Digital Commons Network^™

Calculating Risk: A Scoping Review Of Ncaa D1 Football Players’ Motivations To Play And The Correlation To Demographic Characteristics And Injury Experiences, Kathleen D. Walsh

Honors Theses

The purpose of this research was to investigate the motivations of National Collegiate Athletic Association (NCAA) Division 1 (D1) football players for playing the game and how these motivations are associated with their socioeconomic status (SES). Further, the research aimed to investigate how the uncovered motivations were linked to injury experiences. The original project was designed as a survey-based mixed methods study on a national scale. However, issues with participant recruitment led to sidelining of that primary research. The research presented is a scoping review of the available literature pertaining to the research question: What is known from existing literature …

The Relationship Between Coping Behaviors And Misophonia Symptom Severity And Impairment, Ruth Emmon Tyson

Honors Theses

Misophonia is a complex disorder that is characterized by an extreme disliking of sounds. Individuals with misophonia may engage in anxiety-driven coping behaviors that constitute avoidance and safety behaviors. Current literature shows that while coping behavior may offer temporary relief of anxiety and distress, they can lead to persisting anxiety and avoidance of experiences. Given preliminary evidence demonstrating a link between coping behaviors and maintained or worsening symptoms, additional research is warranted to further understand the role of coping behaviors in misophonia. However, few studies have investigated the relationship between coping behaviors and maintenance or worsening of misophonia symptom severity …

Who Changes Who? Political Implications Of The Rising Hispanic Population, Drayton Purvis

Honors Theses

Studying the growth of the Hispanic population yields specific political implications to be drawn based on the rate of growth for each Congressional District. Using Data from 2000, 2010, and 2020 Censuses along with Harvard’s Data Set titled, “Historical Congressional Legislation and District Demographics 1972-2014”, the information allows for interpretations to be made based on a Congressional District’s NOMINATE score and its percentage of the Hispanic population. After researching specific influences that help shape the Latino population in a political sense, like country of origin and level of generation in the United States, there were certain characteristics that have been …

Medical Cannabis In Mississippi: Practitioner Education And Continuing Research, Andrea Cleveland

Honors Theses

Use of medical cannabis in Mississippi was legalized in February 2022 following many years of cannabis research at the University of Mississippi. Issues immediately became apparent, beginning with the lack of education about medical cannabis among providers. A 2017 study showed that the majority of physicians are not exposed to information about medical cannabis despite its legalization in 37 states. Another issue with Mississippi’s medical cannabis program is the cost of the product itself. The most effective way to decrease spending on medication is for patients to have access to medication that is guaranteed to work. Further research on cannabis …

A Dream Come True: More Than 50 Years After Black Students Demanded Faculty And Student Leadership Roles At The University Of Mississippi, Students Of Color Are Still Grappling With What It Means To Be Included., Kaylynn Steen

Honors Theses

This thesis tells the story of University of Mississippi alumna Treasure Fisher’s journey in the organization Column’s Society, an organization known as the hosts and hostess of the University of Mississippi. Throughout Fisher’s story, historical moments from the university’s complex relationship with its Black students are weaved through in an attempt to provide context for some of the lingering racial issues at the university today. Fisher’s story, these historical moments, and other anecdotal experiences from current and former Black students, faculty, and staff at the university challenges the reader to examine what representation does, and maybe should, mean to this …

The Impact Of A Lower Body Positive Pressure Treadmill On Exercise Regulation, Camille Couey

Honors Theses

Objective: The benefits of lower body positive pressure treadmills have recently been investigated as a tool for rehabilitation, but research is lacking on whether participants can regulate exercise utilizing rate of perceived exertion (RPE) at reduced body weight loads on lower body positive pressure (LBPP) treadmills. The purpose of the study is to examine the potential for RPE production estimation at various body weight loads. Methods: Fifteen apparently healthy young adults between the ages of 18-35 participated and completed this study. Each participant completed a graded VO_2max test after being familiarized with an OMNI pictorial RPE scale ranging from …

