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Addressing Low Vaccination Rates In Lewis County, New York: A Community-Based Participatory Research Study, Samantha Carter May 2026

Addressing Low Vaccination Rates In Lewis County, New York: A Community-Based Participatory Research Study, Samantha Carter

Anthropology

Low rates of on-time human papillomavirus (HPV) vaccination continue to remain a significant public health concern, particularly in rural communities, one being Lewis County NY, which reports the lowest rate of vaccination in the state.  This study, through Upstate Medical University, uses a Community-Based Participatory Research (CBPR) model in efforts to examine barriers to HPV vaccination and identifying community-driven solutions formulated by committee members from within the community.  A steering committee composed of researchers and community members, who were also co-researchers, worked collaboratively to develop and distribute surveys to healthcare providers, dentists, and parents.  Responses revealed that while many parents …


Integrating Doulas Into The Medical Team, Alyssa Shaw May 2026

Integrating Doulas Into The Medical Team, Alyssa Shaw

Anthropology

This thesis explores the potential integration of doulas into the obstetric medical team, defining birth as a cultural and social experience as well as a physiological process. Drawing on anthropological literature and historical accounts, I examine the shift from social, woman-centered childbirth practices to the medicalized model that occurs in modern American obstetrics. While this transformation has improved maternal and infant mortality rates, it has also caused a loss of continuous emotional and social support for laboring mothers, as well as a shift in autonomy from the birthing person to medical professionals. To investigate how doulas may help bridge this …


Microplastics And Generational Harm, Sara Najafi May 2026

Microplastics And Generational Harm, Sara Najafi

Anthropology

Microplastics are persistent environmental contaminants increasingly detected in ecosystems and the human body, raising concerns about their effects on health and future generations. This paper examines the environmental pathways, biological mechanisms, and reproductive consequences of microplastic exposure, with particular attention to female reproductive health and fetal development. Current evidence indicates that microplastics can contribute to oxidative stress, inflammation, endocrine disruption, DNA damage, and cellular dysfunction, while also accumulating in reproductive tissues, follicular fluid, placental tissue, and breast milk. These exposures may impair ovarian function, fetal development, and long-term health outcomes. The paper also considers environmental inequalities that may increase exposure …


Bound To Status: A Comparative Study Of Public And Private College Libraries, Lilianna Fujita May 2026

Bound To Status: A Comparative Study Of Public And Private College Libraries, Lilianna Fujita

Anthropology

This ethnographic study compares student culture and behavior at two upstate New York universities — Rensselaer Polytechnic Institute (RPI), a private STEM-focused institution, and the University at Albany (UAlbany), a public research university. Through two rounds of participant observation conducted in each school's library and three semi-structured student interviews, the author examines how institutional type, admissions selectivity, campus environment, and resource allocation shape student social dynamics, gender experiences, and overall well-being. The author argues that differences in student behavior reflect not only individual student dispositions but broader institutional decisions about who is admitted and what social infrastructure is supported.


Design Of An Extensible And Scalable Data Acquisition System For Pulse Shape Discrimination, Prince John May 2026

Design Of An Extensible And Scalable Data Acquisition System For Pulse Shape Discrimination, Prince John

McKelvey School of Engineering Graduate Student Theses & Dissertations

This thesis presents the design and development of a highly scalable, end-to-end data acquisition (DAQ) system for nuclear physics experiments that can be deployed in configurations ranging from a few to thousands of detector channels. The system is built as an extensible platform composed of modular 16-channel chipboards that support a wide range of scintillator and detector types and perform real-time, on-board data sparsification and pulse-shape processing. Three versions of the chipboard have been fabricated to date.

The DAQ architecture is based on a family of analog pulse-shape-processing application- specific integrated circuits (ASICs) developed by the IC Design Laboratory at …


Conditioning Hierarchical Diffusion Transformers On Rf Circuit Parameters, Ethan Morton May 2026

Conditioning Hierarchical Diffusion Transformers On Rf Circuit Parameters, Ethan Morton

McKelvey School of Engineering Graduate Student Theses & Dissertations

As modern ML techniques have become increasingly advanced, they have begun to be integrated into wireless RF systems for classification, identification, and spectrum management. Deep Neural Networks (DNNs) enable RF system operators and designers to design more flexible systems with greater robustness to errors and attacks. However, neural networks require significant amounts of properly annotated data to train. Current data labeling methods lack the ability to obtain reliable true labels for circuit properties such as carrier frequency offset (CFO), power amplifier (PA) non-linearity, and in-phase/quadrature (IQ) imbalance. This thesis investigates the efficacy of a novel architecture, RF-Diffusion, for generating high-quality …


