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The Diamond, October 16, 2026, Dordt University Oct 2026

The Diamond, October 16, 2026, Dordt University

Dordt Diamond

  • Front Page: Defender Days Sports Preview: What's Going on this Weekend?; Two Years of Collaboration Bring Perennial Game to Iowa Schools; Student Engagement in Midterm Elections
  • Feature: Baja Buggy Blast: Dordt Students Build Offroad Racing Vehicle; Caffeine Craze: Coffee Habits on a College Campus; At Large: Campus Cats and What They Can Tell Us; The Truth About Office Hours; Celebrating Scholarship: "Dordt Writes" on October 16; Dordt's New Symphonic Band
  • News: El Niño: What It Is and Its Impacts for 2026; Dordt University Ranks Among Top Christian Colleges Nationally; Behind the Break: A Look Inside the Heartland Conference Weekend
  • Politics: …


Re: Request For Change To The Butte Priority Soils Operable Unit Clark Tailings Consolidated Waste Management Area Site Investigation Quality Assurance Project Plan Revision 0 (2026 Update), Josh Bryson Oct 2026

Re: Request For Change To The Butte Priority Soils Operable Unit Clark Tailings Consolidated Waste Management Area Site Investigation Quality Assurance Project Plan Revision 0 (2026 Update), Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Proof Of The Wave Function Identity, A New Symmetry Constraint For The Three-Electron Quantum Dot In A Magnetic Field And Ad Hoc Generalization To Bound Many-Electron Systems, Marlina Slamet, Viraht Sahni Oct 2026

Proof Of The Wave Function Identity, A New Symmetry Constraint For The Three-Electron Quantum Dot In A Magnetic Field And Ad Hoc Generalization To Bound Many-Electron Systems, Marlina Slamet, Viraht Sahni

Publications and Research

We prove the Wave Function Identity (WFI), a newly discovered property of solutions to the two-dimensional Schrödinger–Pauli equation for the 𝑁 = 3 electron Coulombically interacting harmonically bound ‘artificial atom’ or quantum dot in a uniform magnetic field. The symmetry is comprised of an interchange of the spatial coordinates of two electrons whilst keeping their spin moments unchanged, followed by an inversion of all three electron coordinates. The proof is achieved by first deriving the general form of the exact correlated wave function in the high-electron-correlation Wigner regime and then proving the WFI employing this form for a ground and …


Jose Santiago V. City Of Philadelphia Oct 2026

Jose Santiago V. City Of Philadelphia

2026 Decisions

USDC for the Eastern District of Pennsylvania


Book Review: Artificial Intelligence, Real Teaching: A Guide To Ai In Elt, Laura Nelson Oct 2026

Book Review: Artificial Intelligence, Real Teaching: A Guide To Ai In Elt, Laura Nelson

The Interdisciplinary Journal for Research on Pedagogy and Learning Design, Vol. 1, Issue 1., Fall 2026

Book Reviewed: Paiz, J. M., Toncelli, R., & Kostka, I. (2025). Artificial intelligence, real teaching: A guide to AI in ELT. University of Michigan Press.

As artificial intelligence continues to impact the learning environment, educators are faced with both the challenges and opportunities of integrating these tools into their classroom. Artificial Intelligence, Real Teaching: A Guide to AI in ELT, authored by Paiz, Tencelli, and Kostka, provides practical information for English language teachers learning to navigate AI in the classroom. The intended audience includes K-12 and higher education English language teachers, instructional coaches, and teacher educators who are …


Threading Tales: Library Engagement Through Stitchcraft​, Jennie Tobler-Gaston, Marina Zendejas Oct 2026

Threading Tales: Library Engagement Through Stitchcraft​, Jennie Tobler-Gaston, Marina Zendejas

Criss Library Faculty Proceedings & Presentations

StitchCraft began as a Crochet 101 session that fell short of its original goal but revealed a strong student desire for connection. In response, our academic library launched a weekly StitchCraft gathering that evolved into a sustained, student-driven community. This table talk explores how consistency, visibility, and student ownership transformed a one-time program into an ongoing outreach initiative, culminating in the distribution of 65 handmade winter items to campus community members.