Spanish Club For Healthcare Professionals, Sophie Stallings

Honors Theses

Spanish Club for Healthcare Professionals was registered as an approved student organization in January of 2023, and the first meeting was January 30. The objective of this club is to educate students entering different healthcare fields on how to communicate with Spanish speaking patients. During my time serving as the founder and president of this organization, I strived to provide a resource that would help lower the language barrier that is present in today’s society with regards to a lack of Spanish- speaking healthcare professionals. The goal is not for students to be fully fluent in Spanish but simply learn …

Sensitive And Makeable Computational Materials For The Creation Of Smart Everyday Objects, Te-Yen Wu Mr

Dartmouth College Ph.D Dissertations

The vision of computational materials is to create smart everyday objects using the materi- als that have sensing and computational capabilities embedded into them. However, today’s development of computational materials is limited because its interfaces (i.e. sensors) are unable to support wide ranges of human interactions , and withstand the fabrication meth- ods of everyday objects (e.g. cutting and assembling). These barriers hinder citizens from creating smart every day objects using computational materials on a large scale.

To overcome the barriers, this dissertation presents the approaches to develop compu- tational materials to be 1) sensitive to a wide variety of …

The Diffuse Ionized Gas Halo Of The Large Magellanic Cloud, L. M. Haffner, B. M. Smart, K. A. Barger, D. A. Ciampa, A. S. Hill, D. Krishnarao, G. J. Madsen

Publications

The Large Magellanic Cloud (LMC) has an extensive Hα emission halo that traces an extended, warm ionized component of its interstellar medium. Using the Wisconsin Hα Mapper telescope, we present the first kinematic Hα survey of an extensive region around the LMC, from (ℓ, b) = (264°.5, − 45°.5) to (295°.5, − 19°.5), covering +150 <= vLSR <= + 390 km s−1 . We find that ionized hydrogen exists throughout the galaxy and extends several degrees beyond detected neutral hydrogen emission (log 18.3 ( )) NH cm I -2 » as traced by 21 cm in current surveys. Using the column density structure of the neutral gas and stellar line-of-sight depths as a guide, we estimate the upper limit mass of the ionized component of the LMC to be roughly Mionized ≈ (0.6–1.8) × 109 M☉, which is comparable to the total neutral atomic gas mass in the same region (Mneutral ≈ 0.76–0.85 × 109 M☉). Considering only the atomic phases, we find Mionized/Mionized+neutral, to be 46%–68% throughout the LMC and its extended halo. Additionally, we find an ionized gas cloud that extends off of the LMC at (ℓ, b) ≈ (285°, − 28°) into a region previously identified as the Leading Arm complex. This gas is moving at a similar line-of-sight velocity as the LMC and has Mionized/Mionized+neutral = 13%–51%. This study, combined with previous studies of the SMC and extended structures of the Magellanic Clouds, continues to suggest that warm, ionized gas is as massive and dynamically important as the neutral gas in the Magellanic System.

Big Ideas In Sports Analytics And Statistical Tools For Their Investigation, Benjamin S. Baumer, Gregory J. Matthews, Quang Nguyen

Mathematics and Statistics: Faculty Publications and Other Works

Sports analytics—broadly defined as the pursuit of improvement in athletic performance through the analysis of data—has expanded its footprint both in the professional sports industry and in academia over the past 30 years. In this article, we connect four big ideas that are common across multiple sports: the expected value of a game state, win probability, measures of team strength, and the use of sports betting market data. For each, we explore both the shared similarities and individual idiosyncracies of analytical approaches in each sport. While our focus is on the concepts underlying each type of analysis, any implementation necessarily …

Documents From The May 10, 2023 Meeting Of The University Of Montana Staff Senate, University Of Montana--Missoula. Staff Senate

University of Montana Staff Senate Meeting Minutes

Agenda and meeting minutes from the May 10, 2023 meeting of the University of Montana Staff Senate.

