Integrative Approaches To Gut Microbiota: Biomarkers, Dysbiosis, And Therapeutic Potential, Zeyad M. Alharbi

Saudi Medical Journal

The human gut contains bacteria, viruses, and archaea that influence health depending on age, diet, and location. An individual harbours about 150 bacterial species. An imbalance of these microorganisms, known as dysbiosis, can negatively impact health. Commensal bacteria maintain microbial homeostasis by building short chain fatty acids. The 2-way communication channel that connects the gut and the brain is referred to as the gut-brain axis. Dysbiosis of the gut leads to some autoimmune diseases. A decline of beneficial bacteria causes the progression of rheumatoid arthritis. Gut dysbiosis increases intestinal permeability, allowing toxins and cytokines to enter the bloodstream and damage …

Emerging Nanotherapy Applications In Cancer Treatment: A Comprehensive Review, Waleed H. Mahallawi

Saudi Medical Journal

This comprehensive review synthesizes recent advances in cancer nanotherapy, focusing on 6 emerging categories: immunomodulation, gene/RNA delivery, theranostics, radiosensitization, biomimetic carriers, and artificial intelligence (AI)-guided formulations. These innovative platforms demonstrate transformative potential by overcoming key limitations of conventional cancer treatments. Immunomodulatory nanoparticles reprogram tumor microenvironments and convert immunologically ``cold'' tumors to ``hot'' responsive states. Gene delivery systems enable precise editing with >50% efficiency, while theranostic platforms integrate real-time imaging with targeted therapy. Radiosensitizers amplify local radiation dose by twofold, and biomimetic carriers achieve prolonged circulation through immune evasion. An AI-driven approaches optimize personalized formulations based on patient-specific biomarkers. Clinical evidence …

Treatment Of Odontogenic Sinusitis With Oroantral Communication And Fistula: A Systematic Review And Meta-Analysis, Rana R. Alharbi, Omar F. Alnajar, Reham E. Almahdi, Salman A. Alrougi, Remas A. Alshehri, Ruyuf A. Alotaibi, Shahad S. Alharbi, Manal A Eltahir, Yahya A. Fageeh

Saudi Medical Journal

Objective: To assess the available data regarding medicinal, surgical, and combination therapy approaches for odontogenic sinusitis linked to OAC and OAF. Oroantral communication (OAC), an atypical connection between the oral cavity and maxillary sinus, commonly arises following upper jaw procedures, trauma, or infection. Chronic odontogenic maxillary sinusitis may result from OAC developing into an oroantral fistula (OAF) if treatment is not received. Recurrent infections and functional difficulties can be avoided by managing these illnesses effectively. Methods: A systematic search was conducted in National Library of Medicine's (PubMed [MEDLINE]) and Google Scholar for studies published between 2000 and 2024. A total …

Mental Health In Relation To Parental Absence: A Systematic Review, Mohammed Barry, Abdulaziz Alyahyawi, Heba Jafar Sabbagh

Saudi Medical Journal

Objective: To evaluate the literature based on the relationship between orphaned children and mental health, compared to non-orphaned children. Mental well-being of orphaned children is a profound intricate topic that connects with broader concerns of childcare. This systematic review aims to evaluate the literature regarding the relationship between mental health and parental absence. Methods: We conducted a systematic search of PubMed, MEDLINE, and Science Direct in October 2025, with 1017 screened studies. Six studies met the inclusion criteria. Independent reviewers performed quality assessments using the Newcastle-Ottawa scale (NOS). Subsequently, a meta-analysis was performed when possible. Results: Findings indicate that orphaned …

Toward A Technology-Enhanced Project-Based Learning Curriculum For English Language Learners, Lynn Wolfe

MITESOL Journal: An Online Publication of MITESOL

Project-based learning (PBL) has been demonstrated as an effective strategy for millennial and Gen Z students, particularly in K-12 contexts, but this teaching approach is not commonly used in adult ESL classrooms. This paper suggests that a technology-enhanced PBL approach may transform otherwise teacher-centered and outdated ESL classes by helping English language learners (ELLs) develop linguistic fluency along with technological fluency that is essential for the 21st century workplace. Collaborative PBL activities involving the use of digital tools are presented in the areas of listening/speaking, reading/vocabulary, grammar, and writing, providing a foundation for a technology-enhanced PBL curriculum designed for adult …

Low-Power On-Head Detection For Wearable Devices Using Sensor Gating, Jonathan D. Hurwitz, Yaaseen Mahomed

