Digital Commons Network^™

Er Translocon Inhibitor Ipomoeassin F Inhibits Triple-Negative Breast Cancer Growth Via Blocking Er Molecular Chaperones, Shishi Tao, Eun Ju Yang, Guanghui Zong, Pui Kei Mou, Guowen Ren, Liang Chen, Ho Jeong Kwon, Jianhong Zhou, Zhijian Hu, Arman Khosravi, Qingyang Zhang, Yuchun Du, Wei Q. Shi, Joong Sup Shim

Biological Sciences Faculty Publications and Presentations

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer where no effective therapy has been developed. Here, we report that the natural product ER translocon inhibitor ipomoeassin F is a selective inhibitor of TNBC cell growth. A proteomic analysis of TNBC cells revealed that ipomoeassin F significantly reduced the levels of ER molecular chaperones, including PDIA6 and PDIA4, and induced ER stress, unfolded protein response (UPR) and autophagy in TNBC cells. Mechanistically, ipomoeassin F, as an inhibitor of Sec61α-containing ER translocon, blocks ER translocation of PDIA6, inducing its proteasomal degradation. Silencing of PDIA6 or PDIA4 by RNA interferences …

Racial Microaggressions In Healthcare Settings: A Scoping Review, Nagina Khan, Danish Hafeez, Tayyib Goolamallee, Ananya Arora, Will Smith, Rohit Shankar, Subodh Dave

Peninsula Medical School

No abstract provided.

Numerical Investigation On The Hydrodynamic Performance Of A 2d U-Shaped Oscillating Water Column Wave Energy Converter, Guixun Zhu, John Samuel, Siming Zheng, Jason Hughes, David Simmonds, Deborah Greaves

School of Engineering, Computing and Mathematics

The U-Oscillating Water Column (U-OWC) is a wave energy harvester exploiting the working principle of oscillating water columns for capturing and converting energy from sea waves. U-OWC devices can be integrated into a breakwater to enable wave energy extraction and provide shelter for port activities. In this work, a coupled Smoothed Particle Hydrodynamics (SPH) model was developed and applied to investigate the hydrodynamics of a U-OWC breakwater. The numerical model is validated against the experimental results over a range of regular wave conditions. An extensive campaign of computational tests is then carried out, studying the effects of geometrical parameters on …

Modeling Of A Hinged-Raft Wave Energy Converter Via Deep Operator Learning And Wave Tank Experiments, Jincheng Zhang, Xiaowei Zhao, Deborah Greaves, Siya Jin

School of Engineering, Computing and Mathematics

Model identification for a hinged-raft wave energy converter (WEC) is investigated in this paper, based on wave tank experiments and deep operator learning. Different from previous works which all formulated this issue as a function approximation task, this work, for the first time, formulates it as an operator approximation task (which learns the mapping from a function space to another function space). As such, a continuous-time WEC model is identified from data, greatly expanding the horizon of data-based WEC modeling because previous works were limited to discrete-time model identification. The error accumulation for multi-step predictions in the discrete-time formulation is …

Who Is Flexible And Adaptive In Everyday Life?, Valentina Vylobkova, Sonja Heintz

School of Psychology

Background: How flexible people react to changes, and adapt their behavior and plans, seems to be crucial in modern society. Nevertheless, no common conceptualization of flexibility exists in the psychological literature. Our work contributes to the scientific understanding of flexibility as a personality trait and offers a novel flexibility questionnaire. Methods and Results: An explorative study ( N = 279) examined three individual-difference concepts of flexibility and their relations with the Big Five personality traits. The results suggested that flexibility consists of predictability, adaptability, and orderliness can be assessed with 24 items (FS-24) and is distinguishable from the Big Five. …

Tennessee Farm Bureau News - July 2023, Tennessee Farm Bureau Federation

Tennessee Farm Bureau News

No abstract provided.

Cognitive Behavioral Therapy For Children And Adolescents With Anxiety Disorders, Jordan T Stiede, Erika S Trent, Andres G Viana, Andrew G Guzick, Eric A Storch, Jonathan Hershfield

Center for Medical Ethics and Health Policy Staff Publications

Anxiety disorders are the most common class of psychiatric conditions among children and adolescents. The cognitive behavioral model of childhood anxiety has a strong theoretic and empirical foundation that provides the basis for effective treatment. Cognitive behavioral therapy (CBT), with an emphasis on exposure therapy, is the gold standard treatment for childhood anxiety disorders, with strong empirical support. A case vignette demonstrating CBT for childhood anxiety disorders in practice, as well as recommendations for clinicians, are also provided.