Assessing Machine Learning Prediction Of Recycled Aggregate Concrete Strength With A Tabular Foundation Model, Jin Fan, Roshani Bharati, Gangyong Zhang, Hui Zhang, Ning Zhang, Yanling Zhang, Aixia Liang, Mandeep Pokhrel Oct 2026

Assessing Machine Learning Prediction Of Recycled Aggregate Concrete Strength With A Tabular Foundation Model, Jin Fan, Roshani Bharati, Gangyong Zhang, Hui Zhang, Ning Zhang, Yanling Zhang, Aixia Liang, Mandeep Pokhrel

Montclair State University Scholarship & Creative Works

Recycled aggregate concrete (RAC) supports more sustainable construction, but recycled concrete aggregate (RCA)'s heterogeneity complicates compressive-strength prediction. This study evaluates the Tabular Prior-data Fitted Network (TabPFN) against nine conventional machine-learning models using a standardized literature-derived database of 833 RAC mixtures. Cube strengths were converted to equivalent cylinder strengths, with conversion sensitivity also assessed. Among conventional models, CatBoost achieved the highest accuracy (R2 = 0.843), whereas TabPFN achieved R2 = 0.870, mean absolute error (MAE) = 3.924 MPa, and root mean squared error (RMSE) = 5.551 MPa. TabPFN also produced a lower RMSE than CatBoost across all four RCA replacement intervals …


Operations And Maintenance Report Grove Gulch Sedimentation Bay - Post-Storm 10.13.26 Silver Bow Creek/Butte Area Npl Site – Butte Priority Soils Operable Unit Consent Decree-Civil Action No. Cv 89-039-Bu-She, Josh Bryson Oct 2026

Operations And Maintenance Report Grove Gulch Sedimentation Bay - Post-Storm 10.13.26 Silver Bow Creek/Butte Area Npl Site – Butte Priority Soils Operable Unit Consent Decree-Civil Action No. Cv 89-039-Bu-She, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Striking Tools Of Indigenous North America: Rethinking Their Representations In Media, Literature, And Collection Systems, Wesley Martin Oct 2026

Striking Tools Of Indigenous North America: Rethinking Their Representations In Media, Literature, And Collection Systems, Wesley Martin

University Research

The striking tool as a concept has existed since time immemorial. Once Europeans began colonizing the North American continent, Indigenous striking tools became conflated with the word “tomahawk.” The meaning of tomahawks and other striking tools is distorted in history, because western scholars and artists saw them from a limited worldview. This distortion made its way into archaeological reports, museum displays, and digital collections’ metadata. Some typologies that collectors and museum staff make for tomahawks continue to limit how the public may see them. Professionals working in the material culture fields should consider how this occurs. This article demonstrates these …


Telling The Real Story: Documenting University And Community History Through Oral History Projects In The Central Washington University Archives And Special Collections, Julia Stringfellow Oct 2026

Telling The Real Story: Documenting University And Community History Through Oral History Projects In The Central Washington University Archives And Special Collections, Julia Stringfellow

Library Scholarship

No abstract provided.


Volume Cxlvi, Number 4, October 16, 2026, Lawrence University Oct 2026

Volume Cxlvi, Number 4, October 16, 2026, Lawrence University

The Lawrentian

No abstract provided.


Frequency-Dependent Cerebellar Circuits Independently Gate Social Vocalizations And Movement, Tao Lin, Benjamin R Arenkiel, Roy V Sillitoe Oct 2026

Frequency-Dependent Cerebellar Circuits Independently Gate Social Vocalizations And Movement, Tao Lin, Benjamin R Arenkiel, Roy V Sillitoe

Faculty, Staff and Students Publications

Communication depends on precise coordination between motor execution and cognition. Here we reveal that the cerebellum exerts real-time control over social vocalizations in adult mice. Optogenetic activation of excitatory cerebellar output in the superior cerebellar peduncle suppressed ultrasonic vocalizations with frequency-dependent potency while inducing distinct motor phenotypes. Systematic functional mapping across cerebellar regions and cell types revealed that vocal suppression can occur in the absence of overt motor impairment, suggesting selective control of vocal output beyond gross movement disruption. We identified the periaqueductal gray (PAG), a conserved midbrain vocal control center, as a key downstream mediator of this effect. Deep …


Becoming People Who See: Walking Alongside Those Impacted By Trauma, Kara L. Nutt Oct 2026

Becoming People Who See: Walking Alongside Those Impacted By Trauma, Kara L. Nutt

Faculty Work Comprehensive List

"In a world fixated on resilience and overcoming hardship, Christians are called to recognize and respond to the realities of trauma."

Posting about hearing and healing trauma­­­­­­­­ from In All Things, a blog which highlights the shared faithful and orthodox Reformed Christian perspective of our writers, exploring how to fearlessly engage with every aspect of modern life—until all is made new.

