A Mathematical Model To Optimize The Neoadjuvant Chemotherapy Treatment Sequence For Triple-Negative Locally Advanced Breast Cancer, Juan C. Lopez-Alvarenga, Antonmaria Minzoni-Alessio, Arturo Olvera-Chávez, Gustavo Cruz-Pacheco, Juan C. Chimal-Eguia, Joselin Hernandez-Ruiz, Mario A. Alvarez-Blanco, Maria Y. Bautista-Hernandez, Rosa M. Quispe-Siccha

School of Medicine Publications

Background: Triple-negative locally advanced breast cancer is an aggressive tumor type. Currently, the standard sequence treatment is applied, administering anthracyclines first and then a taxane plus platinum. Clinical studies for all possible treatment combinations are not practical or affordable, but mathematical modeling of the active mitotic cell population is possible. Our study aims to show the regions with the tumor’s most substantial cellular population variation by utilizing all possible values of the parameters (������) that define the annihilatory drug capacity according to the proposed treatment.

Method: A piecewise linear mathematical model was used to analyze the cell population growth …

Cardiorespiratory Monitoring Data To Predict Respiratory Outcomes In Extremely Preterm Infants, Namasivayam Ambalavanan, Debra E. Weese-Mayer, Anna Maria Hibbs, Nelson Claure, Premananda Indic, Additional Authors, Prematurity-Related Ventilatory Control (Pre-Vent) Investigators

Electrical Engineering Faculty Publications and Presentations

Rationale: Immature control of breathing is associated with apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants. However, it is not clear if such events independently predict worse respiratory outcome. Objectives: To determine if analysis of cardiorespiratory monitoring data can predict unfavorable respiratory outcomes at 40 weeks postmenstrual age (PMA) and other outcomes, such as bronchopulmonary dysplasia at 36 weeks PMA. Methods: The Prematurity-related Ventilatory Control (PreVent) study was an observational multicenter prospective cohort study including infants born at 29 weeks of gestation with continuous cardiorespiratory monitoring. The primary outcome was either "favorable" (alive and previously discharged or …

Catalyst Journal Of The Amateur Yacht Research Society, J Perry, I Ward, P Constantine, J Graham-Jones

School of Engineering, Computing and Mathematics

CATALYST is a journal of yacht research, design and technology published by the Amateur Yacht Research Society, BCM AYRS, London, WC1N 3XX, UK. Articles include 2. Annual General Meeting 3. Increase of subscription from September 2023 4. Obituaries: Slade Penoyre and Tom Speer 8. Balanced Foils, Part 1, by Ian Ward 21. Design Challenge 4: Evaluation, by Paul Constantine 26. AYRS at the 2023 RYA Dinghy and Water Sports Show 28. News from the North West Local Group 29. AYRS Southern Area Meeting 31. North West Local Group Programme for 2023 31. AYRS Calendar of Events

Estate Of Murphy V. New York City Housing Authority

All Decisions

Note: opinion combines cases numbers 36 and 37. In negligence cases involving criminal attacks on tenants, the landlord's duty to provide minimal security, including locking exterior doors, is upheld. The targeted nature of the attacks does not automatically sever the causal link between the landlord's negligence and the injuries sustained by the tenants. Landlords may still be held liable if minimal security measures could have deterred the assailants. Notice of a defective lock is not required to defeat summary judgment, and triable issues of fact regarding breach and proximate cause should advance to a jury trial.

Scurry V. New York City Housing Authority

All Decisions

Note: opinion combines cases numbers 36 and 37. In negligence cases involving criminal attacks on tenants, the landlord's duty to provide minimal security, including locking exterior doors, is upheld. The targeted nature of the attacks does not automatically sever the causal link between the landlord's negligence and the injuries sustained by the tenants. Landlords may still be held liable if minimal security measures could have deterred the assailants. Notice of a defective lock is not required to defeat summary judgment, and triable issues of fact regarding breach and proximate cause should advance to a jury trial.

Pulaski Manor Associates V. Lipscomb

All Decisions

ERAP Case.

Participation Of Academic Libraries And Provision Of Covid-19 Information Services During The Pandemic In Nigeria, Flora Orewa

Library Philosophy and Practice (e-journal)

Information was sought on the level of collaboration between academic libraries and known key players championing the prevention and control of COVID-19, the activities carried out in compliance with set protocols, information services offered, and the challenges faced. Results showed moderate level of collaboration and very limited direct synergistic interaction with public health groups, while they provided patrons with an avenue to source updates from library websites. There was high compliance with COVID-19 prevention guidelines; however, there was no specialized COVID-19 information service desk for patrons' inquiries. Libraries participated in the dissemination of COVID-19 information during the pandemic, especially to …

Pilot Study On The Influence Of Incentive Spirometry On Percutaneous Image-Guided Intra-Abdominal Drainage Catheter Pressure: A Potential Method To Enhance Drainage, Aravinda Ganapathy, David H. Ballard, Grace L. Bishop, Mark J. Hoegger, Nihil Abraham, Horacio B. D'Agostino

2020-Current year OA Pubs

No abstract provided.

