Digital Commons Network^™

Tumor Matrix Stiffness Provides Fertile Soil For Cancer Stem Cells, Sadegh Safaei, Roya Sajed, Ahmad Shariftabrizi, Shima Dorafshan, Leili Saeednejad Zanjani, Masoumeh Dehghan Manshadi, Zahra Madjd, Roya Ghods

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases from the tumor core to the tumor periphery in a gradient pattern in a variety of solid tumors and can promote proliferation, invasion, metastasis, drug resistance, and recurrence. Cancer stem cells (CSCs) are a rare subpopulation of tumor cells with self-renewal, asymmetric cell division, and differentiation capabilities. CSCs are thought to be responsible for metastasis, tumor recurrence, chemotherapy resistance, and consequently poor clinical outcomes. Evidence suggests that matrix stiffness can activate receptors and mechanosensor/mechanoregulator proteins such as integrin, FAK, and YAP, modulating the characteristics of tumor cells …

Primary Issues: Nh Insists First-In-Nation Primary Stays First; Confident Votes Will Be Accurately Counted 7/20/2023, Unh Survey Center

All UNH Survey Center Polls

Six in ten New Hampshire residents support a New Hampshire law that requires the state's Presidential Primary to be held before any similar contest. More than four in five likely New Hampshire primary voters are confident that their vote in upcoming elections will be accurately counted. Undeclared voters, a key voting block who can vote in either party's primary in the state, lean towards participating in the Republican primary over the Democratic primary featuring a sitting President.

The Effects Of Psychological Distress And Retention Intervals On The Fading Affect Bias And Response Time, Kayla Yvette Mccracken

Electronic Theses and Dissertations Archive

The Fading Affect Bias (FAB) is a phenomenon in which emotions associated with negative memories generally tend to fade faster over time than those of positive memories. Although researchers have shown that this phenomenon tends to be reversed in individuals who are diagnosed as depressed, less is known about the degree to which varied or general levels of psychological distress impact this phenomenon. Further, less is known about the impact of varied retention intervals not only on the Fading Affect Bias, but also the degree to which the memories are recalled in a similar manner. The aim of this thesis …

Shared Treatment Decision Making On Hyperthyroidism Among Chinese Women Planning For Pregnancy, Feifei Gu

Electronic Theses and Dissertations Archive

Women of childbearing age are a high-risk group for hyperthyroidism. Although several hyperthyroidism treatment options are available, none are optimal. Women with hyperthyroidism planning to become pregnant may face the challenge of making a “trade-off” treatment decision for a future safe pregnancy. Shared treatment decision making (STDM) is an ideal model for physicians and patients to adopt in reaching an agreement and determining treatment decisions while considering the patient’s preferences, values, treatment costs and side effects. However, limited studies exist on STDM in women with hyperthyroidism before pregnancy. Therefore, this study aims to examine STDM on hyperthyroidism in Chinese women …

You Called Me What?: Threatened Masculinity, Social Dominance, And Attitudes Toward Lgb Laws, Kelli Nicole Wierzbicki

Electronic Theses and Dissertations Archive

The lesbian, gay, and bisexual (LGB) community continues to be impacted by rapidly changing legislative bills and decisions that restrict the rights of the members within the community. This leads to the importance of understanding the variables that might contribute to supporting the policy decisions of legislative representatives. The current study originated from a desire to explore relationships among factors that have been previously related to non-affirming attitudes to LGB individuals in general and restrictive LGB laws in particular. Numerous studies have linked adherence to traditional masculinity ideology and social dominance orientation (SDO) to negative attitudes toward LGB individuals and, …

How Does Our Voice Reflect Who We Are? Different Ways Of Relating To The Voice And The Self Using Implicit Association Tests., Audrey Elizabeth Tucker

Electronic Theses and Dissertations Archive

This study aims to examine individual differences of the voice’s contribution to the self via implicit and explicit associations. A new Implicit Association Test (IAT) about the voice was created and presented to vocal performers and community controls. One-hundred eleven participants completed this voice-related IAT, the Vocal Congruence Scale (VCS), and the Voice Handicap Index (VHI) via an in person, monitored, and timed Qualtrics survey. Findings demonstrated an implicit relationship between the voice and the self. Strength of implicit relationships between self and voice were greater for community controls than vocal performers. This IAT revealed divergent validity with the VCS …

Access To Financial Inclusion: Evidence From South-Asian Lower Middle-Income Country, Bangladesh, Rifat Jahan Loran

