical Parallels To The Causal Mechanisms, Christina Elizabeth Anderson

Undergraduate Honors Capstone Projects

This paper compares the framings of ethnic conflict with theoretical political science explanations of the causes of such conflict. Framings are statements used to portray the who, what, and why of an issue through the emphasis or exclusion of information to create a specific agenda. The theoretical expectation from social science is that ethnic conflict is a result of a commitment problem, where the two parties in the conflict cannot credibly guarantee the protection of the other. This arises from situations where there is a large minority group population that is underrepresented from government and has grievances from economic disparities …

The Levant: Climate Change’S Effects On Domestic And Foreign Security Policy, Mary Mckenna Kump

Undergraduate Honors Capstone Projects

This project applies a comparative analysis of climate effects on security perspectives in the Levant (Israel, Palestine, Jordan, and Lebanon) with evidence from historical events and modern processes. In other words, how do the effects of climate change threaten states’ core national security interests? What areas of the system are likely to be impacted by climate effects? Researchers project that climate change will affect current and future global conditions, so how does it impact how states perceive the environment in relation to their national security interests? To examine these questions, I have developed a relatively informal cause-and-effect relationship between climate …

Working Like A Dog: Literary Analysis Of Multifactorial Service Dog Outcomes., Sarah Brinck

Undergraduate Honors Capstone Projects

What makes a service dog successful? Whether it is genetics or the environment they are raised in, the definition of a successful service dog is complicated. Organizations that set out to train service dogs depend on successful outcomes to continue operating. That makes it particularly important to determine and understand the primary factors that impact the success or failure of dogs bred and/or trained for service dog programs. Given the complexity of the requirements for effective service dogs, it can be costly for an individual or an organization to neglect any factors that contribute to success. Individual components of what …

Imposter Syndrome [Poster], Tristan Snell

Graduation with Distinction Posters

Shows how peer mentors can help other students deal with feeling like an imposter in higher education.

Detection And Microhabitat Use Of The Cryptic Patch-Nosed Salamander (Urspelerpes Brucei) In Three Occupied Streams, Chelsea Anderson

All Theses

Patch-nosed Salamanders (Urspelerpes brucei) are tiny (25.76 ± 0.17 mm [SE] snout-vent length) plethodontids endemic to headwater streams in a small (29 km² at the time of our study) geographic region of northeast Georgia (GA) and northwest South Carolina (SC). Due to its secretive nature and recent discovery (2007), little is known about U. bruceihabitat, life history, or potential threats. Though environmental DNA (eDNA), aquatic leaf litter bags, and opportunistic active searches are successful detection techniques for U. brucei, and other factors influencing detection are unknown. Additionally, while occupied U. brucei streams have been characterized …

The Effect Of Yearly Labor Earnings On Commute Time To Work In South Carolina, Peter Trela

All Theses

In this paper, I attempt to ascertain the effect of labor earnings on commute time to work for individuals in South Carolina by using ACS 1-year Public Use Microdata Sample Estimates. First, I use standard linear regression models with controls to determine the direction and magnitude of the association between yearly labor earnings and commute time to work. I later use standard linear regression models with limited controls to determine how the association between yearly labor earnings and commute time changes before and during the events of the COVID-19 pandemic. There exists a positive relationship between yearly labor earnings and …

Gaslight: Attacking Hard-Label Black-Box Classifiers Via Deep Reinforcement Learning, Rajat Sethi

All Theses

Through artificial intelligence, algorithms can classify arrays of data, such as images or videos, into a predefined set of categories. With enough labeled data, a classifier can analyze an input’s components and calculate confidence scores for each category. However, machine learning relies heavily on approximation, which allows attackers to exploit classifiers by providing adversarial
examples. Specifically, attackers can modify their input so that the victim classifier cannot correctly label it, while a human observer would be unable to notice the difference.
This thesis proposes Gaslight, a system that uses deep reinforcement learning to generate adversarial examples against a victim classifier. …

Force Coefficients And Wind Loads For Wide Flange Section And Retrofitted Pipe Racks, Sovanroth Ou

All Theses

While relatively rare, the failures of steel structures occasionally occur due to extreme wind events such as hurricanes and tornadoes. The American Society of Civil Engineers (ASCE) provides well-defined guidelines for determining wind loads for regular buildings; nonetheless, the actual wind loads for complex open-frame steel structures are not as clearly understood by practicing engineers. Pipe bridges and pipe racks are open-frame structures, commonly used in many petrochemical plants. Over the years, additional pipes are often added to existing pipe racks or pipe bridges to accommodate changes in the operation needs of the petrochemical plant. The objectives of this study …

