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Dimethyl Sulfoxide Inhibits Bile Acid Synthesis In Healthy Mice But Does Not Protect Mice From Bile-Acid-Induced Liver Damage, Jing Qi, Bingning Dong, Shixia Huang, Shangang Zhao, Yi Zhu Aug 2023

Dimethyl Sulfoxide Inhibits Bile Acid Synthesis In Healthy Mice But Does Not Protect Mice From Bile-Acid-Induced Liver Damage, Jing Qi, Bingning Dong, Shixia Huang, Shangang Zhao, Yi Zhu

Faculty, Staff and Students Publications

Bile acids serve a vital function in lipid digestion and absorption; however, their accumulation can precipitate liver damage. In our study, we probed the effects of dimethyl sulfoxide (DMSO) on bile acid synthesis and the ensuing liver damage in mice induced by bile acids. Our findings indicate that DMSO efficaciously curbs bile acid synthesis by inhibiting key enzymes involved in the biosynthetic pathway, both in cultured primary hepatocytes and in vivo. Contrarily, we observed that DMSO treatment did not confer protection against bile-acid-induced liver damage in two distinct mouse models: one induced by a 0.1% DDC diet, leading to bile …

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A Dimensional Approach To Discrepancy In Parenting Styles In Russian Families, Elena L Grigorenko Aug 2023

A Dimensional Approach To Discrepancy In Parenting Styles In Russian Families, Elena L Grigorenko

Faculty, Staff and Students Publications

We investigated the magnitude and direction of differences in parenting styles as they relate to children's mental health problems, as assessed using the CBCL. The sample consisted of 306 families residing in a large industrial city in Russia. We aimed to expand the cross-cultural literature on parenting styles by assessing a sample of Russian families and analyzing how agreement versus disagreement between self-reported and partner-reported parenting styles related to children's mental health problems. The findings suggested that both congruence and incongruence between parenting styles could be associated with children's mental health problems. When parents agreed about high warmth and matched …

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Genetic Control Of Mrna Splicing As A Potential Mechanism For Incomplete Penetrance Of Rare Coding Variants, Jonah Einson, Dafni Glinos, Eric Boerwinkle, Peter Castaldi, Dawood Darbar, Patrick Ellinor, Stacey Gabriel, Soren Germer, Richard Gibbs, Craig P Hersh, Jill Johnsen, Robert Kaplan, Barbara A Konkle, Charles Kooperberg, Rami Nassir, Ruth J F Loos, Deborah A Meyers, Braxton D Mitchell, Bruce Psaty, Ramachandran S Vasan, Stephen S Rich, Michael Rienstra, Jerome I Rotter, Aabida Saferali, Moore Benjamin Shoemaker, Edwin Silverman, Albert Vernon Smith, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium; Pejman Mohammadi, Pejman Mohammadi, Stephane E Castel, Ivan Iossifov, Tuuli Lappalainen Aug 2023

Genetic Control Of Mrna Splicing As A Potential Mechanism For Incomplete Penetrance Of Rare Coding Variants, Jonah Einson, Dafni Glinos, Eric Boerwinkle, Peter Castaldi, Dawood Darbar, Patrick Ellinor, Stacey Gabriel, Soren Germer, Richard Gibbs, Craig P Hersh, Jill Johnsen, Robert Kaplan, Barbara A Konkle, Charles Kooperberg, Rami Nassir, Ruth J F Loos, Deborah A Meyers, Braxton D Mitchell, Bruce Psaty, Ramachandran S Vasan, Stephen S Rich, Michael Rienstra, Jerome I Rotter, Aabida Saferali, Moore Benjamin Shoemaker, Edwin Silverman, Albert Vernon Smith, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium; Pejman Mohammadi, Pejman Mohammadi, Stephane E Castel, Ivan Iossifov, Tuuli Lappalainen

