Digital Commons Network^™

Deep Sea Nature-Based Solutions To Climate Change, Nathalie Hilmi, Michael Sutherland, Shekoofeh Farahmand, Gunnar Haraldsson, Erik Van Doorn, Ekkehard Ernst, Mary S. Wisz, Astrid Claudel Rusin, Laura G. Elsler, Lisa A. Levin

Articles

The deep sea (below 200 m depth) is the largest carbon sink on Earth. It hosts abundant biodiversity that underpins the carbon cycle and provides provisioning, supporting, regulating and cultural ecosystem services. There is growing attention to climate-regulating ocean ecosystem services from the scientific, business and political sectors. In this essay we synthesize the unique biophysical, socioeconomic and governance characteristics of the deep sea to critically assess opportunities for deep-sea blue carbon to mitigate climate change. Deep-sea blue carbon consists of carbon fluxes and storage including carbon transferred from the atmosphere by the inorganic and organic carbon pumps to deep …

Clients In Uganda Accessing Preferred Differentiated Antiretroviral Therapy Models Achieve Higher Viral Suppression And Are Less Likely To Miss Appointments: A Cross-Sectional Analysis, Esther K. Nkolo, Jessica Clinkscales Ejike, Simon Sensalire, Juliana Nabwire Ssali, Immaculate Ddumba, Jacqueline Calnan, Carolina Gonzalez, Nelly Maina, Melaku Dessie, Lauren Bailey, Ugochukwu Amanyeiwe, Thomas Minior, Karishma Srikanth, Herbert Kadama, Khushi Patel, Dina Patel

Publications

INTRODUCTION: The Uganda Ministry of Health recommends facility- and community-based differentiated antiretroviral therapy (DART) models to support person-centred care for eligible clients receiving antiretroviral therapy (ART). Healthcare workers assess client eligibility for one of six DART models upon initial enrolment; however, client circumstances evolve, and their preferences are not routinely adjusted. We developed a tool to understand the proportion of clients accessing preferred DART models and compared the outcomes of clients accessing preferred DART models to the outcomes of clients not receiving preferred DART models. METHODS: We conducted a cross-sectional study. A sample of 6376 clients was selected from 113 …

Actionability Of Unanticipated Monogenic Disease Risks In Newborn Genomic Screening: Findings From The Babyseq Project, Robert C Green, Nidhi Shah, Casie A Genetti, Timothy Yu, Bethany Zettler, Melissa K Uveges, Ozge Ceyhan-Birsoy, Matthew S Lebo, Stacey Pereira, Pankaj B Agrawal, Richard B Parad, Amy L Mcguire, Kurt D Christensen, Talia S Schwartz, Heidi L Rehm, Ingrid A Holm, Alan H Beggs

Center for Medical Ethics and Health Policy Staff Publications

Newborn genomic sequencing (NBSeq) to screen for medically important genetic information is of considerable interest but data characterizing the actionability of such findings, and the downstream medical efforts in response to discovery of unanticipated genetic risk variants, are lacking. From a clinical trial of comprehensive exome sequencing in 127 apparently healthy infants and 32 infants in intensive care, we previously identified 17 infants (10.7%) with unanticipated monogenic disease risks (uMDRs). In this analysis, we assessed actionability for each of these uMDRs with a modified ClinGen actionability semiquantitative metric (CASQM) and created radar plots representing degrees of penetrance of the condition, …

The Development Of An Effective Synthetic Pathway To The Hiv Protease Inhibitor Darunavir And Its Structural Derivatives For Sar Studies Via An Asymmetric Glycolate Aldol Addition Reaction Approach, Emmanuel Ayim

Theses and Dissertations

The Centers for disease control and Prevention (CDC) published an article describing the disease that would later become known as HIV/AIDS in 1981. There were no treatments for this new disease, and by the time patients began exhibiting detectable symptoms, it would be too late to provide any meaningful treatments. Through the efforts made by the scientific community and social activism, new classes of drugs appeared for the treatment of this disease. These drugs are highly effective when combined with other therapeutic agents that suppress the proliferation of the virus. These combined therapies have helped alleviate the previously insurmountable risks …

The Historical Evolution Of State Capacity And Its Effect On Democratization: A Case Study Of Egypt, Ashley Elizabeth Johnson

