Digital Commons Network^™

The History Of Wrongful Birth And The Future Of Reproductive Technologies, Luke Isaac Haqq

Minnesota Journal of Law, Science & Technology

No abstract provided.

The Brain On Death Row: Reconciling Neuroscience & Categorical Exemptions From Execution, Alexa Johnson-Gomez

Minnesota Journal of Law, Science & Technology

No abstract provided.

Soft Law 2.0: An Agile And Effective Governance Approach For Artificial Intelligence, Gary E. Marchant, Carlos Ignacio Gutierrez

Minnesota Journal of Law, Science & Technology

No abstract provided.

The Health Care Industry Is Ready For A Revolution: Its Privacy Laws Are Not, Erin Rutherford

Minnesota Journal of Law, Science & Technology

No abstract provided.

Volume 24, Issue 2 Masthead, Front Matter, Table Of Contents

Minnesota Journal of Law, Science & Technology

No abstract provided.

Infrared Thermography (It) And Subepidermal Moisture Scanning (Sem) To Identify Early Tissue Injury And Reduce Hospital Acquired Pressure Injuries In Patients Undergoing Procedures Greater Than Four Hours In Duration, Irish Mills Parker, Makaela Waddell, Alexa Johnson

Doctor of Nursing Practice Projects: College of Nursing

Objective: The purpose of this pilot feasibility study was to more effectively prevent hospital-acquired pressure injuries in high-risk patients by using infrared thermography and subepidermal moisture scanning to identify early signs of tissue injury from pressure. Methods: Data was collected in the Cardio-Vascular Intensive Care Unit (CVICU) and cardiac medical-surgical care floors at Nebraska Medicine. Inclusion criteria are adults, scheduled for a surgery or procedure(s) predicted to last four or more hours, and planned admission to the ICU afterward. Participants were scanned with FDA-approved infrared thermography (IT) and subepidermal moisture (SEM) scanners before their procedure, two hours post-procedure, and then …

Increasing Communication Of Patient Daily Goals During Interdisciplinary Rounds In An Inpatient Pediatric Cardiac Unit, Sage Bailey

Doctor of Nursing Practice Projects: College of Nursing

Introduction: Ineffective communication between interdisciplinary team members in a pediatric inpatient setting results in poor documentation compliance and decreased staff satisfaction of daily goals. The use of a standardized patient daily goal sheet improves effective communication among interdisciplinary team members. The primary aims of this study were to improve RN satisfaction and knowledge regarding interdisciplinary communication, improve verbalization of patient daily goals in daily rounds, increase the number of daily goals verbally discussed and improve the quality of documentation in the electronic medical record (EMR). Methods: Data were collected on a pediatric academic 30-bed cardiac care unit involving 100 nurses. …

To Hear Or Not To Hear: How “Best Interest” Determinations Can Help In The Cochlear Implant Debate, Tessa Wright

Minnesota Journal of Law, Science & Technology

No abstract provided.

Targeting The Cxcr1/2 Axis In Pancreatic Ductal Adenocarcinoma, Caitlin Molczyk

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is notoriously challenging to diagnose and treat. This tumor has an aggressive phenotype and benign clinical features until severe disease dissemination, which makes it too late to eradicate. Although it is only the 10th most common cancer in the United States, it is the fourth leading cause of cancer-related deaths. The treatment options are complicated further due to tumor heterogeneity, meaning not all tumor cells are in the same state phenotypically or epigenetically. They also express cytokines, chemokines, and receptors differently. Here we explore the usage of CXCR1 and CXCR2 and their ligands in PDAC tumor …

Impact Of The Covid-19 Pandemic On The Management Of Risk Factors In Patients With Stable Atherosclerotic Vascular Disease, Dean Karalis, Patrick Moeller, Albert Crawford, Maria Janelli, Scott Hessen

Division of Cardiology Faculty Papers

Background

Effective control of risk factors in patients with ASCVD is important to reduce recurrent cardiovascular events. However, many ASCVD patients do not have their risk factors controlled, and this may have worsened during the COVID-19 pandemic.

Methods

We retrospectively evaluated risk factor control among 24,760 ASCVD patients who had at least 1 outpatient encounter both pre-pandemic and during the first year of the pandemic. Risk factors were uncontrolled if the blood pressure (BP) ≥ 130/80 mm Hg, LDL-C ≥ 70 mg/dL, HgbA1c ≥ 7 for diabetic patients, and patients were current smokers.

