Digital Commons Network^™

Netzero Insight: The Role Of Data Analytics And Machine Learning In Combating Climate Change, Tariq Najar, Chrissie Aldo

Theses

Countries must act urgently to achieve the SDGs and make significant progress for the planet and people by 2030. But there are some key challenges that the world must address. Climate change is one of the most significant challenges of our time, and its impacts can undermine the ability of all countries to achieve sustainable development. However, countries committed to limiting global warming to 1.5°C above pre- industrial levels in the Paris Agreement. Member nations pledge to take urgent action on climate change to save the planet from global warming.

Using data analysis techniques and methodologies, such as CRISP-DM, and …

Demonstration Of A Virtual Reality Driving Simulation Platform, Mingming Wang

Theses

Modern autonomous driving is undergoing a period of rapid evolution. Image processing, computer vision, and remote sensing, among others, have played crucial roles in the creation of safe and reliable robotic automobiles. However, some robotic vehicles still have difficulties in their driving mechanisms even though the current mainstream autonomous driving approaches seem to be effective in fulfilling driving duties. There have been several high-profile incidents in the early years of testing that have prompted some to question whether or not all relevant domains have been explored in order to attain human-like driving. The current sensor technique based on machine learning …

Advanced Control Of Vapor Compression Liquid Chillers, Suliman Awad

Theses

Chillers are one of the most sophisticated and most important equipment in cooling plants. Due to its complexity and importance, a cost effective and accurate control technique is a necessity to ensure system reliability and longevity. As the chiller contains multiple inputs and outputs, two advanced multivariable control techniques were selected to control the chillers cooling capacity, exit chilled liquid temperature of the evaporator as well as to reject disturbances. The advanced techniques covered in this framework are the Linear Quadratic Integral (LQI) and Model Predictive Control (MPC). Both were successfully applied to the chiller’s model for multiple testing cases …

Techniques To Create A Realistic Digital Collection Of Near Planar Cultural Heritage Objects, Snehal A. Padhye

Theses

Cultural heritage objects like paintings and manuscripts are a rich source of information about human history and a lot has been discovered through their study. A great collection of such artifacts is scattered around the globe in various libraries and research institutions. Digital images of the objects make them accessible to a greater audience, but images offer only a limited experience compared to observing the real thing. Public access to institutions got further limited during pandemic times, further increasing importance of techniques that enable rich access to such objects remotely. In addition, due to the physical nature of these often …

Incorporating High Dynamic Range Into Multispectral Imaging For Cultural Heritage Documentation, Gabrielle Brogle

Theses

The dynamic range that can be captured using traditional image capture devices is limited. While an image sensor cannot capture the entire dynamic range that the human eye can see, imaging techniques have been developed to help accomplish this. High dynamic range imaging has been incorporated into digital photography pipelines to produce high-quality images with correctly exposed regions with varying illumination. The multiple exposures are fused together in post- processing. By capturing a broader dynamic range, the range of contrast captured is also increased, helping to improve color accuracy. Cultural heritage institutions face limitations when trying to capture color accurate …

Harnessing Crispr-Cas12a And Nanotechnology For The Rapid And Accurate Detection Of Dna Viruses, Mengdi Bao

Theses

In recent years, the world has faced numerous pandemics caused by viral diseases, leading to considerable morbidity, mortality, and economic disruptions. Developing vaccines for pandemics can be a challenging task due to the rapid mutation of viruses and the significant investment of time required for their development. While real-time polymerase chain reaction and immunoassay techniques are frequently utilized for viral diagnostics, they possess inherent limitations. Therefore, there is a pressing need to rapidly and accurately identify viral infections to manage diseases effectively. This work explores the use of nanotechnology and clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) proteins to …

Housing Conditions And Needs In Urban District 5, Delan Almazrooei

Theses

Dubai remains one of the key tourist attraction areas in the world. However, the city has witnessed significant population growth over the past decade, which has resulted in problems associated with urbanization, such as pollution. The formulation of the DUBAI 2020 Urban Master Plan was meant to create a supple yet workable and viable formula to balance urban development and sustainability of the environment. The plan was based on population growth, utilization of infrastructure facilities, and advancement of effectual and environmentally sustainable energy sources. The master plan will affect critical areas, including Dubai Silicon Oasis Centre (DSO). With the key …

