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Articles 531121 - 531150 of 5207181
Full-Text Articles in Entire DC Network
Customer Value Co-Creation: Environmental Sustainability As A Tourist Experience, Esi A. Elliot, Russell P. Adams, Ernest Kafui Kwasi Tsetse
Customer Value Co-Creation: Environmental Sustainability As A Tourist Experience, Esi A. Elliot, Russell P. Adams, Ernest Kafui Kwasi Tsetse
International Business and Entrepreneurship Faculty Publications
Increasingly, environmental sustainability has become an important consideration for customer value co-creation, which is collaboration between a firm-provider and its customers to jointly create value. Our research question is therefore “how does customer value co-creation (CVC) enhance environmental sustainability?” We argue that attention to CVC globally would significantly enhance environmental sustainability in emerging markets. The findings of the study revealed that firms that do not enhance customer engagement and their environmental sustainability will lose patronage. Secondly, the attitude of most of these tourists who continually visit unclean tourism destinations such as littered beaches and polluted water bodies would continue to …
Assessment And Documentation Of Social Determinants Of Health Among Health Care Providers: Qualitative Study, Brooks Yelton Ma, Lmsw, Jancham Rachel Rumthao, Mayank Sakhuja, Mark M. Macauda, Lorie Donelle Phd, Rn, Fcan, Michelle Angelique Arent, Xueying Yang, Xiaoming Li, Samuel Noblet, Daniela B. Friedman
Assessment And Documentation Of Social Determinants Of Health Among Health Care Providers: Qualitative Study, Brooks Yelton Ma, Lmsw, Jancham Rachel Rumthao, Mayank Sakhuja, Mark M. Macauda, Lorie Donelle Phd, Rn, Fcan, Michelle Angelique Arent, Xueying Yang, Xiaoming Li, Samuel Noblet, Daniela B. Friedman
Publications
BACKGROUND: Research clearly demonstrates social determinants of health (SDOH) impact health outcomes. Provider consideration of patient SDOH in prevention and treatment planning is critical for improved health care quality and health equity. Despite awareness of the connections between SDOH and improved population health, research demonstrates few providers document patient SDOH. OBJECTIVE: This qualitative study aimed to better understand the barriers and facilitators of SDOH assessment, documentation, and referral in different health care settings and roles. METHODS: Individual semistructured interviews were conducted with practicing health care providers in South Carolina between August 25, 2022, and September 2, 2022. Participants were recruited …
Case Study: The Impact Of Emerging Technologies On Cybersecurity Education And Workforces, Austin Cusak
Case Study: The Impact Of Emerging Technologies On Cybersecurity Education And Workforces, Austin Cusak
Journal of Cybersecurity Education, Research and Practice
A qualitative case study focused on understanding what steps are needed to prepare the cybersecurity workforces of 2026-2028 to work with and against emerging technologies such as Artificial Intelligence and Machine Learning. Conducted through a workshop held in two parts at a cybersecurity education conference, findings came both from a semi-structured interview with a panel of experts as well as small workgroups of professionals answering seven scenario-based questions. Data was thematically analyzed, with major findings emerging about the need to refocus cybersecurity STEM at the middle school level with problem-based learning, the disconnects between workforce operations and cybersecurity operators, the …
Conditional Metastasis Of Uveal Melanoma In 8091 Patients Over Half-Century (51 Years) By Age Group: Assessing The Entire Population And The Extremes Of Age, Carol L. Shields, Annika Samuelson, Glenn Oh, Joseph D. Desimone, Zaynab Sajjadi, Zeynep Bas, Nicholas E Kalafatis, Sara E. Lally, Jerry A. Shields, Philip W. Dockery
Conditional Metastasis Of Uveal Melanoma In 8091 Patients Over Half-Century (51 Years) By Age Group: Assessing The Entire Population And The Extremes Of Age, Carol L. Shields, Annika Samuelson, Glenn Oh, Joseph D. Desimone, Zaynab Sajjadi, Zeynep Bas, Nicholas E Kalafatis, Sara E. Lally, Jerry A. Shields, Philip W. Dockery
Wills Eye Hospital Papers
PURPOSE: To evaluate cumulative incidence of metastasis at specific timepoints after treatment of uveal melanoma in a large cohort of patients and to provide comparison of conditional outcomes in the youngest and oldest cohorts (extremes of age).
