Digital Commons Network^™

The High Obesity Program On Weight For Adults: Integrative Review, Monica Jaramillo

DNP and Student Works

This integrative review is a call to action for all responsible stakeholders to consider implementing an evidence-based intervention to mitigate adult obesity. This review explored the High Obesity Program intervention to address obesity among adults. The scope of this practice problem is as extensive as its negative impact at the individual, local, national, and global levels. Obesity generates an evident burden on global health, well-being, and economies.

Megan Clement, Oral History Interview, 2023, You Li

Collective Memory of Women Journalists in COVID-19

Megan Clement from Montreuil, France, is a journalist, critic, and editor whose work focuses on gender equality, social policy, migration, human rights, arts, and culture. Her work has appeared in The Guardian, Bloomberg, The Sydney Morning Herald, Al Jazeera, The New Humanitarian, and News Deeply, among other publications.

Clement, an Australian journalist living in Paris, France at the time, traveled across three continents and underwent four quarantines for work and family reasons during the pandemic. She published her quarantine experiences in the first-person voice and raised public attention to the mismanagement of quarantine protocols at hotels and public housing. She …

Academic Senate - Minutes, 5/23/2023, Academic Senate

Academic Senate Minutes

No abstract provided.

Approval Letter For The Butte Priority Soils Operable Unit, Residential Metals Abatement Program (Non-Residential Parcels) 2021 Data Summary Report (March 31, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Comments For The Draft Residential Metals Abatement Program – Interior School Dust – Investigation Summary Report – Highland View Christian School (February 2, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Tet2 Truncating Mutations Predict A Worse Outcome In Blastic Plasmacytoid Dendritic Cell Neoplasm, Hannah Beird, C Cameron Yin, Joseph D Khoury, Sherry Pierce, Hussein A Abbas, Li Zhao, Anna Skwarska, Muzaffar Qazilbash, Marina Konopleva, P Andrew Futreal, Naveen Pemmaraju

Faculty, Staff and Student Publications

No abstract provided.

Publisher Correction: A Randomized Pilot Study Of Oncology Massage To Treat Chemotherapy-Induced Peripheral Neuropathy, Gabriel Lopez, Cathy Eng, Michael Overman, David Ramirez, Wenli Liu, Curtiss Beinhorn, Pamela Sumler, Sarah Prinsloo, Yisheng Li, Minxing Chen, Eduardo Bruera, Lorenzo Cohen

Faculty, Staff and Student Publications

No abstract provided.

Pathogenicity Of Multiple Providencia Species (Enterobacteriales: Morganellaceae) To The Mass-Reared Mexican Fruit Fly (Diptera: Tephritidae), Bacilio Salas, Hugh E. Conway, Don C. Vacek, Christopher Vitek, Erin Schuenzel

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Mexican fruit fly (Anastrepha ludens (Loew)) (Diptera: Tephritidae) represents a major threat to fruit production in the Western Hemisphere. Sterile insect technique is used to suppress and eradicate wild populations. Success of this control method necessitates weekly production of hundreds of millions of flies, their sterilization by irradiation, and their aerial release. Diet needed to produce large fly numbers are conducive to the spread of bacteria. Pathogenic bacteria were isolated from 3 rearing facilities and from multiple sources: eggs, larvae, pupae and spent diet, and were found to include some isolates identified to the genus Providencia (Enterobacteriales: Morganellaceae). We …

Novel Microfluidic Devices To Model The Interactions Between Lymphatics And Breast Cancer, Jade Weber

McKelvey School of Engineering Graduate Student Theses & Dissertations

The lymphatic system is responsible for immune circulation and fluid balance in the body. It accomplishes this by draining interstitial fluid from local tissue and transferring it to lymph nodes and back into blood circulation. However, this process is implicated in many pathologies, one of the most dangerous being breast cancer metastasis to the lymph nodes. The largest factor in breast cancer patient mortality is metastasis. Lymphangiogenesis, the growth of new lymphatic vessels, has been thought to play a dynamic role in aiding breast cancer metastasis. Breast cancer tumor cells have been shown to remodel the functionality of local lymph …

Balloon Dilatation In The Management Of Congenital Obstructive Lesions Of The Heart: Review Of Author's Experiences And Observations-Part I, P Syamasundar Rao