Resolution Passed: "SB04-22/23: Resolution Authorizing Approval of Staff Senate Signature " by Kat Cowley, Kenzie Carter et al. (umt.edu)

Newly Diagnosed Papillary Craniopharyngioma With Braf V600e Mutation Treated With Single-Agent Selective Braf Inhibitor Dabrafenib: A Case Report, Mayank Rao, Meenakshi Bhattacharjee, Scott Shepard, Sigmund Hsu

Faculty, Staff and Student Publications

We report a case of a patient with newly diagnosed, locally extensive and cystic, suprasellar papillary craniopharyngioma successfully treated with single-agent Dabrafenib. The patient was symptomatic with gait imbalance with falls, lethargic episodes, fatigue and incontinence. Diagnostic imaging demonstrated a cystic suprasellar tumor extending into the third ventricle causing obstructive hydrocephalus. The tumor was partially debulked, and bilateral shunts were placed. NGS sequencing demonstrated BRAF V600E mutation, and the patient was prescribed dual agent Dabrafenib and Trametinib. However, due to insurance denial for Trametinib, he only received single-agent Dabrafenib (150mg BID). The treatment resulted in a major response (over two …

Functional Neuronal Circuits Promote Disease Progression In Cancer, Anthony C Restaino, Austin Walz, Samuel J Vermeer, Jeffrey Barr, Attila Kovács, Robin R Fettig, Daniel W Vermeer, Hunter Reavis, Caitlin S Williamson, Christopher T Lucido, Tuany Eichwald, Dalia K Omran, Euihye Jung, Lauren E Schwartz, Maria Bell, Desirae M Muirhead, Jody E Hooper, William C Spanos, Ronny Drapkin, Sebastien Talbot, Paola D Vermeer

Faculty, Staff and Student Publications

The molecular and functional contributions of intratumoral nerves to disease remain largely unknown. We localized synaptic markers within tumors suggesting that these nerves form functional connections. Consistent with this, electrophysiological analysis shows that malignancies harbor significantly higher electrical activity than benign disease or normal tissues. We also demonstrate pharmacologic silencing of tumoral electrical activity. Tumors implanted in transgenic animals lacking nociceptor neurons show reduced electrical activity. These data suggest that intratumoral nerves remain functional at the tumor bed. Immunohistochemical staining demonstrates the presence of the neuropeptide, Substance P (SP), within the tumor space. We show that tumor cells express the …

Late Health Outcomes Among Survivors Of Wilms Tumor Diagnosed Over Three Decades: A Report From The Childhood Cancer Survivor Study, Brent R Weil, Andrew J Murphy, Qi Liu, Rebecca M Howell, Susan A Smith, Christopher B Weldon, Elizabeth A Mullen, Arin L Madenci, Wendy M Leisenring, Joseph P Neglia, Lucie M Turcotte, Kevin C Oeffinger, Amanda M Termuhlen, Sogol Mostoufi-Moab, Jennifer M Levine, Kevin R Krull, Yutaka Yasui, Leslie L Robison, Gregory T Armstrong, Eric J Chow, Saro H Armenian

Faculty, Staff and Student Publications

Purpose: To evaluate long-term morbidity and mortality among unilateral, nonsyndromic Wilms tumor (WT) survivors according to conventional treatment regimens.

Methods: Cumulative incidence of late mortality (≥ 5 years from diagnosis) and chronic health conditions (CHCs) were evaluated in WT survivors from the Childhood Cancer Survivor Study. Outcomes were evaluated by treatment, including nephrectomy combined with vincristine and actinomycin D (VA), VA + doxorubicin + abdominal radiotherapy (VAD + ART), VAD + ART + whole lung radiotherapy, or receipt of ≥ 4 chemotherapy agents.