METHODS: Retrospective analysis of 8091 consecutive patients with uveal melanoma at a single center over a 51-year period. The patients were categorized by age at presentation (0-29 years [n = 348, 4%], 30-59 years [n = 3859, 48%], 60-79 years [n = 3425, 42%], 80 to 99 years [n = 459, 6%]) and evaluated for nonconditional (from presentation date) and conditional (from specific …
Presence And Identity Of Babesia Microti In Ireland, A. Zintl, A. Mcmanus, M. Galan, M. Diquattro, L. Giuffredi, N. Charbonnel, J. Gray, C. Holland, Peter Stuart
Presence And Identity Of Babesia Microti In Ireland, A. Zintl, A. Mcmanus, M. Galan, M. Diquattro, L. Giuffredi, N. Charbonnel, J. Gray, C. Holland, Peter Stuart
Publications
Babesia microti is a tick-transmitted protozoan parasite of wildlife that can also cause serious disease in humans. It is now well established that B. microti represents an assemblage of different strains or species, only some of which are important zoonotic pathogens. Therefore, in order to assess the potential public health risk associated with B. microti in any given location, it is important to determine the strains that are present. This is the first study on the presence and identity of B. microti in Ireland. Overall, 314 wood mice (Apodemus sylvaticus), 243 bank voles (Myodes glareolus) and 634 questing Ixodes ricinus …
Cyberbullying: Senior Prospective Teachers’ Coping Knowledge And Strategies, Kürşat Arslan, İnan Aydın
Cyberbullying: Senior Prospective Teachers’ Coping Knowledge And Strategies, Kürşat Arslan, İnan Aydın
Journal of Cybersecurity Education, Research and Practice
This study aimed to determine senior prospective teachers’ coping knowledge and strategies for cyberbullying in terms of demographic variables. The sample consisted of 471 prospective teachers (324 female and 147 male) studying in the 4th grade in Dokuz Eylül University Buca Education Faculty in Izmir in the 2019-2020 academic year. It was a quantitative study using a causal-comparative research design to find out whether prospective teachers’ coping knowledge differed by independent variables. The "Coping with Cyberbullying Scale" developed by Koç et al. (2016) was employed to discover prospective teachers’ coping strategies for cyberbullying. A "Personal Information" form was also prepared …
Nasa Administrator, Sen. Shaheen Visit Unh's Space Science Center, Keith Testa
Nasa Administrator, Sen. Shaheen Visit Unh's Space Science Center, Keith Testa
UNH Today Archive
No abstract provided.
Analyzing Dei Efforts And Curricula In Collegiate Nursing Programs, Samuel Lewis, Ava Biafore, Victoria Hanlon
Analyzing Dei Efforts And Curricula In Collegiate Nursing Programs, Samuel Lewis, Ava Biafore, Victoria Hanlon
Sociology Between the Gaps: Forgotten and Neglected Topics
No abstract provided.
No. 102 An Order Reconstituting The Governor's Council For Armed Forces, Veterans, And Their Families As Tri-Stars And Stripes: The Governor's Council For Service Members, Veterans, And Their Families, Bill Lee
Executive Orders
No abstract provided.
Case Report: Tuberculosis Recall On Bone Graft Patient, Tiffany Ruan, Mustafa Naveed, Hon Vien
Case Report: Tuberculosis Recall On Bone Graft Patient, Tiffany Ruan, Mustafa Naveed, Hon Vien
Student Publications
Background: Bone grafting is commonly used in spine surgery to supplement or replace the need for autografts. This is harvested, prepared, and utilized predominantly for osteoconductive properties. Anterior cervical discectomy and fusion, a procedure to decompress and fuse the spine which treats herniated discs and compressed nerves, commonly uses Polyetheretherketone (PEEK) interbody filled with allograft bone matrices to reconstruct the disc space after a discectomy is performed.
