Digital Commons Network^™

A Unified Switched Nonlinear Dynamic Model Of An Electric Vehicle For Performance Evaluation, Dibyendu Khan, Kuntal Mandal, Anjan Kumar Ray, Abdelali El Aroudi

Department of Electrical and Computer Engineering: Faculty Publications

The advanced modeling and estimation of overall system dynamics play a vital role in electric vehicles (EVs), as the selection of components in the powertrain and prediction of performance are the key market qualifiers. The state-space averaged model and small-signal transfer function model are useful for assessing long-term behavior in system-level analysis and for designing the controller parameters, respectively. Both models take less computation time but ignore the high-frequency switching dynamics. Therefore, these two models could be impractical for the development and testing of EV prototypes. On the other hand, the multi-domain model in available simulation tools gives in-depth information …

Ortho-Fluoro Effect On The C–C Bond Activation Of Benzonitrile Using Zerovalent Nickel, Sébastien Lachaize, Dominique C. Gallegos, Juliana J. Antonio, Abdurrahman C. Atesin, Tülay A. Ateşin, William D. Jones

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

The effect of fluoro substitution on the C–C bond activation of aromatic nitriles has been studied by reacting a variety of fluorinated benzonitriles with the nickel(0) fragment [Ni(dippe)] and by locating the reaction intermediates and transition-state structures on the potential energy surface by using density functional theory calculations with the [Ni(dmpe)] fragment (dippe = 1,2-bis(diisopropylphosphino)ethane, dmpe = 1,2-bis(dimethylphosphino)ethane). As in the previous reports, the reaction of fluorinated benzonitriles with the [Ni(dippe)] fragment initially formed an η2-nitrile complex, which then converted to the C–CN bond activation product. Thermodynamic parameters for the equilibrium between these complexes have been determined experimentally in both …

20230721_Open Educational Resources- What Are They And How Can I Use Them, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

Returning To Northern New Mexico. A Study Of The Nuevomexicano Lexicon., Guevara Del Angel

Spanish and Portuguese ETDs

Spanish in New Mexico prior to the 1900s was the predominant language of the region that began to be displaced with the growth of the English-speaking population during the 20th century. In this dissertation I refer to the Spanish language variety that has had the longest historical presence in northern New Mexico and Southern Colorado as Traditional New Mexican Spanish (TNMS, as per Bills & Vigil, 2008). This study aims to document aspects of maintenance and change regarding TNMS. The traditional heritage variety of New Mexican Spanish is changing in many ways, evolving from what has been documented in the …

State Of Urbanization In Nepal: The Official Definition And Reality, Keshav Bhattarai, Ambika P. Adhikari, Shiva Gautam

Himalayan Research Papers Archive

Nepali government’s official delineation of several human settlements as new urban areas has been questionable because many important criteria such as urban infrastructure and services, open space, population density and economic viability are not thoroughly analyzed while defining what is urban. Many settlements in Nepal officially defined as urban, often driven by political considerations, are operating in the rural framework forming ruralopolises. This paper analyzes various criteria needed for defining urbanization that are internationally accepted to assess Nepal’s official definition of urban settlements. Urban areas have been expanding in Nepal at the cost of agricultural, forest, and shrubland land uses. …

The Effect Of Mandatory Triage Questions On Triage Processes: A Qualitative Exploratory Study, Paul Clark Rn, Phd, Ma, Faen

Faculty and Staff Scholarship

Objective: The study purpose was to obtain an understanding of both the types of questions mandated for the triage encounter in emergency departments across the US, and how emergency nurses (EN) perceive the relevance of these questions to the triage process. Methods: a qualitative descriptive exploratory study using focus group data was used. Data were collected at an in-person emergency nursing conference held in September 2022. Data were analyzed using Mayring’s 8-step process. Results: Participants (n=35) voiced concerns about a lack of expertise at all points in the triage process. The overarching problem is reported as data required by regulatory …

New School Of Education Program Will Retrain Educators To Become School Psychologists, Adam Pope

Browse All News

No abstract provided.