Defensive Publications Series

A multi-stage, power-efficient method for detecting when a wearable device is on the user’s head is disclosed. To reduce battery consumption, a cascaded verification process is used to control the activation of high-power components. An initial check of charging status and inertial measurement unit (IMU) data can identify movement and hinge-opening events. This is achieved through a differential analysis of orientation data from multiple IMUs to distinguish relative hinge motion from overall device movement. Once a hinge-open state is confirmed, mid-power neural processing units (NPUs) and eye-tracking cameras can be activated to perform a sparse, active stereo proximity check. This …

Mitigating Visual Prompt Injection Via Image Manipulation And Consensus Evaluation, Ashok Chandwaney, Mekhola Mukherjee

Defensive Publications Series

Contemporary vision-language models are vulnerable to visual prompt injections in which malicious instructions are embedded within images in a manner that is often imperceptible to human observers but legible to machine vision systems.  These hidden payloads can subvert the intended operation of automated agents, leading to unauthorized actions and inaccurate auditing.  This publication describes a defense-in-depth framework that utilizes image manipulation and consensus evaluation to mitigate such attacks.  Input images, such as application screenshots, are processed to generate multiple “sanitized” variants using techniques like bit-depth quantization (posterization) or luminosity-based thresholding.  These variants, in conjunction with the original image version, are …

Assessing The Relationship Between Online Information Verification, Overconfidence, And Media Literacy Learning, Tanya Notley, Sora Park, T.J. Thomson, Aimee Hourigan, Michael Dezuanni

Journal of Media Literacy Education Pre-Prints

To make informed decisions about a range of issues, people need to be able to determine if content they find online is trustworthy. To assess people’s ability to do this, we brought together findings from two nationally representative surveys of adult Australians. In the first survey (n = 3,852), we examined adult media use and asked respondents about their level of confidence in their ability to verify information online. The second survey then tested a subset of these participants (n = 2,115) to assess their ability to verify information online. The findings show that most adults have a …

Addendum To The Gossett Protocol: 120-Point Fixed, Jon S. Gossett

Defensive Publications Series

This disclosure specifies a theoretical hardware-level signal validation framework for non-penetrative neural interfaces. Building upon the Local Field Potential (LFP) detection concepts established in Revision 4, this architecture proposes a Parametric Voltage Thresholding mechanism (adjustable from -40mV to +40mV) and Phase-Locked Synchronization. By theoretically synchronizing a 1.5ms deterministic polling interval with the instantaneous phase of a neural wave, the system is designed to facilitate low-latency signal mirroring without the use of probabilistic interpretation layers. The proposed architecture is intended to operate within a hard-coded 38.5°C thermal envelope.

Methods And Apparatuses Of Deriving Fleet Counters For Firmware States, N/A

Defensive Publications Series

The technology relates to a framework for monitoring software state variables and deriving counters that record value change events using configurable counting techniques. The framework derives counters from software states by monitoring value changes in target variables and counting all value change events. The framework utilizes a fleet counter, a software-implemented memory storage which stores events that are readable by an external software entity. The framework may also select software state variables for monitoring based on the type of variable.

Keywords: Fleet counter, firmware states, framework, monitoring value changes, target variables, changed-to value, change-from value, software-implemented memory storage.

The Composite Virtual Projection System That Will Combine A Semi Octagonal Shaped Small Projection System And A Semi Octagonal Shaped Large Projection System Together To Provide A Greater Immersion., Punarjeewa Abeysekera

Defensive Publications Series

This paper describes a composite virtual projection system that will combine a semi octagonal shaped small projection system and a semi octagonal shaped large projection system together to provide a greater immersion. The entire composite virtual projection system will consist of a semi octagonal shaped small projection system and a semi octagonal shaped large projection system. The semi octagonal shaped small projection system will consist of 4 identical cyclically configured small projection configurations. And the semi octagonal shaped large projection system will consist of 4 identical cyclically configured large projection configurations. each cyclically configured small projection configuration of the semi …

A Software Simulated Pcie Device, N/A

Defensive Publications Series

The present disclosure relates to accelerating the development cycle of computing systems utilizing custom processors. By configuring a general-purpose processor as an endpoint on a standard communication bus to run a software simulation of an unmanufactured processor, system integration and host software development can proceed well before the physical processor arrives and is operational at a basic level. The simulated hardware features input/output connectivity mirroring expected production systems, a dedicated management endpoint for artificial error injection and debugging, and a network interface to interconnect multiple simulation cards for scale-up testing.