Mapping Information Flows That Support Adaptive Capacity In The Sterile Processing Department (Spd), Jacob Hionis

All Theses

The Sterile Processing Department (SPD) is the part of the hospital that is responsible for decontaminating, assembling, and sterilizing surgical trays for use in the Operating Rooms (ORs). Errors in the SPD can lead to delayed surgeries or patient harm. The SPD is a complex system, with multiple interconnected subdepartments and roles. Complex systems require coordination between stakeholders. This study aims to discover how an organization can adapt to scale, and how information flows support these adaptations. In this study, observations, semi-structured interviews, and on-the-job interviews were conducted with members across the SPD and OR to elicit pressures, adaptations, and …

Unidentified Deceased Persons: Who Are At-Risk?, Sarah Duncan

All Theses

This study explores the silent mass disaster of unidentified deceased persons that is occurring across the United States and identifies the individual and community level characteristics that make a person “at-risk” of becoming an unidentified deceased person within the United States. This study identifies trends-based hotspots by using data reported on the National Missing and Unidentified Persons System (NamUs) and comparing those trends to the gender United States population. It finds that males, and age of death between 20-64 are overrepresented and White persons are underrepresented in the unidentified deceased person sample when compared the general population. Social and human …

Cú Chulainn's "Vigil On The Hound Fords": The Centrality Of Borders In The Táin Bó Cuailnge, David Atkinson

All Theses

This thesis examines the role of the Irish hero Cú Chulainn as a guardian of both supernatural and human borders in the popular medieval Irish saga, the Táin Bó Cuailnge. As a descendent of both the human inhabitants of Ireland and the supernatural síd, Cú Chulainn is uniquely situated to negotiate the border between the two worlds these peoples inhabit. The ambiguous distinction between these two worlds is reflected by the river borders that divide Ireland into its shifting land holdings and kingdoms. The ambiguity at the heart of this saga has given it enormous potential for adaptation through …

Growth, Mortality, And Movement Of Endemic Bartram's Bass And Invasive Alabama Bass In Upper Savannah River Basin Tributaries, Tyler Zumwalt

All Theses

Bartram’s Bass are an endemic to the Upper Savannah River basin in North Carolina, South Carolina, and Georgia. Bartram’s Bass are facing many risks, primary among them being hybridization with nonnative Alabama Bass. More recently, nonnative Alabama Bass and their hybrid congeners have been observed moving from reservoirs into tributaries where the remaining Bartram’s Bass populations exist. Thus, for Chapter 1 we sought to better understand the threat of nonnative gene spreading in tributary systems. To do this, we 1) quantified the movement of pure Alabama Bass, Bartram’s Bass, and their hybrids, 2) assessed correlations between movement and abiotic variables, …

An Investigation Of Community-Defined Boundaries And Important Sites, Emma Grace Sprinkle

All Theses

This thesis research investigates and documents how individuals within the African American settlement communities of Cross Cut, Ferguson Village/Down Cut, and Sol Legare define the boundaries and important sites of their community. The purpose of the study is to better understand how individuals define their community’s boundaries, rather than historic preservation and planning professionals defining them. It seeks to determine the importance of factors such as houses, churches, schools, streets, farm lands, cemeteries, and community gathering spaces to boundary drawings as well as the influence of current address, age, and time spent in the community on participants’ boundaries. Before this …

Kitchen Witch: Animated Independent Property Pitch Bible Research And Development, Kelsey Eaves

All Theses

My thesis project centers around the production process for creating an animated program. My paper is a record of the development of my pitch bible and my efforts to raise outside interest in the property. I intend to use my work here to enter the animation industry as a jumping off point in my career. My research materials include various “Art Of” production books, Creating Cartoons with Character by Rocko’s Modern Life creator Joe Murray, and firsthand interviews from present and former television industry personnel. In this text I explore television animation pre production to highlight the creation of an …

Prey Preference Of Chrysoperla Rufilabris (Burmeister) (Neuroptera: Chrysopidae) For Three Common Pest Species Of Greenhouse Crops, Caitlin Silva

All Theses

Chrysoperla rufilabris (Burmeister) (Neuroptera: Chrysopidae) larvae are voracious generalist predators and important biological control agents on greenhouse crops. This study investigated the prey preference of second-instar C. rufilabris for three common greenhouse pests, namely the twospotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), the Madeira mealybug, Phenacoccus madeirensis Green (Hemiptera: Pseudococcidae), and the melon aphid, Aphis gossypii Glover (Hemiptera: Aphididae). This study also investigated the influence of prey density ratios on the preference of C. rufilabris larvae for T. urticae and A. gossypii. Prey species preference was evaluated in no-choice, two-choice, and all-choice laboratory bioassays. In the no-choice bioassays, …