Digital Commons Network^™

Deepening Integration Of Research And Education, Cultivating Future Leading Talents In Science And Technology, Yanfen Wang, Ji’An Liu, Yueliang Wu, Zuomin Xiao, Jianming Miao, Guoqiang Yang, Haoran Li, Zhongping Xu, Xiaoli Niu, Jichang Dong, Depeng Jin, Hui Huang, Xiao Lin

Bulletin of Chinese Academy of Sciences (Chinese Version)

The new era has put forward new and higher requirements for innovative talents in terms of their moral qualities, knowledge structure, and professional abilities. In this context, the practice to cultivate innovative talents in science and technology world-wide has presented new trends, including multidisciplinary collaborations, coherent processes, open coordination among education, research and industry sectors, and empowerment through digital transformation. Relying on the advantages of the Chinese Academy of Sciences (CAS) in scientific and technological innovation, University of the Chinese Academy of Sciences (UCAS) is exploring educational laws to cultivate high-quality innovative and entrepreneurial talents, especially leading talents in science …

Discussion On Essential Characteristics And Construction Path Of Modernization Of Popular Science, Jiaofeng Pan, Biao Shi, Guanghui Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

This study starts with the new requirements for the popularization of science put forward at the 20th National Congress of the CPC, and proposes the development ideas for modernizing the popularization of science. It is deeply analyzed the dialectical relationship between the popularization of science and modernization with Chinese characteristics, sorted out how the popularization of science has strongly supported and promoted modernization with Chinese characteristics in history, studied the new situation and problems facing scientific innovation and popularization in the current process of modernization, and put forward the direction for innovative development of the popularization of science in the …

Thoughts On Popularization Of Science And Future Development Of China, Yuliang Yang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Science is a great cause for human beings to pursue truth. Popularization of science is an important basic work for achieving innovative development. Throughout the history of scientific development, human beings have realized the opening and sharing of knowledge system, the application and promotion of production technology, the inheritance and development of scientific culture, and the enlightenment and education of civilization and rationality through scientific popularization. This study analyzes the role and value of science popularization, and points out that science popularization is conducive to promoting the benign interaction between science and technology and society, improving the efficiency of science …

Several Thoughts On Information Technology Driving Future Industries, Yungang Bao, Miao Liu, Pinyan Lu, Xipeng Qiu, Jiang Xu

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Research On Rule Of Law In Science Popularization To Guarantee Implementation Of Broad Science Popularization Strategy, Siguang Zhang, Xiaowei Xiang, Jianzhong Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

The construction of the rule of law in science popularization is of great importance to guarantee the implementation of the “Two- Wing theory” and the Broad Science Popularization Strategy. This study systematically reviews the development, status quo, effectiveness and problems of the legal and institutional construction of science popularization in China, and examines the situation, problems and challenges faced by the construction of the rule of law in China’s science popularization in the light of current development situation. Finally, this study puts forward proposals to strengthen the construction of the rule of law in science popularization under the direction of …

Brief Introduction Of Wang Keqiang, Newly Appointed Vice President, Member Of The Party Leader Group Of Cas

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

State-Organized Research (Sor): Chinese Innovation Eco-System To Meet Shift Of World’S Three Major Centers, Jianxun Chu, Chenyang Wang, Zhe Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The coordinated development of education-S&T-talent integration (ESTTI) has pointed out the direction for promoting China’s construction of a world science center, a world higher education center, and a world talent center. The study proposes the concept of “state- organized research” (SOR) based on the trend of “100-year change of centers” of the world’s three major centers and the strengths and weaknesses of China in building the world’s three major centers. The study suggests that the implementation of SOR is the way to transfer the world’s three major centers into China, and puts forward relevant suggestions to build the national innovation …

What Is The Innovativeness Of Innovative Research-Oriented Universities?—Practice Of Shanghaitech University, Jie Yin

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the report of the 20th National Congress of the Communist Party of China, it is emphasized that upholding the principles that science and technology constitute the primary productive force, talent is the primary resource, and innovation is the primary driving force is of utmost importance. The deep implementation of strategies such as the strategy for invigorating the country through science and education, the strategy for strengthening the nation through talent development, and the strategy for driving development through innovation is emphasized. Furthermore, the need to explore new domains and pathways for development, and continuously shape new dynamics and advantages …

Brief Introduction Of Chang Jin, Newly Appointed Vice President, Member Of The Party Leader Group Of Cas

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Bulletin of Chinese Academy of Sciences (Chinese Version)

