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Articles 400171 - 400200 of 5211490
Full-Text Articles in Entire DC Network
Antiviral Cellular Therapy For Enhancing T-Cell Reconstitution Before Or After Hematopoietic Stem Cell Transplantation (Aces): A Two-Arm, Open Label Phase Ii Interventional Trial Of Pediatric Patients With Risk Factor Assessment, Michael D Keller, Jeffrey J Bednarski, Et Al.
Antiviral Cellular Therapy For Enhancing T-Cell Reconstitution Before Or After Hematopoietic Stem Cell Transplantation (Aces): A Two-Arm, Open Label Phase Ii Interventional Trial Of Pediatric Patients With Risk Factor Assessment, Michael D Keller, Jeffrey J Bednarski, Et Al.
2020-Current year OA Pubs
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients with inborn errors of immunity and/or post allogeneic hematopoietic stem cell transplant with refractory viral infections using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus. Primary endpoints were feasibility, safety, and clinical responses (>1 log reduction in viremia at 28 days). Secondary endpoints were reconstitution of antiviral immunity and persistence of the infused VSTs. Suitable VST …
Somatic Mutations Of Esophageal Adenocarcinoma: A Comparison Between Black And White Patients, Jinyoung Byun, Patricia D Castro, Spiridon Tsavachidis, Jianhong Hu, Harshavardhan Doddapaneni, Yi Han, Donna M Muzny, Richard A Gibbs, Christopher I Amos, Aaron P Thrift
Somatic Mutations Of Esophageal Adenocarcinoma: A Comparison Between Black And White Patients, Jinyoung Byun, Patricia D Castro, Spiridon Tsavachidis, Jianhong Hu, Harshavardhan Doddapaneni, Yi Han, Donna M Muzny, Richard A Gibbs, Christopher I Amos, Aaron P Thrift
Faculty, Staff and Students Publications
Esophageal adenocarcinoma is the most common histological subtype of esophageal cancer in Western countries and shows poor prognosis with rapid growth. EAC is characterized by a strong male predominance and racial disparity. EAC is up to fivefold more common among Whites than Blacks, yet Black patients with EAC have poorer survival rates. The racial disparity remains largely unknown, and there is limited knowledge of mutations in EAC regarding racial disparities. We used whole-exome sequencing to show somatic mutation profiles derived from tumor samples from 18 EAC male patients. We identified three molecular subgroups based on the pre-defined esophageal cancer-specific mutational …
Designing, Implementing And Testing An Intervention Of Affective Intelligent Agents In Nursing Virtual Reality Teaching Simulations—A Qualitative Study, Michael Loizou, Sylvester Arnab, Petros Lameras, Thomas Hartley, Fernando Loizides, Praveen Kumar, Dana Sumilo
Designing, Implementing And Testing An Intervention Of Affective Intelligent Agents In Nursing Virtual Reality Teaching Simulations—A Qualitative Study, Michael Loizou, Sylvester Arnab, Petros Lameras, Thomas Hartley, Fernando Loizides, Praveen Kumar, Dana Sumilo
School of Nursing and Midwifery
Emotions play an important role in human-computer interaction, but there is limited research on affective and emotional virtual agent design in the area of teaching simulations for healthcare provision. The purpose of this work is twofold: firstly, to describe the process for designing affective intelligent agents that are engaged in automated communications such as person to computer conversations, and secondly to test a bespoke prototype digital intervention which implements such agents. The presented study tests two distinct virtual learning environments, one of which was enhanced with affective virtual patients, with nine 3rd year nursing students specialising in mental health, during …
Cdk8/Cdk19 Promotes Mitochondrial Fission Through Drp1 Phosphorylation And Can Phenotypically Suppress Pink1 Deficiency In Drosophila, Kenneth Kin Lam Wong, Debdeep Dutta, Zelha Nil, Catherine Grace Burns, Oguz Kanca, Ye-Jin Park, Zhongyuan Zuo, Paul C Marcogliese, Katherine Sew, Hugo J Bellen, Esther M Verheyen
Cdk8/Cdk19 Promotes Mitochondrial Fission Through Drp1 Phosphorylation And Can Phenotypically Suppress Pink1 Deficiency In Drosophila, Kenneth Kin Lam Wong, Debdeep Dutta, Zelha Nil, Catherine Grace Burns, Oguz Kanca, Ye-Jin Park, Zhongyuan Zuo, Paul C Marcogliese, Katherine Sew, Hugo J Bellen, Esther M Verheyen
Faculty, Staff and Students Publications
Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19. These proteins have been shown to modulate transcriptional control by RNA polymerase II. We found that neuronal loss of Cdk8 severely reduces fly lifespan and causes bang sensitivity. Remarkably, these defects can be rescued by expression of human CDK19, found in the cytoplasm of neurons, suggesting a non-nuclear function of CDK19/Cdk8. Here we show that Cdk8 plays a critical role in the cytoplasm, with its loss causing elongated mitochondria in both muscles and neurons. We find that endogenous GFP-tagged Cdk8 can be found in both the cytoplasm and nucleus. …