Electronic Theses and Dissertations Archive

Individuals may become financially vulnerable due to a lack of financial inclusion and services leading to a bad impact on a country’s economy. Earlier research suggests only limited studies were conducted on Bangladesh, a South Asian lower-middle income nation in case of formal finance. This study examines access to financial inclusion of Bangladesh where the analysis from 2017 Global Findex Dataset depicts the status of financial inclusion on different demographic segments. The findings show that larger usages of formal accounts, savings, and credits are strongly correlated with higher earnings and better education. Men and people in the working age range …

Study Of Gas Phase Ion Mutual-Neutralization Through Molecular And Langevin Dynamics Trajectory Simulation, Zhibo Liu

Electronic Theses and Dissertations Archive

Mutual-neutralization (MN) of cation-anion pairs is one of the key processes that determines the chemical compositions of reacting gas mixtures found in combustion, plasmas, and cosmic gas clouds. In the last few decades, experiments and modeling investigations have been conducted in free-molecular limit. However, the MN process is less extensively studied at near or beyond atmospheric pressure for relevant applications and the measured rate constant shows a clear pressure dependency. The present work focuses on developing a method based on trajectory simulation for a pressure range from the free molecular limit to atmospheric pressure. Langevin dynamics is incorporated to capture …

Exploring College Women's Perspectives On How Positive And Negative Body Image Impact Sexual Relationship Power, Jessica Eden Mandell

Electronic Theses and Dissertations Archive

Sexual relationship power (SRP) describes interpersonal power dynamics within romantic relationships. Gender roles reinforce patriarchal ideals of male dominance and contribute to SRP imbalances, which has been linked to numerous negative outcomes including intimate partner violence. Women of color and people in the U.S. MidSouth experience pronounced disparate rates of the negative outcomes associated with imbalanced SRP due to systemic inequities rooted in oppression. Objectification theory posits that the dehumanizing process of viewing women’s bodies as objects can lead to self-objectification and negative body image. Though ample research reveals a connection between body image and behavior in sexual contexts, less …

Does Breath Pattern Influence Reacting And Feeling?, Kiley Hazelton

Electronic Theses and Dissertations Archive

This experimental within-participant reversal paradigm quantified effects of breath manipulation on emotional reactivity and inhibition. Participants were assessed for inhibitory ability and emotional reactivity at baseline and following three breathing conditions: controlled neutral, resonance frequency, and variable breathing; selected to assess a range of breathing behavior from anxious breathing, vegetative breathing, and meditative breathing. Emotional reactivity was elicited using the International Affective Picture System and inhibition utilizing a verbal Stop Signal task. Dependent variables for emotion induction included self-reported mood and arousal using the Self-Assessment Manikin of Valence and Arousal, and for inhibition was response time and accuracy. For twenty-six …

Antiracist Challenges To Whitewashed Pedagogies: Diversifying First-Year Writing Through A Position Of Whiteness, Angela Morris

Electronic Theses and Dissertations Archive

Within the current kairotic moment where political attacks against Critical Race Theory and “woke” curriculums continue to gain traction, this dissertation refutes such attacks by offering investigations on how to best implement more inclusive classrooms that explore and examine the intersections of race and writing using antiracist pedagogical approaches. This dissertation features three separate mixed-methods studies all set within first-year writing (FYW) classrooms. Each study engages with one of the three questions: (1) how do we challenge white language supremacy in our writing classrooms through encouraging and investigating code-meshing, (2) how do challenge predilections towards white meritocratic discourse through the …

Self-Consistency And Self-Care Among Older Adults With Type 2 Diabetes, Jing Hu

Electronic Theses and Dissertations Archive

Evidence from previous studies showed that older adults with diabetes demonstrate low levels of self-care for managing their symptoms and blood glucose and have difficulty adhering to self-care behaviors for long periods of time. Since self-care is motivated by self-concept, the consistency of self-concept may help patients better cope with their health problems and form longstanding healthy behaviors. The purposes of this study are to: (1) examine the relationship between self-consistency and self-care among older Chinese adults with type 2 diabetes; (2) examine the bi-variate relationships among depressive symptoms, self-consistency, and self-care among older Chinese adults with type 2 diabetes; …

Do Individuals With Benign Vocal Fold Lesions Have Increased Vocal Load Due To Nuanced Differences In Language Use?, Samantha Powell