Becoming People Who See: Walking Alongside Those Impacted by Trauma


Determining Optimal Surveillance Practices For Pediatric And Young Adult Germ Cell Tumors, Alexandra M. Dunker Oct 2026

Determining Optimal Surveillance Practices For Pediatric And Young Adult Germ Cell Tumors, Alexandra M. Dunker

Summer Research Program Abstracts

No abstract provided.


Cover And Contents Oct 2026

Cover And Contents

Turkish Journal of Biology

No abstract provided.


The Collagen-Derived Tripeptide Gly-Pro-Hyp Suppresses Fgf-5 Expression And Promotes Anagen Induction In C3h/Hej Mice, Yun-Ho Kim, Jin Seok Kim, Woong Yong Kim, Hyun Jung Jo, Zhe Piao, Yeo Cho Yoon Oct 2026

The Collagen-Derived Tripeptide Gly-Pro-Hyp Suppresses Fgf-5 Expression And Promotes Anagen Induction In C3h/Hej Mice, Yun-Ho Kim, Jin Seok Kim, Woong Yong Kim, Hyun Jung Jo, Zhe Piao, Yeo Cho Yoon

Turkish Journal of Biology

Background/aim: Collagen-derived peptides have shown potential in promoting hair growth, yet their effects on catagen-inducing factors remain unexplored. In this study, the hair growth-promoting effects and molecular mechanisms of Collagen-Tripep20 (CTP), a collagen tripeptide preparation containing 3.2% Gly-Pro-Hyp (GPH), were explored, with a specific focus on fibroblast growth factor 5 (FGF-5) regulation.

Materials and methods: Female C3H/HeJ mice were randomly assigned to four groups (n = 10/group): control, CTP-LOW (400 mg/ kg/day), CTP-HIGH (800 mg/kg/day), and GPH (25.6 mg/kg/day). Following dorsal depilation, test substances were administered dailyvia oral gavage for 7 weeks. Hair regrowth was assessed by visual scoring, histological …


Pifithrin-Α Enhances Ex Vivo Hematopoietic Stem Cell Expansion, Nesli̇han Meri̇ç, Pinar Çolakoğlu Erkan, Fati̇h Kocabaş Oct 2026

Pifithrin-Α Enhances Ex Vivo Hematopoietic Stem Cell Expansion, Nesli̇han Meri̇ç, Pinar Çolakoğlu Erkan, Fati̇h Kocabaş

Turkish Journal of Biology

Background/aim: Hematopoietic stem cells (HSCs) are essential for treating hematological disorders; however, their low abundance and limited proliferative capacity restrict their clinical use. This study investigated whether pifithrin-α (PFT-α), a small-molecule p53 inhibitor with known genoprotective properties, could enhance the ex vivo expansion of HSCs.

Materials and methods: Mouse lineage-negative (Lin⁻) cells were isolated by magnetic depletion, while human umbilical cord blood (hUCB) and mouse bone marrow (mBM) mononuclear cells were obtained using density gradient centrifugation. CD34⁺ cells were subsequently isolated by fluorescence-activated cell sorting using an antimouse CD34 antibody. The isolated cells were cultured in StemSpan SFEM II (STEMCELL …


Anti-Helicobacter Pylori Activity Of Polycation-Coated Plga Nanoparticles Loaded With Juglone–Silver Complex, Tural Safarov, Emrah Şefi̇k Abamor, Serap Acar, Murat Topuzoğullari, Bükre Kiran Üner, Kübra Karadaş, Seçi̇l Kaya, Zi̇şan Toprak Oct 2026

Anti-Helicobacter Pylori Activity Of Polycation-Coated Plga Nanoparticles Loaded With Juglone–Silver Complex, Tural Safarov, Emrah Şefi̇k Abamor, Serap Acar, Murat Topuzoğullari, Bükre Kiran Üner, Kübra Karadaş, Seçi̇l Kaya, Zi̇şan Toprak

Turkish Journal of Biology

Background/aim: The rising antibiotic resistance of Helicobacter pylori requires the development of novel treatment approaches. Although natural products (e.g., juglone (5-hydroxy-1,4-naphthoquinone)) and metal antimicrobials (e.g., silver) hold some promise as alternatives, drawbacks like the toxicity and instability of these materials limit their clinical use. Combining juglone and silver with coordination bonds can overcome these drawbacks and yield a more effective antimicrobial complex.