Monastic Design: Recovering The Sacred, Thomas Larkin Derek Crompton May 2026

Monastic Design: Recovering The Sacred, Thomas Larkin Derek Crompton

Architecture Theses

Throughout history, transcendental meaning has been woven into the very fabric of architecture to awaken and attune our souls toward a greater understanding of the inherent, unquantifiable aspects of life. Design elements such as light, material, proportion, and mystery were used as communicators of meaning rather than merely tools of utility. However, with the rise of positivism in the modern period, many transcendental elements of design were disregarded in favor of a more functionalist approach. The strategies employed by this approach influenced much of modern religious architecture and have resulted in many churches that lack the fundamental principle they claim …


A Translation Of Culture, Dinithi Warnakula May 2026

A Translation Of Culture, Dinithi Warnakula

Architecture Theses

This thesis explores the processes of shared occupation, layering and translation in architecture as a means of cultural cohabitation. Located on the Keating Channel waterfront in Toronto, the project explores themes of migration, shifting identities and communal life in an urban context. The thesis, beginning with the theories of Vilém Flusser and Daniel Heller-Roazen, addresses translation as linguistic and geographical condition. The layered Sinhala, Tamil and English characters produce an artefact that throws dynamic shadows that interact with the physical architecture through tiered thresholds, framed views and filtered light conditions. This created cultural commons, spaces for everyday interaction, narration, socialisation …


Gardens In The Sky: Rooftop Landscaping Design In The Chicago Downtown Environment, Noah Olson May 2026

Gardens In The Sky: Rooftop Landscaping Design In The Chicago Downtown Environment, Noah Olson

Landscape Architecture Theses

Cities around the world are becoming increasingly more susceptible to heat, largely due to the urban heat island effect (UHI). Green roofs, which essentially turn building tops into planted gardens, can be an effective and creative way for landscape architects to combat these problems. This thesis will use a literature review of peer-reviewed studies to examine green roof materials, designs, and performance in reducing UHI impacts and stormwater runoff. Findings show surface temperature reductions of 20-30°C, air cooling of 1-2°C, and 17-51% runoff retention. These results have been applied to redesign three terraces at the St. Regis Chicago: the 11th-floor …


Cooling Washington Avenue: A Guide To Urban Heat Island Effect Mitigation For Detroit Lakes, Mn, Nathan Johnson May 2026

Cooling Washington Avenue: A Guide To Urban Heat Island Effect Mitigation For Detroit Lakes, Mn, Nathan Johnson

Landscape Architecture Theses

This thesis explores the redesign of an urban corridor in Detroit Lakes, Minnesota. Detroit Lakes is a small urban city characterized by its year-round tourism, vibrant downtown, and sandy beachfront. Like many other urban environments, it faces growing challenges associated with the urban heat island effect, as well as stormwater management and pedestrian safety. To address these issues, this project proposes integrating green street design strategies to mitigate the urban heat island effect and increase pedestrian safety. Using design principles drawn from four case studies, this project introduces natural stormwater management systems, designated bike lanes, increased canopy cover, and decreased …


Designing For Neurodivergent Learning In Early Education, Brooklyn Wegner May 2026

Designing For Neurodivergent Learning In Early Education, Brooklyn Wegner

Architecture Theses

This architectural thesis explores the redesign of a 4K-4th-grade school to foster an inclusive, safe, and supportive learning environment for neurodivergent learners. Recognizing that traditional classrooms and makeshift special education spaces fail to meet diverse student needs, this research analyzes the learning processes associated with ADHD, Autism Spectrum Disorder, Dyslexia, Dysgraphia, Dyspraxia, and Dyscalculia. By integrating Montessori and Erikson’s pedagogical theories, the study advocates for universal and flexible design frameworks. The primary outcome of this project is a proposed classroom module and comprehensive school redesign in Osceola, Wisconsin, focused on five key environmental elements: colors, lighting, acoustics, textures, and zoning. …


Illinois State University, One Hundred And Sixty-Seventh Annual Commencement, May 2026, Illinois State Universtiy May 2026

Illinois State University, One Hundred And Sixty-Seventh Annual Commencement, May 2026, Illinois State Universtiy