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Several Thoughts On Empowering High Quality Industrial Development In China Through S&T Innovation, Yiming Wang, Guojie Li, Baichun Zhang, Yongmiao Hong, Yong Geng

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Strengthen Construction Of National Science Popularization Capacity, Serving National Strategic Needs Of The New Era, Ting Wang, Weiying Wang, Lihui Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The national science popularization capacity of the New Era is reflected in the comprehensive strength of one country, which contains the capacity to continuously provide science popularization products and services to the public, improve the scientific literacy of the whole people, cultivate social culture, promote the transformation of scientific and technological achievements, then support the national innovative development. Based on the theoretical research and construction practice of China’s science popularization capacity , this study analyzes the deficiencies in the current construction of China’s science popularization capacity and the development direction of national science popularization capacity to serve the national development …

Thinking And Suggestions On Practice Of Science Popularization By Academicians In Broad Science Popularization Strategy, Xiu Wei, Liang Xi, Qiang Ma, Yongfeng Yang

Bulletin of Chinese Academy of Sciences (Chinese Version)

As one of the two wings of innovation and development, science popularization has become one of the most fundamental factors determining the level of material culture development and national creativity. Academician of Chinese Academy of Sciences and Academicians of Chinese Academy of Engineering (Academicians for short), as outstanding role models of China’s scientific and technological community, have actively borne social responsibility for science popularization and played an important role in different development periods. Entering a high-quality development stage, promoting the transformation of science popularization concepts, achieving high-quality science popularization supply, constructing a large-scale science popularization pattern, and planning a large-scale …

Path And Required Environment For Growth Of Innovative Talents In The New Era, Tao Dai, Jie Song, Bo Zhang, Weiqiang Chen, Kaihua Chen

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

2023 Issue 5 Content

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Shedding Light On Racial Realist Parent Engagement Through The Experiences Of Black Families And Othermothers, Rebecca Rogers, Kelly Byrd

The Qualitative Report

As educator-scholars committed to building family learning communities rooted in principles of educational liberation, McCarthy Foubert’s book Reckoning with Racism in Family-School Partnerships caught our attention because of its promise to expose the challenges of systematically racist ideologies about family-school partnerships, to confront these issues during a toxic time in race relations and elucidate the narratives of Black racial realist parents. Our reading and discussion of the book were informed by our own experiences as an inter-racial reviewing team with shared commitments to anti-racist family engagement.

Methodological Challenges In Interviewing Elite Women In A Patriarchal Society, Amira Firdaus Dr., Iffat Aksar Dr., Mahmoud Danaee Dr., Jiakun Gong, Nasrullah Dharejo Mr

The Qualitative Report

The current article reflects on the challenges of selecting and accessing participants from societies where power relations are gender-based. The paper discusses the methodological difficulties of gaining research access to professionally and educationally elite women in Pakistan's patriarchal society and suggests a strategy of "referral in-group" for recruiting interview participants. Drawing on the author's purposive sampling-based research in Pakistan, this article proposes a methodological strategy to recruit an elite population to participate in research interviews on a culturally sensitive subject, namely, patriarchal control over Pakistani women's digital lives. Furthermore, coupled with purposive sampling, this article contributes to the existing literature …

A Comparative Study On The Design Typology Of Dense, High-Rise Housing, Nikita Mansinghani

Honors Program: Senior Projects (Public)

The three case studies are multi-unit residential buildings located in three vastly different European cities and designed in different times periods of architectural transformations and technology help us understand the value and development of these units and the significance of them in the future design typologies. The understanding of housing complex has been occupied with the exercise of control as a design tool for demarcating variation to further the purpose of housing and shift in approaches from typical architecture to non-standard creative practices, this article focuses on three precedents: the Unite de habitation, VM houses and The Whale. The three …

Creating Systemic Support: Cross-Sector Partnerships As A Catalyst To Institutional Transformation For Southeast Asian Student Support, Brianna Lourdes Edoria Pascua

Master's Projects and Capstones

This paper investigates the potential impact of cross-sector partnerships between nonprofit organizations (NPOs) and universities on the educational attainment of Southeast Asian American (SEAA) students, particularly those from disenfranchised or nontraditional backgrounds. Guided by the research question, "Can cross-sector partnerships between NPOs and universities contribute to increased educational attainment among SEAA students?", the study seeks to comprehensively explore SEAA student experiences, challenge the Model Minority Stereotype, enrich SEAA higher educational achievement literature, underline the significance of disaggregated data and cross-sector collaborations, and create an adaptable framework for other communities. By adopting an Asian Critical Race Theory (AsianCrit) lens, the research …