Materials and methods: Juglone–silver (J–Ag) complex was synthesized, encapsulated into PLGA nanoparticles (J–Ag@PLGA), and coated with Eudragit (J–Ag@PLGA+eu). Structural and physicochemical properties of the produced samples were examined using MALDI-TOF MS, FTIR, and UV–Vis spectroscopies; dynamic light scattering; …


Understanding Antimicrobial Peptide Activation In Mesenchymal Stem Cells Through The Aryl Hydrocarbon Receptor Pathway And Inflammatory Signals, Cansu Özdemi̇r Saka, Beyza Turgut, Ceren Tuncay, Cemi̇l Can Eylem, Emi̇rhan Nemutlu Oct 2026

Understanding Antimicrobial Peptide Activation In Mesenchymal Stem Cells Through The Aryl Hydrocarbon Receptor Pathway And Inflammatory Signals, Cansu Özdemi̇r Saka, Beyza Turgut, Ceren Tuncay, Cemi̇l Can Eylem, Emi̇rhan Nemutlu

Turkish Journal of Biology

Background/aim: Antimicrobial peptides (AMPs) are small peptides involved in host defense and have been widely studied for their roles in innate immunity against microbial pathogens. Mesenchymal stem cells (MSCs), which provide stromal support in tissues such as bone marrow, are also capable of secreting AMPs, although the signaling pathways controlling this function remain unclear. The present study investigates the role of the aryl hydrocarbon receptor (AHR) signaling, a xenobiotic response pathway, in AMP production by MSCs.

Materials and methods: To assess AMP activation, human MSCs were stimulated with the agonist FICZ and antagonist SR1. TNF-α + IL-1β and LPS were …


Design And Synthesis Of A Novel Benzoxazine-Based Fluorophore With Potential For Lipid Droplet Targeting In Cancer Cells, Eda Açikgöz, Burak Kuzu, Mustafa Çakir Oct 2026

Design And Synthesis Of A Novel Benzoxazine-Based Fluorophore With Potential For Lipid Droplet Targeting In Cancer Cells, Eda Açikgöz, Burak Kuzu, Mustafa Çakir

Turkish Journal of Biology

Background/aim: Fluorescence-based visualization of lipid droplets is essential for understanding lipid-related mechanisms in cancer and other metabolic diseases. This study aimed to design and evaluate a novel benzoxazine-based fluorescent probe for selective lipid droplet imaging compatible with multiplexed fluorescence applications.

Materials and methods: A novel benzoxazine-based fluorophore (EA), inspired by the structural features of Nile Red, was synthesized via a two-step strategy. Structural characterization was performed using nuclear magnetic resonance and high-resolution mass spectrometry. Biological performance was assessed in cancer cells under fixed- and live-cell imaging conditions, including cytotoxicity evaluation and compatibility with dual staining.

Results: EA selectively localized to …


Msx2 Is An Erα-Associated Transcription Factor That Sustains Proliferative Capacity And Is Associated With Favorable Prognosis In Luminal Breast Cancer​​, Gamze Turan, Eli̇f Kansiz, Gözde Korkmaz, Hande Özkan Oct 2026

Msx2 Is An Erα-Associated Transcription Factor That Sustains Proliferative Capacity And Is Associated With Favorable Prognosis In Luminal Breast Cancer​​, Gamze Turan, Eli̇f Kansiz, Gözde Korkmaz, Hande Özkan

Turkish Journal of Biology

Background/aim: Breast cancer (BC) is the most frequently diagnosed malignancy among women and exhibits substantial molecular heterogeneity. Luminal tumors represent the largest molecular subtype and are primarily driven by estrogen receptor alpha (Erα), ahormone-dependent transcription factor (TF) that regulates gene expression programs controlling proliferation, differentiation, and endocrine response. Herein, the study aimed to identify functionally relevant TFs regulated by ERα as part of a complex regulatory program in luminal BC.

Materials and methods: An integrative transcriptomic approach was applied to identify TFs regulated by ERα in luminal BC. Differential gene expression analysis was integrated with RNA-seq data obtained from estrogen …


Comparison Of Tnfα, Ifnγ, And Dss In Modeling Inflammatory Bowel Disease In Murine Enteroids And Assessment Of The Role Of Zonulin Inhibitor Larazotide Acetate, Sema Nur Gür, Burcu Pervi̇n, Mehmet Emi̇n Şeker, Fati̇ma Aerts Kaya Oct 2026

Comparison Of Tnfα, Ifnγ, And Dss In Modeling Inflammatory Bowel Disease In Murine Enteroids And Assessment Of The Role Of Zonulin Inhibitor Larazotide Acetate, Sema Nur Gür, Burcu Pervi̇n, Mehmet Emi̇n Şeker, Fati̇ma Aerts Kaya

Turkish Journal of Biology

Background/aim: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. We hypothesized that the zonulin inhibitor larazotide acetate (LA), designed to regulate loss of tight junctions between intestinal cells and currently used for the treatment of celiac disease, could also have potential therapeutic value in the treatment of IBD.