Case description: The presented case is one of a 57-year-old male patient who underwent an uneventful cervical 5-6 and cervical 6-7 discectomy and fusion using a PEEK interbody and bone allograft. The allograft …
Physician-Investigator, Research Coordinator, And Patient Perspectives On Dual-Role Consent In Oncology: A Qualitative Study, Stephanie R Morain, Dorit Barlevy, Steven Joffe, Emily A Largent
Physician-Investigator, Research Coordinator, And Patient Perspectives On Dual-Role Consent In Oncology: A Qualitative Study, Stephanie R Morain, Dorit Barlevy, Steven Joffe, Emily A Largent
Center for Medical Ethics and Health Policy Staff Publications
Importance: Classic statements of research ethics generally advise against dual-role consent in which physician-investigators seek consent for research participation from patients with whom they have preexisting treatment relationships. Yet dual-role consent is common in clinical oncology research, as studies are often conducted in close relationship with clinical care.
Objective: To explore key stakeholders' perspectives on dual-role consent in clinical oncology trials.
Design, setting, and participants: This qualitative study with 43 participants was conducted at a National Cancer Institute-designated comprehensive cancer center from 2018 to 2022. Semistructured qualitative interviews of physician-investigators, research coordinators, and patients were performed. Respondents were recruited from …
Trends And Seasonality Of Emergency Department Visits And Hospitalizations For Suicidality Among Children And Adolescents In The Us From 2016 To 2021
Faculty, Staff and Student Publications
IMPORTANCE: The detection of seasonal patterns in suicidality should be of interest to clinicians and US public health officials, as intervention efforts can benefit by targeting periods of heightened risk.
OBJECTIVES: to examine recent trends in suicidality rates, quantify the seasonality in suicidality, and demonstrate the disrupted seasonality patterns during the spring 2020 COVID-19-related school closures among US children and adolescents.
DESIGN, SETTING, AND PARTICIPANTS: This population-based, descriptive cross-sectional study used administrative claims data from Optum's deidentifed Clinformatics Data Mart Database. Participants included children aged 10 to 12 years and adolescents aged 13 to 18 years who were commercially insured …
Can Video Comparison Facilitate Children's Stem Learning?, Alexis Rene Colwell
Can Video Comparison Facilitate Children's Stem Learning?, Alexis Rene Colwell
Theses and Dissertations
The goal of the current study was to examine the effectiveness of a video comparison activity in teaching 6- and 7-year-old children that a diagonal brace provides stability in structures, which is an important engineering principle. Children were randomly assigned to one of three groups: Comparison, Single Model, or No Training. The children in the Comparison group saw two metal towers in a training video where the researcher pushed on the towers to demonstrate that one was stable (diagonal brace tower), and one was unstable (horizontal crosspiece tower). Children in the Single Model group saw a video of the one …
Compete To Learn: Toward Cybersecurity As A Sport, Tj Oconnor, Dane Brown, Jasmine Jackson, Bryson Payne, Suzanna Schmeelk
Compete To Learn: Toward Cybersecurity As A Sport, Tj Oconnor, Dane Brown, Jasmine Jackson, Bryson Payne, Suzanna Schmeelk
Journal of Cybersecurity Education, Research and Practice
To support the workforce gap of skilled cybersecurity professionals, gamified pedagogical approaches for teaching cybersecurity have exponentially grown over the last two decades. During this same period, e-sports developed into a multi-billion dollar industry and became a staple on college campuses. In this work, we explore the opportunity to integrate e-sports and gamified cybersecurity approaches into the inaugural US Cyber Games Team. During this tenure, we learned many lessons about recruiting, assessing, and training cybersecurity teams. We share our approach, materials, and lessons learned to serve as a model for fielding amateur cybersecurity teams for future competition.
