Digital Commons Network^™

Cdk8 And Cdk19 Mediator Kinases As Novel Targets In Advanced Prostate Cancer, Jing Li

Theses and Dissertations

Following androgen deprivation therapy (ADT), prostate cancers (PCa) progress to castration resistant prostate cancer (CRPC) status, where their growth becomes independent of androgen signaling, through altered androgen receptor (AR) signaling or other genetic or transcriptional changes. Metastatic CRPC remains incurable, and the most potent new drugs prolong survival by only a few months. There is an urgent need for novel agents against advanced CRPC. Here we have investigated the roles of CDK8 and CDK19, two isoforms of Mediator kinase, which regulates transcriptional reprogramming, in regard to their biological activities and as potential novel targets for the treatment of CRPC.

To …

Prenatal Depression And Breastfeeding Practices Healthy Start Participants, 2019-2022, Peyton Ashleigh Mosher

Theses and Dissertations

Background: Breastfeeding has health benefits for both mother and child, but breastfeeding practices among Black and lower-income women are the poorest in the United States. Few studies have examined the associations between maternal prenatal depression and breastfeeding duration, even fewer among a predominantly low-income Black population. Objective: To explore the association between prenatal depression and breastfeeding practices among low-income Black women during the COVID-19 pandemic.

Methods: Prospective cohort data from Midlands Healthy Start (MHS) was analyzed to examine women’s depression symptoms during pregnancy and their breastfeeding initiation and duration through two and six months. Perinatal depressive symptoms were identified using …

Babe (Body Appreciation And Better Eating), Just Add A Dash Of Self-Compassion: A Randomized Controlled Pilot Study For Black/African American Teenage Girls, Nkechi Bianca Okpara

Theses and Dissertations

Introduction

Body dissatisfaction contributes to disproportionately high rates of disordered eating behaviors observed in Black teenagers. Given that self-compassion is found to buffer against eating pathology and body dissatisfaction and is linked to reduced incidences of binge eating and disordered eating behavior. Incorporating the self-compassion construct, specifically centering on nutrition, with a program that combats negative body image, like the Body Project, may further help decrease body dissatisfaction and improve overall nutrition.

Purpose

The aim of this dissertation was to test (1) the acceptability and feasibility of a novel program, Body Appreciation and Better Eating, add self-compassion (BABE+SC), and to …

Beyond Vaccination Coverage: A Critical Look At Zero-Dose Children In Sub-Saharan Africa, Chamberline Ekene Ozigbu

Theses and Dissertations

Background: Despite continuous efforts to enhance childhood vaccination coverage, a considerable number of children in sub-Saharan Africa (SSA) remain unvaccinated (zero-dose). Recent estimates indicate that approximately 17 million zero-dose children reside mainly in 10 Low- and Middle-Income Countries (LMICs) in SSA. The Immunization Agenda 2030 (IA2030) aims to reduce the number of zero-dose children by half, necessitating research to identify populations and groups at higher risk of being unvaccinated.

Objectives: This research sought to (1) examine individual and contextual factors associated with zero-dose status in SSA, (2) assess the geographical clustering of zero-dose children aged 12-59 months in SSA and …

Assessment And Development Of Collaboration Framework For Less-Than-Truckload Carriers, Bhavya Padmanabhan

Theses and Dissertations

The growth of e-commerce is changing consumer expectations for delivery services. Competition is making “faster and cheaper” a nonnegotiable part of success; hence, retailers are seeking carriers that can deliver with ever-shorter lead times and at the lowest possible cost. In this environment, large carriers have a competitive advantage due to their market power. For small-to-medium-sized less-than-truckload (LTL) carriers to stay in business, they must improve their efficiency and lower cost. A potential strategy to achieve these goals is to collaborate with other carriers. In collaborating, carriers would exchange and perform certain jobs for each other to lower their transportation …

Complementary And Integrative Health (Cih) And Opioid Use Among Adults With Chronic Noncancer Pain In The Us, Yi-Wen Shih

Theses and Dissertations

Chronic noncancer pain (CNCP) is defined as persistent pain lasting for more than three months due to conditions other than malignancy. This condition affects one in five American adults annually. The prescribing of opioids to individuals experiencing CNCP has been recognized as a critical contributor to the ongoing opioid crisis. In 2016, the Centers for Disease Control and Prevention (CDC) recommended Complementary and Integrative Health (CIH) as a nonpharmacologic treatment to be used among adults with CNCP. Despite the potential benefits of CIH for pain relief, there may be a discrepancy between individuals with CNCP and their insurance coverage for …