Child And Adolescent Psychiatrists’ Use, Attitudes, And Understanding Of Genetic Testing And Pharmacogenetics In Clinical Practice, Takahiro Soda, Amanda R Merner, Brent J Small, Laura N Torgerson, Katrina Muñoz, Jehannine Austin, Eric A Storch, Stacey Pereira, Gabriel Lázaro-Muñoz

Center for Medical Ethics and Health Policy Staff Publications

The purpose of this study was to report current practices and attitudes of child and adolescent psychiatrists (CAP) regarding diagnostic genetic and pharmacogenetic (PGx) testing. We surveyed 958 US-based practicing CAP. 54.9% of respondents indicated that they had ordered/referred for a genetic test in the past 12 months. 87% of respondents agreed that it is their role to discuss genetic information regarding psychiatric conditions with their patients; however, 45% rated their knowledge of genetic testing practice guidelines as poor/very poor. The most ordered test was PGx (32.2%), followed by chromosomal microarray (23.0%). 73.4% reported that PGx is at least slightly …

A Dynamical Systems Approach To Characterizing Brain–Body Interactions During Movement: Challenges, Interpretations, And Recommendations, Derek C. Monroe, Nathaniel T. Berry, Peter C. Fino, Christopher K. Rhea

Rehabilitation Sciences Faculty Publications

Brain–body interactions (BBIs) have been the focus of intense scrutiny since the inception of the scientific method, playing a foundational role in the earliest debates over the philosophy of science. Contemporary investigations of BBIs to elucidate the neural principles of motor control have benefited from advances in neuroimaging, device engineering, and signal processing. However, these studies generally suffer from two major limitations. First, they rely on interpretations of ‘brain’ activity that are behavioral in nature, rather than neuroanatomical or biophysical. Second, they employ methodological approaches that are inconsistent with a dynamical systems approach to neuromotor control. These limitations represent a …

Association Of Chronic Pancreatitis Pain Features With Physical, Mental, And Social Health, Dhiraj Yadav, Robert L Askew, Tonya Palermo, Liang Li, Dana K Andersen, Minxing Chen, William E Fisher, Evan L Fogel, Christopher E Forsmark, Phil A Hart, Mohamed O Othman, Stephen J Pandol, Walter G Park, Mark D Topazian, Stephen K Van Den Eeden, Santhi Swaroop Vege, Yunlong Yang, Jose Serrano, Darwin L Conwell, Consortium For The Study Of Chronic Pancreatitis, Diabetes, Pancreatic Cancer (Cpdpc)

Faculty, Staff and Students Publications

BACKGROUND AND AIMS: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities.

METHODS: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants …

External Validation Of A Novel Electronic Risk Score For Cancer-Associated Thrombosis In A Comprehensive Cancer Center, Ang Li, Giordana De Las Pozas, Clark R Andersen, Chijioke C Nze, Katy M Toale, Emily M Milner, Nathanael R Fillmore, Elizabeth Yu Chiao, Cristhiam Rojas Hernandez, Michael H Kroll, Kelly W Merriman, Christopher R Flowers

Faculty, Staff and Students Publications

Venous thromboembolism (VTE) is a significant complication for cancer patients undergoing systemic therapy. We performed an independent external validation for a recently derived and validated a novel electronic health record (EHR) VTE risk score in a comprehensive cancer center. Adult patients with incident cancer diagnoses were identified from MD Anderson Cancer Center Tumor Registry 1/2017-1/2021. Baseline covariates extracted at the time of first-line systemic therapy included demographics, cancer site/histology, stage, treatment, complete blood count, body mass index, recent prolonged hospitalization, and history of VTE or paralysis. VTE was ascertained using an institution-specific natural language processing radiology algorithm (positive predictive value …

Defining The Full Spectrum Of Pediatric Firearm Injury And Death In The United States: It Is Even Worse Than We Think, Bindi J Naik-Mathuria, Cary M Cain, Elizabeth A Alore, Liang Chen, Lisa A Pompeii

Faculty, Staff and Students Publications

OBJECTIVE: To characterize the full spectrum of pediatric firearm injury in the United States by describing fatal and nonfatal injury data epidemiology, vulnerable populations, and temporal trends.

BACKGROUND: Firearm injury is the leading cause of death in children and adolescents in the United States. Nonfatal injury is critical to fully define the problem, yet accurate data at the national level are lacking.