Electronic Theses and Dissertations Archive

Individuals who engage in larger amounts of voice use have greater vocal loads, which may contribute to the development of benign vocal fold lesions (BVFL). The Personality traits of extroversion and talkativeness has been a predominant theory about increased vocal load in those with BVFL. Ambulatory monitoring has verified increased vocal use in those with BVFL, adding intensity and fundamental frequency to describe vocal load. Three vocally healthy women and three women with BVFL provided conversation and narrative language samples that underwent language analysis. Descriptive analyses of language samples revealed those with BVFL used up to twice as many words …

The Role Of Civil Society In Authoritarian Legitimation In Bangladesh, Md Sahidul Islam

Electronic Theses and Dissertations Archive

While civil society is treated as a helpful instrument for democratization, it is not always a positive force in hybrid regimes. A robust civil society in a hybrid regime can be a threat to democracy. Moreover, civil society in a competitive authoritarian regime, a form of hybrid regime, can be a tool for the regime’s stability. A growing body of literature explains various strategies for maintaining authoritarian regime stability. Within the regime stability scholarship, researchers explain three pillars of stability: repression, co-optation, and legitimation. Along with repression and co-optation strategies, authoritarian regimes also focus on legitimation pillars due to the …

Protections For All? Attitudes Toward Civil Rights Protections For Trans And Gender Non-Binary Individuals, Morgan Bailey Bullard

Electronic Theses and Dissertations Archive

Despite the increase in visibility and recognition, the rights of LGBTQ+ people continue to be debated and politically challenged. Transgender and gender non-binary people specifically face barriers to healthcare, government documents, and public accommodations. Due to the lack of literature connecting attitudes and expansive systemic protections for this population, this study aims to examine the impact of several constructs and identify what may be critical to explore in future research as components of attitudinal change. Empathy, contact, salience of religious identity, gender role belief, political affiliation, and gender were all identified in previous literature as having a relationship with attitudes …

Survey Of Personalized Learning Software Systems: A Taxonomy Of Environments, Learning Content, And User Models, Heba Ismail, Nada Hussein, Saad Harous, Ashraf Khalil

All Works

This paper presents a comprehensive systematic review of personalized learning software systems. All the systems under review are designed to aid educational stakeholders by personalizing one or more facets of the learning process. This is achieved by exploring and analyzing the common architectural attributes among personalized learning software systems. A literature-driven taxonomy is recognized and built to categorize and analyze the reviewed literature. Relevant papers are filtered to produce a final set of full systems to be reviewed and analyzed. In this meta-review, a set of 72 selected personalized learning software systems have been reviewed and categorized based on the …

Genome-Wide Identification And Phenotypic Characterization Of Seizure-Associated Copy Number Variations In 741,075 Individuals, Shridhar Parthasarathy, Tobias Brünger, Rhys H Thomas, Michael Talkowski, Epi25 Collaborative, Ingo Helbig, Costin Leu, Dennis Lal

Faculty, Staff and Student Publications

Copy number variants (CNV) are established risk factors for neurodevelopmental disorders with seizures or epilepsy. With the hypothesis that seizure disorders share genetic risk factors, we pooled CNV data from 10,590 individuals with seizure disorders, 16,109 individuals with clinically validated epilepsy, and 492,324 population controls and identified 25 genome-wide significant loci, 22 of which are novel for seizure disorders, such as deletions at 1p36.33, 1q44, 2p21-p16.3, 3q29, 8p23.3-p23.2, 9p24.3, 10q26.3, 15q11.2, 15q12-q13.1, 16p12.2, 17q21.31, duplications at 2q13, 9q34.3, 16p13.3, 17q12, 19p13.3, 20q13.33, and reciprocal CNVs at 16p11.2, and 22q11.21. Using genetic data from additional 248,751 individuals with 23 neuropsychiatric phenotypes, …

Skidmore, Deceased, Appellants/Plaintiffs V. Sandy Health & Rehab; Daffodil : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Third Judicial District Court, Salt Lake County, Judge Amy Oliver, Case No. 180907304

Robert D. Strieper Strieper Law Firm Attorney for Appellant

Alexander Dushku (7712) Justin W Starr (10708) James T. Burton (11875) Austin D. Westerberg (16983) KIRTON McCONKIE Attorneys for Appellees

Phase Ii, Open-Label Study Of Encorafenib Plus Binimetinib In Patients With Brafv600-Mutant Metastatic Non-Small-Cell Lung Cancer, Gregory J Riely, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

PURPOSE: The combination of encorafenib (BRAF inhibitor) plus binimetinib (MEK inhibitor) has demonstrated clinical efficacy with an acceptable safety profile in patients with