First Principles Doping Analysis Of Perovskite- And Ruddlesden-Popper-Based Solid Oxide Fuel Cells, Nicholas Alexander Szaro

Theses and Dissertations

Solid oxide fuel cells (SOFCs) have shown significant promise as a high efficiency energy conversion technology. SOFCs are solid-state, high temperature (600 – 1000 °C), and electrochemical conversion devices that can operate with a wide variety of fuels such as hydrogen, syngas, and hydrocarbon feedstocks. The state-of-the-art SOFC is manufactured with a lanthanum strontium manganite (LSM) cathode, an yttria-stabilizedzirconia electrolyte (YSZ), and a nickel on yttria-stabilized-zirconia (Ni/YSZ) cermet anode. LSM || YSZ || Ni/YSZ SOFCs operate at or above 800 °C to achieve sufficient oxide mobility. The high temperatures introduce problems such as long device start-up, particle sintering, and material …

Prevalence, Disparities, And Health Outcomes In Patients With Alzheimer’S Disease, Dementia, And Mild Cognitive Impairment, Xiaomo Xiong

Theses and Dissertations

Background: Alzheimer’s disease and related dementias (ADRD), an umbrella term to describe progressive neurodegenerative disorders linked to cognitive impairment and dementia, impose significant disease and economic burdens on the patients. Therefore, understanding the prevalence of these disorders is crucial, particularly for mild cognitive impairment (MCI), an intermediate phase between normal aging and dementia that may be reversible through early detection and intervention. Moreover, it is essential to identify the predictors of MCI to facilitate early detection. Additionally, addressing the existing health disparities in the prevalence and treatment of ADRD and MCI is imperative to help improve patients’ health outcomes. Meanwhile, …

Patient Experiences And Disparities In Telehealth Hiv Care During The Covid-19 Pandemic: Study Results From The Southern United States, Valerie Yelverton

Theses and Dissertations

Background: To maintain HIV care continuity during the COVID-19 pandemic, most HIV care facilities in the United States adopted telehealth. However, not everyone was participating in telehealth equally. This dissertation seeks to understand experiences with and the use of telehealth in HIV care, and decision processes guiding the selection of visit type during the COVID-19 pandemic.

Methods: Qualitative interviews explored people living with HIV’s (PWH) and HIV care provider’s experiences with telehealth HIV care and visit type decision processes. Quantitative analyses of electronic health record (EHR) data characterized patterns of and disparities in telehealth HIV care during the COVID-19 pandemic. …

Molecular Mediators Of Axonal Transport And Local Translation Of Cdc42, Rhoa Molecular Mediators Of Axonal Transport And Local Translation Of And Calreticulin Mrnas And Their Implications For Axon Growth And Regeneration, Matthew Davis Zdradzinski

Theses and Dissertations

Neurons are highly polarized cells with expansive cytoplasmic processes, axons and dendrites, which create unique subcellular domains. Localization and translation of mRNAs in these subcellular regions is now recognized as a critical mechanism through which polarized cells establish and maintain the specialized domains that are needed for their functions. RNA profiling studies have uncovered hundreds to thousands of mRNAs in axons and these axonal mRNA profiles differ across neuronal populations, physiological conditions, and developmental growth states. Functionally organizing these mRNA populations into cohorts of coregulated mRNAs via RNA binding proteins allows us to better understand how the transcriptome is regulated …

Effects Of A Self-Monitoring Tracking System Combined With Blended Learning Intervention Time On Students’ Self-Regulated Learning Skills And Academic Performance, Jennifer E. Augustine

Theses and Dissertations

The purpose of this action research was to evaluate the effects of the implementation of blended learning combined with a self-monitoring achievement system on students’ self-regulated learning (SRL) skills and academic performance in an eighth-grade English language arts classroom. SRL has been linked to higher academic achievement and success in and out of school. However, many students lack SRL skills, especially at the middle school level. This study addressed three research questions in order to better understand how students’ SRL skills and academic performance could be improved: (1) How and in what ways does the implementation of blended learning, combined …

Empowering Teachers To Support Mtss Students: An Action Research Study, Sahalija Dentico