METHODS: A cross-sectional study combining national firearm injury data from the Centers for Disease Control (fatal) and the National Trauma Data Bank (nonfatal) between 2008 and 2019 for ages 0 to 17 years. Data were analyzed using descriptive …

A Serological Assay To Detect And Differentiate Rodent Exposure To Soft Tick And Hard Tick Relapsing Fever Infections In The United States, Christina M Parise, Ying Bai, Kevin S Brandt, Shelby L Ford, Sarah Maes, Adam J Replogle, Alexander R Kneubehl, Job E Lopez, Rebecca J Eisen, Andrias Hojgaard

Faculty, Staff and Students Publications

Human cases of relapsing fever (RF) in North America are caused primarily by Borrelia hermsii and Borrelia turicatae, which are spread by argasid (soft) ticks, and by Borrelia miyamotoi, which is transmitted by ixodid (hard) ticks. In some regions of the United States, the ranges of the hard and soft tick RF species are known to overlap; in many areas, recorded ranges of RF spirochetes overlap with Lyme disease (LD) group Borrelia spirochetes. Identification of RF clusters or cases detected in unusual geographic localities might prompt public health agencies to investigate environmental exposures, enabling prevention of additional cases through locally …

Multiple Primary Lung Cancers: Treatment Outcomes After Stereotactic Body Radiotherapy (Sbrt), Gyujae Choi, George Chen, Weiyuan Mai, Albert Chen, Angela Zhu

Faculty, Staff and Students Publications

PURPOSE/OBJECTIVES: Patients with lung cancer sometimes present with multiple primary lung cancers (MPLCs), either simultaneously (synchronous) or after treatment of an initial lesion (metachronous). Although open surgery remains a treatment mainstay for patients with stage I-II non-small-cell lung cancer (NSCLC), stereotactic body radiation therapy (SBRT) is an acceptable alternative for patients who are medically unfit for or who refuse surgery. In this study, we retrospectively examine the outcome among patients with early-stage MPLCs treated at our institution with SBRT.

MATERIALS/METHODS: Patients at our institution receiving SBRT for MPLC between June 2011 and March 2020 were reviewed retrospectively. Prior to undergoing …

The Association Of Academic Cosmetic Dermatology: Improving Cosmetic Dermatology Education Through Collaboration, Research, And Advocacy, Kira Minkis, Diana Bolotin, M Laurin Council, Anna Bar, Ronda S Farah, Nour Kibbi, Rachel Y N Miest, Jeffrey S Orringer, Arisa Ortiz, Kathleen C Suozzi, Neelam A Vashi, Simon S Yoo, Joerg Albrecht, Travis W Blalock, Alison J Bruce, Min Deng, Shraddha Desai, Milad Eshaq, Lori A Fiessinger, Erica Ghareeb, Tanya Greywal, Adelaide A Hebert, Deirdre Hooper, Maria Hordinsky, Jenny C Hu, Atieh Jibbe, Jayne Joo, Kristen M Kelly, Sonya Kenkare, Shilpi Khetarpal, Lauren C S Kole, A Shadi Kourosh, Helena Kuhn, Kachiu C Lee, Roberta Lucas, Janiene Luke, Mariam Mafee, Tiffany T Mayo, Zeena Y Nawas, Edit B Olasz Harken, Michelle V Pearlstein, Vesna Petronic-Rosic, Carolyn A Robinson, Megan N Rogge, Dana L Sachs, Sami K Saikaly, Olivia L Schenck, Cynthia A Schlick, Ladan Shahabi, Desmond M Shipp, Melissa Shive, Sirunya Silapunt, Amanda K Suggs, Leila Tolaymat, Kimberley H M Ward, Mara Weinstein Velez, Joshua Zeichner, Bianca Y Kang, Sarah A Ibrahim, Rachel E Christensen, Noor Anvery, Mckenzie A Dirr, Naomi Lawrence, Murad Alam

Faculty, Staff and Students Publications

Cosmetic and laser procedures are increasingly popular among patients and are skills in which dermatologists are regarded as well trained. Most dermatology residents intend to incorporate cosmetic procedures into their practice and prefer to learn such procedures during residency through direct patient care. However, there are notable challenges in optimizing how residents are trained in cosmetic and laser dermatology. To address these barriers and elevate the practice of cosmetic dermatology in academic medicine, the Association of Academic Cosmetic Dermatology (AACD) was founded in 2021 as the lead professional society for dermatologists who direct the education of resident trainees in cosmetic …

Epileptic Spasms In Cdkl5 Deficiency Disorder: Delayed Treatment And Poor Response To First-Line Therapies, Heather E Olson, Scott Demarest, Elia Pestana-Knight, Ahsan N Moosa, Xiaoming Zhang, José R Pérez-Pérez, Judy Weisenberg, Erin O'Connor Prange, Eric D Marsh, Rajsekar R Rajaraman, Bernhard Suter, Akshat Katyayan, Isabel Haviland, Carolyn Daniels, Bo Zhang, Caitlin Greene, Michelle Deleo, Lindsay Swanson, Jamie Love-Nichols, Timothy Benke, Chellamani Harini, Annapurna Poduri

Faculty, Staff and Students Publications

OBJECTIVE: We aimed to assess the treatment response of infantile-onset epileptic spasms (ES) in CDKL5 deficiency disorder (CDD) vs other etiologies.

