Digital Commons Network^™

Feasibility And Safety Of Personalized, Multi-Target, Adoptive Cell Therapy (Ima101): First-In-Human Clinical Trial In Patients With Advanced Metastatic Cancer, Apostolia M Tsimberidou, Kerstin Guenther, Borje S Andersson, Regina Mendrzyk, Amir Alpert, Anna Nowak, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I Wistuba, David Fuhrmann, Nuhad K Ibrahim, Van Karlyle Morris, Bryan K Kee, Daniel M Halperin, Graciela M Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter

Faculty, Staff and Student Publications

IMA101 is an actively personalized, multi-targeted adoptive cell therapy (ACT), whereby autologous T cells are directed against multiple novel defined peptide-HLA (pHLA) cancer targets. HLA-A*02:01-positive patients with relapsed/refractory solid tumors expressing ≥1 of 8 predefined targets underwent leukapheresis. Endogenous T cells specific for up to 4 targets were primed and expanded in vitro. Patients received lymphodepletion (fludarabine, cyclophosphamide), followed by T-cell infusion and low-dose IL2 (Cohort 1). Patients in Cohort 2 received atezolizumab for up to 1 year (NCT02876510). Overall, 214 patients were screened, 15 received lymphodepletion (13 women, 2 men; median age, 44 years), and 14 were treated with …

Catalytic Enantioselective Synthesis Of 3-Piperidines From Arylboronic Acids And Pyridine

Faculty, Staff and Student Publications

Piperidines are frequently found in natural products and are of importance to the pharmaceutical industry. A generally useful asymmetric route to enantiomerically enriched 3-substituted piperidines remains elusive. Here we report a cross-coupling approach to enantioenriched 3-piperidines from pyridine- and sp²-hybridized boronic acids. The key step involves a Rh-catalyzed asymmetric reductive Heck reaction of aryl, heteroaryl, or vinyl boronic acids and phenyl pyridine-1(2H)-carboxylate to provide 3-substituted tetrahydropyridines in high yield and excellent enantioselectivity with a wide functional group tolerance. A three-step process involving i) partial reduction of pyridine, ii) Rh-catalyzed asymmetric carbometalation, and then iii) another reduction …

Accuracy Of Baseline Prevalence Estimates For Sample-Size Calculations In Randomized Controlled Trials, Andrew Aultman, Kelly C Ditter, Hector Mendez-Figueroa, Megha Gupta, Michal Fishel Bartal, Suneet P Chauhan, Stephen Wagner

Faculty, Staff and Student Publications

No abstract provided.

Hhv-6 Myocarditis Progressing To Ventricular Standstill Requiring Cardiac Transplant, Navneet Narula

Faculty, Staff and Student Publications

Human herpesvirus-6 (HHV-6) is an increasingly recognized cause of myocarditis. We present the case of a 46-year-old woman who presented with fulminant HHV-6 myocarditis requiring heart transplantation. (Level of Difficulty: Advanced.)

Tissue Mass Spectrometry: How Solid Is Our Future?, Daisy Unsihuay, William S Phipps, Amanda G Paulovich, Jessica R Chapman, Axel Ducret, Livia S Eberlin, Jeffrey M Spraggins, Richard J A Goodwin

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

Constraining The Contribution Of The Antarctic Ice Sheet To Last Interglacial Sea-Level, Robert L. Barnett, Jacqueline Austermann, Blake Dyer, Matt W. Telfer, Natasha L.M. Barlow, Sarah J. Boulton, Andrew S. Carr, Roger C. Creel

School of Geography, Earth and Environmental Sciences

Polar temperatures during the Last Interglacial [LIG; ~129 to 116 thousand years (ka)] were warmer than today, making this time period an important testing ground to better understand how ice sheets respond to warming. However, it remains debated how much and when the Antarctic and Greenland ice sheets changed during this period. Here, we present a combination of new and existing absolutely dated LIG sea-level observations from Britain, France, and Denmark. Because of glacial isostatic adjustment (GIA), the LIG Greenland ice melt contribution to sea-level change in this region is small, which allows us to constrain Antarctic ice change. We …

Circadian Disruption And Colorectal Cancer Incidence In Black Women, Hemant K Roy, Julie R Palmer, Kimberly A Bertrand

Faculty, Staff and Students Publications

BACKGROUND: Animal and experimental studies suggest circadian disruption increases colorectal cancer risk, but evidence in humans is limited. We examined night shift work, chronotype, and residential position within a time zone, proxies for circadian disruption, in relation to colorectal cancer risk.