Commencement Programs

Illinois State University

One Hundred and Sixty-Seventh Annual Commencement

May 2026


Birds, Bees, + Butterflies: Restoring Suburban Wildlife Homes And Habitats In Bismarck, Nd, Elena Joubert May 2026

Birds, Bees, + Butterflies: Restoring Suburban Wildlife Homes And Habitats In Bismarck, Nd, Elena Joubert

Landscape Architecture Theses

For centuries humanity has been expanding its borders, stretching in and across a wide range of ecosystems, optimizing the land for human use and habitation. Animal-aided design is a possible solution to the loss of habitats; a new methodology of designing green spaces for the use of specific native species. Green spaces are vital to the mental and physical well-being of people, and the presence of native species such as songbirds or butterflies can further increase those benefits. Only 4.2% of North Dakota is developed land, referring to urban and industrial usage, but within these spaces are opportunities to conserve …


Byproducts In Bakken: Integrating Agricultural Waste Into Architecture As A Path To Sustainable Design In Western North Dakota, Noah Boen May 2026

Byproducts In Bakken: Integrating Agricultural Waste Into Architecture As A Path To Sustainable Design In Western North Dakota, Noah Boen

Architecture Theses

Sustainable design can be seen as threatening in regions where local industries are expected to decline if introduced. This thesis explores how this can be solved in western North Dakota where fracking is a large part of the economy. North Dakota leads the nation in wheat production, and recent advancements have allowed for the waste product from harvest to be utilized in architectural applications. By introducing this as a feasible means for sustainable design in the region, through the typology of a visitor center in the North Unit of Theodore Roosevelt National Park, the local population can become better educated …


Surgical Timing After Acromioclavicular Joint Separation: Association With Clinical Outcomes, Mallory B Lane, Jacob Siahaan, James M Gregory May 2026

Surgical Timing After Acromioclavicular Joint Separation: Association With Clinical Outcomes, Mallory B Lane, Jacob Siahaan, James M Gregory

Faculty, Staff and Student Publications

Background: Treatment of acromioclavicular joint (ACJ) separations continually lacks consensus between providers, and while low-grade injuries generally respond well to conservative management, high-grade injury management is more complex. For patients requiring surgery, the effect of the timing of surgery with respect to the original injury on clinical outcomes remains unclear.

Hypothesis: Clinical outcome measures would worsen as the time between ACJ dislocation injury and surgery increased.

Study design: Cohort study; Level of evidence, 3.

Methods: A large nationwide insurance claims database was queried for patients who had an ACJ dislocation injury using International Classification of Diseases, Ninth and Tenth Revision …


Multidisciplinary Approach To Complex Lower Extremity Limb Salvage In Pyogenic Arthritis, Pyoderma Gangrenosum, And Acne (Papa) Syndrome: A Case Report, Michael M Talanker, Anthony V Basta, Tien Do, Robert Tung, Addison Allen, Morgan Martin, Bryan L Ruygrok, Patrick J Kellam, Jeffrey G Trost, Mohin A Bhadkamkar May 2026

Multidisciplinary Approach To Complex Lower Extremity Limb Salvage In Pyogenic Arthritis, Pyoderma Gangrenosum, And Acne (Papa) Syndrome: A Case Report, Michael M Talanker, Anthony V Basta, Tien Do, Robert Tung, Addison Allen, Morgan Martin, Bryan L Ruygrok, Patrick J Kellam, Jeffrey G Trost, Mohin A Bhadkamkar

Faculty, Staff and Student Publications

Limb salvage using free tissue transfer in patients with rare autoinflammatory syndromes is poorly described, and the safety of microvascular reconstruction in this population remains uncertain. Hereditary pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome is characterized by dysregulated inflammation, pathergy, and impaired wound healing, raising concern for flap compromise and postoperative complications. We report a rare case of lower extremity free tissue transfer in a patient with PAPA syndrome. A 66-year-old woman with rheumatoid arthritis and PAPA syndrome presented with rapid wound breakdown, violaceous ulceration, exposed hardware, and periprosthetic joint infection following left total knee arthroplasty (TKA). Examination revealed …


Severe, Non-Apneic Respiratory Dysfunction And Hypoxia Following Generalized Convulsive Seizures, Haley E Pysick, Rup K Sainju, Roshni Nair, Deidre N Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D Lhatoo, George B Richerson, Brian K Gehlbach May 2026

Severe, Non-Apneic Respiratory Dysfunction And Hypoxia Following Generalized Convulsive Seizures, Haley E Pysick, Rup K Sainju, Roshni Nair, Deidre N Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D Lhatoo, George B Richerson, Brian K Gehlbach

Faculty, Staff and Student Publications

Objective: Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non-apneic ventilation or identifying other dysfunctional breathing patterns. We hypothesized that GCS frequently induce immediate, severe, non-apneic respiratory dysfunction that can induce critical hypoxia and bradycardia and sought to characterize breathing patterns after GCS.