Psychological Trauma In Terrorism (Pt2r): Phase 1 End Of Year Report, Matthew Crayne, Neil Shortland, Jennifer L. Mezzapelle, National Counterterrorism Innovation, Technology, And Education Center

Reports, Projects, and Research

About the Report. This report summarizes the findings of Phase 1 of the PT2R project, a study in the structural design of terrorism and targeted violence research as a profession. Drawn from qualitative analysis of interviews with 35 active terrorism and targeted violence researchers, this report provides a comprehensive job analysis of terrorism research which can be used to inform future selection, assessment, and training of researchers. Additionally, we explore the issue of exposure to traumatic material as a necessary component of terrorism and targeted violence research and identify job-embedded risk factors for psychosocial harm to researchers.

Optimizing Large-Capacity Key-Value Systems For Efficient Data Management, Kefei Wang

LSU Doctoral Dissertations

In today's Internet services, key-value system is playing a crucial and indispensable role, and has attracted extensive research in both academia and industry. During the past years, we have witnessed an unprecedented quick development of both memory-based and flash-based key-value systems. With the rapid evolution of memory and storage technologies, we are seeing both challenges and research opportunities.

In this dissertation, we focus on understanding and optimizing the efficiency of large-capacity, high-speed key-value systems from the perspective of both software and hardware to meet the ever-growing performance expectations. We first propose a multi-tier mapping structure, called Cascade Mapping, exploring the …

Clinical And Functional Correlates Of Parkinsonism In A Population-Based Sample Of Individuals Aged 75 +: The Pietà Study, Thiago Cardoso Vale, Francisco Eduardo Costa Cardoso, Danilo Jorge Da Silva, Elisa De Paula Franca Resende, Débora Palma Maia, Henrique Cerqueira Guimarães, Antônio Lúcio Teixeira, Paulo Caramelli, Maira Tonidandel Barbosa

Faculty, Staff and Student Publications

BACKGROUND: Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG].

METHODS: The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG …

Targeting Polyploid Giant Cancer Cells Potentiates A Therapeutic Response And Overcomes Resistance To Parp Inhibitors In Ovarian Cancer, Xudong Zhang, Jun Yao, Xiaoran Li, Na Niu, Yan Liu, Guang Peng, Anil K Sood, Jinsong Liu

Faculty, Staff and Student Publications

To understand the mechanism of acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells (PGCCs) in ovarian and breast cancer cell lines, high-grade serous cancer (HGSC)-derived organoids, and patient-derived xenografts (PDXs). Time-lapse tracking of ovarian cancer cells revealed that PGCCs primarily developed from endoreplication after exposure to sublethal concentrations of olaparib. PGCCs exhibited features of senescent cells but, after olaparib withdrawal, can escape senescence via restitutional multipolar endomitosis and other noncanonical modes of cell division to generate mitotically competent resistant daughter cells. The contraceptive drug mifepristone blocked PGCC formation and daughter cell …

Single-Cell Sequencing Reveals The Landscape Of The Human Brain Metastatic Microenvironment, Qianqian Song, Jimmy Ruiz, Fei Xing, Hui-Wen Lo, Lou Craddock, Lance D Miller, Stacey S O'Neill, Kounosuke Watabe, Michael D Chan, Jing Su

Faculty, Staff and Student Publications

Brain metastases is the most common intracranial tumor and account for approximately 20% of all systematic cancer cases. It is a leading cause of death in advanced-stage cancer, resulting in a five-year overall survival rate below 10%. Therefore, there is a critical need to identify effective biomarkers that can support frequent surveillance and promote efficient drug guidance in brain metastasis. Recently, the remarkable breakthroughs in single-cell RNA-sequencing (scRNA-seq) technology have advanced our insights into the tumor microenvironment (TME) at single-cell resolution, which offers the potential to unravel the metastasis-related cellular crosstalk and provides the potential for improving therapeutic effects mediated …

Genome-Wide Crispr-Cas9 Screen Analyzed By Slider Identifies Network Of Repressor Complexes That Regulate Trim24, Lalit R Patel, Sabrina A Stratton, Megan Mclaughlin, Patrick Krause, Kendra Allton, Daniela Barbosa, Michelle C Barton

Faculty, Staff and Student Publications

TRIM24 is an oncogenic chromatin reader that is frequently overexpressed in human tumors and associated with poor prognosis. However, TRIM24 is rarely mutated, duplicated, or rearranged in cancer. This raises questions about how TRIM24 is regulated and what changes in its regulation are responsible for its overexpression. Here, we perform a genome-wide CRISPR-Cas9 screen by fluorescence-activated cell sorting (FACS) that nominated 220 negative regulators and elucidated a regulatory network that includes the KAP1 corepressor, CNOT deadenylase, and GID/CTLH E3 ligase. Knocking out required components of these three complexes caused TRIM24 overexpression, confirming their negative regulation of TRIM24. Our findings …