The Effectiveness Of Eye-Hand Coordination Training In Virtual Reality, Kelley Burger

LSU Doctoral Dissertations

Virtual environments (VE) and virtual reality (VR) through head-mounted displays (HMD) have been used to test and train eye-hand coordination skills in a way that is more immersive than traditional 2D video training. As this technology continues to evolve, researchers have sought to determine the degree to which these new technologies can augment training. This research attempts to expand the literature on sport skill training in VE and VR to elucidate the training protocols that support learning. The first study was designed to determine how a single session of occlusion training would affect football catching skills in VR. While adding …

A History Of The Construction And Financing Of Division I Football Bowl Subdivision And Ivy League Stadia: An Ideal-Type On Financial Modernization, Tiffany E. Demiris

LSU Doctoral Dissertations

This dissertation seeks to introduce financial modernization as a distinct subcategory of modernization and present practical applications for sport managers. Modernization literature has shown that, as society advances, levels of complexity increase. Modernization is generally concerned about the impact of technology, transportation, financial operations, and the reduction of risk in society (Seifried & Novicevic, 2017). These facets are not only important to established modernization subcategories, reflexive and ecological, but are also applicable to financial systems and demonstrate how financial modernization is both complementary and a distinct type of modernization. It is possible to take larger risks over time because so …

Smarcb1 Regulates The Hypoxic Stress Response In Sickle Cell Trait, Melinda Soeung, Luigi Perelli, Ziheng Chen, Eleonora Dondossola, I-Lin Ho, Federica Carbone, Li Zhang, Hania Khan, Courtney N Le, Cihui Zhu, Michael D Peoples, Ningping Feng, Shan Jiang, Niki Millward Zacharias, Rosalba Minelli, Daniel D Shapiro, Angela K Deem, Sisi Gao, Emily H Cheng, Donatella Lucchetti, Cheryl L Walker, Alessandro Carugo, Virginia Giuliani, Timothy P Heffernan, Andrea Viale, Nizar M Tannir, Giulio F Draetta, Pavlos Msaouel, Giannicola Genovese

Faculty, Staff and Student Publications

Renal medullary carcinoma (RMC) is an aggressive kidney cancer that almost exclusively develops in individuals with sickle cell trait (SCT) and is always characterized by loss of the tumor suppressor SMARCB1. Because renal ischemia induced by red blood cell sickling exacerbates chronic renal medullary hypoxia in vivo, we investigated whether the loss of SMARCB1 confers a survival advantage under the setting of SCT. Hypoxic stress, which naturally occurs within the renal medulla, is elevated under the setting of SCT. Our findings showed that hypoxia-induced SMARCB1 degradation protected renal cells from hypoxic stress. SMARCB1 wild-type renal tumors exhibited lower levels …

Tau Polarizes An Aging Transcriptional Signature To Excitatory Neurons And Glia, Timothy Wu, Jennifer M Deger, Hui Ye, Caiwei Guo, Justin Dhindsa, Brandon T Pekarek, Rami Al-Ouran, Zhandong Liu, Ismael Al-Ramahi, Juan Botas, Joshua M Shulman

Faculty, Staff and Students Publications

Aging is a major risk factor for Alzheimer’s disease (AD), and cell-type vulnerability underlies its characteristic clinical manifestations. We have performed longitudinal, single-cell RNA-sequencing in Drosophila with pan-neuronal expression of human tau, which forms AD neurofibrillary tangle pathology. Whereas tau- and aging-induced gene expression strongly overlap (93%), they differ in the affected cell types. In contrast to the broad impact of aging, tau-triggered changes are strongly polarized to excitatory neurons and glia. Further, tau can either activate or suppress innate immune gene expression signatures in a cell-type-specific manner. Integration of cellular abundance and gene expression pinpoints nuclear factor kappa B …

Reducing Recycling Contamination Using An Information Nudge, Mimi Rivette

LSU Master's Theses

Recycling contamination is a central challenge to recycling programs but is infrequently studied due to the difficulty of measuring contents and the inconvenience of sorting through recycling bags by hand. We conducted two simultaneous experiments to address both the issue of recycling contamination and the infrequency of its study at Louisiana State University in Fall 2021. We implemented two signage treatments, the first explicitly instructing passersby not to recycle a short list of common recycling contaminants, including Styrofoam, food wrappers, plastic bags, and face masks, and the second generally encouraging recycling but excluding specific instructions on what to recycle. To …

My Promise To Nature., Kathleen Mcvea

LSU Master's Theses

My Promise to Nature is a body of work created to emphasize the importance of conserving natural habitats in Louisiana’s Tunica Hills. The decision to do Land Art and select the Tunica Hills as the subject did not come to me right away. Nature and family have been woven throughout my work throughout my time in the M.F.A. program.