Faculty, Staff and Student Publications

Balloon dilatation techniques became available to treat congenital obstructive lesions of the heart in the early/mid-1980s. The purpose of this review is to present the author's experiences and observations on the techniques and outcomes of balloon dilatation of pulmonary stenosis (PS), aortic stenosis (AS) and aortic coarctation (AC), both native and postsurgical re-coarctations. Balloon dilatation resulted in a reduction of peak pressure gradient across the obstructive lesion at the time of the procedure as well as at short-term and long-term follow-ups. Complications such as recurrence of stenosis, valvar insufficiency (for PS and AS cases) and aneurysm formation (for AC cases) …

Sequential Absorption Of Two Photons Creates A Bistable Form Of Rubyacr Responsible For Its Strong Desensitization, Oleg A Sineshchekov, Elena G Govorunova, Hai Li, Yumei Wang, John L Spudich

Faculty, Staff and Student Publications

Channelrhodopsins with red-shifted absorption, rare in nature, are highly desired for optogenetics because light of longer wavelengths more deeply penetrates biological tissue. RubyACRs (Anion ChannelRhodopsins), a group of four closely related anion-conducting channelrhodopsins from thraustochytrid protists, are the most red-shifted channelrhodopsins known with absorption maxima up to 610 nm. Their photocurrents are large, as is typical of blue- and green-absorbing ACRs, but they rapidly decrease during continuous illumination (desensitization) and extremely slowly recover in the dark. Here, we show that long-lasting desensitization of RubyACRs results from photochemistry not observed in any previously studied channelrhodopsins. Absorption of a second photon by …

Membrane Bending And Sphingomyelinase-Associated, Sulfatide-Dependent Hypoxic Adhesion Of Sickle Mature Erythrocytes, Utku Goreke, Erdem Kucukal, Fang Wang, Ran An, Nicole Arnold, Erina Quinn, Charlotte Yuan, Allison Bode, Ailis Hill, Yuncheng Man, Bryan C. Hambley, Robert Schilz, Mahazarin Ginwalla, Umut A. Gurkan, Umut A. Gurkan

Faculty Scholarship

Abnormal erythrocyte adhesion owing to polymerization of sickle hemoglobin is central to the pathophysiology of sickle cell disease (SCD). Mature erythrocytes constitute >80% of all erythrocytes in SCD; however, the relative contributions of erythrocytes to acute and chronic vasculopathy in SCD are not well understood. Here, we showed that bending stress exerted on the erythrocyte plasma membrane by polymerization of sickle hemoglobin under hypoxia, enhances sulfatide-mediated abnormal mature erythrocyte adhesion. We hypothesized that sphingomyelinase (SMase) activity, which is upregulated by accumulated bending energy, leads to elevated membrane sulfatide availability, and thus, hypoxic mature erythrocyte adhesion. We found that mature erythrocyte …

Medical Systems Data Security And Biometric Authentication In Public Cloud Servers, Nelson Santos, Bogdan Ghita, Giovanni Masala

School of Engineering, Computing and Mathematics

Advances in distributed computing and virtualization allowed cloud computing to establish itself as a popular data management and storage option for organizations. However, unclear safeguards, practices, as well as the evolution of legislation around privacy and data protection, contribute to data security being one of the main concerns in adopting this paradigm. Another important aspect hindering the absolute success of cloud computing is the ability to ensure the digital identity of users and protect the virtual environment through logical access controls while avoiding the compromise of its authentication mechanism or storage medium. Therefore, this paper proposes a system that addresses …

Balance & Juggle, Ellen Zhang

Journal of Wellness

This poem is a work of fiction inspired by experiences, observations, and conversations I have had with female physicians, colleagues, and mentors. They shared their stories of balancing their personal and professional life as they navigated titles ranging from trainee to mother. This piece aims to shed light on recent research highlighting that female surgeons face higher rates of infertility and are more likely to miscarry during pregnancy than the overall US female population. This piece is a reminder to all that being a physician is a choice, but also a sacrifice.