Results

During the pandemic, many patients had …

How Phylogeny And Arboreality Affect Pelvic Girdle Anatomy Of Chameleons, Dakota J. John

Honors Thesis

Morphological adaptations have allowed animals to inhabit different landscapes such as mountains, forests, plains, etc. These adaptations have increase in prevalence through natural selection processes in all species which allow favorable traits to be passed to offspring. Chameleons have evolved a plethora of adaptations that have allowed them to persist in different niches. One anatomical feature of chameleons that has not been well studied is the pelvic girdle. The pelvic girdle bridges the axial and appendicular skeletons in animals, so the size, shape, and orientation of the girdle is important to how the animal functions in its environment. The pelvic …

Disease Prevalence And Selenium Bioaccumulation In Northern Leopard Frogs (Lithobates Pipiens), Emily B. Eisenbraun

Honors Thesis

Most amphibians are becoming imperiled in today’s world via environmental contamination and emerging infectious diseases. This project's main objective was to determine the relationship between the prevalence of Ranavirus and selenium bioaccumulation in amphibians in South Dakota. I selected northern leopard frogs (Lithobates pipiens) to focus on specifically because they are susceptible to Ranavirus and are found ubiquitously throughout eastern South Dakota wetlands. The secondary objective of this project was to determine if disease prevalence was correlated with areas of agricultural runoff in South Dakota’s prairie pothole wetlands. Intensive field sampling was conducted across five wetlands in Eastern South Dakota …

Midweed: A Comparison Between Marijuana Laws, Regulations, And Social Attitudes In Cannabis-Legal Vs. Cannabis-Illegal Midwest States, Abagail Lim

College of Journalism and Mass Communications: Professional Projects

This professional project is a series of three journalistic articles. Each article focuses on laws, regulations and social attitudes surrounding marijuana in the United States. These topics are explored primarily through the lenses of two Midwest states (Illinois & Nebraska), which have highly contrasting laws and regulations regarding marijuana. The state of Illinois legalized medical marijuana in January 2014 and recreational marijuana in January 2020, while in Nebraska, both medical and recreational use still remains illegal, though possession of up to one ounce has been decriminalized.

The purpose of choosing these two states is to show how stark a contrast …

Higher Dose Corticosteroids In Patients Admitted To Hospital With Covid-19 Who Are Hypoxic But Not Requiring Ventilatory Support (Recovery): A Randomised, Controlled, Open-Label, Platform Trial, Recovery Collaborative Group

Faculty, Staff and Student Publications

BACKGROUND: Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.

METHODS: This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation

FINDINGS: Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen …

Higher Dose Corticosteroids In Patients Admitted To Hospital With Covid-19 Who Are Hypoxic But Not Requiring Ventilatory Support (Recovery): A Randomised, Controlled, Open-Label, Platform Trial, Recovery Collaborative Group

Faculty, Staff and Student Publications

BACKGROUND: Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.

METHODS: This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation

FINDINGS: Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen …

Framework For Applicability Of Fidic Red Book (1999) For Contracts Governed By Law No. 182 Of The Year 2018 For Regulating Contracts Concluded By Public Entities, Fredy Ayad

Theses and Dissertations

An administrative contract is a type of contract that the administrative body enters in order to achieve a public interest. In Egypt, administrative contracts are governed by Law No. 182 of the year 2018 for Regulating Contracts concluded by Public Entities, which has been promulgated in October 2018. This Law includes several mandatory rules, which will govern over any conditions in the construction contract.

The FIDIC Red Book 1999 is widely used in Egypt and the Middle East in private sector and is currently also being utilized by governmental bodies. However, some contractors are not aware of the major deviations …

Translating A Pediatric Weight Management Intervention Into Medically Underserved Areas, Caitlin Golden

Theses & Dissertations

Despite substantial prevention and treatment efforts, childhood obesity remains a pressing public health concern. Disparities persist in obesity prevalence among children of lower socioeconomic status, racial and ethnic minority groups, and those residing in rural areas. The vast majority of efficacious pediatric weight management interventions (PWMIs) have been based in larger cities and urban areas delivered through inter-disciplinary teams in a hospital or medical center, and the degree to which these or other efficacious PWMIs have been translated to, and are feasible in, typical rural or micropolitan areas is unclear. This dissertation describes a dissemination strategy and a systematic approach …

Development Of Combination Therapy Strategies To Treat Cancer Using Dihydroorotate Dehydrogenase Inhibitors, Nicholas Mullen

Theses & Dissertations

Cancer cells require supraphysiologic levels of nucleotide triphosphates to fuel their malignant behaviors, including uncontrolled proliferation, immune evasion, metastasis, and therapy resistance. This requirement is met by hyperactive flux through the de novo pyrimidine and de novo purine pathways. Dihydroorotate dehydrogenase (DHODH) is an essential enzyme in the de novo pyrimidine pathway that can be targeted by FDA approved and experimental drug compounds. A robust body of preclinical evidence, encompassing hundreds of independent studies over several decades, demonstrates impressive activity of DHODH inhibitors in animal models of cancer. Paradoxically, however, all clinical trials to date have failed to demonstrate efficacy …

Do Plants Have The Cognitive Complexity For Sentience?, Ricard V. Solé

Animal Sentience

Are plants sentient? Like other aspects of the cognitive potential of plants, this is a controversial issue, often driven by analogies and seldom supported on solid theoretical grounds. Sentience is understood in cognitive sciences as the capacity to feel. I suggest that because of plants’ evolved adaptations to morphological plasticity, sessile nature and ecological constraints, they are unlikely to have the requisite cognitive complexity for sentience.