METHODS: In this ongoing, open-label, single-arm, phase II study, patients with

RESULTS: At data cutoff, 98 patients (59 treatment-naïve and 39 previously treated) with

CONCLUSION: For patients with treatment-naïve and previously treated

Dynamic Mapping Of Proteome Trafficking Within And Between Living Cells By Transitid, James Messing, Brian D Freibaum, Steven Boeynaems, J Paul Taylor, Namrata D Udeshi, Steven A Carr, Alice Y Ting

Faculty, Staff and Students Publications

The ability to map trafficking for thousands of endogenous proteins at once in living cells would reveal biology currently invisible to both microscopy and mass spectrometry. Here, we report TransitID, a method for unbiased mapping of endogenous proteome trafficking with nanometer spatial resolution in living cells. Two proximity labeling (PL) enzymes, TurboID and APEX, are targeted to source and destination compartments, and PL with each enzyme is performed in tandem via sequential addition of their small-molecule substrates. Mass spectrometry identifies the proteins tagged by both enzymes. Using TransitID, we mapped proteome trafficking between cytosol and mitochondria, cytosol and nucleus, and …

Effect Of Implantable Cardiac Monitors On Preventing Stroke: A Systematic Review And Meta-Analysis Of Randomized Clinical Trials, Jialing He, Yaxin Jiang, Yangchun Xiao, Pengfei Hao, Tiangui Li, Liyuan Peng, Yuning Feng, Xin Cheng, Haidong Deng, Peng Wang, Weelic Chong, Yang Hai, Lvlin Chen, Chao You, Lu Jia, Fang Fang, Shui Yu, Yu Zhang

Department of Medical Oncology Faculty Papers

BACKGROUND AND AIM: Implantable cardiac monitors (ICM) can facilitate the detection of asymptomatic atrial fibrillation episodes. We performed a systematic review and meta-analysis to investigate whether ICM can prevent stroke in patients with prior stroke and risk factors for stroke.

METHODS: This study included randomized controlled trials comparing ICM with conventional (non-ICM) external cardiac monitoring in patients with prior stroke and risk factors for stroke. We searched Medline, Embase, and CENTRAL from inception until January 5, 2022, without language restriction. Quantitative pooling of the data was undertaken using a random-effects model. The primary outcome was ischemic stroke at the longest …

Two-Particle Azimuthal Correlations In Γp Interactions Using Ppb Collisions At √SNn=8.16tev, A. Tumasyan

Department of Physics and Astronomy: Faculty Publications

The first measurements of the Fourier coefficients (V_nΔ) of the azimuthal distributions of charged hadrons emitted from photon-proton (γp) interactions are presented. The data are extracted from 68.8nb⁻¹of ultra-peripheral proton-lead (pPb) collisions at √s_NN=8.16 TeVusing the CMS detector. The high energy lead ions produce a flux of photons that can interact with the oncoming proton. This γp system provides a set of unique initial conditions with multiplicity lower than in photon-lead collisions but comparable to recent electron-positron and electron-proton data. The V_nΔ coefficients are presented in ranges of event multiplicity and transverse momentum …

Ranchsatdb: A Genome-Wide Simple Sequence Repeat (Ssr) Markers Database Of Livestock Species For Mutant Germplasm Characterization And Improving Farm Animal Health, Naveen Duhan, Simardeep Kaur, Rakesh Kaundal

Plants, Soils and Climate Student Research

Microsatellites, also known as simple sequence repeats (SSRs), are polymorphic loci that play an important role in genome research, animal breeding, and disease control. Ranch animals are important components of agricultural landscape. The ranch animal SSR database, ranchSATdb, is a web resource which contains 15,520,263 putative SSR markers. This database provides a comprehensive tool for performing end-to-end marker selection, from SSRs prediction to generating marker primers and their cross-species feasibility, visualization of the resulting markers, and finding similarities between the genomic repeat sequences all in one place without the need to switch between other resources. The user-friendly online interface …

Game-Theoretic Analysis Of Financing Problems In Online Operations, Dianyao Kang

Lingnan Theses (MPhil & PhD)

Collaboration between banks and online platforms for financial services can help small- and medium-sized enterprises (SMEs) transform their actual transaction data into E-commerce credit, o§ering innovative solutions to their financing challenges. We consider an online system involving a bank, a platform, and a retailer who serves price-sensitive customers on the platform. The retailer receives a loan from the bank and pays a loan interest which is shared by the bank and the platform according to their negotiated allocation ratio. We examine two categories of scenarios to identify the optimal decisions and profit levels for the three firms involved in the …