Results: Among 2,008 unilateral WT survivors, 142 deaths occurred (standardized mortality ratio, 2.9, 95% CI, 2.5 to …

Genome Graphs Detect Human Polymorphisms In Active Epigenomic State During Influenza Infection., Cristian Groza, Xun Chen, Alain Pacis, Marie-Michelle Simon, Albena Pramatarova, Katherine A. Aracena, T Pastinen, Luis B. Barreiro, Guillaume Bourque

Manuscripts, Articles, Book Chapters and Other Papers

Genetic variants, including mobile element insertions (MEIs), are known to impact the epigenome. We hypothesized that genome graphs, which encapsulate genetic diversity, could reveal missing epigenomic signals. To test this, we sequenced the epigenome of monocyte-derived macrophages from 35 ancestrally diverse individuals before and after influenza infection, allowing us to investigate the role of MEIs in immunity. We characterized genetic variants and MEIs using linked reads and built a genome graph. Mapping epigenetic data revealed 2.3%-3% novel peaks for H3K4me1, H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq), and ATAC-seq. Additionally, the use of a genome graph modified some quantitative trait loci estimates …

Sirolimus Versus Cyclosporine A In Patients With Primary Acquired Pure Red Cell Aplasia: A Prospective Cohort Study, Yuan Yang, Zengwei Tang, Yuzhou Huang, Qinglin Hu, Shuqing Wang, Jiang Ji, Yali Du, Chen Yang, Miao Chen, Shimin Hu, Bing Han

Faculty, Staff and Student Publications

No abstract provided.

A Stability Indicating Lc-Ms/Ms Method For Quantification Of A Nox Inhibitor R14 In Its Bisulfite Adduct Form For Pharmacokinetic Studies, Yang Wang, Jing Ma, Shiaw-Yih Lin, Huan Xie, Dong Liang

Faculty, Staff and Student Publications

R14, also known as NOX Inhibitor VII, is a potent inhibitor of NADPH oxidases (NOX) which has recently been identified as a novel agent targeting to triple-negative breast cancer. It is also rapidly degraded in collected pharmacokinetic plasma and blood samples even stored under - 70 °C. The purpose of this study was to develop a stability indicating LC-MS/MS assay that would be suitable for quantification of R14 in plasma and blood. In the presence of sodium sulfite under acidic pH, R14, an aryl lactam compound which is not a typically reactive compound for bisulfite addition, readily and completely converted …

Ppigcf: A Protein-Protein Interaction-Based Gene Correlation Filter For Optimal Gene Selection, Soumen Kumar Pati, Manan Kumar Gupta, Ayan Banerjee, Saurav Mallik, Zhongming Zhao

Faculty, Staff and Student Publications

Biological data at the omics level are highly complex, requiring powerful computational approaches to identifying significant intrinsic characteristics to further search for informative markers involved in the studied phenotype. In this paper, we propose a novel dimension reduction technique, protein-protein interaction-based gene correlation filtration (PPIGCF), which builds on gene ontology (GO) and protein-protein interaction (PPI) structures to analyze microarray gene expression data. PPIGCF first extracts the gene symbols with their expression from the experimental dataset, and then, classifies them based on GO biological process (BP) and cellular component (CC) annotations. Every classification group inherits all the information on its CCs, …

Immune Checkpoint B7-H3 Is A Therapeutic Vulnerability In Prostate Cancer Harboring Pten And Tp53 Deficiencies, Wei Shi, Yin Wang, Yuehui Zhao, Justin Jimin Kim, Haoyan Li, Chenling Meng, Feiyu Chen, Jie Zhang, Duncan H Mak, Vivien Van, Javier Leo, Brad St Croix, Ana Aparicio, Di Zhao