A Phase 2 Study Of Nivolumab Combined With Ibrutinib In Patients With Diffuse Large B-Cell Richter Transformation Of Cll, Nitin Jain, Jayastu Senapati, Beenu Thakral, Alessandra Ferrajoli, Philip Thompson, Jan Burger, Sreyashi Basu, Tapan Kadia, Naval Daver, Gautam Borthakur, Marina Konopleva, Naveen Pemmaraju, Erin Parry, Catherine J Wu, Joseph Khoury, Carlos Bueso-Ramos, Naveen Garg, Xuemei Wang, Wanda Lopez, Ana Ayala, Susan O'Brien, Hagop Kantarjian, Michael Keating, James Allison, Padmanee Sharma, William Wierda

Faculty, Staff and Student Publications

Richter transformation (RT) is a rare complication of chronic lymphocytic leukemia (CLL) that has dismal outcomes. Upregulation of PD-1/PD-L1 drives immunological evasion in patients with RT. We hypothesized that combining nivolumab, a PD-1 blocking antibody, with the BTK inhibitor (BTKi) ibrutinib could potentiate tumor-cell killing. We conducted an investigator-initiated phase 2 clinical trial to assess the efficacy of combined nivolumab and ibrutinib in patients with diffuse large B-cell lymphoma (DLBCL) RT and CLL. Patients included were ≥18 years of age with adequate hepatic and renal function. Patients received nivolumab every 2 weeks of a 4-week cycle for a maximum of …

Investigating Risk Factors Of The Development Of Compulsive Exercise And Eating Disorder Symptoms In College Students, Madeline Palermo

USF Tampa Graduate Theses and Dissertations

Compulsive exercise (e.g., high exercise frequency combined with the inability to reduce or stop exercising) is associated with a variety of maladaptive outcomes in college students, such as quality of life impairment, body dissatisfaction, and poor physical health outcomes. Recent research suggests that compulsive exercise is highly prevalent among college students and that engagement in compulsive exercise behaviors may increase over the first year of college. Given that college is an important developmental period for establishing behavioral patterns that affect long-term health, developing effective preventative interventions for compulsive exercise among early college students is paramount. Extant cross-sectional work suggests that …

University Administrators’ Visions For The Recovery Of International Student Exchange In A Post–Covid-19 World, Yusuke Sakurai, Yukiko Ishikura, Ryoko Nakano, Yuki Nabeshima, Yu Sengoku, Akito Okada, Sachihiko Kondo

Higher Learning Research Communications

Objectives: Little is known about how international functions of higher education, such as exchange programmes, can be resumed during recovery from a disruptive global crisis, such as COVID-19. We collected the opinions of administrators of international exchange programmes regarding their plans to resume their exchange programmes in the recovery phase and identified variations in the responses concerning institution type (public vs. private) and the presence or absence of a medical school.

Method: We used multiple-choice survey questions in our study, resulting in 180 valid responses. We examined overall patterns using descriptive statistics and institutional uniqueness using Fisher’s exact test.

Results: …

Inflammation Modulates The Activation Of Autophagy In C2c12 Myotubes, Robert S. Rogers, Parker G. Howe, Annemarie Hayes, Justin Yeung, Jeff Staudinger

Student Publications

Autophagy is a cellular housekeeping process by which proteins and damaged organelles are targeted for engulfment by autophagosomes ultimately culminating in degradation within the lysosomes. Chronic inflammation has been shown to disrupt normal physiological homeostasis leading to increased risk of cardiovascular disease, type 2 diabetes mellitus and muscle atrophy. The purpose of this study was to investigate whether inflammation disrupts the activation of autophagy in C2C12 myotubes. Myoblasts were grown in 10% fetal bovine serum supplemented DMEM until confluent and then differentiated for 5 d in 2% FBS-DMEM. Autophagy was monitored by Western blotting for changes in p62/sequestosome 1 (p62/sqstm1) …

A Mathematical Model To Optimize The Neoadjuvant Chemotherapy Treatment Sequence For Triple-Negative Locally Advanced Breast Cancer, Juan C. Lopez-Alvarenga, Antonmaria Minzoni-Alessio, Arturo Olvera-Chávez, Gustavo Cruz-Pacheco, Juan C. Chimal-Eguia, Joselin Hernandez-Ruiz, Mario A. Alvarez-Blanco, Maria Y. Bautista-Hernandez, Rosa M. Quispe-Siccha

School of Medicine Publications

Background: Triple-negative locally advanced breast cancer is an aggressive tumor type. Currently, the standard sequence treatment is applied, administering anthracyclines first and then a taxane plus platinum. Clinical studies for all possible treatment combinations are not practical or affordable, but mathematical modeling of the active mitotic cell population is possible. Our study aims to show the regions with the tumor’s most substantial cellular population variation by utilizing all possible values of the parameters (������) that define the annihilatory drug capacity according to the proposed treatment.