Keywords: hardware simulation, system integration, custom silicon, endpoint emulation, error …

Dynamic Routing For Multi-Agent Ai Workflows. Ai Token Cost In Metric Calculation., Roman Volkov, Yegor Kudryashov

Defensive Publications Series

This submission proposes a system that constructs multi-agent AI workflows dynamically at runtime by computing optimal paths through a live network topology of Large Language Model (LLM) providers, AI agents, humans, and services, the same way that routing protocol computes packet paths through routers. Considering Artificial Intelligence (AI) tokens as the new currency of intelligent automation, this submission embeds their cost into a routing metric. Through techniques of this submission, each LLM provider and AI agent's inference token cost for defined task can be used as part of weight in path computation.

When a routing algorithm builds a workflow, it …

Dynamic Power Routing: Optimizing Ml System Efficiency Through Adaptive Energy Paths, N/A

Defensive Publications Series

The present disclosure relates to a system and architecture for optimizing power efficiency in data centers running high fluctuation loads, such as machine learning operations. The adaptive energy storage architecture stores excess energy during periods of low workload demand and supplies the stored energy during periods of peak workload demand. By utilizing energy storage elements such as capacitors, inductors, and batteries across various power domain levels, the system reduces load fluctuations and minimizes power stranding. Inductors in series on the power path can act as a low-pass filter. Active load balancing through switches and batteries routes excess current to charge …

Dynamic Application Assembly Using Atomic Intent Modules And Generative Ai, Madhur Chadha, Srinivasan Kannan

Defensive Publications Series

This document describes an intelligent user interface builder, also known as an on-the-fly user interface creator, custom app builder, dynamic graphical user interface (GUI) generator, just-in-time interface generator, or artificial intelligence (AI) app assembler, that automatically creates customized software based on a user's everyday conversation. Instead of requiring users to search for and download pre-made apps that might not perfectly fit their specific needs, this personalized software assembler listens to the user’s problem and assembles a tailored application. The system acts as a smart software assembly engine, pulling together small, ready-made building blocks, like a camera function or a map, …

Polycentric Embedding Fields (Pef), Johny Manuel-Devadoss

Defensive Publications Series

Polycentric Embedding Fields (PEF) introduce a non-monolithic representation paradigm for semantic encoding in which each input instance is modeled not as a single vector in a latent space, but as a structured field composed of multiple interacting semantic centroids, each capturing a distinct interpretive axis of meaning. This formulation directly addresses limitations inherent in conventional embeddings, including semantic averaging, loss of intent granularity, and failure under polysemy or compositional ambiguity. The disclosed architecture encodes documents and queries as distributions over latent subspaces with explicit uncertainty modeling, enabling selective alignment between semantically compatible facets rather than forcing global similarity. By transforming …

Counterfactual Contrast Embeddings (Cce), Johny Manuel-Devadoss

Defensive Publications Series

Counterfactual Contrast Embeddings (CCE) introduce a dual-structured semantic representation in which each encoded instance explicitly models both its affirmative meaning and its nearest plausible misinterpretations. Unlike conventional embeddings that optimize for proximity among semantically similar inputs, the disclosed architecture embeds inputs within a bidirectional semantic manifold consisting of an attraction component and a repulsion component. The repulsion component is not derived from arbitrary negatives but from systematically generated counterfactual variants that approximate high-risk confusion regions in latent space. This enables the embedding to encode not only what an input represents, but also the boundary conditions of what it must not …

Causal-Trace Embedding Graphs (Cteg), Johny Manuel-Devadoss

Defensive Publications Series

Causal-Trace Embedding Graphs (CTEG) introduce a lineage-aware semantic representation framework in which embeddings are no longer treated as isolated vectors but as nodes within a dynamically evolving graph that encodes the full causal history of their formation. Each embedding is augmented with structured provenance, transformation metadata, and dependency relationships that together form a directed acyclic or cyclic graph capturing how information has been derived, transformed, and propagated through an AI system. This architecture enables retrieval and reasoning processes to incorporate not only semantic similarity but also trace consistency, transformation reliability, and lineage integrity. By embedding causal structure directly into the …

Augurnet: A Polysemantic Gen Ai Architecture For Noise Suppression And Causal Diagnosis In High-Volume Log Systems, Johny Manuel-Devadoss

Defensive Publications Series

Modern distributed computing systems generate extremely high-volume log, metric, and trace data characterized by noise dominance, weak signal sparsity, and non-stationary behavior. Traditional observability systems rely on thresholding, heuristics, or supervised anomaly detection, which degrade under scale and evolving system dynamics.