Theses and Dissertations

Why are some states able to democratize while others are not? This thesis examines the connection between state capacity and democratization utilizing a case study of Egypt and a controlled comparison with Tunisia. Via process tracing, I determine that Egypt has a deeply institutionalized, strong coercive state capacity and a weak administrative capacity. These iterations of state capacity developed during Egyptian state formation from 1805-1840 and were further institutionalized at two critical junctures: early British occupation from 1883-1907, and Nasser’s presidency from 1952-1967. Path dependency makes successful democratization unlikely because of the significant legacy left in Egypt during these critical …

Individualized Therapeutic Composition As A Method Of Improving Sleep Quality In College Students, Nicholas Lanz

Theses and Dissertations

The life of a college student is often bombarded with circumstances, emotions, and decisions that produce stress and anxiety, affecting sleep quality and daily function. Listening to music designed for relaxation has the potential to decrease stress and improve factors of healthy sleep quality. The purpose of this study was to explore the effects of listening to music uniquely composed for each individual on stress relief and sleep quality in college students. The music therapy intervention utilized in this study was individual composition sessions. The researcher met with each participant individually to compose an instrumental piece of music that was …

Public Sector Bim Adoption: Development And Evaluation Of Government Policy Interventions: A Systematic Literature Review, Shiyao Kuang, Alan Hore, Ahmed Hassan, Barry Mcauley, Roger West

Conference Papers

Rapid technological advancements in the Architecture, Engineering and Construction (AEC) sector have provided a significant opportunity for improving the industry's efficiency, performance and sustainability. Building Information Modelling (BIM) is an innovative approach to information management in construction that provides a structured methodology for storing and analysing building information exchanged between project stakeholders. However, successful interventions and supports introduced by the public sector in accelerating BIM adoption can be seen through BIM mandates, promotion of information management ISO standards, guidance, funding and procurement integration. In this study, a systematic literature review is adopted to identify BIM policy interventions. The study aims …

Apoe Gene Associated With Dementia-Related Traits, Depression, And Anxiety In The Hispanic Population, Chun Xu, Victoria Padilla, Stephanie Lozano, Daniela Gamez, Brenda Bin Su, Xuan Wang, Gladys Maestre, Kesheng Wang

Health & Biomedical Sciences Faculty Publications

Alzheimer's disease (AD), a main cause of dementia, is commonly seen in aging populations with a strong genetic component. AD is one of the most common neurodegenerative disorders; it is a genetically and clinically heterogeneous disease. Specific demographic factors and genetic variants have been identified in non-Hispanic populations; however, limited studies have observed the Hispanic population. Therefore, we focused on investigating a known gene, APOE, associated with AD-related phenotypes and two psychiatric diseases (depression and anxiety) within the U.S. Hispanic population in our current study. A total of 1382 subjects were studied based on data collected from the Texas Alzheimer's …

2023 July 6 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Climate Change And Farmer Mental Health: A Participatory And Systems-Based Approach, Christopher Weatherly

Brown School Graduate Student Theses and Dissertations

Because of their closeness to and dependence on the land, climate change will disproportionately impact farmer mental health. Despite local and global reliance on U.S. Midwest farmers' mental health and wellbeing, there are limited studies elucidating the impacts of our changing climate on their mental health. The proposed dissertation addresses this gap by leveraging qualitative data from community stakeholders and applying a systems perspective in two phases to address the research question: How does climate change impact farmer mental health? The study takes place in farming communities in rural southeastern Iowa, which have experienced demonstrated increases in daily average temperature, …

Exploring The Complex Relationship Between Social Needs And Health, Rachel Catherine Garg

Brown School Graduate Student Theses and Dissertations

Over the past two decades, the healthcare sector has increasingly sought to assess and address patients’ health-related social needs with the dual aim of health improvement and cost reduction. However, evidence for the health impact of social needs interventions is mixed. Most interventions are not guided by theories or conceptual models that specify causal pathways or mechanisms for how unmet social needs impact health. It is also currently unknown how social needs change over time and the timeframe over which social needs impact health outcomes. This dissertation seeks to fill these gaps by (1) critically reviewing existing conceptual models proposing …