Materials and methods: BALB/c enteroids were exposed to dextran sulfate sodium (DSS), tumor necrosis factor-alpha (TNFα), or interferon-gamma (IFNγ) for 48 h to induce an IBD-like environment, followed by treatment with LA. Organoids were assessed for intestinal permeability, viability, and expression of the zonulin (Hp), occludin (Ocln), …


Targeting Mitochondrial And Inflammatory Pathways In Abdominal Aortic Aneurysm: Discovery Of Sigma-1 And Ppar-Γ Agonists Through Plasma Microrna Profiling, Defne Çiğ Kabakcioğlu, İrem Peker Eyüboğlu, Medi̇ Kori̇, Fatma Betül Çeli̇k, Semra Meli̇s Soyer, Mustafa Çalişkan, Can Erzi̇k, Kazim Yalçin Arga, Ceyda Kasavi̇ Oct 2026

Targeting Mitochondrial And Inflammatory Pathways In Abdominal Aortic Aneurysm: Discovery Of Sigma-1 And Ppar-Γ Agonists Through Plasma Microrna Profiling, Defne Çiğ Kabakcioğlu, İrem Peker Eyüboğlu, Medi̇ Kori̇, Fatma Betül Çeli̇k, Semra Meli̇s Soyer, Mustafa Çalişkan, Can Erzi̇k, Kazim Yalçin Arga, Ceyda Kasavi̇

Turkish Journal of Biology

Background/aim: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease marked by progressive aortic dilation, high rupture-associated mortality, and a complete lack of effective pharmacological therapies. Because microRNAs (miRNAs) are key regulators of vascular inflammation, extracellular matrix remodeling, and smooth muscle cell function, they represent highly promising therapeutic targets. The aim of this study was to employ an integrative systems biology framework to identify novel miRNA-drug regulatory axes for AAA intervention.

Materials and methods: AAA transcriptome data were integrated with experimentally validated miRNA–mRNA interactions to prioritize candidate miRNAs. A total of 22 previously unreported miRNAs were selected for further analysis. …


Resveratrol Modulates Oxidative Stress-Associated Responses And Restores Keratinocyte Migration Following Lps-Induced Inflammatory Injury, Şeyma Dümür, Burcu Bi̇lteki̇n, Hafi̇ze Uzun Oct 2026

Resveratrol Modulates Oxidative Stress-Associated Responses And Restores Keratinocyte Migration Following Lps-Induced Inflammatory Injury, Şeyma Dümür, Burcu Bi̇lteki̇n, Hafi̇ze Uzun

Turkish Journal of Biology

Background/aim: Persistent inflammation disrupts keratinocyte migration and contributes to delayed wound healing. Lipopolysaccharide (LPS)-induced inflammatory models are widely used to investigate impaired reepithelialization and inflammatory cellular dysfunction. Resveratrol, a naturally occurring polyphenolic compound, exhibits antiinflammatory and antioxidant properties; however, its therapeutic effects on established inflammatory dysfunction remain insufficiently characterized. This study investigates the effects of resveratrol on LPS-induced keratinocyte dysfunction and compares them with those of boric acid (BA) under inflammatory conditions.

Methods: Human HaCaT keratinocytes were exposed to 10 μg/mL LPS to establish an inflammatory microenvironment. Following LPS pretreatment, the cells were treated with resveratrol (2, 5, or 10 …


Pgcc-Derived Daughter Cells Are Associated With Aggressive Phenotypes In Gastric Cancer​, Özlem Türksoy Terzi̇oğlu Oct 2026

Pgcc-Derived Daughter Cells Are Associated With Aggressive Phenotypes In Gastric Cancer​, Özlem Türksoy Terzi̇oğlu

Turkish Journal of Biology

Background/aim: Polyploid giant cancer cells (PGCCs) have been implicated in tumor recurrence, therapeutic resistance, and cellular plasticity; however, the biological properties of PGCC-derived daughter cells (PGCC-DCs) in gastric cancer remain poorly understood. The present study aimed to evaluate the molecular and functional characteristics of these progeny cells in a gastric cancer model.