Kenyon Collegian - April 18, 2024
Diagnosis And Current Treatment Strategies For Adult And Juvenile Hereditary Hemochromatosis, Tori Tyler, Amber Wiggins-Mcdaniel, Staton Mcbroom, Caroline Parry, Robert Tyler, Robert A. White
Diagnosis And Current Treatment Strategies For Adult And Juvenile Hereditary Hemochromatosis, Tori Tyler, Amber Wiggins-Mcdaniel, Staton Mcbroom, Caroline Parry, Robert Tyler, Robert A. White
Student Publications
Hemochromatosis is a common genetic disorder manifesting as an iron overload state requiring complex processes in diagnosis, treatment, and management of both adult, and pediatric, populations. This review outlines general diagnostic and treatment strategies for hemochromatosis detailing fundamental processes in iron excess, or iron overload, through physiologic function and associated pathological effects. Genetic mutations, as ascribed to hemochromatosis, have significant impact in producing pathophysiology. Understanding basic pathophysiological mechanisms can inform future diagnosis and treatment through advances such as erythrocytophoresis. Linking concepts related to the diagnosis, treatment, and management of adult and juvenile hereditary hemochromatosis with scientific advances may enlighten clinical …
Exogenous Oxytocin Increases Gaze To Humans In Male Cats, Madoka Hattori, Kodzue Kinoshita, Atsuko Saito, Shinya Yamamoto
Exogenous Oxytocin Increases Gaze To Humans In Male Cats, Madoka Hattori, Kodzue Kinoshita, Atsuko Saito, Shinya Yamamoto
Faculty, Staff and Students Publications
Although oxytocin (OT) plays a role in bonding between heterospecifics and conspecifics, the effects of OT on the formation of such interspecific social behavior have only been investigated between humans and dogs (Canis familiaris). In this study, for comparative evaluation of the effects of OT between dog-human and cat-human social interaction, we investigated the effects of exogenous OT on the behavior of domestic cats (Felis silvestris catus) toward humans. We intranasally administered OT or saline to 30 cats using a nebulizer and recorded their behavior (gaze, touch, vocalization, and proximity). The results showed an interaction between the administration condition and …
A Multimodal Study Of Augmented Reality In The Architectural Design Studio, Alejandro Veliz Reyes
A Multimodal Study Of Augmented Reality In The Architectural Design Studio, Alejandro Veliz Reyes
School of Art, Design and Architecture
Architectural design representations comprise physical (models, drawings) and digital media (3D models). Multimodal combinations of physical and digital representations are commonplace in professional contexts such as design reviews or building sites, and ‘making sense’ of these assemblies requires complex socio-cognitive processes and professional expertise. In that context, this paper follows a ‘sense-making’ approach, and theorises the impact of multimodal representations in architectural design tutorials. Hybrid physical/digital representations have been built using Augmented Reality (AR) and utilised in dialogues between students’ groups and design tutors. Design tutorials have been documented through video, workshops, observational notes and interviews to generate a grounded …
Benchmarking Your Cold Chain - Benchmarking Tool, Mark Mitchell, Adam Wade
Benchmarking Your Cold Chain - Benchmarking Tool, Mark Mitchell, Adam Wade
Turning The Dial conference
No abstract provided.
Benchmarking Your Cold Chain - Bega Case Study, Mark Mitchell, Adam Wade
Benchmarking Your Cold Chain - Bega Case Study, Mark Mitchell, Adam Wade
Turning The Dial conference
No abstract provided.
Benchmarking Your Cold Chain - Overview And Optimisation, Mark Mitchell, Adam Wade
Benchmarking Your Cold Chain - Overview And Optimisation, Mark Mitchell, Adam Wade
Turning The Dial conference
No abstract provided.
Communicating Sustainability Through Brand And Packaging, Min Teah
Communicating Sustainability Through Brand And Packaging, Min Teah
Turning The Dial conference
No abstract provided.
Design Principles For Sustainable Packaging, Nerida Kelton, Ralph Moyle
Design Principles For Sustainable Packaging, Nerida Kelton, Ralph Moyle
Turning The Dial conference
No abstract provided.
”Widsith Came To Talk: Preservation Of The Scop Within Old English Poetry”, Maya Johnson-Mccauley
”Widsith Came To Talk: Preservation Of The Scop Within Old English Poetry”, Maya Johnson-Mccauley
CURIO Symposium
No abstract provided.
After Fye: Exploring Sophomore Support At Gsu, Alex Gholston
After Fye: Exploring Sophomore Support At Gsu, Alex Gholston
CURIO Symposium
No abstract provided.