Faculty, Staff and Student Publications

Exonic variants present some of the strongest links between genotype and phenotype. However, these variants can have significant inter-individual pathogenicity differences, known as variable penetrance. In this study, we propose a model where genetically controlled mRNA splicing modulates the pathogenicity of exonic variants. By first cataloging exonic inclusion from RNA-sequencing data in GTEx V8, we find that pathogenic alleles are depleted on highly included exons. Using a large-scale phased whole genome sequencing data from the TOPMed consortium, we observe that this effect may be driven by common splice-regulatory genetic variants, and that natural selection acts on haplotype configurations that reduce …

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Highlighting Rare Disease Research With A Genetics And G3 Series On Genetic Models Of Rare Diseases, Hugo Bellen Aug 2023

Highlighting Rare Disease Research With A Genetics And G3 Series On Genetic Models Of Rare Diseases, Hugo Bellen

Faculty, Staff and Students Publications

No abstract provided.

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Optimized Beam-Forming For Massive Mimo- Ofdm System, Nelly M. Shafik, Hazem H. El-Banna Aug 2023

Optimized Beam-Forming For Massive Mimo- Ofdm System, Nelly M. Shafik, Hazem H. El-Banna

Mansoura Engineering Journal

Massive Multiple-Input Multiple-Output (MIMO) wireless communication systems, achieved by large number of antennas, is the main secrete of Fifth Generation (5G) wireless communication networks powerful. In this paper, novel active antennas selection algorithm is proposed with resulted in efficient system performance with only half number of antenna elements. In order to gain optimum performance of massive MIMO wireless communication systems, it is vital to well analyze channel models which is glory indication for massive MIMO system characteristics. In this paper, MIMO system is simulated in bad frequency selective fading channel which is considered the most matching channel in case of …

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Full Issue Aug 2023

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

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Abraham And Isaac Story On Video Aug 2023

Abraham And Isaac Story On Video

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A new film produced by the LDS motion picture studio, Akedah: The Binding, richly portrays Abraham's great test of faith when God commanded him to sacrifice his son, Isaac.

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New Book Brings Isaiah's Writings To Life Aug 2023

New Book Brings Isaiah's Writings To Life

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Understanding Isaiah, a new book by Donald W. Parry, Jay A. Parry, and Tina Peterson, published by Deseret Book, examines Isaiah's message in light of historical and prophetic details.

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Reprint Probes How Evidence Facilitates Belief Aug 2023

Reprint Probes How Evidence Facilitates Belief

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A new FARMS reprint makes available a lengthy paper first presented by John W. Welch in 1995 at the twenty-fourth annual Sidney B. Sperry Symposium at BYU. In "The Power of Evidence in the Nurturing of Faith," Welch offers the most extensive analysis available of the role of evidence in strengthening one's faith in the Book of Mormon.

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Farms Welcomes Two New Staff Members Aug 2023

Farms Welcomes Two New Staff Members

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

FARMS is pleased to welcome Wendy C. Thompson and Jann E. Cahoon as its newest staff members.

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Lds Scholar Reviews Southern Baptists' Attempt To Understand So-Called Mormon Puzzle Aug 2023

Lds Scholar Reviews Southern Baptists' Attempt To Understand So-Called Mormon Puzzle

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

In anticipation of its June 1998 national meeting in Salt Lake City, the Southern Baptist Convention (SBC) released a kit of curriculum materials designed to assist Southern Baptists in understanding and evangelizing Latter-day Saints. Daniel C. Peterson's thorough and penetrating review of this material appears in the current FARMS Review of Books. Because of heavy prepublication interest, we are also making this review available as a separate reprint (see the order form).

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Byu Scholar Clarifies Mormon Faith Aug 2023

Byu Scholar Clarifies Mormon Faith

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

"One need not become either a convert to or a crusader for the LDS Church to understand the phenomenon or the people," Robert L. Millet explains in the preface to his new book, The Mormon Faith: A New Look at Christianity. "And if anything is needed in this complex and confusing world, it is understanding." To help promote understanding concerning the church and its members, Dr. Millet, BYU professor of ancient scripture, attempts to objectively and accurately inform the reader about LDS beliefs and practices.