METHODS: Participants in the Black Women's Health Study, a prospective cohort of 59,000 Black American women established in 1995, reported history of night shift work and chronotype on follow-up questionnaires. Residential position within a time zone was estimated using participant addresses at each questionnaire cycle. Number of colorectal cancer cases and follow-up duration varied by analysis depending on timing …

Tiam1 Coordinates Synaptic Structural And Functional Plasticity Underpinning The Pathophysiology Of Neuropathic Pain, Xing Fang, Guanxing Chen, Ali Bin Saifullah, Changqun Yao, Kimberley F Tolias

Faculty, Staff and Students Publications

Neuropathic pain is a common, debilitating chronic pain condition caused by damage or a disease affecting the somatosensory nervous system. Understanding the pathophysiological mechanisms underlying neuropathic pain is critical for developing new therapeutic strategies to treat chronic pain effectively. Tiam1 is a Rac1 guanine nucleotide exchange factor (GEF) that promotes dendritic and synaptic growth during hippocampal development by inducing actin cytoskeletal remodeling. Here, using multiple neuropathic pain animal models, we show that Tiam1 coordinates synaptic structural and functional plasticity in the spinal dorsal horn via actin cytoskeleton reorganization and synaptic NMDAR stabilization and that these actions are essential for the …

You Ca N’T Police Your Way Out Of These Problems: Disregarding The Structural Components Of Community Problems, Kian Spencer Gaines

Theses and Dissertations

Community-Oriented Policing Services (COPS) emerged in response to longstanding criticisms revolving around police accountability and effectiveness. It emphasizes civilian participation in crime-prevention and problem-solving efforts to build trust between the police and minoritized communities with whom they have had an antagonistic relationship. Traditional policing is reactive in nature, with officers acting only after crime has been committed or a call for service has been made; it enforces the law; “legitimizes” use of violence; and emulates military structure and tactics. In this study I describe it as “enforcement” or “crime-fighting policing.” COPS programs are embedded within this structure. Unlike traditional policing, …

A Comprehensive Analysis Of Lung Cancer Highlighting Epidemiological Factors And Psychiatric Comorbidities From The All Of Us Research Program, Younghun Han, David A Hsiou, Luke A Nordstrom, Christopher I Amos

Faculty, Staff and Students Publications

Lung cancer is the leading cause of cancer-related mortality in the United States. Investigating epidemiological and clinical parameters can contribute to an improved understanding of disease development and management. In this cross-sectional, case-control study, we used the All of Us database to compare healthcare access, family history, smoking-related behaviors, and psychiatric comorbidities in light smoking controls, matched smoking controls, and primary and secondary lung cancer patients. We found a decreased odds of primary lung cancer patients versus matched smoking controls reporting inability to afford follow-up or specialist care. Additionally, we found a significantly increased odds of secondary lung cancer patients …

Endothelial Foxc1 And Foxc2 Promote Intestinal Regeneration After Ischemia-Reperfusion Injury., Can Tan, Pieter R. Norden, Wei Yu, Ting Liu, Naoto Ujiie, Sun Kyong Lee, Xiaocai Yan, Yaryna Dyakiv, Kazushi Aoto, Sagrario Ortega, Isabelle G. De Plaen, Venkatesh Sampath, Tsutomu Kume

Manuscripts, Articles, Book Chapters and Other Papers

Intestinal ischemia underlies several clinical conditions and can result in the loss of the intestinal mucosal barrier. Ischemia-induced damage to the intestinal epithelium is repaired by stimulation of intestinal stem cells (ISCs), and paracrine signaling from the vascular niche regulates intestinal regeneration. Here, we identify FOXC1 and FOXC2 as essential regulators of paracrine signaling in intestinal regeneration after ischemia-reperfusion (I/R) injury. Vascular endothelial cell (EC)- and lymphatic EC (LEC)-specific deletions of Foxc1, Foxc2, or both in mice worsen I/R-induced intestinal damage by causing defects in vascular regrowth, expression of chemokine CXCL12 and Wnt activator R-spondin 3 (RSPO3) in blood ECs …