Identity In Kievan Rus’: An Inquiry Into Staraya Ladoga’S Ethnic Composition, Sutton Patterson
Identity In Kievan Rus’: An Inquiry Into Staraya Ladoga’S Ethnic Composition, Sutton Patterson
CURIO Symposium
No abstract provided.
Student Papers On New England's Contributions To Textiles And Design, Kristine Bolarinho, Allie Iaciofano, Ayelet Birmen
Student Papers On New England's Contributions To Textiles And Design, Kristine Bolarinho, Allie Iaciofano, Ayelet Birmen
Seminar in Textiles and Clothing
No abstract provided.
The Adequacy Of Foreign Direct Investment Guarantees - A Critical Analytical Study In Accordance With The Provisions Of Federal Law No. (32) Of 2021, Mohammed Ibrahim Almemari
The Adequacy Of Foreign Direct Investment Guarantees - A Critical Analytical Study In Accordance With The Provisions Of Federal Law No. (32) Of 2021, Mohammed Ibrahim Almemari
Thesis/ Dissertation Defenses
The great economic competition between countries, and their endeavor to strengthen their economy through various fields; Make them compete with each other in attracting foreign direct investments to their territories; However, these investments cannot move from their home country to another country without having economic advantages and incentives that encourage them to invest in a country other than the home country. Likewise, these investments cannot carry out their work in any country without having the investor has many guarantees that protect this investment, and these guarantees can only be achieved through the presence of a strong, renewable legislative environment that …
Brain/Computer Interfaces, Relational Ethics, And The Habitus Of Ableism, Rosie Wilkinson '06
Brain/Computer Interfaces, Relational Ethics, And The Habitus Of Ableism, Rosie Wilkinson '06
Midwest Ethics Symposium
No abstract provided.
Affinity: A Celebration Of Community Through Poetry, Evan A. Gates
Affinity: A Celebration Of Community Through Poetry, Evan A. Gates
Student Scholar Showcase
The language of poetry extends far beyond the creative writing classroom; song lyrics, Bible verses, instruction manuals, and even advertisements utilize the power of words to portray a message. Like an art portrait, everyone’s unique perception helps to create a larger sense of unity through diversity. Poets emphasize the many ways culture constructs varying opinions amongst the human race. At the University of Lynchburg, people of many different demographics share one common thread: the pursuit of community. Whether local or foreign, English teacher or scientist, white or black, Lynchburg is the centerpiece of intellectual curiosity. While the school remains situated …
Praise In The Collegiate Classroom: How Narcissism, Entitlement, Empathy, And A Desire For Fame Impact Student’S Preferences For Praise, Alexandra Crissman
Praise In The Collegiate Classroom: How Narcissism, Entitlement, Empathy, And A Desire For Fame Impact Student’S Preferences For Praise, Alexandra Crissman
Student Scholar Showcase
The purpose of this study was to examine the relationship between personality traits, namely narcissism, entitlement, empathy, and a desire for fame, and a preference for public praise in a student population. Past research has shown that those who are higher in narcissism are also higher in entitlement and that these rates have been rising with future generations. Past research has also indicated a negative relationship between narcissistic tendencies and empathy, inferring that those higher in narcissism tend to score lower on empathy measures. In this study, undergraduate students were surveyed online to determine scores on four measures of traits …
Music Therapy Techniques In The Commercial Music Industry, Sarah Heath
Music Therapy Techniques In The Commercial Music Industry, Sarah Heath
Liberty University Research Week
Despite the fact that music is commonly described as free therapy with easily accessible content in the modern age of streaming, most people do not realize that music they already listen to contains many legitimate, psychologically tested therapy. This creative artistic research study examines the role that music therapy processes and techniques play in affecting the form, songwriting and creative processes of the modern music industry. These foundational aspects of songs elicit neurological responses, the emotional effect of which is discussed and incorporated through creative research and implementation through a creative artifact. This study explores songwriting techniques found in various …
Epistolary Glossopoesis Tolkien’S Letter Writing And Language Invention, Andrew Higgins
Epistolary Glossopoesis Tolkien’S Letter Writing And Language Invention, Andrew Higgins
Journal of Tolkien Research
This paper was given when I was the Guest Speaker at The Annual Meeting of the UK Tolkien Society on 13 April 2024.