Theses and Dissertations

In 2018, the elementary school where I serve as an instructional interventionist adopted a data-based multi-tiered system of supports (MTSS). Although our process has evolved over the years, I saw room for improvement. Therefore, the purpose of this action research study was to improve the MTSS process at my school, specifically by addressing teachers’ lack of awareness of their role. Framing the study with a combination of social cognitive theory and curriculum ideologies, I explored 12 English language arts teachers’ perceptions of the MTSS model, curricular views, and sense of self-efficacy. Through a two-phase, mixed-method approach, I investigated how sharing …

Comorbid Adhd And Pediatric Sickle Cell Disease: Prevalence And Risk Factors, Sarah Bills

Theses and Dissertations

Objective: Sickle cell disease (SCD) is a genetic blood condition that places youth at increased risk for deficits in attention and executive functioning suggestive of increased rates of Attention Deficit/Hyperactivity Disorder (ADHD). There is pronounced inconsistency in reported prevalence rates for attention deficits and ADHD diagnoses among youth with SCD, which is due in part to variability in methodology of previous studies. The primary aim of the present study is to use systematic screening to identify the prevalence of inattentive ADHD symptoms and ADHD diagnoses in a pediatric SCD population seen at a large hematology clinic. A secondary aim is …

An Examination Of Sustained Attention During Complex Multitasking Scenarios, Jonathan Cheshire Rann

Theses and Dissertations

This dissertation project examined the time-course of vigilance decrements that occur when operators perform demanding multitasking activities. For this aim, we conducted three experiments which implemented a novel paradigm we developed that measured performance during two sessions: a Single-Task session in which participants performed a go-no-go target detection task in the absence of any other task for approximately 12 minutes; and a Multi-Task session in which participants performed the detection task simultaneously with a driving-based tracking task for the same duration. A total of 183 participants from the University of South Carolina Department of Psychology took part in this study. …

The Effects Of Variations In Light And Nutrient Availability On Phytoplankton And Zooplankton, Jake Anthony Swanson

Theses and Dissertations

Aquatic ecosystems experience a wide range of variation in resource availability; two of the resources that are most essential to phytoplankton and zooplankton are light and nutrients. Light can vary in both its color and intensity; these variations can directly impact phytoplankton by altering the amount and color of light available for photosynthesis. Nutrient variability, particularly increases in nutrient levels, also alter phytoplankton communities by favoring the growth of certain taxa such as cyanobacteria.

To understand whether phytoplankton respond differently to changes in light availability I investigated whether the diversification of cryptophytes, phytoplankton with diverse light-capturing pigments, showed evidence of …

Exploring Literary Responses To Culturally Relevant Texts Through An Asiancrit Lens: A Collective Case Study Of Chinese American Students In A Community-Based Book Club, Wenyu Guo

Theses and Dissertations

Building on AsianCrit, reader response theory, and critical literacy perspective, this dissertation study investigated how second-generation Chinese American students at age eight to twelve respond to culturally relevant texts which portray contemporary and historical Chinese American people’s lives and experiences in the United States. In addition, this study explored how these students negotiate their understanding of race, racism, and anti-Asian racism through associating with the stories, their everyday experiences, family traditions, and interactions with peers and researcher in a community-based book club. Specifically, this study examined how students of Chinese descent respond to xenophobia, discrimination, and racism towards Asian people, …

What Are They Thinking?: A Qualitative Study Of Secondary Students’ Critical Thinking In Online Classes, Scott Allan Nolt

Theses and Dissertations

This action research study emerged in response to students’ struggle to understand what critical thinking is and teachers’ corresponding struggle to develop students’ critical thinking skills. In my role as an instructional designer, I studied student and teacher reactions to interdisciplinary course design that used disciplinary inquiry, problem-posing, and concept-based online learning. The primarily qualitative study focused on students’ reflections across five different social studies and English courses, along with interview data from their teachers and post-course survey data. Exploring how students experience instruction designed to develop their critical thinking skills and how instruction in critical thinking impacts students’ critical …

A Descriptive Study Of Factors That Support And Hinder Classroom Discourse With English Learners, Jillian Camille Plum

Theses and Dissertations

The population of English Learner (EL) students in the United States is increasing and is projected to represent 40% of our country by 2030 (Flynn and Hill, 2005). Many educators do not feel prepared to teach this marginalized group of students effectively. Therefore, EL coaches in this urban district in the Midwest collaborate with teachers to support instruction for EL students. However, teachers in this district still have a difficult time implementing classroom discourse, one of many EL components to help EL students achieve Fluent English Proficiency (FEP) status. This dissertation in practice (DIP) seeks to investigate and answer two …