An Undesired Implication From Globalization: Isis, An Adaptive Threat In A Dormant Phase, Abel Josafat Manullang, Raden Ap Wicaksono, Arfin Sudirman

Global: Jurnal Politik Internasional

Globalization has brought about numerous changes to the world. However, those changes and advances have also been enjoyed by terrorist groups, one of them is ISIS which uses those things in its terror acts. This article seeks to explain how ISIS has adapted and enhanced its capacity as a result of globalization. Apart from employing the qualitative research method, this article also uses concepts and theories like terrorism, globalization, and James D. Kiras's theory on how globalization enhances terrorism. This article would then proceed to the three matters of ISIS as a threat to national and international security, how ISIS …

Asean’S Role In The Regional Comprehensive Economic Partnership (Rcep) Formation To Enhance Regional Economic Integration, Shofiya Adila, Dadan Suryadipura S.Ip., M.Ipol.

Global: Jurnal Politik Internasional

The RCEP agreement is currently the largest free trade agreement involving ten ASEAN member countries and their trading partners, comprising around 30% of the world’s GDP. As an international organisation in the Southeast Asian region, ASEAN has the desire to increase its regional economic integration, one of which is through the RCEP agreement. This article aims to discuss how ASEAN attempts to enhance regional economic integration through its roles during the RCEP agreement's formation process. The author uses role theory by Lisbeth Aggestam (2006), which elaborates on four role concepts: role expectations, role conception, role performance, and role-set. This research …

Turning Ubud Into Unwto's Prototype For A World Gastronomic Destination Through Gastrodiplomacy, Alessandro Kurniawan Ulung

Global: Jurnal Politik Internasional

In 2019, the Indonesian Government proposed Ubud in Bali to become the United Nations World Tourism Organization (UNWTO) 's prototype for a world gastronomic destination. It turned out that, despite its rich inventory of gastronomic assets and attractions, Ubud met with challenges when convincing UNWTO to give it the title. To deal with this problem, the Indonesian Government practised gastrodiplomacy to influence UNWTO to endorse Ubud as the world gastronomic destination. This research, therefore, aims to explain the implementation of Indonesia's gastrodiplomacy. By using a qualitative method with interpretative analysis in place, I argued that the Government used gastrodiplomacy to …

Urban Memory Becomes An Idea In The Concept Of Spatial Planning (Study Case: Restoration Area Of Tambora District, West Jakarta), Riska Phillia, Antony Sihombing

Smart City

Urban heritage is a small part of the past of the city that holds the roots of the city's identity and culture, which are the city's identity. The strong identity of the historic area must be maintained, but this has a dilemma because of the need for change today. Therefore efforts are needed to create adaptive urban heritage areas. City spaces have a deep relationship with the people who inhabit them, with the most memorable or most memorable experiences and memories for them. This research contributes to exploring urban memory to develop conceptual spatial plans in restoration areas, using qualitative …

Study Of The Impact Of The Incompatibility Of Space Utilization In The Krukut River, Kevin Daniel Mangasi, Dwinanti Rika Marthanty

Smart City

The emergence of development on riverbanks has raised environmental problems in Indonesia, such as flooding, one of which is in the Krukut River Basin which crosses the province of DKI Jakarta. The land use change around the Krukut River causes narrowing and disrupts the absorption of rainwater and triggers sedimentation. This study aims to identify risks in the Krukut riverbank area based on the variable area of land use mismatch, population density, frequency and depth of flooding, volume of waste production, availability of waste management for water bodies and waste banks. The method used in this research is to load …

Major Paths Changes In 2013-2022 To Walkability (Case Study: Dukuh Atas Tod), Daniel Harvey Tulis, Antony Sihombing