Gold Nanoparticles For Monitoring Of Mesenchymal Stem-Cell-Loaded Bioresorbable Polymeric Wraps For Arteriovenous Fistula Maturation, Allan John R Barcena, Joy Vanessa D Perez, Jossana A Damasco, Marvin R Bernardino, Erin Marie D San Valentin, Benjamin Martin, Gino Martin Canlas, Huckie C Del Mundo, Francisco M Heralde, Rony Avritscher, Natalie Fowlkes, Richard R Bouchard, Jizhong Cheng, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

Mesenchymal stem cell (MSC)-seeded polymeric perivascular wraps have been shown to enhance arteriovenous fistula (AVF) maturation. However, the wraps' radiolucency makes their placement and integrity difficult to monitor. Through electrospinning, we infused gold nanoparticles (AuNPs) into polycaprolactone (PCL) wraps to improve their radiopacity and tested whether infusion affects the previously reported beneficial effects of the wraps on the AVF's outflow vein. Sprague Dawley rat MSCs were seeded on the surface of the wraps. We then compared the effects of five AVF treatments-no perivascular wrap (i.e., control), PCL wrap, PCL + MSC wrap, PCL-Au wrap, and PCL-Au + MSC wrap-on AVF …

Differential Effects Of Bariatric Surgery And Caloric Restriction On Hepatic One-Carbon And Fatty Acid Metabolism, Arnon Haran, Michael Bergel, Doron Kleiman, Liron Hefetz, Hadar Israeli, Bella Agranovich, Rachel Ben-Haroush Schyr, Eyal Gottlieb, Danny Ben-Zvi

Faculty, Staff and Student Publications

Weight loss interventions, including dietary changes, pharmacotherapy, or bariatric surgery, prevent many of the adverse consequences of obesity, and may also confer intervention-specific benefits beyond those seen with decreased weight alone. We compared the molecular effects of different interventions on liver metabolism to understand the mechanisms underlying these benefits. Male rats on a high-fat, high-sucrose diet underwent sleeve gastrectomy (SG) or intermittent fasting with caloric restriction (IF-CR), achieving equivalent weight loss. The interventions were compared to

Intraoperative Cortical Localization Of Music And Language Reveals Signatures Of Structural Complexity In Posterior Temporal Cortex, Cale W Morse

Faculty, Staff and Student Publications

Language and music involve the productive combination of basic units into structures. It remains unclear whether brain regions sensitive to linguistic and musical structure are co-localized. We report an intraoperative awake craniotomy in which a left-hemispheric language-dominant professional musician underwent cortical stimulation mapping (CSM) and electrocorticography of music and language perception and production during repetition tasks. Musical sequences were melodic or amelodic, and differed in algorithmic compressibility (Lempel-Ziv complexity). Auditory recordings of sentences differed in syntactic complexity (single vs. multiple phrasal embeddings). CSM of posterior superior temporal gyrus (pSTG) disrupted music perception and production, along with speech production. pSTG and …

Do Not Forget Them, Steve Minton

School of Psychology

Thousands of Indigenous children suffered and died in residential ‘schools’ around the world. Their stories must be heard.

Single-Cell Chromatin Accessibility Profiling Of Acute Myeloid Leukemia Reveals Heterogeneous Lineage Composition Upon Therapy-Resistance, Katarzyna Tomczak, Praveen Barrodia, Shaoheng Liang, Ken Chen, Linghua Wang, Zhongming Zhao, Kunal Rai, Abhinav K Jain, John Dick, Naval Daver, Andy Futreal, Hussein A Abbas

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by high rate of therapy resistance. Since the cell of origin can impact response to therapy, it is crucial to understand the lineage composition of AML cells at time of therapy resistance. Here we leverage single-cell chromatin accessibility profiling of 22 AML bone marrow aspirates from eight patients at time of therapy resistance and following subsequent therapy to characterize their lineage landscape. Our findings reveal a complex lineage architecture of therapy-resistant AML cells that are primed for stem and progenitor lineages and spanning quiescent, activated and late stem cell/progenitor states. Remarkably, …