Faculty, Staff and Student Publications

Checkpoint immunotherapy has yielded meaningful responses across many cancers but has shown modest efficacy in advanced prostate cancer. B7 homolog 3 protein (B7-H3/CD276) is an immune checkpoint molecule and has emerged as a promising therapeutic target. However, much remains to be understood regarding B7-H3's role in cancer progression, predictive biomarkers for B7-H3-targeted therapy, and combinatorial strategies. Our multi-omics analyses identified B7-H3 as one of the most abundant immune checkpoints in prostate tumors containing PTEN and TP53 genetic inactivation. Here, we sought in vivo genetic evidence for, and mechanistic understanding of, the role of B7-H3 in PTEN/TP53-deficient prostate …

Addendum: Newly Diagnosed Papillary Craniopharyngioma With Braf V600e Mutation Treated With Single-Agent Selective Braf Inhibitor Dabrafenib: A Case Report, Mayank Rao, Meenakshi Bhattacharjee, Scott Shepard, Sigmund Hsu

Faculty, Staff and Student Publications

No abstract provided.

Brexucabtagene Autoleucel For Relapsed Or Refractory Mantle Cell Lymphoma In Standard-Of-Care Practice: Results From The Us Lymphoma Car T Consortium, Yucai Wang, Preetesh Jain, Frederick L Locke, Matthew J Maurer, Matthew J Frank, Javier L Munoz, Saurabh Dahiya, Amer M Beitinjaneh, Miriam T Jacobs, Joseph P Mcguirk, Julie M Vose, Andre Goy, Charalambos Andreadis, Brian T Hill, Kathleen A Dorritie, Olalekan O Oluwole, Abhinav Deol, Jonas Paludo, Bijal Shah, Trent Wang, Rahul Banerjee, David B Miklos, Aaron P Rapoport, Lazaros Lekakis, Armin Ghobadi, Sattva S Neelapu, Yi Lin, Michael L Wang, Michael D Jain

Faculty, Staff and Student Publications

Purpose: Brexucabtagene autoleucel (brexu-cel) is an autologous CD19-directed chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory mantle cell lymphoma (MCL). This therapy was approved on the basis of the single-arm phase II ZUMA-2 trial, which showed best overall and complete response rates of 91% and 68%, respectively. We report clinical outcomes with brexu-cel in the standard-of-care setting for the approved indication.

Patients and methods: Patients who underwent leukapheresis between August 1, 2020 and December 31, 2021, at 16 US institutions, with an intent to manufacture commercial brexu-cel for relapsed/refractory MCL, were included. Patient data were collected for analyses of …

Computational Analysis Of Steady Hypersonic Flow Fields Of Nasa Benchmark Geometries Utilizing Ansys Fluent, Aidan Murphy

McKelvey School of Engineering Graduate Student Theses & Dissertations

The Hypersonic International Flight Research Experimentation (HIFiRE) program explores and advances hypersonic aerospace systems by developing a multitude of test flight geometries and conducting experimental test flights to obtain data for use in validation of computational models and results. This study focuses on computational validation of heat flux, and calculation of static pressure profiles, skin friction coefficient profiles, and flow contours. The flow fields studied are for Mach number 7.18 and angles of attack (α) of 0° & 2°. These flow fields include many compressible flow features such as an expansion wave at the intersection of the cone and flat …

Integrated Agriculture-Aquaculture As An Alternative To Improving Small-Scale Fish Production In Zambia, Oliver J. Hasimuna, Sahya Maulu, Kundananji Nawanzi, Benjamin Lundu, Joseph Mphande, Chisomo J. Phiri, Edwin Kikamba, Enock Siankwilimba, Sillah Siavwapa, Moses Chibesa

School of Biological and Marine Sciences

Aquaculture is a significant industry in food production, and its contribution to food and nutrition security is well acknowledged. Zambia’s aquaculture production has continued to increase significantly, thus playing a key role in supplying animal protein sources for human consumption. However, recent estimates show that 75% of the national aquaculture production comes from large-scale commercial producers despite being by far the minority while the majority of small-scale producers contribute the remaining 25% of the total annual production. This low production by small-scale producers is attributed to insufficient financial resources, poor management and utilization of farm resources, lack of access to …

This Is A Present From A Small, Distant World, Samantha Slone

MFA in Visual Art

I make toxic pastoral paintings in the style of the Dutch and Old Masters, and media installations which depict natural landscapes as distanced, deconstructed forms. What I explore most in my practice is our damaged relationship with land and nature, and our capitalist and media ecologies as artificial landscapes which suspend us from the natural. In a dissection of the dualisms of man and nature, and progress and sustainability, I create microcosms of our detached condition.