Smart City

Development area with the concept of Transit Oriented Development (TOD) occurs so rapidly in big cities, which aims to create an integrated transportation system and is supported by the surrounding area. TOD area must have good road access for vehicles and space for pedestrians. Dukuh Atas TOD is one of the transit-oriented areas planned to be the largest TOD area in Jakarta so that developments are felt every year, including visuals and the road traffic system and pedestrian space. This research is using qualitative method by answering specific and actual variables. Time series analysis to see changes every year combined …

A Study On The Influence And Importance Of Black Science Teachers, Demetrice Smith-Mutegi

Journal of Research Initiatives

Black teachers have been known to provide positive experiences and outcomes for students, especially Black students. Nevertheless, Black science teachers are marginally represented in public classrooms across the United States, and Black students are marginally under-represented in science, technology, engineering, and mathematics (STEM). Black science teachers provide an inherent value to the education of Black children, including their ability to make science meaningful and relevant, contribute to the community where they live and work, and relate to students' experiences more intimately. Further, All levels of education should prioritize Black science teacher recruitment, and educational researchers should provide more evidence of …

A Multivariate Investigation Of The Motivational, Academic, And Well-Being Characteristics Of First-Generation And Continuing-Generation College Students, Christopher L. Thomas, Staci Zolkoski

Journal of Research Initiatives

Prior research has noted differences in motivational, academic, and well-being factors between first-generation and continuing-education students. However, past investigations have primarily overlooked the interactive influence of protective and risk factors when comparing the characteristics of first-generation and continuing-education students. Thus, the current study adopted a multivariate approach to gain a more nuanced understanding of the influence of generational status on students' self-regulated learning capabilities, academic anxiety, sense of belonging, academic barriers, mental health concerns, and satisfaction with life. University students (N = 432, 67.46% Caucasian, 87.55% female, _Age = 28.10 ± 9.46) completed the Cognitive Test Anxiety Scale-2^{nd …}

An Overview On The Validation Of The Critical Race Theory Measurement, Erica Campbell

Journal of Research Initiatives

The Critical Race Theory Measurement (CRTM) was developed to evaluate the understanding of the six major principles of CRT and the significance of race relating to the preparation of practitioners providing services to people of color. The objective of this study was to evaluate the scale's psychometric properties. The CRTM self-assessment instrument measures the six Critical Race Theory principles. It consists of 19 items assessing endemic racism, the social construction of race, differential racialization, convergence/determinism, racial narratives, and intersectionality. The validation of the CRTM was based on its administration to 175 social work and counseling practitioners. This paper discusses the …

Higher Education Leaders’ Perceptions On The Angry Black Woman Syndrome, Latisha L. Marion, Linda Wilson-Jones

Journal of Research Initiatives

Capturing the voices of Black women on their experiences leading to senior-level leadership positions in higher education warranted research. University leaders must ensure that units implement fair and equitable hiring practices to promote diversity and leadership from all backgrounds. Therefore, this study intended to take an in-depth look into Black women's trajectory in higher education. For this study, the researcher proposed interviewing Black women who have acquired senior-level leadership positions in higher education. The senior-level leadership positions included deans of student affairs, vice presidents of enrollment management, vice presidents of student affairs, college or university presidents, and other senior leadership …

Supporting Students In Learning English Outside The Classroom, Mubariz Zirman

Journal of Research Initiatives

Both inside and outside the classroom are essential in learning a language. However, the importance of these two environments may change from here to there. For instance, in Afghanistan, English is a foreign language, and it is mainly learned inside the classroom. Therefore, the classroom is considered an essential place for learning. This paper aims to identify ways of supporting students in learning a language outside the classroom. Specifically, it will discuss ways of learning English outside the classroom, such as the flipped classroom approach, involving students in out-of-classroom learning, online learning, project-based learning, interacting with native speakers, surfing social …

Future Trends And Directions For Secure Infrastructure Architecture In The Education Sector: A Systematic Review Of Recent Evidence, Isaac Atta Senior Ampofo, Isaac Atta Junior Ampofo