METHODS: We evaluated patients with ES from the CDKL5 Centers of Excellence and the National Infantile Spasms Consortium (NISC), with onset from 2 months to 2 years, treated with adrenocorticotropic hormone (ACTH), oral corticosteroids, vigabatrin, and/or the ketogenic diet. We excluded children with tuberous sclerosis complex, trisomy 21, or unknown etiology with normal development because of known differential treatment responses. We compared the two cohorts for time to treatment and ES remission at 14 days and 3 months.

RESULTS: …

Arterial Spin Labeling Changes Parallel Asymmetric Perisylvian And Perirolandic Symptoms In 3 Pediatric Cases Of Anti-Nmdar Encephalitis, Alexander J Sandweiss, Varun Kannan, Nilesh K Desai, Stephen F Kralik, Eyal Muscal, Kristen S Fisher

Faculty, Staff and Students Publications

BACKGROUND AND OBJECTIVES: Anti-NMDA receptor autoimmune encephalitis (NMDAR AE) is an autoantibody-mediated disorder characterized by seizures, neuropsychiatric symptoms, movement disorder, and focal neurologic deficits. Conventionally defined broadly as an inflammatory brain disease, the heterotopic localization is rarely discussed in children. Imaging findings are often nonspecific, and there are no early biomarkers of disease other than the presence of anti-NMDAR antibodies.

METHODS: We conducted a retrospective analysis of our pediatric NMDAR AE cases (as determined by either positive serum or CSF antibodies or both) at Texas Children's Hospital between 2020-2021 and extracted medical record data of those patients who had arterial …

The Impact Of Covid-19 On Maritime Pilots: Evidence And Lessons, Zhiwei Zhao, Lijun Tang

Plymouth Business School

The COVID-19 pandemic led to port congestion and disruption to global logistics and supply chains. While previous research has examined the impact on port performance and economics, social issues, such as the impact on port personnel (including pilots), have been overlooked. In this context, this paper examines the challenges experienced by Chinese pilots during the pandemic through in-depth interviews with 28 pilots. It shows that the draconian pandemic control measures adopted in China, rather than the pandemic itself, impaired pilots’ physical and mental health, reduced their availability, and introduced new safety hazards, which curtailed both the port’s capacity and ability …

Mapping California Rice Using Optical And Sar Data Fusion With Phenological Features In Google Earth Engine, Li Wenzhao, Hesham El-Askary, Daniele C. Struppa

Mathematics, Physics, and Computer Science Faculty Articles and Research

California, known for its diverse agriculture, is also a major producer of rice, especially in its northern regions in Sacramento River Valley. Traditional methods, predominantly reliant on optical-based satellite imagery, encounter limitations due to atmospheric interference and sensor resolution. The ability of Synthetic Aperture Radar (SAR) to penetrate atmospheric distortions and exhibit high sensitivity to vegetation structure presents a distinct advantage over optical-based methods. Utilizing Optical and SAR data fusion, this study advances the enhanced pixel-based phenological feature composite (Eppf) method using SVM classification algorithm, which can track phenological changes and patterns, providing valuable insights for agricultural planning and management. …

Monitoring Dam Stability Using Psi And Sbas Analysis, Rejoice Thomas, Wenzhao Li, Shahryar Fazli, Nikolay Grisel Todorov, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

Water preservation and maximization of its efficient use is key in areas facing water scarcity like California. One of the most important resources available to us are dams, which are useful to address a variety of needs like water supply, flood control, and maintaining environmental flows. However, if not managed properly, dams can be disastrous to humans and wildlife alike, different water species, habitats, and even impact water quality for a region. In this context, we have used newer Synthetic Aperture Radar Interferometry techniques like Persistent Scatterer Interferometry (PSI) and Small Baseline Subset (SBAS) to estimate the displacement rates at …

Impacts Of Land Use On Stormwater Runoff In The Lower Rio Grande Valley And Improving Long Term Municipal Stormwater Management Systems, Maria Vanessa Pruneda