Burnout: An Examination Of How Human Services’ Cultures Impact Person-Centered Care And Job Satisfaction, Ebony Webb

Master's Projects and Capstones

In a world that demands the constant requirement of adaptability and technology, the need for ‘hands on the ground’ continues to persist, and perhaps even grow. This research project explores burnout in the healthcare and nonprofit settings, as a pre-existing and ongoing issue, that was brought to centre-stage during the Covid-19 pandemic. The researcher explores the intersections of burnout with workplace culture, person-centered care (PCC), sweat equity and duty-of-care, through expert interviews and literature reviews. Data collected provides an immediate understanding of current workplace cultures and environments for human service providers, in both healthcare and nonprofit sectors. While the data …

Carbon Free Colorado: An Integrated Resource Plan For The Public Service Company Of Colorado 2020-2050, Vignesh Devaki Murugesan, Adam Lokar

Master's Projects and Capstones

This Integrated Resource Plan (IRP) outlines the Public Service Company of Colorado’s (PSCo) strategy to accommodate the growing energy demand of its customers while transitioning to renewable energy. The IRP attempts to quantify the impact of Colorado’s clean energy and climate policy by comparing three different scenarios:

1. Reference Scenario. New capacity is met with the lowest cost of generation ignoring Colorado Renewable Energy Standard.

2. 100% Carbon Free by 2050. Additional capacity is met with lowest cost mix of renewables sufficient to meet Colorado’s Renewable Energy Standard.

3. High Electrification. Adheres to Colorado’s Renewable Energy Standard while also accommodating …

Phase Ii Clinical Trial Of Axitinib And Avelumab In Patients With Recurrent/Metastatic Adenoid Cystic Carcinoma, Renata Ferrarotto, Luana G Sousa, Lei Feng, Frank Mott, George Blumenschein, Mehmet Altan, Diana Bell, Flavia Bonini, Kaiyi Li, Mario L Marques-Piubelli, Eduardo A Dal Lago, Jason J Johnson, Yoshitsugu Mitani, Myrna Godoy, Anna Lee, Michael Kupferman, Ehab Hanna, Bonnie S Glisson, Yasir Elamin, Adel El-Naggar

Faculty, Staff and Student Publications

Purpose: We conducted a phase II trial evaluating the efficacy of VEGFR inhibitor axitinib and PD-L1 inhibitor avelumab in patients with recurrent/metastatic adenoid cystic carcinoma (R/M ACC).

Patients and methods: Eligible patients had R/M ACC with progression within 6 months before enrollment. Treatment consisted of axitinib and avelumab. The primary end point was objective response rate (ORR) per RECIST 1.1; secondary end points included progression-free survival (PFS), overall survival (OS), and toxicity. Simon's optimal two-stage design tested the null hypothesis of ORR ≤5% versus ORR ≥20% at 6 months; ≥4 responses in 29 patients would reject the null hypothesis.

Results: …

Magrolimab In Combination With Azacitidine In Patients With Higher-Risk Myelodysplastic Syndromes: Final Results Of A Phase Ib Study, David A Sallman, Monzr M Al Malki, Adam S Asch, Eunice S Wang, Joseph G Jurcic, Terrence J Bradley, Ian W Flinn, Daniel A Pollyea, Suman Kambhampati, Tiffany N Tanaka, Joshua F Zeidner, Guillermo Garcia-Manero, Deepa Jeyakumar, Rami Komrokji, Jeffrey Lancet, Hagop M Kantarjian, Lin Gu, Yajia Zhang, Anderson Tan, Mark Chao, Carol O'Hear, Giridharan Ramsingh, Indu Lal, Paresh Vyas, Naval G Daver

Faculty, Staff and Student Publications

Purpose: Magrolimab is a monoclonal antibody that blocks cluster of differentiation 47, a don't-eat-me signal overexpressed on cancer cells. Cluster of differentiation 47 blockade by magrolimab promotes macrophage-mediated phagocytosis of tumor cells and is synergistic with azacitidine, which increases expression of eat-me signals. We report final phase Ib data in patients with untreated higher-risk myelodysplastic syndromes (MDS) treated with magrolimab and azacitidine (ClinicalTrials.gov identifier: NCT03248479).