The Intertwined Renewable Energy–Water–Environment (Rewe) Nexus Challenges And Opportunities: A Case Study Of California, Shahryar Jafarinejad, Rebecca R. Hernandez, Sajjad Bigham, Bryan S. Beckingham

Michigan Tech Publications, Part 1

In our built environment, societal production of energy and clean water is inextricably linked to the natural resources from which they are derived. Acknowledgement and consideration of the coupling of energy, water, and the environment (the energy–water–environment nexus) will be critical to a sustainable future. This is particularly true as we transition away from historical energy sources (e.g., coal, petroleum, natural gas) and into the widespread adaptation of renewable energy (RE) sources (e.g., solar, wind, geothermal, hydro, bioenergy) as a strategy to decrease greenhouse gas emissions and consequently slow global climate change. This transition is fraught with both challenges and …

Are The Imposed Principles Standard? A Review Of Imposing Standards: The North-South Dimension To Global Tax Politics By Martin Hearson, Opeyemi Bello

Dalhousie Law Journal

The publication of Martin Hearson’s book, Imposing Standards: The North-South Dimension to Global Tax Politics, coincided with heated international discussions of the most substantial policy proposals in the field of international taxation in the last century.1 Hearson’s work provides insights on how the developed countries exerted control over the negotiations of the double taxation agreement (DTA) regime, which is the basis of the current international taxation framework. It explains how the negotiations resulted in a framework that works well for the developed countries, but does not substantially address the tax revenue needs of the developing countries. The publication of the …

Endoscopic Sleeve Gastroplasty (Esg) Versus Laparoscopic Sleeve Gastroplasty (Lsg): A Comparative Review, Basil N. Nduma, Kelly A. Mofor, Jason Tatang, Loica Amougou, Stephen Nkeonye, Princess Chineme, Chukwuyem Ekhator, Solomon Ambe

Health & Biomedical Sciences Faculty Publications

Obesity is one of the most debilitating conditions. In a quest to mitigate disease severity, various interventions have been proposed, with endoscopic sleeve gastroplasty (ESG) and laparoscopic sleeve gastroplasty (LSG) being among the recent interventions that have received growing attention. This systematic review sought to conduct a comparative analysis regarding the efficacy, effectiveness, and safety of both interventions.

The study involved a systematic review in which key search engines were used to select articles documented and published in the last decade. The articles for inclusion were those existing as peer-reviewed studies touching upon the aforementioned subject, with both controlled and …

Targeting Gbm With An Oncolytic Picornavirus Svv-001 Alone And In Combination With Fractionated Radiation In A Novel Panel Of Orthotopic Pdx Models, Sophie Xiao, Frank K Braun, Mari Kogiso, Yulun Huang, Frank Huang, Aalaa Abdallah, Milagros Suarez, Sekar Karthick, Nabil M Ahmed, Vita S Salsman, Patricia A Baxter, Jack M Su, Daniel J Brat, Paul L Hellenbeck, Wan-Yee Teo, Akash J Patel, Xiao-Nan Li

Faculty, Staff and Students Publications

BACKGROUND: Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It's capacity of passing through the blood brain barrier makes is an attractive novel approach for GBM.

MATERIALS AND METHODS: 23 patient tumor samples were implanted into the brains of NOD/SCID mice (1 × 105 cells/mouse). Tumor histology, gene expression (RNAseq), and growth rate of the developed patient-derived orthotopic xenograft (PDOX) models were compared with the originating patient tumors during serial subtransplantations. Anti-tumor activities of SVV-001 were examined in vivo; and therapeutic efficacy validated …

Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors For Tendon Tissue Engineering, Chiara Rinoldi, Ewa KijeńSka-GawrońSka, Marcin Heljak, Jakub Jaroszewicz, Artur KamińSki, Ali Khademhosseini, Ali Tamayol, Wojciech Swieszkowski

Department of Mechanical and Materials Engineering: Faculty Publications

In recent years, fiber-based systems have been explored in the frame of tissue engineering due to their robustness in recapitulating the architecture and mechanical properties of native tissues. Such scaffolds offer anisotropic architecture capable of reproducing the native collagen fibers’ orientation and distribution. Moreover, fibrous constructs might provide a biomimetic environment for cell encapsulation and proliferation as well as influence their orientation and distribution. In this work, we combine two fiber fabrication techniques, such as electrospinning and wet-spinning, in order to obtain novel cell-laden 3D fibrous layered scaffolds which can simultaneously provide: (i) mechanical support; (ii) suitable microenvironment for 3D …