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Former Farms President Receives Byu Appointment Aug 2023

Former Farms President Receives Byu Appointment

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Noel B. Reynolds, who recently stepped down as president of FARMS, has been named associate academic vice president for undergraduate studies at BYU. Reynolds has served on the FARMS board of directors for the past eleven years, as the organization's president for the past six years, and as director of the FARMS Center for the Preservation of Ancient Religious Texts for the past two years. BYU president Merrill J. Bateman extended the new appointment to Reynolds in April.

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Better That One Man Perish, John W. Welch, Heidi H. Parker Aug 2023

Better That One Man Perish, John W. Welch, Heidi H. Parker

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

When constraining Nephi to slay Laban, the Spirit gave the sober justification that "it is better that one man should perish than that a nation should dwindle and perish in unbelief" (1 Nephi 4:13). Alma invoked this same justification when reluctantly subjecting Korihor to divine punishment (see Alma 30:47). This principle runs sharply contrary to modern liberal jurisprudence, but a different view prevailed in certain cases under biblical law.

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Farms Review Of Books Examines Works That Misrepresent The Church Aug 2023

Farms Review Of Books Examines Works That Misrepresent The Church

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The new issue of the FARMS Review of Books (volume 10, number 1) reviews several recent publications that are critical of the LDS Church. The Review also examines a Book of Mormon study aid and two novels related to the Book of Mormon.

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Byu Research Center Gets New Director Aug 2023

Byu Research Center Gets New Director

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

One of the newest entities at Brigham Young University has a new director. The university administration has appointed Daniel C. Peterson, chairman of the FARMS board, to be the director of the Center for the Preservation of Ancient Religious Texts (CPART), a subsidiary of the Foundation for Ancient Research and Mormon Studies. He succeeds Noel B. Reynolds, who was recently named associate academic vice president of BYU (see story on page 3). This appointment will constitute Peterson's primary university assignment, and he will be released from most of his teaching duties during his service as director.

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Full Issue Aug 2023

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

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Elder Holland's Published Address On Isaiah Is Also Available On Tape Aug 2023

Elder Holland's Published Address On Isaiah Is Also Available On Tape

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

In the wake of the recent FARMS release of Isaiah in the Book of Mormon (1998), we have received a number of requests for the audiotape of the first chapter by Elder Jeffrey R. Holland, which was the keynote address at the FARMS symposium that resulted in the book. We are pleased to make that tape available again at a discount through the order form included with this issue of INSIGHTS.

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"Weasel Words"- A Feature Of Careful Scholarship Aug 2023

"Weasel Words"- A Feature Of Careful Scholarship

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Sometimes readers misunderstand the careful, deliberate phrasing that scholars commonly employ to ensure accuracy in their assertions. So-called weasel words like possibly and likely do not simply reflect timidity on the author's part; rather, they are often necessary to avoid overstatement and other misrepresentations of the facts.

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Books On Cd And Web Aug 2023

Books On Cd And Web

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Two new FARMS books, Book of Mormon Authorship Revisited and LDS Perspectives on the Dead Sea Scrolls, plus other FARMS volumes and more than two thousand other works, are included on a new CD, "Infobases Collectors Library."

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Imaging The Fire-Damaged Petra Scrolls Aug 2023

Imaging The Fire-Damaged Petra Scrolls

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A FARMS-sponsored team specializing in state-of-the-art imaging technology is producing remarkable images of the Petra scrolls. These ancient papyrus documents were found in a charred heap during the 1993 excavation of a sixth-century Byzantine church in Petra, in southwestern Jordan.

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Byu Symposium Honors Renowned Lds Scholar Aug 2023

Byu Symposium Honors Renowned Lds Scholar

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Scholars who contributed to the newly released FARMS book Mormons, Scripture, and the Ancient World: Studies in Honor of John L. Sorenson presented their papers at a symposium held at Brigham Young University on 21 March 1998. Sponsored by the BYU Department of Anthropology and FARMS, the half-day event featured seven LDS scholars who summarized their recent research and then responded to questions from the audience.