Method: A piecewise linear mathematical model was used to analyze the cell population growth …

Cardiorespiratory Monitoring Data To Predict Respiratory Outcomes In Extremely Preterm Infants, Namasivayam Ambalavanan, Debra E. Weese-Mayer, Anna Maria Hibbs, Nelson Claure, Premananda Indic, Additional Authors, Prematurity-Related Ventilatory Control (Pre-Vent) Investigators

Electrical Engineering Faculty Publications and Presentations

Rationale: Immature control of breathing is associated with apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants. However, it is not clear if such events independently predict worse respiratory outcome. Objectives: To determine if analysis of cardiorespiratory monitoring data can predict unfavorable respiratory outcomes at 40 weeks postmenstrual age (PMA) and other outcomes, such as bronchopulmonary dysplasia at 36 weeks PMA. Methods: The Prematurity-related Ventilatory Control (PreVent) study was an observational multicenter prospective cohort study including infants born at 29 weeks of gestation with continuous cardiorespiratory monitoring. The primary outcome was either "favorable" (alive and previously discharged or …

Catalyst Journal Of The Amateur Yacht Research Society, J Perry, I Ward, P Constantine, J Graham-Jones

School of Engineering, Computing and Mathematics

CATALYST is a journal of yacht research, design and technology published by the Amateur Yacht Research Society, BCM AYRS, London, WC1N 3XX, UK. Articles include 2. Annual General Meeting 3. Increase of subscription from September 2023 4. Obituaries: Slade Penoyre and Tom Speer 8. Balanced Foils, Part 1, by Ian Ward 21. Design Challenge 4: Evaluation, by Paul Constantine 26. AYRS at the 2023 RYA Dinghy and Water Sports Show 28. News from the North West Local Group 29. AYRS Southern Area Meeting 31. North West Local Group Programme for 2023 31. AYRS Calendar of Events

Estate Of Murphy V. New York City Housing Authority

All Decisions

Note: opinion combines cases numbers 36 and 37. In negligence cases involving criminal attacks on tenants, the landlord's duty to provide minimal security, including locking exterior doors, is upheld. The targeted nature of the attacks does not automatically sever the causal link between the landlord's negligence and the injuries sustained by the tenants. Landlords may still be held liable if minimal security measures could have deterred the assailants. Notice of a defective lock is not required to defeat summary judgment, and triable issues of fact regarding breach and proximate cause should advance to a jury trial.

Scurry V. New York City Housing Authority

All Decisions

Note: opinion combines cases numbers 36 and 37. In negligence cases involving criminal attacks on tenants, the landlord's duty to provide minimal security, including locking exterior doors, is upheld. The targeted nature of the attacks does not automatically sever the causal link between the landlord's negligence and the injuries sustained by the tenants. Landlords may still be held liable if minimal security measures could have deterred the assailants. Notice of a defective lock is not required to defeat summary judgment, and triable issues of fact regarding breach and proximate cause should advance to a jury trial.

Pulaski Manor Associates V. Lipscomb

All Decisions

ERAP Case.

Participation Of Academic Libraries And Provision Of Covid-19 Information Services During The Pandemic In Nigeria, Flora Orewa

Library Philosophy and Practice (e-journal)

Information was sought on the level of collaboration between academic libraries and known key players championing the prevention and control of COVID-19, the activities carried out in compliance with set protocols, information services offered, and the challenges faced. Results showed moderate level of collaboration and very limited direct synergistic interaction with public health groups, while they provided patrons with an avenue to source updates from library websites. There was high compliance with COVID-19 prevention guidelines; however, there was no specialized COVID-19 information service desk for patrons' inquiries. Libraries participated in the dissemination of COVID-19 information during the pandemic, especially to …

Pilot Study On The Influence Of Incentive Spirometry On Percutaneous Image-Guided Intra-Abdominal Drainage Catheter Pressure: A Potential Method To Enhance Drainage, Aravinda Ganapathy, David H. Ballard, Grace L. Bishop, Mark J. Hoegger, Nihil Abraham, Horacio B. D'Agostino

2020-Current year OA Pubs

No abstract provided.