This was not out of reach, and I was already extremely passionate about the subject. It might be a pain due to location, but my family owned 400 acres of property in the Tunica Hills with a cabin that they had …

Remote Sensing And Artificial Intelligence-Based Modeling And Prediction Of Harmful Algal Blooms In Lake Pontchartrain, Ian Smith

LSU Master's Theses

Harmful Algal Blooms (HABs) and particularly toxic cyanobacterial harmful algal blooms (CyanoHABs) have become a growing threat to the environment, economy, communities, and human and animal health. This is particularly true for Lake Pontchartrain. Forecasting the occurrence of cyanobacterial HABs in Lake Pontchartrain is a process that currently does not exist, as nowcasting by the NCCOS Algal Bloom Monitoring System or the similar system implemented by the U.S. EPA is currently the only method to monitor HAB production in the Lake. This thesis made this process possible by identifying antecedent environmental conditions controlling CyanoHABs, describing the conditions using NASA satellite …

Book Club As Collaborative Intervention To Reduce Aliteracy Among In-School Adolescents In Nigeria :The Roles Of Library School Educators, Dr Margret Olusola Abimbola 010, Aramide Akinjide Kolawole Dr

Library Philosophy and Practice (e-journal)

Abstract

Aliteracy, the lack of interest in reading by capable readers among the in-school adolescents in Nigeria, has raised many concerns among the stakeholders. This study examines the role of Library School educators in reducing aliteracy through the cooperative intervention of Book Clubs establishment and sustenance in secondary schools. This paper presents opinion reports through a literature search and review. The study was carried out to describe aliteracy and its prevalence among in-school adolescents, ascertain the need for cooperative intervention to reduce aliteracy among in-school adolescents and examine the role of Library School Educators. Literature search and review were used …

Missense Vkor Mutants Exhibit Severe Warfarin Resistance But Lack Vkcfd Via Shifting To An Aberrantly Reduced State, Shuang Li, Jie Sun, Shixuan Liu, Fengbo Zhou, Michael L Gross, Weikai Li

2020-Current year OA Pubs

Missense vitamin K epoxide reductase (VKOR) mutations in patients cause resistance to warfarin treatment but not abnormal bleeding due to defective VKOR activity. The underlying mechanism of these phenotypes remains unknown. Here we show that the redox state of these mutants is essential to their activity and warfarin resistance. Using a mass spectrometry-based footprinting method, we found that severe warfarin-resistant mutations change the VKOR active site to an aberrantly reduced state in cells. Molecular dynamics simulation based on our recent crystal structures of VKOR reveals that these mutations induce an artificial opening of the protein conformation that increases access of …

Targeted Neurostimulation Reverses A Spatiotemporal Biomarker Of Treatment-Resistant Depression, Anish Mitra, Marcus E Raichle, Andrew D Geoly, Ian H Kratter, Nolan R Williams

2020-Current year OA Pubs

Major depressive disorder (MDD) is widely hypothesized to result from disordered communication across brain-wide networks. Yet, prior resting-state-functional MRI (rs-fMRI) studies of MDD have studied zero-lag temporal synchrony (functional connectivity) in brain activity absent directional information. We utilize the recent discovery of stereotyped brain-wide directed signaling patterns in humans to investigate the relationship between directed rs-fMRI activity, MDD, and treatment response to FDA-approved neurostimulation paradigm termed Stanford neuromodulation therapy (SNT). We find that SNT over the left dorsolateral prefrontal cortex (DLPFC) induces directed signaling shifts in the left DLPFC and bilateral anterior cingulate cortex (ACC). Directional signaling shifts in the …

Mechanically Manipulating Glymphatic Transport By Ultrasound Combined With Microbubbles, Dezhuang Ye, Si Chen, Yajie Liu, Charlotte Weixel, Zhongtao Hu, Jinyun Yuan, Hong Chen