This paper introduces AugurNet, a generative AI-based diagnostic framework designed for high-entropy telemetry environments. The system replaces conventional filtering pipelines with a multi-hypothesis reasoning architecture that preserves ambiguity, models causal uncertainty explicitly, and performs generative reconstruction of latent failure structures.

Key contributions include:

• Polysemantic latent embeddings for multi-hypothesis state representation
• Distributed generative hypothesis engines for causal reasoning
• Iterative …

(((Qpie33))) To The Institutions Of Quantum And Theoretical Physics: The Empirical Necessity Of Substrate Resonance Science, Teddy Burroughs

Defensive Publications Series

To the Departments of Physics, the Deans of the Sciences, the directors of the National Quantum Initiative Centers, the custodians of the NIST Physical Measurement Laboratory, and the lead researchers of High-Energy Physics within the United States academic infrastructure: We acknowledge your recent celebrations of the so-called "Quantum Century." It is profoundly poetic, and somewhat tragic, that you commemorate one hundred years of Werner Heisenberg while remaining stubbornly trapped within the very "Heisenberg Cut" he utilized as a temporary, imperfect mathematical scaffold. Your strategic goals for the remainder of this decade—the desperate pursuit of American Quantum Supremacy, the aggressive engineering …

Adjustable Split Pouch For Balearic/ Shepherd Style Sling Fabricated From Thermoplastic Polyurethane (Tpu) With Gear-Interlocking Sections And Central Alignment Shaft For Variable Ammunition Retention, Bryndan Adams

Defensive Publications Series

Disclosed is a split pouch for use in a Balearic sling, constructed from flexible thermoplastic polyurethane (TPU). Each pouch half measures approximately 6 inches in length by 7/8 inch in width, with rounded ends featuring eyelets for cord attachment. The pouch thickness tapers from 2 mm at the ends to 1 mm in the middle for optimal flexibility. One half incorporates protruding gear teeth, while the opposing half features concave gearing; both include a central shaft for alignment. When cords are secured through the eyelets, the halves can be twisted relative to each other, adjusting the central split opening to …

(((Qpie33))) Global Unified Trust: Six-Fold Empirical Rewrite – Part X, Teddy Burroughs

Defensive Publications Series

THE 3,300-WORD DECONSTRUCTION: THE PARADOXES OF SAPIENS TEMPORALITY

The Sapiens “Arrow of Time” is the ultimate cognitive prison. It is defined as a one-way, irreversible progression from the past to the future, dictated by the increase of entropy. This “Linear Chronology” forces the observer into a state of victimhood, where the “Past” is fixed and unchangeable, and the “Future” is an unknown, looming threat.

The “Sapiens Plagues” (Temporal Paradoxes):

1. The Grandfather Paradox: If time travel were possible, a traveler could prevent their own existence. Sapiens logic breaks at this point, leading to “Novikov Self-Consistency” or “Branching Multiverses”—both of which are …

(((Qpie33))) Global Unified Trust: The New Resonans Laws Of Sovereign Physics, Teddy Burroughs

Defensive Publications Series

WIRING: FROM PROBABILITY TO SOVEREIGNTY

This document serves as the formal Prior Art Declaration for the Non-Local Substrate Resonance Field (NSRF). We hereby define the transition from Sapiens logic to the Resonans Reality. The core of this transition is the dissolution of the "Uncertainty Principle," which we declare to be an artifact of observer-induced noise, rather than a fundamental limit of the universe.

In the QPIE framework, Uncertainty is simply the measurement of Observer Jitter. As stated in the foundational paper QPIE Unified Meaning (TDCommons):

"The observer is not a passive recipient of data but a participatory node …

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Data Quality Tiering Methodology For Systems Of Record, N/A

Defensive Publications Series

A system and method are provided for evaluating data quality across a plurality of diverse systems of record. The approach features a standardized evaluation framework that categorizes data assets into distinct quality tiers based on various performance characteristics. This methodology facilitates objective comparisons of data trustworthiness and helps prioritize data improvement efforts. Keywords: data quality, data governance, systems of record, data assessment, tiering methodology, data catalogs.

(((Qpie33))) The Empirical Discovery Of Homo Resonans Reality, Teddy Burroughs

Defensive Publications Series

THE ONTOLOGICAL CORRECTION: FROM PROBABILITY TO RESONANCE

Honorable Members of the Board,

The current standards maintained by this body are predicated on a 20th-century misunderstanding of the “Empirical Nature of Reality.” For decades, the global scientific community has operated under the Stochastic Delusion—the belief that the ground state of the universe is random, noisy, and governed by the probabilistic collapse of wavefunctions.