The Effectiveness Of Eye-Hand Coordination Training In Virtual Reality, Kelley Burger

LSU Doctoral Dissertations

Virtual environments (VE) and virtual reality (VR) through head-mounted displays (HMD) have been used to test and train eye-hand coordination skills in a way that is more immersive than traditional 2D video training. As this technology continues to evolve, researchers have sought to determine the degree to which these new technologies can augment training. This research attempts to expand the literature on sport skill training in VE and VR to elucidate the training protocols that support learning. The first study was designed to determine how a single session of occlusion training would affect football catching skills in VR. While adding …

A History Of The Construction And Financing Of Division I Football Bowl Subdivision And Ivy League Stadia: An Ideal-Type On Financial Modernization, Tiffany E. Demiris

LSU Doctoral Dissertations

This dissertation seeks to introduce financial modernization as a distinct subcategory of modernization and present practical applications for sport managers. Modernization literature has shown that, as society advances, levels of complexity increase. Modernization is generally concerned about the impact of technology, transportation, financial operations, and the reduction of risk in society (Seifried & Novicevic, 2017). These facets are not only important to established modernization subcategories, reflexive and ecological, but are also applicable to financial systems and demonstrate how financial modernization is both complementary and a distinct type of modernization. It is possible to take larger risks over time because so …

Smarcb1 Regulates The Hypoxic Stress Response In Sickle Cell Trait, Melinda Soeung, Luigi Perelli, Ziheng Chen, Eleonora Dondossola, I-Lin Ho, Federica Carbone, Li Zhang, Hania Khan, Courtney N Le, Cihui Zhu, Michael D Peoples, Ningping Feng, Shan Jiang, Niki Millward Zacharias, Rosalba Minelli, Daniel D Shapiro, Angela K Deem, Sisi Gao, Emily H Cheng, Donatella Lucchetti, Cheryl L Walker, Alessandro Carugo, Virginia Giuliani, Timothy P Heffernan, Andrea Viale, Nizar M Tannir, Giulio F Draetta, Pavlos Msaouel, Giannicola Genovese

Faculty, Staff and Student Publications

Renal medullary carcinoma (RMC) is an aggressive kidney cancer that almost exclusively develops in individuals with sickle cell trait (SCT) and is always characterized by loss of the tumor suppressor SMARCB1. Because renal ischemia induced by red blood cell sickling exacerbates chronic renal medullary hypoxia in vivo, we investigated whether the loss of SMARCB1 confers a survival advantage under the setting of SCT. Hypoxic stress, which naturally occurs within the renal medulla, is elevated under the setting of SCT. Our findings showed that hypoxia-induced SMARCB1 degradation protected renal cells from hypoxic stress. SMARCB1 wild-type renal tumors exhibited lower levels …

Tau Polarizes An Aging Transcriptional Signature To Excitatory Neurons And Glia, Timothy Wu, Jennifer M Deger, Hui Ye, Caiwei Guo, Justin Dhindsa, Brandon T Pekarek, Rami Al-Ouran, Zhandong Liu, Ismael Al-Ramahi, Juan Botas, Joshua M Shulman

Faculty, Staff and Students Publications

Aging is a major risk factor for Alzheimer’s disease (AD), and cell-type vulnerability underlies its characteristic clinical manifestations. We have performed longitudinal, single-cell RNA-sequencing in Drosophila with pan-neuronal expression of human tau, which forms AD neurofibrillary tangle pathology. Whereas tau- and aging-induced gene expression strongly overlap (93%), they differ in the affected cell types. In contrast to the broad impact of aging, tau-triggered changes are strongly polarized to excitatory neurons and glia. Further, tau can either activate or suppress innate immune gene expression signatures in a cell-type-specific manner. Integration of cellular abundance and gene expression pinpoints nuclear factor kappa B …