Methods: The PGCCs were induced in HGC-27 gastric cancer cells using cobalt(II) chlorideCoCl2-mediated hypoxic stress and enriched by size-based filtration. The PGCC-DCs were isolated through single-cell culture and characterized using molecular and functional assays. Clinical assessments of the cellular parameters were conducted by comparing the PGCC-DCs with parental …


North Georgia Honor Orchestra 2026 Oct 2026

North Georgia Honor Orchestra 2026

Bailey School of Music Concert Programs

The North Georgia Honor Orchestra is a unique event designed to bring together the most talented pre-college string instrumentalists in and around North Georgia to focus on developing advanced technical and musical skills under the guidance of the exceptional KSU Bailey School of Music faculty. The two-day event includes orchestral rehearsals and sectionals, and other activities, culminating in a performance by the orchestra in KSU’s renowned Morgan Concert Hall. Students are invited to participate based on nominations submitted by their orchestra directors.


You Can’T Spell Remediation Without Ai: Generative Ai Across The Resident Remediation Cycle, Timothy Kuchera, Md, Peter Yen, Md Oct 2026

You Can’T Spell Remediation Without Ai: Generative Ai Across The Resident Remediation Cycle, Timothy Kuchera, Md, Peter Yen, Md

Department of Medicine Posters

BACKGROUND 

  • Remediation is high-stakes, longitudinal, and documentationintensive.¹ 
  • Faculty synthesize fragmented qualitative and performance data into individualized plans and high-stakes decisions.¹,⁴ 
  • GenAI is increasingly studied in GME assessment and feedback; longitudinal remediation remains underexplored.²,⁵

OBJECTIVE
Map current and emerging GenAI applications across the remediation cycle, including opportunities, limitations, and priorities for responsible implementation.


Vina V. Cuevas Oct 2026

Vina V. Cuevas

All Decisions

In consolidated Small Claims actions, the court holds that a prime tenant who sublet an illegal basement apartment (no CO) is barred from collecting rent under MDL § 302(1)(b). The sublease was also independently void because the prime tenant's lease expressly excluded the basement, leaving him no possessory interest to convey. The prime tenant is ordered to return the security deposit for failure to comply with GOL § 7-108 itemization requirements, but is awarded damages for unpaid electricity.


Preliminary Investigations Into Measuring Cold Hardiness Of Passiflora Hybrids, Eric Stafne, Haley Williams, Jenny Ryals, Blair Sampson Oct 2026

Preliminary Investigations Into Measuring Cold Hardiness Of Passiflora Hybrids, Eric Stafne, Haley Williams, Jenny Ryals, Blair Sampson

Publications

Measuring cold hardiness of Passionfruit (Passiflora spp.) is an area of significant interest, especially in new regions where the crop is expanding. However, few studies have explored it in a controlled manner. A previous study by Quesada (1992) revealed that lethal temperatures (LT50) for P. edulis f. flavicarpa were -9 to -10.5°C and -10 to -12.5°C for P. edulis f. edulis. Another species, P. incarnata, was also tested and found to have a cold hardiness level of -11.1 to -13.5°C. In the present study, differential thermal analysis was used on roots of P. incarnata selections from different …


Astaxanthin Elicits A Shared Transcriptional Core And Divergent Cell-Type-Specific Responses In Mcf-7 Breast And Ovcar-3 Ovarian Carcinoma Cells, Duygu Aygüneş Jafari Oct 2026

Astaxanthin Elicits A Shared Transcriptional Core And Divergent Cell-Type-Specific Responses In Mcf-7 Breast And Ovcar-3 Ovarian Carcinoma Cells, Duygu Aygüneş Jafari

Turkish Journal of Biology

Background/aim: Astaxanthin, a marine carotenoid, shows antiproliferative activity across cancer models, but its reported mechanisms vary widely by cell type and comparative studies with a common protocol are scarce. This study compared MCF-7 breast (estrogen/ progesterone receptor-positive; wild-type TP53) and OVCAR-3 ovarian carcinoma (high-grade serous; homozygous TP53 R248Q) cells after astaxanthin treatment at cell-line-specific IC50 concentrations.

Materials and methods: Cytotoxicity was measured by WST-1, apoptosis by annexin V/propidium iodide flow cytometry, and 43 cancer-associated genes by a pathway-focused RT-qPCR array (n = 3). Relative expression was calculated by comparative ΔΔCt method with ACTB as the reference gene.

Results: At 72 …