2020-Current year OA Pubs

The glymphatic system is a perivascular fluid transport system for waste clearance. Glymphatic transport is believed to be driven by the perivascular pumping effect created by the pulsation of the arterial wall caused by the cardiac cycle. Ultrasound sonication of circulating microbubbles (MBs) in the cerebral vasculature induces volumetric expansion and contraction of MBs that push and pull on the vessel wall to generate a MB pumping effect. The objective of this study was to evaluate whether glymphatic transport can be mechanically manipulated by focused ultrasound (FUS) sonication of MBs. The glymphatic pathway in intact mouse brains was studied using …

Upregulation Of The Oct3/4 Network In Basal Breast Cancer Is Associated With Its Metastatic Potential And Shows Tissue Dependent Variability, Robin G Rajan, Raisa I Krutilina, Tatyana N Ignatova, Zoran S Pavicevich, Galina M Dulatova, Maria A Lane, Arindam R Chatterjee, Robert J Rooney, Mymoon Antony, Vivian R Hagerty, Nickolay V Kukekov, Khalid A Hanafy, Frank D Vrionis

2020-Current year OA Pubs

Adaptive plasticity of Breast Cancer stem cells (BCSCs) is strongly correlated with cancer progression and resistance, leading to a poor prognosis. In this study, we report the expression profile of several pioneer transcription factors of the

Assessment Of Design Standards For Fish Landing Centers In The City Of Aden, Abdulnasser Abdulla Alkaderi, Gawaher Khaled Fadhl

Emirates Journal for Engineering Research

ABSTRACT

The existence of fishing harbors became one of the factor that implies the performance of local fishermen. Since 2015, the fishing industry in Yemen has faced increased challenges, including a significant drop in the level of production; fish processing plants halting, and the disempowerment of the Ministry of Fish Wealth. Local fish landing centers and auction squares in the city of Aden suffer from a specific problem, which lies in their lack of many important services. Based on the problem, the study purposes to facilitate handling of fish products and provide comfortable environment for sellers, and consumers. Considering the …

The Translation Of Inclusion/Acceptance, Accessibility, And Empathy With Online Community Engagement, Jessie C. Feng

VA Engage Journal

Service-learning at Virginia Commonwealth University traditionally involves students performing community service to address community needs, coupled with guided reflection for holistic growth. In the spring of 2020 in-person courses were suspended due to the Covid-19 pandemic, necessitating a transition to online classes. This study aimed to determine if online service-learning provided the same benefits as in-person experiences, focusing on students' perceptions of inclusion/acceptance, empathy, and accessibility. Online surveys were administered to students enrolled in service-learning courses during the semester. Results showed reduced levels of support compared to Fall 2019, but increased social activism and awareness. The study noted that remote …

Where To Draw The Line: An Important Discussion On Maid And Mental Illness, Lauren Liu

Budding Writers Contest 2023

No abstract provided.

Growing Pains, Aanjalin Iruthayanathan

Budding Writers Contest 2023

No abstract provided.

Into The Future, Deepshikha Deepshikha

Budding Writers Contest 2023

No abstract provided.

Wayfarer, Victoria Chharawala

Budding Writers Contest 2023

No abstract provided.

Contact, Vivian Ren

Budding Writers Contest 2023

No abstract provided.

Futurio Inc., Angwara Nilanont

Budding Writers Contest 2023

No abstract provided.

Overview Of The Proceedings Of The 2022 Inclusion In Science, Learning A New Direction, Conference On Disability (Island), Cary A. Supalo, Jasodhara Bhattacharya, Daniel Steinberg

Journal of Science Education for Students with Disabilities

The 13th annual Inclusion in Science, Learning a New Direction, Conference on Disability was hosted by the Princeton Center for Complex Materials (PCCM), a National Science Foundation funded Materials Research Science and Engineering Center (MRSEC), and Princeton University on September 16-17, 2022 at Bowen Hall. This annual conference included presentations that featured innovative research done by science educators in formal and informal education contexts, ranging from pre-K-12 to higher education, and science education researchers, access technology developers, and others interested in the full inclusion of persons with disabilities into the Science, Technology, Engineering, and Mathematics (STEM) workforce. The 2022 ISLAND …

A Confluence Of Cultural And Water History With The Seli’Š Ksanka Qlispe’ Dam Formerly Named The Kerr Dam, Allisen A. Hansen

2023 Symposium

The Seli’š Ksanka Qlispe’ Dam (SKC Dam), formerly known as the Kerr Dam is the first Native American tribally owned dam in the United States. Located on the Confederated Salish and Kootenai Tribes(CSKT) of the Flathead Reservation, on the Flathead River in Montana, the dam was once considered the blight of the Whiteman’s landgrab and genocide of culture and language. Now it is a source of hope to the tribe to help its members and improve its future. Completed in 1938, it is one of two dams on the Flathead River, just south of the Flathead Lake. By following the …