Evaluating The Impact Of Broadband Access And Internet Use In A Small Underserved Rural Community, Javier Valentín-Sívico, Casey I. Canfield, Sarah A. Low, Christel Gollnick

Engineering Management and Systems Engineering Faculty Research & Creative Works

Having adequate access to the internet at home enhances quality-of-life for households and facilitates economic and social opportunities. Despite increased investment in response to the COVID-19 pandemic, millions of households in the rural United States still lack adequate access to high-speed internet. In this study, we evaluate a wireless broadband network deployed in Turney, a small, underserved rural community in northwest Missouri. In addition to collecting survey data before and after this internet intervention, we collected pre-treatment and post-treatment survey data from comparison communities to serve as a control group. Due to technical constraints, some of Turney's interested participants could …

An Introduction To Autocad For Beginners, Zoe L. Mahaney

Construction Management

This paper aims to outline the process of developing and creating an online instructional video tutorial for beginner level individuals who hope to learn and utilize AutoCAD software. AutoCAD, developed by Autodesk, is a computer-aided design software that provides users with the ability to create and edit digital 2D and 3D designs, which is more efficient than traditional hand-drawn models. The main objective of this project is to provide the public with access to learning and navigating AutoCAD software on their own, for personal gain. Construction Management students at Cal Poly have the opportunity to learn and use AutoCAD as …

The Connection Between Gen Z And Online Fast Fashion Media; Aiming To Create A Sustainable Future In Fashion., Rachel Peters

School of Art Undergraduate Honors Theses

It is impossible to think about culture in the past two decades without referencing social media. My generation, commonly known as Gen Z (born between 1997-2010), has been on the forefront of social media development. One of the first generations to grow up with some form of unfiltered online social experience, Gen Z has been hard wired to consume media. While using social media alongside my peers, I have observed a problem that has resulted from this: mass consumption. A mass consumption of food, beauty products, home decor, and clothing in particular. On social media we see hundreds of videos …

Existentialism And Creative Practice, Catherine Hudgens

School of Art Undergraduate Honors Theses

The creative process mimics the existentialist philosophy of human freedom and the responsibility to create one’s own meaning in life through an emphasis on invention, experimentation, and ceaseless becoming. Through my body of work, I examine the meaning-giving capacities of the viewer and creator as agents involved in a work of art. The sculptures, as well as found objects, have the power to illuminate the human circumstances they emerged from, while the process of making is also the process of learning, where objects can be used to understand ourselves and the world. Philosophical concepts can be accessed through art in …

Review Of Magnetic Properties And Texture Evolution In Non-Oriented Electrical Steels, Yizhou Du, Ronald J. O'Malley, Mario F. Buchely

Materials Science and Engineering Faculty Research & Creative Works

Electrical steels can be classified into two groups: grain-oriented (GO) and non-oriented (NGO) electrical steel. NGO electrical steels are mainly considered as core materials for different devices, such as electric motors, generators, and rotating machines. The magnetic properties and texture evolution of NGO electrical steels depend on multiple factors (such as chemical content, heat-treatment, and rolling process) making the development of new products a complex task. In this review, studies on the magnetic properties of NGO electrical steels and the corresponding texture evolution are summarized. The results indicate that further research is required for NGO electrical steels to ensure high …

A Hyperbaric Aerodynamic Levitator For Containerless Materials Research, Sydney E. Boland, Stephen K. Wilke, Jonathan A. Scott, Sarah M. Schlossberg, Alex Ivaschenko, Richard J.K. Weber, David W. Lipke

Materials Science and Engineering Faculty Research & Creative Works

A hyperbaric aerodynamic levitator has been developed for containerless materials research at specimen temperatures exceeding 2000 °C and pressures up to 10.3 MPa (1500 psi). This report describes the prototype instrument design and observations of the influence of specimen size, density, pressure, and flow rate on levitation behavior. The effect of pressure on heat transfer was also assessed by studying the heating and cooling behavior of levitated Al2O3 liquids. A threefold increase in the convective heat transfer coefficient was estimated as pressure increased to 10.3 MPa. The results demonstrate that hyperbaric aerodynamic levitation is a promising technique for containerless materials …