Methods: Adult patients admitted to an epilepsy monitoring unit were studied. The effects of GCS on breathing and heart rate were analyzed using nasal pressure transducers, chest and abdominal …


Assessment Of Skin In Patients With Systemic Sclerosis Using High-Frequency Ultrasound And Shear Wave Elastography: A Comparative Study With Histology, Molecular, And Clinical Parameters, Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V Larin, Maureen Mayes, Shervin Assassi May 2026

Assessment Of Skin In Patients With Systemic Sclerosis Using High-Frequency Ultrasound And Shear Wave Elastography: A Comparative Study With Histology, Molecular, And Clinical Parameters, Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V Larin, Maureen Mayes, Shervin Assassi

Faculty, Staff and Student Publications

Objective: Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US-based skin assessments for their face validity (differentiation between involved SSc and healthy control [HC] skin), construct validity (comparison to modified Rodnan skin score [mRSS]), and criterion validity (comparison to histologic and gene expression fibrosis markers).

Methods: Twenty HCs and 52 patients with SSc underwent clinical and US assessment followed by a forearm skin biopsy. Predefined areas were assessed on the finger, hand, …


Brief Report: Hepatitis B Vaccination Histories In Persons With Hiv Needing Revaccination, Minhee Kang, Triin Umbleja, Anchalee Avihingsanon, Sandra W Cardoso, Josphat Kosgei, Karen J Vigil, Ta Thi Dieu Ngan, Unoda Chakalisa, Stephanie Caruso, Kenneth E Sherman, Kristen M Marks May 2026

Brief Report: Hepatitis B Vaccination Histories In Persons With Hiv Needing Revaccination, Minhee Kang, Triin Umbleja, Anchalee Avihingsanon, Sandra W Cardoso, Josphat Kosgei, Karen J Vigil, Ta Thi Dieu Ngan, Unoda Chakalisa, Stephanie Caruso, Kenneth E Sherman, Kristen M Marks

Faculty, Staff and Student Publications

Introduction: Past studies of hepatitis B vaccines in people with HIV (PWH) have shown mixed results about improving responses with increases in dose or dose frequency, leading to inconsistent guidelines and practice. We examined vaccine series completion and revaccinations in PWH lacking a seroprotective response.

Methods: Hepatitis B vaccination histories were evaluated as a retrospective study in 561 participants of A5379 trial (NCT04193189). Individuals in 41 sites in Africa, Asia, South America, and the United States qualified for the trial with antibody titers below the seroprotective level (< 10 mIU/mL) despite past hepatitis B vaccinations. The primary measure of interest was the number of vaccines in the past vaccination records.

Results: Of the 1098 trial candidates, 561 (51%) did not …


Quantitative Muscle Magnetic Resonance Imaging Demonstrates Resolution Of Muscle Edema In Refractory Dermatomyositis: A Post Hoc Analysis Of A Proof-Of-Concept Clinical Trial Of Tofacitinib, Mona Dabiri, Anshula Nallapati, Marwin Groener, Patrick Debs, Jemima Albayda, Eleni Tiniakou, Lisa Christopher-Stine, Laura Fayad, Julie J Paik May 2026

Quantitative Muscle Magnetic Resonance Imaging Demonstrates Resolution Of Muscle Edema In Refractory Dermatomyositis: A Post Hoc Analysis Of A Proof-Of-Concept Clinical Trial Of Tofacitinib, Mona Dabiri, Anshula Nallapati, Marwin Groener, Patrick Debs, Jemima Albayda, Eleni Tiniakou, Lisa Christopher-Stine, Laura Fayad, Julie J Paik

Faculty, Staff and Student Publications

Objective: To evaluate changes in muscle edema using short-tau inversion recovery (STIR) imaging and quantitative diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping in patients with refractory dermatomyositis (DM) treated with tofacitinib.