China’S Governance: Strategy Choice And Future Vision For Combating Desertification, Guipeng Cui, Chunlei Xiao, Jiaqiang Lei, Xiaosong Li, Yingshuang Bao, Qi Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

China has made remarkable achievements in combating desertification over the past 70 years. At present, China has entered a new stage of combating desertification while facing many problems such as large desertification land base and high difficulty in combating desertification, and it is more important to meet the national strategic needs of ecological construction, rural revitalization, and the development and utilization of renewable energy in desert, Gobi, and wasteland areas. The strategic choice of combating desertification in China in the new era is overall improvement and key breakthroughs. The core of the strategy is whole-area governance, innovation-driven, and technology integration. …

Implementation Path And Strategic Planning Of Winning The Battle Of “Three-North” And Reconstructing “New Three-North”, Qi Lu, Chunlei Xiao, Yingshuang Bao, Mengchun Cui, Xiaoming Cao, Xiao Que, Liu Yang, Guipeng Cui

Bulletin of Chinese Academy of Sciences (Chinese Version)

Over the past 45 years, China has accomplished great achievements in carrying out “Three-North” project. Through largescale vegetation construction, the trends of land desertification, soil salinization, soil erosion and the deterioration of people’s living environment in the “Three-North” areas have been effectively restrained. The people in the desert area are getting rid of poverty and living a healthy life. In the new era, the “Three-North” project has encountered new demands, new challenges and new opportunities, and it is urgent to achieve a significant transform and upgrade and to improve quality and efficiency. This paper summarizes the current situation of the …

The Battle On The Edge Of Hexi Corridor–Taklimakan Desert: Wind-Blown Sand Situation And Prevention Tasks Of Desertification Control, Jiaqiang Lei, Xin Gao, Yongcheng Zhao, Heqiang Du, Qing He, Hongjing Ren, Xiaoyu Meng, Zihao Hu, Zuowei Yang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In order to implement the spirit of General Secretary Xi Jinping’s important speech on strengthening the comprehensive control of desertification and promoting key ecological engineering projects such as the “Three-North Shelterbelt Program”, this study is designated to make concrete efforts to win the battle against desertification on the edge of Hexi Corridor—Taklimakan Desert. The study deeply explores the situation of wind-blown sand flux and prevention tasks in the area. Based on the characteristics of desertified land and wind-blown sand activities on the edge of Hexi Corridor—Taklimakan Desert, the goal is set to effectively prevent the spread of sand and control …

Connotation And Countermeasures Of Scientific Research Paradigm Transformation In The New Era, Peng Du, Bingyu Zhao, Li Sun, Xiaojing Sha, Liqian Zhang, Zidan Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The purpose of this study is to comprehensively explore the main connotation and important impact of scientific research paradigm change from both theoretical and practical perspectives. On the theoretical level, starting with Kuhn and his The Structures of the Scientific Revolution, this study explores the logical essence of the concept of “paradigm”. At the practical level, through various forms such as questionnaires and interviews, the three connotations of scientific research paradigm change in the new era have been condensed. Namely, solving systematic and complex problems has become the main driving force for scientific research paradigm change in the new era, …

Philosophy Of Meta Publishing And Practice Of Platform Construction Toward Open Science, Jiansheng Qu, Chunjiang Liu, Qianfei Tian, Kemin Huang, Enbo Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Based on full investigation of the field of open publishing at home and abroad, this study expounds the role of open science in promoting the evolution of academic exchange system and mechanism, focuses on analyzing and summarizing the historical evolution, development change, and evolution law of academic publishing mode, and puts forward the meta-publishing concept that meets the needs of the open science era, so as to adapt to the development evolution and mode transformation of academic publishing. Based on the concept of “meta-publishing”, the idea of building a meta-publishing platform is proposed to promote the construction of a new …

International Soft Law Governance Of Artificial Intelligence Ethics: Current Situation, Challenges And Countermeasures, Mingting Zhu, Chongli Xu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Artificial intelligence (AI) technology not only rapidly empowers economic and social development, but may also trigger many ethical issues highly related to the characteristics and development of AI technology itself. The rise of international soft law in the field of AI ethical governance is almost inevitable due to its flexibility, efficiency, low application cost, ability to fill the gap in hard law, and convenience in distinguishing governance and layered response to ethical issues. Under the current situation of developed international soft law and outdated hard law in this field, faced with the governance challenge of unstable cooperation among subjects of …