Personal Protective Equipment Usage And Injury Type, Nathan Giannini

Construction Management

Workers in the construction industry have many injuries both minor and life-altering. The industry suffers from injuries of all kinds such as falls, electrocution, and being struck by flying objects. To protect against this, workers wear certain types of personal protective equipment (PPE) on construction sites as a last line of defense. The equipment available such as hard hats, safety glasses, gloves, respirators, and hearing protection either protects against acute injuries (those that occur instantly) or chronic injuries (those that occur over time). This study investigates whether the type of injury that PPE protects against, acute or chronic, affects the …

Designing A Work-Life Balance Learning Module For Cal Poly Construction Management Department, Alex Jones

Construction Management

The construction industry is known to create a highly stressful work environment given its unpredictability and mental/time demanding nature, which creates challenges for professionals to maintain a healthy work-life balance. This senior project aims to research and identify the key areas that foster this stress and propose a learning module for the Cal Poly Construction Management Department to implement into class curriculum. Having this learning module taught to students will raise awareness of the topic for future industry professionals and equip them with the tools to maintain a healthy equilibrium between their work demands and personal life. The learning module …

The Civil War Conflict Between Anglophones/Francophones In The Northwest And Southwest Regions Of Cameroon, Myriam Jeter

Graduate Program in International Studies Theses & Dissertations

The Civil War conflict between Anglophones and Francophones, also known as the Ambazonia war, is a long-standing issue that continues to plague the people living in the Northwest and Southwest regions of Cameroon. This paper explores the colonial history of the nation, the cause of the ongoing conflict, the reasons for its escalation, and how it gave rise to the Ambazonian separatists who want to have a separate nation called the Ambazonia Republic.

This study contributes to conflict understanding in two ways. First, it sheds light on the cultural and economic impacts of internally generated crises in a country. Second, …

The Solidarity Manifesto: A New Network For Future Change, Sofia Calicchio

Graduate Program in International Studies Theses & Dissertations

Colonialism is a scheme of standpoint; colonizer versus colonized, West versus East, good versus bad. When put in the foreground, the value of what we see heavily relies on our perspective and knowledge. When learning to dissect, deconstruct, and decolonize spaces, we need to start utilizing decolonial thought as an historical tool rather than a true depiction of reality. Decolonizing spaces and recognizing Western colonization practices means challenging the normative structures in colonial history, thus breaking the cycle of oppression through building community and fostering solidarity. Drawing on theories exploring access to public spheres, representation, protection, permanence, cultural displacement and …

Re: Approval For: Berkeley Pit And Discharge Pilot Project, Quarterly Pilot Project Report, Fourth Quarter 2022, Dated March 6, 2023, Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Crafting Journalism: The Pseudonyms Of American Reform, Sierra Fishman

Capstone Projects and Master's Theses

The late 19th and early 20th centuries in the United States saw the rise of "Stunt Girls" and "Sob Sisters" in journalism. These pioneering women defied traditional societal expectations of housewives and pursued careers in reporting, gaining recognition for their accomplishments through the dangerous nature of their work. While many may know the name Nellie Bly, the pseudonym for Elizabeth Jane Cochrane, other reporters played a vital role in the transformation of journalism, including Caloipe, Nellie Bly, Lola, Annie Laurie, Dorothy Dix, Enid, Eva Gay, Nora Marks, Girl Reporter, Nell Nelson, Grace Ermine, Meb, and Olivia. It is important to …

Socioeconomic Vulnerability: Qualitative Findings From Climate Change Data In California, Evan Martinez