Methods: This post hoc imaging analysis included patients from a 12-week, open-label trial of tofacitinib 11 mg daily in refractory DM. Bilateral thigh magnetic resonance imaging was obtained at baseline and week 12 using standardized STIR, T1-weighted, and DWI sequences. Muscle edema (ME) and fascial edema were assessed qualitatively on STIR imaging. ADC values were measured in muscles demonstrating baseline STIR hyperintensity using three nonoverlapping regions of …


Race To Mitigate Aortic Dissection: Exercise, Pde5a, And The Dissecting Aorta, Siddharth K Prakash May 2026

Race To Mitigate Aortic Dissection: Exercise, Pde5a, And The Dissecting Aorta, Siddharth K Prakash

Faculty, Staff and Student Publications

No abstract provided.


The Impact Of Rapid Infusers On The Hemostatic Potential Of Cryoprecipitate Products, Connor D Purvis, Samantha Redden, Andrew Jacobson, Yao-Wei Wang, Julie Campbell, Jessica Cardenas, Jan-Michael Van Gent, Bryan A Cotton May 2026

The Impact Of Rapid Infusers On The Hemostatic Potential Of Cryoprecipitate Products, Connor D Purvis, Samantha Redden, Andrew Jacobson, Yao-Wei Wang, Julie Campbell, Jessica Cardenas, Jan-Michael Van Gent, Bryan A Cotton

Faculty, Staff and Student Publications

Background: In cases of massive transfusion, intravenous access can be limited. Additionally, delivering different products through separate lines and infusion methods adds unnecessary steps. RBC, plasma, and whole blood (WB) are delivered via rapid infusers; cryoprecipitate (CRYO) is infused through separate access and is not approved with these devices.

Study design and methods: We examined the impact of different transfusion methods on hemostatic performance and factor activity using two available CRYO products. Ten bags of CRYO, ten bags pathogen-reduced CRYO (Intercept® Fibrinogen Complex, IFC), and 20 units of WB were obtained. Each CRYO bag was infused with one unit of …


Estrogen As A Therapeutic Agent: Targeting Endotheliopathy And Coagulopathy In Trauma, Niruktha Raghavan, Mira Patel, Bryan A Cotton, Julia Coleman, Donald Jenkins May 2026

Estrogen As A Therapeutic Agent: Targeting Endotheliopathy And Coagulopathy In Trauma, Niruktha Raghavan, Mira Patel, Bryan A Cotton, Julia Coleman, Donald Jenkins

Faculty, Staff and Student Publications

Background: Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma-induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need for new precision resuscitation strategies that acknowledge factors like biological sex.

Design: The central hypothesis is that estrogen confers a survival advantage in hormonally active females through a dual action: endothelial cell stabilization (halting glycocalyx shedding) and its inherent procoagulant effect. The analysis assesses the therapeutic potential of both exogenous estrogen and female-derived blood products …


Declaring Futility After Traumatic Injury And The Burden Of Failure On The Surgeon, Jan-Michael Van Gent, Bryan A Cotton May 2026

Declaring Futility After Traumatic Injury And The Burden Of Failure On The Surgeon, Jan-Michael Van Gent, Bryan A Cotton

Faculty, Staff and Student Publications

In this edition of the THOR supplement in Transfusion, there are two articles that deal with resuscitation futility and transfusion. In one article, Yazer et al. delve into the details of the studies outlined in this editorial and summarize the literature on the topic of transfusion and futility. The second article by Dr. Jay Malone discusses the ethical issues surrounding massive transfusion and resuscitation. Taken together, these articles address the clinical and ethical issues surrounding this very emotive and difficult topic.


Rethinking Mixed Dka-Hhs: An Extreme Presentation Of Hyperosmolar Hyperglycemic State, Sajith Silva, Umair Malik, Amin Pasha, Sujata Kambhatla May 2026

Rethinking Mixed Dka-Hhs: An Extreme Presentation Of Hyperosmolar Hyperglycemic State, Sajith Silva, Umair Malik, Amin Pasha, Sujata Kambhatla

Conference Presentation Abstracts

Introduction: The American Diabetes Association (ADA) recognizes diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) as life-threatening hyperglycemic emergencies that can overlap clinically; approximately 10% of presentations are described as mixed DKA–HHS. Because current guidelines do not define a single “mixed” category, overlap is best understood as concurrent fulfillment of key elements of both syndromes: DKA-type anion-gap metabolic acidosis with ketonemia or ketonuria, together with HHS-type severe hyperglycemia, hyperosmolality, and dehydration. We report an extreme HHS presentation (glucose >2,100 mg/dL) with limited DKA overlap. Case Description: A 34-year-old woman with longstanding type 1 diabetes mellitus managed with an insulin pump, …