Theses and Dissertations

Exponentially noticeable growth in population and land development in the Lower Rio Grande Valley has directly influenced growth in urbanization. Urbanization is the leading cause for lower pervious cover, and the increase in storm water runoff. The increase of storm water runoff leads to excess flooding areas and higher peak flows. The overflow flows freely and is exposed to contaminants, affecting the consumption and use factors. The changes of land use have a direct relationship with impervious cover limitations and individual site retentions. This study will assess the relationship between stormwater quantity and land use in the Lower Rio Grande …

Utrgv Edinburg Campus Two-Dimensional Flood Modeling For Development Of Flood Inundation Map, Roxana Tello

Theses and Dissertations

Severe flooding is a natural hazard worldwide, potentially subjecting people to life threatening situations and leaving infrastructure vulnerable to structural damage or complete destruction. The common threat of flooding poses constant challenges for state and local agencies in identifying flood risks and proposing the necessary mitigation improvements. Developing hydraulic models to predict the hydrological interactions and identify areas at risk is a beneficial tool for urban planning. The Lower Rio Grande Valley (LRGV) is a rapid growing region in South Texas along the border of Mexico and west of the Gulf of Mexico. The LRGV has historically suffered through various …

Measuring Social Vulnerability And Exposure To Potential Risks Induced By Spaceport Operations In South Texas: An Empirical Study Utilizing Gis Methods And Social Vulnerability Indicators, Evan D. Garcia

Theses and Dissertations

The commercialization of space has increased spaceport development and activity across the United States. The magnitude of growth can be witnessed through the spaceport expansion and spacecraft testing at the SpaceX “Starbase” Launch Facility, located along the Texas-Mexico border. Matching the pace of SpaceX’s growth while evaluating levels of risk, the Federal Aviation Administration (FAA) diligently conducted a comprehensive Programmatic Environmental Assessment (PEA). While this assessment provides significant environmental impact data and risk analysis, much is left to understand regarding hazards and risk exposure to local communities. More specifically, research is needed to understand hazards associated with operational- and anomaly- …

Spatiotemporal Modulated Non-Hermitian Structures And Their Application In Photonic Devices, Amir Targholizadeh

Theses and Dissertations

Periodically refractive index modulation has been known as a novel method to introduce non-reciprocity in optical lattices inspiring many works to propose on-chip optical components such as optical insulators and amplifiers. This type of modulation by coupling two waveguide propagating modes, let them exchange a population called photonic intraband transition. This modulation type also can be applied to the imaginary part of the refractive index, which perturbs the absorption in the waveguide. Non-hermitian physics is a promising field that studies physical effects in such systems without energy conservation. These systems have degeneracy points called Exceptional points in which two or …

Development Of Intensity Duration Frequency Curve Of The Lower Rio Grande Valley, Binaya Poudel

Theses and Dissertations

Section 1: This chapter incorporates extensive information about the concept of Intensity-Duration-Frequency (IDF) curves, their historical development and usage, specific focus on the Lower Rio Grande Valley, and the importance of using a comprehensive 32-year data set from 1990-2022 to develop these curves.

Section 2: This chapter provides detailed information about the rigorous comparison of the developed IDF curves with previous ones, where past IDF curves were developed using an empirical formula method. The research presented here employs the Gumbel distribution method, providing a fresh perspective and potentially more accurate predictions of future weather extremes.

Section 3: This chapter outlines …

Navigating Context And Perception: A Qualitative Study On Instructional Coaching, Christie Lizette Esparza

Theses and Dissertations

This qualitative case study explored the perceptions of instructional coaches in order to understand the ways in which context influenced their view of their roles and how they supported teacher growth. The theoretical and conceptual foundations for this study include a distributed perspective, a phenomenologically informed lens, and a pragmatic worldview. The sample consisted of 9 elementary instructional coach participants from different content areas and programs provided within the site. Semi-structured interviews, a focus group, and a review of the district’s instructional coaching program documents were used, and thematic analysis led to four findings that encompassed the contextual conditions that …

The Effect Of Two Sintering Cycles And Aging On Biaxial Flexural Strength Of Strength Gradient Multi-Layered Zirconia (An Vitro Study), Passent Hm El Galab, Maged Zohdy, Fatma Makkeyah, Mustafa Noor

Dentistry

No abstract provided.

Administrative Appeal Decision - Morgan, Charles (2019-07-25)

Parole Administrative Appeal Decisions

No abstract provided.

Administrative Appeal Decision - Gantt, Jonnell (2019-07-10)

Parole Administrative Appeal Decisions

No abstract provided.

Administrative Appeal Decision - James, Cory (2019-07-10)

Parole Administrative Appeal Decisions

No abstract provided.