Patients and methods: Patients with previously untreated Revised International Prognostic Scoring System intermediate-/high-/very high-risk MDS received magrolimab intravenously as a priming dose (1 mg/kg) followed by ramp-up to a 30 mg/kg once-weekly or once-every-2-week …

Efficacy Of A Smoking Cessation Intervention For Survivors Of Cervical Intraepithelial Neoplasia Or Cervical Cancer: A Randomized Controlled Trial, Jennifer I Vidrine, Steven K Sutton, David W Wetter, Ya-Chen Tina Shih, Lois M Ramondetta, Linda S Elting, Joan L Walker, Katie M Smith, Summer G Frank-Pearce, Yisheng Li, Sarah R Jones, Darla E Kendzor, Vani N Simmons, Damon J Vidrine

Faculty, Staff and Student Publications

PURPOSE: Women who smoke and have a history of cervical intraepithelial neoplasia (CIN) or cervical cancer represent a vulnerable subgroup at elevated risk for recurrence, poorer cancer treatment outcomes, and decreased quality of life. The purpose of this study was to evaluate the long-term efficacy of Motivation And Problem Solving (MAPS), a novel treatment well-suited to meeting the smoking cessation needs of this population.

METHODS: Women who were with a history of CIN or cervical cancer, age 18 years and older, spoke English or Spanish, and reported current smoking (≥100 lifetime cigarettes plus any smoking in the past 30 days) …

Insight Into The Desolvation Of Quaternary Ammonium Cation With Acetonitrile As A Solvent In Hydroxyl-Flat Pores: A First-Principles Calculation, Fudong Liu, Shaobin Yang, Xu Zhang, Shuwei Tang, Yingkai Xia

Faculty, Staff and Student Publications

Supercapacitors have a wide range of applications in high-technology fields. The desolvation of organic electrolyte cations affects the capacity size and conductivity of supercapacitors. However, few relevant studies have been published in this field. In this experiment, the adsorption behavior of porous carbon was simulated with first-principles calculations using a graphene bilayer with a layer spacing of 4-10 Å as a hydroxyl-flat pore model. The reaction energies of quaternary ammonium cations, acetonitrile, and quaternary ammonium cationic complexes were calculated in a graphene bilayer with different interlayer spacings, and the desolvation behavior of TEA+ and SBP+ ions was described. The critical …

Toll-Like Receptors 2, 4, And 9 Modulate Promoting Effect Of Copd-Like Airway Inflammation On K-Ras-Driven Lung Cancer Through Activation Of The Myd88/Nf-ĸb Pathway In The Airway Epithelium, Walter V Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T Grimaldo, Avantika Krishna, Michael J Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina De La Garza, Marco Ramos-Castaneda, Scott E Evans, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

INTRODUCTION: Toll-like receptors (TLRs) are an extensive group of proteins involved in host defense processes that express themselves upon the increased production of endogenous damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) due to the constant contact that airway epithelium may have with pathogenic foreign antigens. We have previously shown that COPD-like airway inflammation induced by exposure to an aerosolized lysate of nontypeable

METHODS: In the present study, we have dissected the role of TLRs in this process by knocking out TLR2, 4, and 9 and analyzing how these deletions affect the promoting effect of COPD-like airway inflammation on …

Mitochondrial Replication Assay (Mira) For Efficient In Situ Quantification Of Nascent Mtdna And Protein Interactions With Nascent Mtdna (Mitosirf), Macy Lozen, Yue Chen, Rebecca A Boisvert, Katharina Schlacher

Faculty, Staff and Student Publications

Mitochondria play decisive roles in bioenergetics and intracellular communication. These organelles contain a circular mitochondrial DNA (mtDNA) genome that is duplicated within one to two hours by a mitochondrial replisome, independently from the nuclear replisome. mtDNA stability is regulated in part at the level of mtDNA replication. Consequently, mutations in mitochondrial replisome components result in mtDNA instability and are associated with diverse disease phenotypes, including premature aging, aberrant cellular energetics, and developmental defects. The mechanisms ensuring mtDNA replication stability are not completely understood. Thus, there remains a need to develop tools to specifically and quantifiably examine mtDNA replication. To date, …

Teacher Perceptions On The Influence Of The Amistad Integrated Units On Instructional Practices And Black Female Students' Academic Experiences, Tiffany Wicks

Seton Hall University Dissertations and Theses (ETDs)

ABSTRACT

The purpose of this study is to understand the thoughts of teachers on the Amistad Integrated Units and the influence of the culturally relevant units on Black female students. The researcher identified if culturally relevant pedagogy influenced teacher instructional practices and the classroom academic experiences of Black female students. The findings helped to explain the needs of Black girls in an urban classroom and possible solutions that can benefit them within classroom environments.

For this study, the researcher used a narrative inquiry research design to examine and understand the perspectives of teachers and the influence of culturally relevant curriculum …