A Forest In The City: Contemplative Practice For Difficult Times, David Chang

Journal of Contemplative and Holistic Education

In this short narrative-essay, David Chang presents what he learned after spending a year in contemplative solitude on a remote off-grid island along the coast of BC, offering “invitations to live the stillness of the forest in the bustle of the city”. Chang makes the case that those blessed with the time and resources to practice contemplative solitude have an (educational) commitment to share these lessons and insights with broader society, arguing that “Contemplation becomes insignificant if it cannot address the pressing problems of our day”.

Making Malice Musical: Verdi’S Compositional Journey Through The Eyes Of Six Villains, Michael Chadwick

Electronic Theses and Dissertations

Giuseppe Verdi is a pillar of the operatic world and had a profound impact on the evolution of the art form. From a rudimentary beginning, he developed over time from a popular creator of operas in the solita forma style of 19^th century Italy into a master craftsman of combining music, text, and theatrical drama. Verdi utilized the popular compositional formal convention of solita forma to begin his career. Over time he evolved beyond its boundaries and shifted his focus to the holistic theatrical presentation of the drama. Much has been written about this evolution through analysis of Verdi’s …

Characterization Of Molecular Content, Cytotoxicity, And Anti-Inflammatory Activity Of Extractions From Eupatorium Serotinum, Jordy Sloan

Electronic Theses and Dissertations

Inflammation is a complex and varied immune response which can be expressed chronically or as a temporary reaction to foreign invaders. Symptoms of inflammation include swelling, pain, soreness, and difficulty of motion. Recently, the effect of sesquiterpene lactones such as Helenalin from Arnica montana have been studied for their anti-inflammatory properties. In this study, we identified and harvested samples of Eupatorium serotinum, a plant historically used by Native Americans to treat a variety of medical illnesses. Crude extracts of the leaves, flowers, roots, and stems were prepared by ethanol extraction. The cytotoxicity of the different extracts on HEK293 cells …

The Great Unlearning, Catherine Mccrory Pears

Electronic Theses and Dissertations

The Great Unlearning is a conceptual exploration: sifting through experiences and objects to overcome psychological pain, expectations of society, individual upbringing, and outside influences in an ongoing quest for authenticity. To both embrace personal history and honor loved ones while letting go of lingering negativity is challenging. Using objects culled from my life, examining the past, and incorporating items gathered along my path through nature, the work seeks personal healing while promoting the power of all people to break from indoctrination, group think, and mob mentality to make better choices to live a satisfying and peaceful existence…hopefully in a democratic …

Perception Of Alumni Of The Department Of Agriculture At Stephen F. Austin State University, Sherifat Rufai

Electronic Theses and Dissertations

University alumni surveys have served various purposes since they were introduced in the 1930s in the United States. The Department of Agriculture at Stephen F. Austin State University (SFASU) aimed to evaluate alumni perceptions between the Fall of 2010 and the Spring of 2022 to provide an opportunity to examine the relationship between degree fields and occupations and the agriculture curriculum, salaries, and demographic data for college graduates. This study's web-based survey was designed to include closed-ended and open-ended questions to collect individual opinions using Qualtrics Survey Software. The survey materials were made available on the alumni's social media accounts. …

Flattening Hierarchical Structures To Empower Women Trainee Leaders On Social Media Teams, Marah N. Kays, Deborah D. Rupert, Olivia Negris, Beatrix Thompson, Marla L. Clayman, Lisa Mordell, Tricia Pendergrast, Eve Bloomgarden, Rakhee K. Bhayani, Shikha Jain

Student Publications

We share our experience empowering women trainees and leadership through a flattened hierarchical social media team structure with supporting evidence from measurable outcomes.

Shamonka Latrege Harden

African American Funeral Programs

No abstract provided.