T-Bet And Eomes Sustain Mature Human Nk Cell Identity And Antitumor Function, Pamela Wong, Jennifer A. Foltz, Lily Chang, Carly C. Neal, Tony Yao, Celia C. Cubitt, Jennifer Tran, Samantha Kersting-Schadek, Sathvik Palakurty, Natalia Jaeger, David A. Russler-Germain, Nancy D. Marin, Margery Gang, Julia A. Wagner, Alice Y. Zhou, Miriam T. Jacobs, Mark Foster, Timothy Schappe, Lynne Marsala, Ethan Mcclain, Patrick Pence, Michelle Becker-Hapak, Bryan Fisk, Allegra A. Petti, Obi L. Griffith, Malachi Griffith, Melissa M. Berrien-Elliott, Todd A. Fehniger
T-Bet And Eomes Sustain Mature Human Nk Cell Identity And Antitumor Function, Pamela Wong, Jennifer A. Foltz, Lily Chang, Carly C. Neal, Tony Yao, Celia C. Cubitt, Jennifer Tran, Samantha Kersting-Schadek, Sathvik Palakurty, Natalia Jaeger, David A. Russler-Germain, Nancy D. Marin, Margery Gang, Julia A. Wagner, Alice Y. Zhou, Miriam T. Jacobs, Mark Foster, Timothy Schappe, Lynne Marsala, Ethan Mcclain, Patrick Pence, Michelle Becker-Hapak, Bryan Fisk, Allegra A. Petti, Obi L. Griffith, Malachi Griffith, Melissa M. Berrien-Elliott, Todd A. Fehniger
2020-Current year OA Pubs
Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear. To address this, T-BET and EOMES were deleted in unexpanded primary human NK cells using CRISPR/Cas9. Deleting these TFs compromised in vivo antitumor response of human NK cells. Mechanistically, T-BET and EOMES were required for normal NK cell proliferation and persistence in vivo. NK cells lacking T-BET and EOMES also exhibited defective responses to cytokine stimulation. Single-cell RNA-Seq revealed a specific T-box transcriptional program in human NK cells, which …
Baseline Features And Reasons For Nonparticipation In The Colonoscopy Versus Fecal Immunochemical Test In Reducing Mortality From Colorectal Cancer (Confirm) Study, A Colorectal Cancer Screening Trial, Douglas J Robertson, Jill Elwing, Et Al.
Baseline Features And Reasons For Nonparticipation In The Colonoscopy Versus Fecal Immunochemical Test In Reducing Mortality From Colorectal Cancer (Confirm) Study, A Colorectal Cancer Screening Trial, Douglas J Robertson, Jill Elwing, Et Al.
2020-Current year OA Pubs
IMPORTANCE: The Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) randomized clinical trial sought to recruit 50 000 adults into a study comparing colorectal cancer (CRC) mortality outcomes after randomization to either an annual fecal immunochemical test (FIT) or colonoscopy.
OBJECTIVE: To (1) describe study participant characteristics and (2) examine who declined participation because of a preference for colonoscopy or stool testing (ie, fecal occult blood test [FOBT]/FIT) and assess that preference's association with geographic and temporal factors.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study within CONFIRM, which completed enrollment through 46 Department of Veterans Affairs …
Genetic Characterization Of Primary And Metastatic High-Grade Serous Ovarian Cancer Tumors Reveals Distinct Features Associated With Survival, Emilee N Kotnik, Mary M Mullen, Nicholas C Spies, Tiandao Li, Matthew Inkman, Jin Zhang, Fernanda Martins-Rodrigues, Ian S Hagemann, Carolyn K Mccourt, Premal H Thaker, Andrea R Hagemann, Matthew A Powell, David G Mutch, Dineo Khabele, Gregory D Longmore, Christopher A Maher, Christopher A Miller, Katherine C Fuh, Et Al.
Genetic Characterization Of Primary And Metastatic High-Grade Serous Ovarian Cancer Tumors Reveals Distinct Features Associated With Survival, Emilee N Kotnik, Mary M Mullen, Nicholas C Spies, Tiandao Li, Matthew Inkman, Jin Zhang, Fernanda Martins-Rodrigues, Ian S Hagemann, Carolyn K Mccourt, Premal H Thaker, Andrea R Hagemann, Matthew A Powell, David G Mutch, Dineo Khabele, Gregory D Longmore, Christopher A Maher, Christopher A Miller, Katherine C Fuh, Et Al.