Recognizing Traps And Frightening Wolves: Foxes And Lions As A Representative Of Machiavellian Political Ideology In Shakespeare’S Comedies, Grace A. Powell
Recognizing Traps And Frightening Wolves: Foxes And Lions As A Representative Of Machiavellian Political Ideology In Shakespeare’S Comedies, Grace A. Powell
Student Scholar Showcase
While William Shakespeare’s plays and sonnets have been discussed time and time again over the past few centuries, one topic that has been less traversed is the connection between his Comedies and Niccolò Machiavelli’s political ideologies. This project will explore references of lions and foxes in Shakespeare’s Comedies and the leaders and monarchs within them to determine how beliefs about Machiavelli’s political ideology influenced Shakespeare’s literature and became symbols for leadership and power. This project will be important for gaining historical context on Machiavellian political discourse and how it was represented in the contemporary dramatic literature of William Shakespeare. I …
“I Thought I Knew”: Teaching Graduate Students New Ways Of Understanding Meanings Of Diverse Social Identities, Maria S. Johnson
“I Thought I Knew”: Teaching Graduate Students New Ways Of Understanding Meanings Of Diverse Social Identities, Maria S. Johnson
Feminist Pedagogy
Instructors should not assume that graduate students understand meanings of terms for various social identities. In this article, I highlight a teaching activity I created titled, “What’s in a name?” that requires graduate students to research historical and contemporary uses of various racial, ethnic, gender, sexuality, and immigration terms. The assignment helps graduate students develop inclusive vocabulary and deepen their understanding of their positionality. It also supports braver classroom contexts for students and instructors. The assignment is best facilitated by instructors informed of diverse social identities, open to difficult conversations, and aware of the influence of their own social identities …
Mocra And The New Cosmetics Gmps, Brandi Reinbold
Mocra And The New Cosmetics Gmps, Brandi Reinbold
Oxford ICSB
The Modernization of Cosmetics Regulation Act (MoCRA) enacted by Congress December 29th, 2022, includes provisions for the FDA to publish proposed Good Manufacturing Practice (GMP) regulations by the end of 2024 and a final rule by the end of 2025. In this talk we will explore what the language of MoCRA tells us about what GMPs are likely to be promulgated with a focus on GMPs related to ingredient and finished product identity and purity. MoCRA exempts small cosmetics manufacturers from GMP compliance requirements and directs FDA to “take it easy” on other not-quite-so-small manufacturers. Despite these exemptions, most cosmetics …
East Vs. West And Its Relationship With Violence Among College Students And Myanmar, Bryce Davis
East Vs. West And Its Relationship With Violence Among College Students And Myanmar, Bryce Davis
Student Scholar Showcase
With over 10 million men and women being targeted by domestic violence every year it has increased the need for research on the issue. Previous research has been conducted on how various crimes involving interpersonal violence can occur. The current study looks to expand on this previous research by assessing how interpersonal violence can occur. The study examines Eastern and Western cultures and how they can impact interpersonal violence. Previous research has shown that people born in eastern countries such as Asia have more of an acceptance of dating violence and rape. One hundred and thirty-six participants participated in the …
Birds Of Society: Applying External Adjustments And Conceptual Metaphor To The Importance Of Being Earnest, Morgan Forehand
Birds Of Society: Applying External Adjustments And Conceptual Metaphor To The Importance Of Being Earnest, Morgan Forehand
Liberty University Research Week
Despite the fact that music is commonly described as free therapy with easily accessible content in the modern age of streaming, most people do not realize that music they already listen to contains many legitimate, psychologically tested therapy. This creative artistic research study examines the role that music therapy processes and techniques play in affecting the form, songwriting and creative processes of the modern music industry. These foundational aspects of songs elicit neurological responses, the emotional effect of which is discussed and incorporated through creative research and implementation through a creative artifact. This study explores songwriting techniques found in various …
Input And Output In An English Classroom: A Young Learner Corpus Of English (Yolecore), Thomas Zapounidis, Marina Mattheoudakis
Input And Output In An English Classroom: A Young Learner Corpus Of English (Yolecore), Thomas Zapounidis, Marina Mattheoudakis
Journal of Educational Research and Innovation
This article highlights the need for a new type of corpus that will combine both a learner and a pedagogic corpus. The need for such a type of corpus is underlined by the interaction between input and output and the expected impact of the former on the latter within all instructional settings. Such a corpus will allow us to collect data, including teacher language, learner language, coursebook content, etc. and relate it to students’ output at specific points in time. Our study aims to present and describe the Young Learner Corpus of English (henceforth,YoLeCorE), which is an …
Critical Raw Material In Mineral Elements Found In Fly Ashes From The Czech Republic Power Plant, Agnieszka Klupa
Critical Raw Material In Mineral Elements Found In Fly Ashes From The Czech Republic Power Plant, Agnieszka Klupa
Journal of Sustainable Mining
The economic development of EU countries is limited due to limited access to a number of mineral raw materials, which necessitates actions aimed at securing the supply of CRM. For this reason, CRMs constitute elements of particular importance for the EU. The aim of the study was to assess the content of CRMs as a potential source of REY in fly ash resulting from the coal combustion in one of the power plants in the Czech Republic. In the tested ash the main phases are: glassy phase, mullite and quartz. The chemical composition of the tested fly ashes showed dominance …