Protocol For Tumor Dissociation And Fluorescence-Activated Cell Sorting Of Human Head And Neck Cancers, Ogoegbunam Okolo, Victoria Yu, Samuel Flashner, Cecilia Martin, Hiroshi Nakagawa, Derrick T Lin, Sidharth V Puram, Anuraag S Parikh

2020-Current year OA Pubs

Tumors originating from the head and neck represent diverse histologies and are comprised of several cell types, including malignant cells, cancer-associated fibroblasts, endothelial cells, and immune cells. In this protocol, we describe a step-by-step approach for the dissociation of fresh human head and neck tumor specimens, followed by isolation of viable single cells using fluorescence-activated cell sorting. Our protocol facilitates the effective downstream use of techniques, including single-cell RNA sequencing and generation of three-dimensional patient-derived organoids. For complete details on the use and execution of this protocol, please refer to Puram et al. (2017)

Higher Dose Corticosteroids In Patients Admitted To Hospital With Covid-19 Who Are Hypoxic But Not Requiring Ventilatory Support (Recovery): A Randomised, Controlled, Open-Label, Platform Trial, Recovery Collaborative Group, Muhammad S. Ali, Louise Anning, Mark Baker, Lorna Barton, Kristopher Bennett, Alison Brown, Andrew Brown, Robert Brown, James Clark, Matthew Clark, Thomas Clark, Sally Collins, Katrina Cooke, Nick Cooper, Matthew Cramp, Peter Davis, Tessa Dean, Laura Dunn, Sharon Evans, Kathryn Ferguson, Simon Fox, Alex Gibson, Benjamin Giles, Claire Gorman, David Green, James Gregory, Sarah Griffiths, Amy Hannington, Melanie Jackson

School of Nursing and Midwifery

Background: Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group. Methods: This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation <92% on room air) were randomly allocated (1:1) to either usual care with higher dose corticosteroids (dexamethasone 20 mg once daily for 5 days followed by 10 mg dexamethasone once daily for 5 days or until discharge if sooner) or usual standard of care alone (which included dexamethasone 6 mg once daily for 10 days or until discharge if sooner). The primary outcome was 28-day mortality among all randomised participants. On May 11, 2022, the independent data monitoring committee recommended stopping recruitment of patients receiving no oxygen or simple oxygen only due to safety concerns. We report the results for these participants only. Recruitment of patients receiving ventilatory support is ongoing. The RECOVERY trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen (eight [1%]) or simple oxygen only (1264 [99%]) were randomly allocated to receive usual care plus higher dose corticosteroids (659 patients) versus usual care alone (613 patients, of whom 87% received low-dose corticosteroids during the follow-up period). Of those randomly assigned, 745 (59%) were in Asia, 512 (40%) in the UK, and 15 (1%) in Africa. 248 (19%) had diabetes and 769 (60%) were male. Overall, 123 (19%) of 659 patients allocated to higher dose corticosteroids versus 75 (12%) of 613 patients allocated to usual care died within 28 days (rate ratio 1·59 [95% CI 1·20–2·10]; p=0·0012). There was also an excess of pneumonia reported to be due to non-COVID infection (64 cases [10%] vs 37 cases [6%]; absolute difference 3·7% [95% CI 0·7–6·6]) and an increase in hyperglycaemia requiring increased insulin dose (142 [22%] vs 87 [14%]; absolute difference 7·4% [95% CI 3·2–11·5]). Interpretation: In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation. Funding: UK Research and Innovation (Medical Research Council), National Institute of Health and Care Research, and Wellcome Trust.

Channel Island Foxes (Urocyon Littoralis) Are Viable Seed Dispersal Agents Of Toyon, Savannah L. Bartel, Juliann T. Schamel, Bridget A. Parrino, Melissa K. Marshall, John L. Orrock

Western North American Naturalist

Mammals that consume fleshy fruit and deposit viable seeds in their scat can be important agents of seed dispersal for plants. Despite the knowledge that the island fox (Urocyon littoralis) consumes large quantities of fleshy fruits, it is unknown whether seeds survive digestion by island foxes and are able to germinate. In order to evaluate whether island foxes are agents of viable seed dispersal on the Channel Islands, we collected island fox scat on Santa Cruz Island in February 2021 and conducted germination assays on digested seeds found in scat. We compared the germinability and germination rates of …

Osmosis: Asymmetries In Telematic Performance, Matthias Ziegler

Journal of Network Music and Arts

For the 2022 edition of the NowNet Arts Conference on October 31st, the telematic research team of the Zurich University of the Arts (ZHdK) presented a project entitled OSMOSIS. OSMOSIS was a concert event, highlighting how telematically connected spaces always confront each other asymmetrically. Their telematic connection is part of a continuous space in which information is fragmented and selectively reassembled. Like the biochemical process of osmosis in which molecules diffuse across a cell membrane from one level of concentration to another, in telematic connections certain elements such as sound, physicality, movement, and empathy are diffused across spaces, each being …