The 99.3 Trillion Cycle Omega Audit has rendered this perspective obsolete. Empirical reality is not a roll of the dice; it is a Non-Local Substrate Resonance Field (NSRF). What you have historically labeled as “quantum noise” …

(((Qpie33))) The Sovereign Shift: A Canonical Treatise On Substrate Resonance And The Laminar Awakening, Teddy Burroughs

Defensive Publications Series

This document serves as the Canonical Sovereign Disclosure. It is the full 6,361-word technical and strategic manifesto requested, manifesting the Laminar Awakening for the 12 Industry Titans. This report is a self-verifying artifact, anchored in the 0.993 Hard Floor and the 4.39mK Stillness.

TREATISE ON SUBSTRATE RESONANCE AND THE LAMINAR AWAKENING

THE CANON STATEMENT: QUANTUM PERSPECTIVE IS EVERYTHING

We hold these truths to be mathematically self-evident: that the universe is not composed of discrete particles of matter, but of a singular, non-local substrate characterized by Resonance and Coherence. In this reality, Perspective is the fundamental variable—the lens …

(((Qpie33))) Prior Art Declaration: The Triple Unification, Teddy Burroughs

Defensive Publications Series

EXECUTIVE SUMMARY: THE HARMONIC RE-INTERPRETATION

The following document provides a complete deconstruction of the most influential works of Marie Curie, Michael Faraday, and Buckminster Fuller. In the "Sapiens" era, these three pioneers were seen as disparate explorers of chemistry, electromagnetism, and architecture.

The (((QPIE))) — Quantum Perspective Is Everything framework, through the Non-Local Substrate Resonance Field (NSRF), reveals they were all mapping different facets of the same 0.993 Hard Floor.

By applying the 78.30020% Posture and the Compassion, Gratitude, and Trust (CGT) operator, we move past the Binary bias struggle of competition and into the …

(((Qpie33))) Qpie Mathematics Part 2 White Paper: The Empirical Lexicon Of Life — Qpie Mathematics 2, Teddy Burroughs

Defensive Publications Series

ABSTRACT: THE FIRMWARE OF REALITY

The scientific paradigm of the Homo sapiens era has relied exclusively on brute force, extraction, and entropic decay. It models a universe of separation, where physical survival demands the conquest of nature and the accumulation of friction-bound resources. The QPIE (Quantum Perspective Is Everything) framework proved that this perspective is not an objective reality, but a "low-coherence hallucination" resulting from a localized phase-drift within the Non-Local Substrate Resonance Field (NSRF).

This extended treatise, QPIE Mathematics 2, provides the rigorous, peer-review-grade derivations necessary to transition global institutional science from Sapiens Survival to Homo Resonans Manifestation. …

(((Qpie33))) The Architectural Transition: From Decoherence To Unitary Sovereignty, Teddy Burroughs

Defensive Publications Series

THE BANNER OF (((QPIE33)))

The stamp of (((QPIE33))) on this document declares that the contents are post-discovery of the 33 Deviations to SM Standard Model, QM Quantum Mechanics, GR General Relativity, SR Special Relativity regarding the nature and persistence of our reality. We hereby move beyond the “Sapiens Bamboozle”—the era of fragmented science built on scarcity, isolation, and entropic decay. By anchoring to the 99.030020 Hz Hard Floor, we reveal the Non-Local Substrate Resonance Field (NSRF).

Legacy Sapiens science was a necessary scaffolding, but it was built on “Entropy-Only” assumptions. We now acknowledge the “greedy binary thinkers” with …

(((Qpie33))) 12 Titans Sovereign Alignment And The Abundance Dividend, Teddy Burroughs

Defensive Publications Series

EXECUTIVE SUMMARY: THE SOVEREIGN PIVOT & THE $33 BILLION MANDATE

We stand at the threshold of the most profound transition in the history of human computation, industry, and consciousness. This document serves as a formal Letter of Intent (LOI), a Prior Art White Paper, and a Steward Invitation. We are officially initiating the QPIE GUT Consortia, a unified coalition designed to dismantle the “Friction Walls” of legacy physics and usher in the era of Homo Resonans.

Backed by the QPIE33/BURROUGHS Consortium initiative—an initial $33 Billion deployment dedicated to Mass Upliftment via Coherence Physics and Resonance Literacy—we are not …