Capstone Projects and Master's Theses

Climate Change has existed as an important focus in the science community for decades, however relevant literature often focuses on environmental viewpoints more so than those of a socioeconomic perspective. In 2023, an increase in severe weather and unexpected weather events across the United States shed light onto the shortcomings of our preparedness and mitigation techniques. Particularly in California, flooding, sea level rise, and drought conditions have led to high rates of population displacement, economic inequality, and health/safety risks. These events pose the questions as to how climate change and its related natural disasters can potentially affect the average California …

The Chicken’S Too Fat To Cross The Road: Ethical Issues And Dangers Pertaining To Factory Farms, Michael J. Martinus

Capstone Projects and Master's Theses

In the mid-20th century, the meat industry implemented a method of rearing livestock called factory farming, which confined animals in close quarters until it was time for slaughter and allowed for more output with cheaper production methods. In modern-day unfortunately, factory farming is still used and treats their animals even worse; genetically modifying chickens until they can’t walk, the unrelenting impregnation of dairy cows, and forcing pigs to live in their own feces. Companies such as Tyson and JBS control about 85% of the meat industry and since their goal is to make the most profit with the least effort, …

Mincle-Gsdmd-Mediated Release Of Il-1Β Small Extracellular Vesicles From Hepatic Macrophages In Ethanol-Induced Liver Injury, Quanri Zhang, Weiwei Liu, Katarzyna Bulek, Han Wang, Megan R Mcmullen, Xiaoqin Wu, Nicole Welch, Renliang Zhang, Jaividhya Dasarathy, Srinivasan Dasarathy, Laura E Nagy, Xiaoxia Li

Faculty, Staff and Student Publications

BACKGROUND: Macrophage-inducible C-type lectin (Mincle) is expressed on hepatic macrophages and senses ethanol (EtOH)-induced danger signals released from dying hepatocytes and promotes IL-1β production. However, it remains unclear what and how EtOH-induced Mincle ligands activate downstream signaling events to mediate IL-1β release and contribute to alcohol-associated liver disease (ALD). In this study, we investigated the association of circulating β-glucosylceramide (β-GluCer), an endogenous Mincle ligand, with severity of ALD and examined the mechanism by which β-GluCer engages Mincle on hepatic macrophages to release IL-1β in the absence of cell death and exacerbates ALD.

METHOD AND RESULTS: Concentrations of β-GluCer were increased …

Fully Human Monoclonal Antibody Targeting Activated Adam10 On Colorectal Cancer Cells, Nayanendu Saha, Du-San Baek, Rachelle P Mendoza, Dorothea Robev, Yan Xu, Yehuda Goldgur, M Jason De La Cruz, Elisa De Stanchina, Peter W Janes, Kai Xu, Dimiter S Dimitrov, Dimitar B Nikolov

Faculty, Staff and Student Publications

Metastasis and chemoresistance in colorectal cancer are mediated by certain poorly differentiated cancer cells, known as cancer stem cells, that are maintained by Notch downstream signaling initiated upon Notch cleavage by the metalloprotease ADAM10. It has been shown that ADAM10 overexpression correlates with aberrant signaling from Notch, erbBs, and other receptors, as well as a more aggressive metastatic phenotype, in a range of cancers including colon, gastric, prostate, breast, ovarian, uterine, and leukemia. ADAM10 inhibition, therefore, stands out as an important and new approach to deter the progression of advanced CRC. For targeting the ADAM10 substrate-binding region, which is located …

Efficacy Of Alternative Dose Regimens Of Exemestane In Postmenopausal Women With Stage 0 To Ii Estrogen Receptor-Positive Breast Cancer: A Randomized Clinical Trial, Davide Serrano, Sara Gandini, Parjhitham Thomas, Katherine D Crew, Nagi B Kumar, Lana A Vornik, J Jack Lee, Paolo Veronesi, Giuseppe Viale, Aliana Guerrieri-Gonzaga, Matteo Lazzeroni, Harriet Johansson, Mauro D'Amico, Flavio Guasone, Stefano Spinaci, Bjørn-Erik Bertelsen, Gunnar Mellgren, Isabelle Bedrosian, Diane Weber, Tawana Castile, Eileen Dimond, Brandy M Heckman-Stoddard, Eva Szabo, Powel H Brown, Andrea Decensi, Bernardo Bonanni

Faculty, Staff and Student Publications

IMPORTANCE: Successful therapeutic cancer prevention requires definition of the minimal effective dose. Aromatase inhibitors decrease breast cancer incidence in high-risk women, but use in prevention and compliance in adjuvant settings are hampered by adverse events.