2020-Current year OA Pubs
High-grade serous ovarian cancer (HGSC) is the most lethal histotype of ovarian cancer and the majority of cases present with metastasis and late-stage disease. Over the last few decades, the overall survival for patients has not significantly improved, and there are limited targeted treatment options. We aimed to better characterize the distinctions between primary and metastatic tumors based on short- or long-term survival. We characterized 39 matched primary and metastatic tumors by whole exome and RNA sequencing. Of these, 23 were short-term (ST) survivors (overall survival (OS) < 3.5 years) and 16 were long-term (LT) survivors (OS > 5 years). We compared somatic mutations, copy number alterations, mutational burden, differential gene …
A Rapid Cell-Free Expression And Screening Platform For Antibody Discovery, Andrew C Hunt, Bastian Vögeli, Ahmed O Hassan, Laura Guerrero, Weston Kightlinger, Danielle J Yoesep, Antje Krüger, Madison Dewinter, Michael S Diamond, Ashty S Karim, Michael C Jewett
A Rapid Cell-Free Expression And Screening Platform For Antibody Discovery, Andrew C Hunt, Bastian Vögeli, Ahmed O Hassan, Laura Guerrero, Weston Kightlinger, Danielle J Yoesep, Antje Krüger, Madison Dewinter, Michael S Diamond, Ashty S Karim, Michael C Jewett
2020-Current year OA Pubs
Antibody discovery is bottlenecked by the individual expression and evaluation of antigen-specific hits. Here, we address this bottleneck by developing a workflow combining cell-free DNA template generation, cell-free protein synthesis, and binding measurements of antibody fragments in a process that takes hours rather than weeks. We apply this workflow to evaluate 135 previously published antibodies targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including all 8 antibodies previously granted emergency use authorization for coronavirus disease 2019 (COVID-19), and demonstrate identification of the most potent antibodies. We also evaluate 119 anti-SARS-CoV-2 antibodies from a mouse immunized with the SARS-CoV-2 spike …
The Kalamazoo Promise: 2022 By The Numbers, Kathleen Bolter, Brad J. Hershbein, Alfonso Hernandez, Bridget Timmeney
The Kalamazoo Promise: 2022 By The Numbers, Kathleen Bolter, Brad J. Hershbein, Alfonso Hernandez, Bridget Timmeney
Reports
No abstract provided.
Genetic Resources And Precise Gene Editing For Targeted Improvement Of Barley Abiotic Stress Tolerance, Sakura Karunarathne, Esther Walker, Darshan Sharma, Chengdao Li, Yong Han
Genetic Resources And Precise Gene Editing For Targeted Improvement Of Barley Abiotic Stress Tolerance, Sakura Karunarathne, Esther Walker, Darshan Sharma, Chengdao Li, Yong Han
Grain and Other Field Crops Research Articles
Abiotic stresses, predominately drought, heat, salinity, cold, and waterlogging, adversely affect cereal crops. They limit barley production worldwide and cause huge economic losses. In barley, functional genes under various stresses have been identified over the years and genetic improvement to stress tolerance has taken a new turn with the introduction of modern gene-editing platforms. In particular, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) is a robust and versatile tool for precise mutation creation and trait improvement. In this review, we highlight the stress-affected regions and the corresponding economic losses among the main barley producers. We collate about …
Privacy Preserving Signals, Philipp Strack, Kai Hao Yang
Privacy Preserving Signals, Philipp Strack, Kai Hao Yang
Cowles Foundation Discussion Papers
A signal is privacy-preserving with respect to a collection of privacy sets, if the posterior probability assigned to every privacy set remains unchanged conditional on any signal realization. We characterize the privacy-preserving signals for arbitrary state space and arbitrary privacy sets. A signal is privacy-preserving if and only if it is a garbling of a reordered quantile signal. These signals are equivalent to couplings, which in turn lead to a characterization of optimal privacy-preserving signals for a decisionmaker. We demonstrate the applications of this characterization in the contexts of algorithmic fairness, price discrimination, and information design.
Editorial - 2023 - 1, Hossain Shahriar, Herbert J. Mattord, Michael E. Whitman
Editorial - 2023 - 1, Hossain Shahriar, Herbert J. Mattord, Michael E. Whitman
Journal of Cybersecurity Education, Research and Practice
No abstract provided.