Ticks And Tick-Borne Pathogens From Wild Pigs In Northern And Central Florida, Sarah E. Mays Maestas, Lindsay P. Campbell, Michael P. Milleson, Lawrence E. Reeves, Phillip E. Kaufman, Samantha M. Wisely

School of Integrative Biological & Chemical Sciences Faculty Publications

Simple Summary

Ticks are vectors of several agents of human disease, and improvements to traditional surveillance methods are needed to aid in tick-borne disease monitoring and prevention. Invasive wild pigs are broadly distributed in the southern U.S., and removal efforts are often undertaken by local, state, and federal entities. Wild pigs are hosts to several human-biting tick species associated with agents of human disease. This research examines the use of tick collection from wild pigs in the state of Florida as a method of surveillance for ticks and tick-borne pathogens of human concern. Four species of human-biting ticks were collected …

Crazier Hypotheses: Panpsychism, José E. Burgos, Giselle M. Castañeda

Animal Sentience

Abstract: Segundo-Ortin & Calvo (S&C) invite readers to consider seriously the hypothesis that plants have phenomenal consciousness or sentience. Their case is based on behavioral evidence to support their hypothesis. While the hypothesis seems crazy to many, there is a crazier hypothesis – panpsychism – according to which everything is sentient. We discuss panpsychism to raise a number of philosophical questions about S&C’s hypothesis.

Affect Variability And Physical Health: The Moderating Role Of Mean Affect, Brooke N. Jenkins, Lydia Q. Ong, Hee Youn (Helen) Lee, Anthony D. Ong, Julia K. Boehm

Psychology Faculty Articles and Research

Research has only begun to explore how affect variability relates to physical health and has typically not assessed long-term associations nor considered the moderating role of mean affect. Therefore, we used data from the Midlife in the United States Study waves 2 (N = 1512) and 3 (N = 1499) to test how affect variability predicted concurrent and long-term physical health while also testing the moderating role of mean affect. Results indicated that greater negative affect variability was associated concurrently with a greater number of chronic conditions (p = .03) and longitudinally with worse self-rated physical health (p …

3 Chosen As Uab Vips For Second-Quarter 2023, Staff

Browse All News

No abstract provided.

One-Of-A-Kind Alabama Ovarian Cancer Car Tags Raise Nearly $1.7 Million For Ovarian Cancer Research At Uab, Shawna Masters

Browse All News

No abstract provided.

Extracellular Cytochrome Nanowires Appear To Be Ubiquitous In Microbes, Public Relations

Browse All News

No abstract provided.

Simulation As A Key Training Method For Inculcating Public Health Leadership Skills: A Mixed Methods Study, Keren Dopelt, Itamar Shevach, Ofek Eliad Vardimon, Katarzyna Czabanowska, Jascha De Nooijer, Robert Otok, Lore Leighton, Osnat Bashkin, Mariusz Duplaga, Hagai Levine, Fiona Macleod, Maureen Malowany, Leah Okenwa-Emegwa, Shira Zelber-Sagi, Nadav Davidovitch, Paul Barach

College of Population Health Faculty Papers

BACKGROUND: Successful management of public health challenges requires developing and nurturing leadership competencies. We aimed to evaluate the effectiveness of training simulations to assess public health leadership and decision-making competencies during emergencies as an effective learning and training method.