Where Race Has No Place: English Teachers’ Efforts To Maintain Space For Diversity In The Ela Classroom, Muzical D. Waite

Theses and Dissertations

The anti-critical race theory movement began in 2020, propelled by the fear of topics on race and racism overtaking lesson objectives, course content, and class discussion, and, in turn, making some students feel uncomfortable (Duhaney, 2022). Opposition to critical race theory (CRT) and any initiative considered adjacent to the concept, such as the promotion of diversity, equity, and inclusion, set in motion legislative proposals in nearly every state and enactment in many (Greene, 2022). Anti- CRT regulation of the content and activities teachers can use comes at a time when American student enrollment has never been more diverse (Carrillo, 2022). …

Southeastern Conference (Sec) International Student-Athlete (Isa) Career Transitions - A Cultural Intelligence (Cq) Perspective, Tsu-Lin Yeh

Theses and Dissertations

This dissertation investigated international student-athletes’ (ISAs’) transition experiences of being recruited for, matriculating in, and then leaving high-performance and commercialized Southeastern Conference (SEC) institutions. Adopting the Cultural Intelligence (CQ) theory, this dissertation specifically examined how the four CQ elements (metacognition CQ, cognition CQ, motivation CQ, and behavior CQ) existed in an ISA’s transition process. CQ explains a person’s capability for performing well in culturally diverse environments (Fang et al., 2018). Traditional CQ studies have been utilized to manage international organizations’ diversity and inclusion (Triandis, 2006), particularly regarding employee retention, career transition and development (Mangla, 2021). However, although sports management is …

Exploring Chinese International Students’ Motivational Factors In Non-Mandatory Event Participation, Aimin Liao

Theses and Dissertations

This action research investigated Chinese international students’ motivational/demotivational factors and their perspectives on Virginia Tech’s non-mandatory events. The theoretical framework guided the research questions, literature reviews, and data design collection/analysis process. The self-determination theory provided the primary motivational factors for Chinese international students. The literacy/discourse theory explained their difficulties when practicing secondary Discourses in an American college. This action research utilized open-ended surveys and semi-structured interviews to understand Chinese international students’ motivations, struggles, and feedback in non-mandatory event participation. The qualitative research findings indicated that Chinese international students are motivated by autonomy, competency, and relatedness. Some Chinese international students’ inadequate …

The Emergence And Predictive Utility Of Early Markers Of Social Anxiety In Young Children With Fragile X Syndrome, Conner James Black

Theses and Dissertations

Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder characterized by elevated rates of intellectual disability, autism, and anxiety. Social anxiety affects approximately 60 percent of individuals with FXS and is cited as one of the most impairing comorbid disorders in FXS; however, little is understood about the developmental patterns of social anxiety markers in young children with FXS. The current study investigates cardiac and behavioral markers of social anxiety across the first five years of life and tests the predictive utility of these variables on social anxiety symptomatology. Participants included 80 children with FXS and 50 neurotypical controls. Participants …

Colored Lawyer, Topeka: The Legend And Legacy Of Elisa Scott, Jeffery Scott Williams

Theses and Dissertations

Attorney Elisha Scott’s reputation for fighting injustice grew so large he received letters addressed only, “Colored Lawyer, Topeka, Kansas.” He was born in obscurity in 1890, but his death made national news in 1963. Scott’s story may not be known at all if his name was not often listed as counsel in Brown v. Board of Education, the 1954 case that desegregated public schools. But it was his sons who filed the case and helped fight it from Topeka to the United States Supreme Court. He was never officially part of the legal team. He had, however, won a …

Prosecutorial Discretion: District Attorneys, Public Opinion,And The Localized Rule Of Law, Yu-Hsien Sung

Theses and Dissertations

This dissertation addresses three fundamental questions regarding the politics of prosecutorial behavior. Specifically, it examines how the selectors of prosecutors influence prosecutorial decision-making under different selection methods, including electionbased systems and appointment-based systems. By using a political responsiveness framework and utilizing empirical strategies, including an experiment and the construction of prosecutor policy position data, this study offers novel insights into the subject. First, I find that voters care about prosecutors’ issue positions and rely on various cues to identify candidates whose policy positions align with their preferences, even in low-information elections. Second, elections show promise as a mechanism for holding …