Pragmatic, Randomized, Blinded Trial To Shorten Pharmacologic Treatment Of Newborns With Neonatal Opioid Withdrawal Syndrome (Nows), Alan Simon, Jessica Snowden, Claudia Pedroza, Barry Lester, Barry Eggleston, Drew Bremer, Elisabeth Mcgowan

Faculty, Staff and Student Publications

BACKGROUND: The incidence of maternal opioid use in the USA has increased substantially since 2000. As a consequence of opioid use during pregnancy, the incidence of neonatal opioid withdrawal syndrome (NOWS) has increased fivefold between 2002 and 2012. Pharmacological therapy is indicated when signs of NOWS cannot be controlled, and the objective of pharmacological therapy is to control NOWS signs. Once pharmacologic therapy has started, there is great variability in strategies to wean infants. An important rationale for studying weaning of pharmacological treatment for NOWS is that weaning represents the longest time interval of drug treatment. Stopping medications too early …

Blood Flow Restriction As A Potential Therapy To Restore Physical Function Following Covid-19 Infection, Isaac J. Wedig, John J. Durocher, John Mcdaniel, Steve Elmer

Michigan Tech Publications

Accumulating evidence indicates that some COVID-19 survivors display reduced muscle mass, muscle strength, and aerobic capacity, which contribute to impairments in physical function that can persist for months after the acute phase of illness. Accordingly, strategies to restore muscle mass, muscle strength, and aerobic capacity following infection are critical to mitigate the long-term consequences of COVID-19. Blood flow restriction (BFR), which involves the application of mechanical compression to the limbs, presents a promising therapy that could be utilized throughout different phases of COVID-19 illness. Specifically, we hypothesize that: 1) use of passive BFR modalities can mitigate losses of muscle mass …

Slow-Wave Modulation Analysis During States Of Unconsciousness Using The Novel Tau-Modulation Method, Tao Xie, Zehan Wu, Thomas J Foutz, Xinjun Sheng, Xiangyang Zhu, Eric C Leuthardt, Jon T Willie, Liang Chen, Peter Brunner

2020-Current year OA Pubs

No abstract provided.

Kappa Opioid Receptor Activation Increases Thermogenic Energy Expenditure Which Drives Increased Feeding, Aaron L Cone, Kenny K Wu, Alexxai V Kravitz, Aaron J Norris

2020-Current year OA Pubs

Opioid receptors, including the kappa opioid receptor (KOR), exert control over thermoregulation and feeding behavior. Notably, activation of KOR stimulates food intake, leading to postulation that KOR signaling plays a central role in managing energy intake. KOR has also been proposed as a target for treating obesity. Herein, we report studies examining how roles for KOR signaling in regulating thermogenesis, feeding, and energy balance may be interrelated using pharmacological interventions, genetic tools, quantitative thermal imaging, and metabolic profiling. Our findings demonstrate that activation of KOR in the central nervous system causes increased energy expenditure via brown adipose tissue activation. Importantly, …

Comparison Of Dna Vaccines With As03 As An Adjuvant And An Mrna Vaccine Against Sars-Cov-2, Navid Sobhani, George Udeani, Yong Li

Faculty, Staff and Students Publications

Emerging variants of SARS-CoV-2 call for frequent changes in vaccine antigens. Nucleic acid-based vaccination strategies are superior as the coding sequences can be easily altered with little impact on downstream production. mRNA vaccines, including variant-specific boosters, are approved for SARS-CoV-2. Here, we tested the efficacy of DNA vaccines against the SARS-CoV-2 Spike aided by the AddaS03 adjuvant using electroporation and compared their immunogenicity with an approved mRNA vaccine (mRNA-1273). DNA vaccination elicited robust humoral and cellular immune responses in C57BL/6 mice with Spike-specific antibody neutralization and T cells produced from 20 μg DNA vaccines similar to that from 0.5 μg …