METHODS: We examined the effects of two simulation scenarios on public health school students in terms of their experience (compared to face-to-face learning) and new skills acquired for dealing with similar emergent situations in the future. A mixed-methods design included developing a validated and pre-tested questionnaire with open-and closed-ended questions that examined the simulation impact and the degree of student satisfaction …

Residential Building Flood Risk Assessment And The Benefits Of Home Elevation, Ayat Al Assi

LSU Doctoral Dissertations

Evaluating flood risk is an essential component of understanding and increasing community resilience. A robust approach for quantifying flood risk in terms of average annual loss (AAL) in dollars is needed to provide valuable information for stakeholder decision-making inside and outside the special flood hazard area (SFHA, which corresponds to the 100-year floodplain). To further inform flood mitigation strategies, quantifying flood risk reduction with home elevation above an initial first-floor height (FFH₀) and the cost effectiveness of federal mitigation assistance for elevation are important steps to enhance awareness of the effect of elevation in reducing flood risk. …

Impact Of Blood Flow Restricted Resistance Training On Skeletal Muscle Strength, Hypertrophy, Fatigue, Mitochondrial Response, And Activation, Brett Davis

LSU Doctoral Dissertations

Abstract

Blood flow restricted resistance exercise (BFR-RE) is a novel method that is effective at increasing strength and hypertrophy using much lower loads than the higher loads typical in progressive resistance exercise. However, the effects of BFR-RE on skeletal muscle fatigue, mitochondrial response, and activation are still being explored. This dissertation will discuss the impacts of BFR-RE, how it affects college-aged individuals that are trained and untrained, and the effects of BFR-RE on skeletal muscle fatigue, mitochondrial response, and activation.

The first study examined the effects of 6-weeks of low load blood flow restricted resistance exercise (LLBFR) on muscular strength, …

Interactive Effects Of The Partial Pressure Of Co2, Temperature, And Nutrient-Limitation On The Physiology And Growth Of The Coccolithophore E. Huxleyi Grown On A 12:12 L:D Cycle Of Illumination, James Bradley

LSU Master's Theses

I studied the interactive effects of pCO2, temperature, and nutrient limitation on the growth and physiology of the marine coccolithophore, Emiliania huxleyi. This was done to look at the effect of climate change factors on the widespread and abundant calcifying marine organism as a predictor of what the future has to hold. The strain of E. huxleyi (PnB 272 B10) was grown on a 12:12 L:D cycle of illumination and exposed to either high or low pCO2 under nutrient-replete or nitrate-limited conditions across a temperature range of 10–28C. I examined the direct and interactive effects of temperature, pCO2, and nutrient …

Evaluating Approaches For Constructing Polygenic Risk Scores For Prostate Cancer In Men Of African And European Ancestry, Burcu F Darst, Jiayi Shen, Ravi K Madduri, Alexis A Rodriguez, Yukai Xiao, Edward J Saunders, Mark N Brook, Thomas J Hoffmann, Kenneth Muir, Peggy Wan, Loic Le Marchand, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J Macinnis, Cezary Cybulski, David E Neal, Børge G Nordestgaard, Sune F Nielsen, Jyotsna Batra, Judith A Clements, Australian Prostate Cancer Bioresource, Henrik Grönberg, Nora Pashayan, Ruth C Travis, Jong Y Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A Mucci, David J Hunter, Kathryn L Penney, Catherine M Tangen, Robert J Hamilton, Marie-Élise Parent, Janet L Stanford, Stella Koutros, Alicja Wolk, Karina D Sørensen, William J Blot, Edward D Yeboah, James E Mensah, Yong-Jie Lu, Daniel J Schaid, Stephen N Thibodeau, Catharine M West, Christiane Maier, Adam S Kibel, Géraldine Cancel-Tassin, Florence Menegaux, Esther M John, Eli Marie Grindedal, Kay-Tee Khaw, Sue A Ingles, Ana Vega, Barry S Rosenstein, Manuel R Teixeira, Nc-La Pcap Investigators, Manolis Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J Leach, Hermann Brenner, Ann W Hsing, Rick A Kittles, Adam B Murphy, Christopher J Logothetis, Susan L Neuhausen, William B Isaacs, Barbara Nemesure, Anselm J Hennis, John Carpten, Hardev Pandha, Kim De Ruyck, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Canary Pass Investigators, Lisa F Newcomb, Jay H Fowke, Christine Neslund-Dudas, Benjamin A Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Jose Esteban Castelao, Paul A Townsend, Dana C Crawford, Gyorgy Petrovics, Graham Casey, Monique J Roobol, Jennifer F Hu, Sonja I Berndt, Stephen K Van Den Eeden, Douglas F Easton, Stephen J Chanock, Michael B Cook, Fredrik Wiklund, John S Witte, Rosalind A Eeles, Zsofia Kote-Jarai, Stephen Watya, John M Gaziano, Amy C Justice, David V Conti, Christopher A Haiman