A Rare Price Of Pain Control: Methemoglobinemia From A Lidocaine Patch, Sushmita Mantravadi, Kesava Mankikanta Achuta, Aaron Goyal, Amin Pasha, Abed L. Dabaja May 2026

A Rare Price Of Pain Control: Methemoglobinemia From A Lidocaine Patch, Sushmita Mantravadi, Kesava Mankikanta Achuta, Aaron Goyal, Amin Pasha, Abed L. Dabaja

Conference Presentation Abstracts

Introduction The overall prevalence of methemoglobinemia is around 0.035%. Methemoglobinemia is a rare but potentially life-threatening complication of local anesthetic use. While all patients are at risk, those with cardiac or pulmonary compromise are more susceptible to developing clinical manifestations. We report a case of acquired methemoglobinemia following topical lidocaine patch application for post-operative pain management in an elderly patient. Case Presentation 84-year-old male with a past medical history of aortic stenosis status post Transcatheter aortic valve replacement, Coronary artery disease, gastrointestinal bleed due to colon polyps, obstructive sleep apnea, chronic kidney disease, trigeminal neuralgia, obesity, essential hypertension, chronic atrial …


Neurointerventional Advances In 2025, Amol Mehta, Sunil A Sheth, Ashutosh P Jadhav May 2026

Neurointerventional Advances In 2025, Amol Mehta, Sunil A Sheth, Ashutosh P Jadhav

Faculty, Staff and Student Publications

No abstract provided.


Antidepressant-Like Effects Of Extinction Learning As An Animal Model Of Behavioral Therapy, Jing Liu, Sarah E Bulin, David A Morilak May 2026

Antidepressant-Like Effects Of Extinction Learning As An Animal Model Of Behavioral Therapy, Jing Liu, Sarah E Bulin, David A Morilak

Faculty, Staff and Student Publications

Exposure-based behavioral therapy, the most effective treatment for posttraumatic stress disorder (PTSD), also reduces depressive symptoms. However, neurobiological mechanisms underlying the beneficial effects of exposure-based behavioral therapy on depression remain unknown. Our lab has established fear extinction as a rat model of exposure therapy to investigate the mechanisms underlying its therapeutic behavioral effects in chronically stressed rats. In this study, we demonstrated that extinction learning reduced immobility in the forced-swim test and reversed chronic stress-induced reduction in sucrose preference. Chemogenetic inactivation of pyramidal neurons in the ventral medial prefrontal cortex (vmPFC) prevented these antidepressant-like effects of extinction. Extinction learning enhanced …


Creating Space For New Ideas And Advancing Gender Equity In Physical Activity And Health Research: Reflections On The Nature Portfolio Physical Activity Series, Andrea Ramírez Varela, Deborah Salvo, Pedro C Hallal, Erica Hinckson May 2026

Creating Space For New Ideas And Advancing Gender Equity In Physical Activity And Health Research: Reflections On The Nature Portfolio Physical Activity Series, Andrea Ramírez Varela, Deborah Salvo, Pedro C Hallal, Erica Hinckson

Faculty, Staff and Student Publications

No abstract provided.


Computational Modeling Meets 3d Bioprinting: Emerging Synergies In Cardiovascular Disease Modeling, Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L Tomov, Emilio A Mendiola, Vahid Serpooshan, Reza Avazmohammadi May 2026

Computational Modeling Meets 3d Bioprinting: Emerging Synergies In Cardiovascular Disease Modeling, Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L Tomov, Emilio A Mendiola, Vahid Serpooshan, Reza Avazmohammadi

Faculty, Staff and Student Publications

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, underscoring the need for improved strategies in diagnosis, treatment, and disease modeling. Traditional in vitro models often fall short in replicating human CV physiology, prompting efforts to advance cardiac tissue engineering and computational modeling. Among these, three-dimensional (3D) bioprinting has emerged as a transformative tool, enabling the creation of biomimetic CV constructs that more faithfully replicate native tissue structure and function. However, challenges persist in achieving appropriate mechanical properties and long-term performance of engineered CV constructs. Computational modeling offers powerful solutions to assist with these challenges, providing predictive insights into …