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New Volume Of Research Honors John L. Sorenson Aug 2023

New Volume Of Research Honors John L. Sorenson

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

To many, John L. Sorenson is best known for his research on the lands and cultures of Book of Mormon peoples, the topic of his 1985 book, An Ancient American Setting for the Book of Mormon, and the focus of his most recent book, Images of Ancient America: Visualizing Book of Mormon Life (see article on page 1). A highly trained anthropologist, Sorenson has often broken new ground in other areas of his discipline as well, such as his penetrating empirical studies of Mormon culture. Aside from teaching courses in anthropology and archaeology at BYU for many years, Sorenson …

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Deadline For Nibley Fellowships Aug 2023

Deadline For Nibley Fellowships

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Each year FARMS grants fellowships in the name of Hugh Nibley to promising graduate students pursuing degrees in fields of interest to FARMS. The fellowships honor Nibley's contributions to LDS scholarship. They are intended to help young scholars make contributions to research in fields related to ancient scripture.

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Farms Board Elects Oswald As Next President Aug 2023

Farms Board Elects Oswald As Next President

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The FARMS board of trustees has elected Daniel Oswald to serve as the next president of the Foundation. His title will change, becoming executive director of FARMS as the affiliation with Brigham Young University is completed. He replaces Noel B. Reynolds, who has served marvelously as president since November 1991.

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Drought In The Time Of Abraham, John A. Tvedtnes Aug 2023

Drought In The Time Of Abraham, John A. Tvedtnes

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Recent evidence of a three-hundred-year drought in ancient Mesopotamia is consistent with references in the Bible and in the book of Abraham to famine during Abraham's time (see Genesis 12:10; Abraham 1:29-30; 2:1, 4-5, 15-17).

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New Volume Explores King Benjamin's Speech Aug 2023

New Volume Explores King Benjamin's Speech

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A long-awaited, 679-page volume on King Benjamin's speech has just come off the press-one of four books that FARMS is pleased to have published independently in 1998 (see the articles above and on page 4). Edited by John, W. Welch and Stephen D. Ricks, King Benjamin's Speech: "That Ye May Learn Wisdom" is the culmination of many years' research on numerous aspects of this profound address.

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Images Of Ancient America Connects Mesoamerican Peoples And Lands To The Book Of Mormon Aug 2023

Images Of Ancient America Connects Mesoamerican Peoples And Lands To The Book Of Mormon

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Images of Ancient America: Visualizing Book of Mormon Life, by John L. Sorenson, richly portrays the daily lives of the ancient peoples of Mesoamerica and their likely connections to the record known as the Book of Mormon. This fullcolor, large-format volume, the newest release from FARMS, contains careful research and over five hundred high-quality illustrations and photographs that shape vague ghosts from the past into fleshand- blood people.

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Sprite, A Modular Template Of In-Space Propulsion, Mackenzie Kilcoin, Daniel Cavender, Nathan Daniel, Allison Lentz Aug 2023

Sprite, A Modular Template Of In-Space Propulsion, Mackenzie Kilcoin, Daniel Cavender, Nathan Daniel, Allison Lentz

Small Satellite Conference

Huntsville, AL is home to Plasma Processes, a materials company that creates high temperature material solutions for aerospace and defense applications. Their capabilities include several thermal spray coating techniques, near-net shape refractory metal fabrication, and an array of government and commercial customer entities. A Small Business Innovation Research (SBIR) contract received in 2016 pushed the development of Plasma's first fully integrated thruster assembly using component processes for thrust chambers, injector heads, and high temperature parts that Plasma creates daily for various entities. The thruster assembly used the ASCENT, or AF-M315E, propellant, which was first demonstrated on the Green Propulsion Infusion …

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Full Issue Aug 2023

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

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