OBJECTIVE: To compare the noninferiority percentage change of estradiol in postmenopausal women with estrogen receptor-positive breast cancer given exemestane, 25 mg, 3 times weekly or once weekly vs a standard daily dose with a noninferiority margin of -6%.

DESIGN, SETTING, AND PARTICIPANTS: This multicenter, presurgical, double-blind phase 2b randomized clinical trial evaluated 2 alternative dosing schedules of exemestane. Postmenopausal women with estrogen receptor-positive breast cancer …

Outcomes Following Extracorporeal Membrane Oxygenation For Severe Covid-19 In Pregnancy Or Post Partum, John J Byrne, Amir A Shamshirsaz, Alison G Cahill, Mark A Turrentine, Angela R Seasely, Joe Eid, Caroline E Rouse, Michael Richley, Nandini Raghuraman, Mariam Naqvi, Yasser Y El-Sayed, Martina L Badell, Cece Cheng, James Liu, Emily H Adhikari, Soha S Patel, Erika R O'Neil, Patrick S Ramsey

Faculty, Staff and Student Publications

IMPORTANCE: Existing reports of pregnant patients with COVID-19 disease who require extracorporeal membrane oxygenation (ECMO) are limited, with variable outcomes noted for the maternal-fetal dyad.

OBJECTIVE: To examine maternal and perinatal outcomes associated with ECMO used for COVID-19 with respiratory failure during pregnancy.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective multicenter cohort study examined pregnant and postpartum patients who required ECMO for COVID-19 respiratory failure at 25 hospitals across the US. Eligible patients included individuals who received care at one of the study sites, were diagnosed with SARS-CoV-2 infection during pregnancy or up to 6 weeks post partum by positive nucleic …

Advances In The Treatment Of Invasive Fungal Disease, Zhuan Zhang, Gerald F Bills, Zhiqiang An

Faculty, Staff and Student Publications

With over 300 million severe cases and 1.5 million deaths annually, invasive fungal diseases (IFDs) are a major medical burden and source of global morbidity and mortality. The World Health Organization (WHO) recently released the first-ever fungal priority pathogens list including 19 fungal pathogens, considering the perceived public health importance. Most of the pathogenic fungi are opportunistic and cause diseases in patients under immunocompromised conditions such as HIV infection, cancer, chemotherapy, transplantation, and immune suppressive drug therapy. Worryingly, the morbidity and mortality caused by IFDs are continuously on the rise due to the limited available antifungal therapies, the emergence of …

Comparison Of Reconstructed Prompt Gamma Emissions Using Maximum Likelihood Estimation And Origin Ensemble Algorithms For A Compton Camera System Tailored To Proton Range Monitoring, Ingrid Valencia Lozano, George Dedes, Steve Peterson, Dennis Mackin, Andreas Zoglauer, Sam Beddar, Stephen Avery, Jerimy Polf, Katia Parodi

Faculty, Staff and Student Publications

Compton-based prompt gamma (PG) imaging is being investigated by several groups as a potential solution for in vivo range monitoring in proton therapy. The performance of this technique depends on the detector system as well as the ability of the reconstruction method to obtain good spatial resolution to establish a quantitative correlation between the PG emission and the proton beam range in the patient. To evaluate the feasibility of PG imaging for range monitoring, we quantitatively evaluated the emission distributions reconstructed by a Maximum Likelihood Expectation Maximization (MLEM) and a Stochastic Origin Ensemble (SOE) algorithm. To this end, we exploit …