Faculty, Staff and Student Publications

Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several GW-PRS approaches to a recently developed PRS of 269 established prostate cancer-risk variants from multi-ancestry GWASs and fine-mapping studies (PRS269). GW-PRS models were trained with a large and diverse prostate cancer GWAS of 107,247 cases and 127,006 controls that we previously used to develop the multi-ancestry PRS269. Resulting models were independently tested in 1,586 cases and 1,047 controls of African ancestry from the California Uganda Study and 8,046 cases and …

Changes In Outcomes And Factors Associated With Survival In Melanoma Patients With Brain Metastases, Merve Hasanov, Denái R Milton, Alicia Bea Davies, Elizabeth Sirmans, Chantal Saberian, Sylvia Opusunju, Carlos A Torres-Cabala, Elizabeth M Burton, Rivka R Colen, Jason T Huse, Isabella C Glitza Oliva, Caroline Chung, Mary Frances Mcaleer, Susan L Mcgovern, Debra N Yeboa, Betty Y S Kim, Sujit S Prabhu, Ian E Mccutcheon, Jeffrey S Weinberg, Frederick F Lang, Hussein A Tawbi, Jing Li, Lauren E Haydu, Michael A Davies, Sherise D Ferguson

Faculty, Staff and Student Publications

BACKGROUND: Treatment options for patients with melanoma brain metastasis (MBM) have changed significantly in the last decade. Few studies have evaluated changes in outcomes and factors associated with survival in MBM patients over time. The aim of this study is to evaluate changes in clinical features and overall survival (OS) for MBM patients.

METHODS: Patients diagnosed with MBMs from 1/1/2009 to 12/31/2013 (Prior Era; PE) and 1/1/2014 to 12/31/2018 (Current Era; CE) at The University of Texas MD Anderson Cancer Center were included in this retrospective analysis. The primary outcome measure was OS. Log-rank test assessed differences between groups; multivariable …

Long-Term Bilateral Neuromuscular Function And Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction, Janine Molino

Faculty, Staff and Student Publications

Neuromuscular function is thought to contribute to posttraumatic osteoarthritis (PTOA) risk in anterior cruciate ligament (ACL)-reconstructed (ACLR) patients, but sensitive and easy-to-use tools are needed to discern whether complex muscle activation strategies are beneficial or maladaptive. Using an electromyography (EMG) signal analysis technique coupled with a machine learning approach, we sought to: (1) identify whether ACLR muscle activity patterns differed from those of healthy controls, and (2) explore which combination of patient outcome measures (thigh muscle girth, knee laxity, hop distance, and activity level) predicted the extent of osteoarthritic changes via magnetic resonance imaging (MRI) in ACLR patients. Eleven ACLR …

A Functional Link Between Lariat Debranching Enzyme And The Intron-Binding Complex Is Defective In Non-Photosensitive Trichothiodystrophy, Brittany A Townley, Luke Buerer, Ning Tsao, Albino Bacolla, Fadhel Mansoori, Nathanial Clark, Nicolas Schmidt, Sridhar Nonavinkere Srivatsan, Hua Sun, Reilly A Sample, Joshua R Brickner, Drew Mcdonald, Miaw-Sheue Tsai, Matthew J Walter, David F Wozniak, Alex S Holehouse, Vladimir Pena, John A Tainer, William G Fairbrother, Nima Mosammaparast

Faculty, Staff and Student Publications

The pre-mRNA life cycle requires intron processing; yet, how intron-processing defects influence splicing and gene expression is unclear. Here, we find that TTDN1/MPLKIP, which is encoded by a gene implicated in non-photosensitive trichothiodystrophy (NP-TTD), functionally links intron lariat processing to spliceosomal function. The conserved TTDN1 C-terminal region directly binds lariat debranching enzyme DBR1, whereas its N-terminal intrinsically disordered region (IDR) binds the intron-binding complex (IBC). TTDN1 loss, or a mutated IDR, causes significant intron lariat accumulation, as well as splicing and gene expression defects, mirroring phenotypes observed in NP-TTD patient cells. A Ttdn1-deficient mouse model recapitulates intron-processing defects and certain …