Memory Rescue And Learning In Synaptic Impaired Neuronal Circuits

Faculty, Staff and Students Publications

Neuronal impairment is a characteristic of Alzheimer's disease (AD), but its effect on neural activity dynamics underlying memory deficits is unclear. Here, we studied the effects of synaptic impairment on neural activities associated with memory recall, memory rescue, and learning a new memory, in an integrate-and-fire neuronal network. Our results showed that reducing connectivity decreases the neuronal synchronization of memory neurons and impairs memory recall performance. Although, slow-gamma stimulation rescued memory recall and slow-gamma oscillations, the rescue caused a side effect of activating mixed memories. During the learning of a new memory, reducing connectivity caused impairment in storing the new …

Itag An Optimized Imid-Induced Degron For Targeted Protein Degradation In Human And Murine Cells, Elizabeth A Bowling, Cheyenne Calderon, John J Caldwell, Brinley Harrington, Angela Hayes, P Craig Mcandrew, Costas Mitsopoulos, Fernando Jr Sialana, Andrea Scarpino, Mark Stubbs, Arjun Thapaliya, Siddhartha Tyagi, Hannah Z Wang, Francesca Wood, Rosemary Burke, Florence Raynaud, Jyoti Choudhary, Rob L M Van Montfort, Amine Sadok, Thomas F Westbrook, Ian Collins, Rajesh Chopra

Faculty, Staff and Students Publications

To address the limitation associated with degron based systems, we have developed iTAG, a synthetic tag based on IMiDs/CELMoDs mechanism of action that improves and addresses the limitations of both PROTAC and previous IMiDs/CeLMoDs based tags. Using structural and sequence analysis, we systematically explored native and chimeric degron containing domains (DCDs) and evaluated their ability to induce degradation. We identified the optimal chimeric iTAG(DCD23 60aa) that elicits robust degradation of targets across cell types and subcellular localizations without exhibiting the well documented "hook effect" of PROTAC-based systems. We showed that iTAG can also induce target degradation by murine CRBN and …

A Daily Investigation Of The Recovery Paradox: Examining The Dynamic Interplay Of Workload, Recovery Experiences, And Microbreaks, Morgan Rose Taylor

Dissertations and Theses

Research has highlighted the importance of recovery from work stress during non-work time for employee health and wellbeing. Building on the recovery from work stress literature, this study examines the recovery paradox which suggests that employees may recover from work demands the least when they need it the most. Therefore, the purpose of this study is to shed light on the mechanisms underlying the recovery paradox. Specifically, this study examined whether a common work stressor, workload in the morning, is indirectly related to poorer recovery experiences in the evening through negative states at the end of workday. Furthermore, this study …

Accent Adjustment Based On Spoken Feedback, Keith Griffin

Defensive Publications Series

In some instances, such as for online video conferences, call center interactions, etc., it can be difficult to understand what someone is saying based on their accent. Presented herein is a solution through which natural language processing (NLP) can be utilized to facilitate an accent detector that can determine a problematic accent intent and adjust a speaker's accent by adjusting and normalizing the speaker's speech to a more relatable accent of a person with whom the speaker is communicating.

Back Cover, Maria Cruz

McNair Research Journal SJSU

No abstract provided.

A Cost-Effective And Smart Sensing Tissue-Like Testbed For Surgical Training, Lysette Zaragoza

McNair Research Journal SJSU

A low-cost tissue-like testbed with six nodes of varying stiffness was developed for surgical training to provide pressure and force feedback data through image reception to human operators. Using SolidWorks, a 3D model of the box trainer housing was created. A pad for the distribution of smartsensing nodes and microcontroller connections was designed with open spaces for the respective components. The pad was 3D-printed with PLA filament. Flat piezoelectric pressure sensors were fabricated with conductive materials and velostat sensor material. Using static and dynamic analyses, three top sensors were chosen to be used in three pressure sensing nodes. A calibration …

The Red Ribbon And The Black Cross: A Qualitative Study Of The Relationship Between Social Activism And Contemporary Black Church Responses To Hiv In Oakland, Ca, Justise Wattree

McNair Research Journal SJSU

The Black Church as a social institution has been a source of social activism during racial crises, but there is a lacking social activist response by Black churches to HIV’s disparate impact on Black communities. Previous research does not adequately explore the influence of community-based organizations on Black church responses to HIV in the context of social activism. This study examines the relationship between social activism and contemporary Black church responses to HIV in Oakland. It considers community-based organizations (CBOs) as potential drivers of social activism. Semi-structured interviews with Black church leaders in Oakland were conducted and content analyzed along …