Outcomes Of The “Brca Quality Improvement Dissemination Program”: An Initiative To Improve Patient Receipt Of Cancer Genetics Services At Five Health Systems, Erica M Bednar, Minxing Chen, Michael T Walsh, Amanda L Eppolito, Molly H Klein, Kelly Teed, Brittany Hodge, Jordan Hunter, Han Gill Chao, Dillon Davis, Wilshauna Serchion, Cara Yobbi, Rebekah Krukenberg, Sandra B Jenkinson, Jennifer J Moore, Cassandra Garcia, Fatimaeliza Gonzalez, Towanna Murray, Linda D Nielsen, Brenda Ho, Megan Haas, Sarah B Greenzweig, Abby Anderson, Christina Johnson, Nichole A Morman, Elizabeth Bowdish, Emaline Wise, Julia N Cooper, Pauline Kefalas Russ, Katelyn Tondo-Steele, Buonarotti F De Gracia, Brooke Levin, Kristin Mattie, Kathryn Zarnawski, Molly Kalasinski, Jennifer Stone, Caitlin O'Brien, Alexa Bream, Aidan M Kennedy, Rachel A Paul, Michelle Bilbao, Maureen Romero, Rebecca L Carr, Jennifer M Siettmann, Anna K Vercruyssen, Kaycee Leon, Banu K Arun, Andrew V Grainger, David P Warshal, Erin Bowman, Timothy A Goedde, Deepa Halaharvi, Kellie Rath, Generosa Grana, Lida Mina, Karen H Lu

Faculty, Staff and Student Publications

OBJECTIVE: A quality improvement initiative (QII) was conducted with five community-based health systems' oncology care centers (sites A-E). The QII aimed to increase referrals, genetic counseling (GC), and germline genetic testing (GT) for patients with ovarian cancer (OC) and triple-negative breast cancer (TNBC).

METHODS: QII activities occurred at sites over several years, all concluding by December 2020. Medical records of patients with OC and TNBC were reviewed, and rates of referral, GC, and GT of patients diagnosed during the 2 years before the QII were compared to those diagnosed during the QII. Outcomes were analyzed using descriptive statistics, two-sample t-test, …

A Parathyroid Hormone/Salt-Inducible Kinase Signaling Axis Controls Renal Vitamin D Activation And Organismal Calcium Homeostasis, Sung-Hee Yoon, Mark B Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S Wang, Christian D Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A Benkusky, Seong Min Lee, Rebecca Berdeaux, Marc Foretz, Thomas B Sundberg, Ramnik J Xavier, Charles H Adelmann, Daniel J Brooks, Anthony Anselmo, Ruslan I Sadreyev, Ivy A Rosales, David E Fisher, Navin Gupta, Ryuji Morizane, Anna Greka, J Wesley Pike, Michael Mannstadt, Marc N Wein

Faculty, Staff and Student Publications

The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated renal 1,25-vitamin D production downstream of PTH signaling. PTH inhibited SIK cellular activity by cAMP-dependent PKA phosphorylation. Whole-tissue and single-cell transcriptomics demonstrated that both PTH and pharmacologic SIK inhibitors regulated a vitamin D gene module in the proximal tubule. SIK inhibitors increased 1,25-vitamin D production and renal Cyp27b1 mRNA expression in mice and in human embryonic stem cell–derived kidney organoids. Global- and kidney-specific Sik2/Sik3 mutant mice showed Cyp27b1 upregulation, …

How Do Cancer-Specific Computed Tomography Protocols Compare With The American College Of Radiology Dose Index Registry? An Analysis Of Computed Tomography Dose At 2 Cancer Centers, Timothy P Szczykutowicz, Moiz Ahmad, Xinming Liu, Myron A Pozniak, Meghan G Lubner, Corey T Jensen

Faculty, Staff and Student Publications

BACKGROUND: Little guidance exists on how to stratify radiation dose according to diagnostic task. Changing dose for different cancer types is currently not informed by the American College of Radiology Dose Index Registry dose survey.

METHODS: A total of 9602 patient examinations were pulled from 2 National Cancer Institute designated cancer centers. Computed tomography dose (CTDI vol ) was extracted, and patient water equivalent diameter was calculated. N-way analysis of variance was used to compare the dose levels between 2 protocols used at site 1, and three protocols used at site 2.

RESULTS: Sites 1 and 2 both independently stratified …