Examination Of Cybersecurity Technologies, Practices, Challenges, And Wish List In K-12 School Districts, Florence Martin, Julie Bacak, Erik Jon Byker, Weichao Wang, Jonathan Wagner, Lynn Ahlgrim-Delzell
Examination Of Cybersecurity Technologies, Practices, Challenges, And Wish List In K-12 School Districts, Florence Martin, Julie Bacak, Erik Jon Byker, Weichao Wang, Jonathan Wagner, Lynn Ahlgrim-Delzell
Journal of Cybersecurity Education, Research and Practice
With the growth in digital teaching and learning, there has been a sharp rise in the number of cybersecurity attacks on K-12 school networks. This has demonstrated a need for security technologies and cybersecurity education. This study examined security technologies used, effective security practices, challenges, concerns, and wish list of technology leaders in K-12 settings. Data collected from 23 district websites and from interviews with 12 district technology leaders were analyzed. Top security practices included cloud-based technologies, segregated network/V-LAN, two-factor authentication, limiting access, and use of Clever or Class Link. Top challenges included keeping users informed, lack of buy-in from …
A Systematic Mapping Study On Gamification Applications For Undergraduate Cybersecurity Education, Sherri Weitl-Harms, Adam Spanier, John Hastings, Matthew Rokusek
A Systematic Mapping Study On Gamification Applications For Undergraduate Cybersecurity Education, Sherri Weitl-Harms, Adam Spanier, John Hastings, Matthew Rokusek
Journal of Cybersecurity Education, Research and Practice
Gamification in education presents a number of benefits that can theoretically facilitate higher engagement and motivation among students when learning complex, technical concepts. As an innovative, high-potential educational tool, many educators and researchers are attempting to implement more effective gamification into undergraduate coursework. Cyber Security Operations (CSO) education is no exception. CSO education traditionally requires comprehension of complex concepts requiring a high level of technical and abstract thinking. By properly applying gamification to complex CSO concepts, engagement in students should see an increase. While an increase is expected, no comprehensive study of CSO gamification applications (GA) has yet been undertaken …
Electrically-Evoked Referred Sensations Induce Embodiment Of Rubber Limb, Anthony Nguyen, Brooke Draggoo, Brooklyn Tobias, Payton Dubose, Katharine Polasek
Electrically-Evoked Referred Sensations Induce Embodiment Of Rubber Limb, Anthony Nguyen, Brooke Draggoo, Brooklyn Tobias, Payton Dubose, Katharine Polasek
Faculty Publications
Introduction: Electrical stimulation is increasingly relevant in a variety of medical treatments. In this study, the quality of referred sensations evoked using surface electrical stimulation was evaluated using the rubber hand and foot illusions.
Methods: The rubber hand and foot illusions were attempted under 4 conditions: (1) multi-location tapping; (2) one-location tapping; (3) electrical stimulation of sensation referred to the hand or foot; (4) asynchronous control. The strength of each illusion was quantified using a questionnaire and proprioceptive drift, where a stronger response suggested embodiment of the rubber limb.
Results: 45 able-bodied individuals and two individuals with amputations participated in …
Uab Sports Medicine Provides Student-Athlete Physicals For Birmingham City Schools, Staff
Uab Sports Medicine Provides Student-Athlete Physicals For Birmingham City Schools, Staff
Browse All News
No abstract provided.
20230703_Independence Day Hours, Brandon Carroll
20230703_Independence Day Hours, Brandon Carroll
HSLIC Blog Post
No abstract provided.
20230703_Celebrate National Stay Out Of The Sun Day, Gale G. Hannigan Phd
20230703_Celebrate National Stay Out Of The Sun Day, Gale G. Hannigan Phd
HSLIC Blog Post
No abstract provided.
Prognostic And Predictive Value Of Endothelial Dysfunction Biomarkers In Sepsis-Associated Acute Kidney Injury: Risk-Stratified Analysis From A Prospective Observational Cohort Of Pediatric Septic Shock., Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Stuart L. Goldstein, Natalja L. Stanski
Prognostic And Predictive Value Of Endothelial Dysfunction Biomarkers In Sepsis-Associated Acute Kidney Injury: Risk-Stratified Analysis From A Prospective Observational Cohort Of Pediatric Septic Shock., Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Stuart L. Goldstein, Natalja L. Stanski
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement therapy (CRRT). Systemic inflammation and endothelial dysfunction are key drivers of SA-AKI. We sought to measure differences between endothelial dysfunction markers among children with and without SA-AKI, test whether this association varied across inflammatory biomarker-based risk strata, and develop prediction models to identify those at highest risk of SA-AKI.
METHODS: Secondary analyses of prospective observational cohort of pediatric septic shock. Primary outcome of interest was the presence of ≥ Stage II KDIGO SA-AKI on day 3 based on serum creatinine …