Dear Sycamore, Anna Schenker

MFA in Visual Art

I create paintings, sculptures, and rubbings to pay tribute to the earthly beings found within my immediate surroundings. I use indexical processes that stain, trace, and record to preserve a moment in time. The process of rubbing is a tactile and meticulous activity of excavation. It is an imprint of what was once there, a mapping of attentive contact. The works are dependent upon the physicality of the host as I engage directly with the plants, seeds, weather, and trees that surround me. The rubbing’s flatness actively constructs a new reality; a liminal space hovers between the impression and the …

The Voice Of One Crying In The Wilderness, Megan Kenyon

MFA in Visual Art

I am a Midwestern, Christian, and feminist artist. I make work about the beautiful, broken, and absurd ways in which American evangelical culture influences lives, especially women’s lives. I’m dragging everything into the light by deconstructing and critiquing the world in which I live, move, and have my being. I do this by harnessing prophetic imagination and incarnational space to shine a light on how patriarchy infects evangelical Christian theology and practice. Using prophetic imagination through photographic self-portraiture and text (my own and found texts using the Bible), I seek to make plain the effects of white, Christian patriarchy on …

Every Rock Has A Soul, Karen Yung

MFA in Visual Art

My studio practice focuses on the Asian American diaspora and the feelings of displacement that arise from being away from one’s homeland. This paper traces the beginning of my journey to find a way to make art that observes and applies Buddhist philosophies, practices and acknowledges the intrinsic energy found in all things. I create sculptures inspired by the qi of rocks to explore my ongoing struggles with my bicultural identity. Through the continuous pouring of wax and plaster that create stalagmites on to domestic objects, I imbue positive qi into my artworks to pass on to whoever seeks it. …

Land | Lineage, Allena Marie Brazier

MFA in Visual Art

Land | Lineage is an in-depth text of my thoughts and tha artistic choices I make within my work. In my thesis I use tha concept of Black Ecology to understand art rooted in tha relationship between race and geography. Black culture and city spaces in proximity to natural landscapes, or edgelands, reveal tha social and physical conditions of a place where these two worlds collide and form distinct characteristics of site, sound, and human interaction.

My research also focuses on tha theory of place-based works to reconceptualize the lost stories and complexities of city trauma and joy within my …

Azul, Amarillo, Rojo, Jorge Rios Morales

MFA in Visual Art

My most recent body of work was produced out of the pleasure of exploring pure formal and processual painting. In this text—divided by sections titled like a traditional opera to highlight the mise-en-scene quality of my artwork—the reader will find clues about the context, inspirations, and desires that led to my current practice, such as my ambivalent condition as an immigrant, my exposure to post-conceptual abstraction embodied in Christopher Wool’s provocative oeuvre, and my interest in offering the viewer the experience of what I call “an aesthetic interrogation.” l have privileged in this thesis my own voice and character with …

Queering Up For Battle, Alex Davis

MFA in Visual Art

In this text, I explore the potential for interwar European art to serve as a catalyst for the contemporary Queer rights movement. Drawing on the works of Remy Jungerman, LJ Roberts, michá cardenas, and Joar Nango, alongside the insights of Queer theorists Lisa Duggan and José Esteban Muñoz, I analyze my own artwork and the way I remix elements of both Russian Constructivism and Queer culture.

Amidst the current proliferation of anti-Queer violence and legislation, I highlight the importance of safeguarding Queer spaces and communities. To this end, I collect Queer objects and organize them into an arsenal of triangular …