Tip Of The Iceberg In Changing School Culture: Acknowledging And Addressing Microaggressions, Nicole Lauren Becker

Theses and Dissertations

Providing a culturally responsive learning environment that allows students and faculty to feel safe and welcomed is essential. This action research study examined the harmful impact of microaggressions in the school and how providing targeted and comprehensive professional development sessions helped faculty members be able to acknowledge and address microaggressions. The research study was conducted in a large elementary school in the northeast United States that serves approximately 800 students. The researcher worked with the school administration team to identify microaggressions as a problem of practice. The focus group interviews, and six-week professional development series aided in the participants’ journey …

The Evolution Of Contextualized, Discourse-Based Professional Development To Support Elementary Teachers In The Implementation Of Conceptual Mathematical Teaching Practices, Jennifer Aren Kueter

Theses and Dissertations

This holistic, mixed-methods action research case study aimed to determine the influence of professional development on participants' mathematical teaching practices and how the changes influenced students’ opportunities for discourse. In this two-year study, participants engaged in two professional development phases and implemented new conceptual teaching practices. Quantitative data were collected through surveys and observations. Qualitative data were collected through observations and interviews. Phase-one findings showed that while teachers changed their practices, they were not proficient in conceptual and discourse-based teaching practices. A second phase of professional development occurred using a Community of Practice model. Phase-two findings showed conceptual teaching practices …

Approaches To Detecting And Modeling Over-And Underdispersion In Alternative Count Data Distributions And An Application Of Logistic Regression And Random Forest Modeling To Improve Screening Tools For Tic Disorders In Children, Rebecca C. Wardrop

Theses and Dissertations

This dissertation focuses on theory and application of discrete data methods, particularly approaches to over- and underdispersion relative to the Poisson distribution and an application of random forest and logistic regression modeling. The first chapter derives a score test for over- and underdispersion in the heaped generalized Poisson distribution. Equi-, over-, and underdispersed heaped generalized Poisson and heaped negative binomial data are simulated to evaluate the performance of the score test by comparing the power it achieves to that of Wald and likelihood ratio tests. We find that the score test we derive performs comparably to both the Wald and …

Computational Studies Of Bond Dissociation Energies And Organic Reaction Mechanisms, Shehani Thishakkya Wetthasinghe

Theses and Dissertations

This dissertation presents the progress of two independent projects. Chapter 2 and Chapter 3 focus on the first project, which involves material exploration utilizing machine learning techniques. We explore the potential use of cobaltocenium (CoCp⁺₂) derivatives as metal cations in anion exchange membranes (AEMs) for alkaline fuel cells, highlighting their superior thermal and alkaline stability compared to ammonium derivatives. The stability of CoCp⁺₂ can be fine-tuned by varying the substituent groups attached to the cyclopentadienyl ring (Cp) in CoCp⁺₂ .These derivatives encompass a variety of electron-donating and electron-withdrawing groups as substituents on both …

Liquid Cooling System For A High Power, Medium Frequency, And Medium Voltage Isolated Power Converter, Hooman Taghavi

Theses and Dissertations

Controlling and transforming electrical power from one form into another is the Primary function of the power electronics systems that are employed today. These systems have a wide variety of applications and are utilized in things like industrial automation, electric cars, consumer electronics, and renewable energy systems, among other things. The functioning of power electronics systems results in the production of a substantial quantity of heat, despite the fact that these systems are very dependable and efficient. This heat must be dispersed to preserve system performance and avoid component damage. By ensuring that the working temperature of the components stays …

Utilizing Case Studies To Increase Critical Thinking In An Undergraduate Anatomy & Physiology Classroom, Sarah E. Lehman

Theses and Dissertations

The purpose of this study was to determine the effectiveness of the implementation of case-based learning compared to traditional lecture in increasing critical thinking skills in an undergraduate Anatomy & Physiology I classroom. Throughout the course of one semester, five units were taught with the addition of a case study as an instructional tool while the other four units were taught utilizing only didactic (lecture) methods and did not teach content utilizing case study methodology. Two types of content-specific critical thinking data were analyzed: selected multiple-choice exam questions and End of Chapter (EOC) assignments. The Cornell Critical Thinking Test (CCTT) …