Journal of Research Initiatives

The most efficient approach to giving large numbers of students’ access to computational resources is through a data center. A contemporary method for building the data center's computer infrastructure is the software-defined model, which enables user tasks to be processed in a reasonable amount of time and at a reasonable cost. The researcher examines potential directions and trends for a secured infrastructure design in this article. Additionally, interoperable, highly reusable modules that can include the newest trends in the education industry are made possible by cloud-based educational software. The Reference Architecture for University Education System Using AWS Services is presented …

Practical Strategies For School Leaders To Improve African American Males’ Reading Achievement, Faye C. Bradley

Journal of Research Initiatives

The study identified parental involvement activities that significantly influenced the reading achievement of the African American male learner. Teachers and administrators were surveyed using an instrument adapted from Epstein's School, Family, and Community Partnership Survey, The Virginia Standards of Learning reading and language arts assessments provided data for reading achievement of fourth-grade African American males. Significant differences were found between principals and teachers in their ratings of Teacher Reports of Total School Program to Involve Families. A correlation was found between teacher estimates of parents' involvement and the mean SOL English score for African American male fourth-grade students.

Gender In Cultural History: Gender And Education, Dimitra Kalodimou, Maria Kapalika

Journal of Research Initiatives

The position of women in the oldest societies has often occupied the scientific community, which is a great reason to study it. Today's societies put tremendous effort into highlighting the importance of women's contribution. In this text, we will deal with the position of women in the recording of history, with women’s presence within the historical sources as well as the roles held in family business and education. In addition, the gradual changes regarding women's recovery in society will be presented and highlighted. The first steps to improve women's image started in Europe and continued worldwide. The critically studied articles …

Exploring The Challenges Of Breaking The Glass-Ceiling: A Historical Perspective, Tonya P. Cooper, Linda Wilson-Jones

Journal of Research Initiatives

The purpose of this qualitative study was to explore the voices, experiences, and factors promoting the leadership career paths of senior-level women of color in higher education and to capture their voices how they were able to overcome the barriers and challenges to breaking the glass ceiling on leadership career paths to senior-level administration in higher education. A phenomenological research method was employed to capture the participants’ voices, experiences, and leadership career paths of their roles in higher education. Results show that the women of color in the study confirmed the perceived challenges and barriers, perceptions of establishing a career …

The Association Of Neighborhood Schools Assignment Plan With Economic, Racial And Academic Outcomes In One North Carolina District, Theodore Kaniuka

Journal of Research Initiatives

When unified status was granted to numerous school districts, school boards developed redistricting plans to implement neighborhood schools. Social justice advocates decried these plans as they reversed over 40 years of progress, as many of these efforts resulted in resegregating schools homogenously grouped by race and wealth. Using piecewise and Difference in Difference regression with publicly facing data, this study assessed the association between neighborhood school attendance plans, school racial and economic balance, and student reading achievement. The results indicate that in one North Carolina school district over 15 years, (a) schools became more racially segregated, and (b) the achievement …

A Temporary Card Lending System And A Method Thereof, Reshu Pratap Ms

Defensive Publications Series

Present disclosure discloses a temporary card lending system (104) and a method thereof. The temporary card lending system may receive a request for issuing the temporary card and thereafter, the temporary card lending system may send an evaluation request for evaluating user details to bank A (106). Bank A (106) may evaluate the user details based on one or more parameters using one or more evaluation techniques and may send an evaluation report which includes an evaluation score to the temporary card lending system. Thereafter the temporary card lending system may send a card issuance request and the evaluation report …

Online Real-Life Situation Questionnaires To Develop Top-Down Reading Skill, Erni Adelina, Peny Meliaty Hutabarat

Jurnal Vokasi Indonesia

The top-down reading approach is generally applied in upper-intermediate to advanced ESL classes. The approach is thought to be too overwhelming for students who are at pre-intermediate, intermediate, or even beginner levels. Instructors may think that involving students’ background information or past knowledge in a passage topic will be burdensome for ESL students in a lower-level class. As a matter of fact, many students in any level of English class were experiencing or questioning the same issues in their routines. Separating students’ past knowledge from reading activity is impossible. This study was conducted to find out students’ past experience or …

My Name Is Max, Max Bowman

Faculty Scholarship

No abstract provided.