Digital Commons Network^™

A Tetravalent Nanovaccine That Inhibits Growth Of Hpv-Associated Head And Neck Carcinoma Via Dendritic And T Cell Activation, Eva M Sevick-Muraca

Faculty, Staff and Student Publications

The global incidence of human papillomavirus (HPV) associated head and neck carcinoma is on the rise, in response to this a tetravalent therapeutic vaccine named Qβ-HPVag was developed. This vaccine, utilizing virus-like particles (VLPs) loaded with toll-like receptor ligands and chemically coupled to four HPV16-derived peptides, demonstrated strong anti-tumor effects in a murine head and neck cancer model. Qβ-HPVag impeded tumor progression, increased infiltration of HPV-specific T cells, and significantly improved survival. The vaccine`s efficacy was associated with immune repolarization in the tumor microenvironment, characterized by expanded activated dendritic cell subsets (cDC1, cDC2, DC3). Notably, mice responding to treatment exhibited …

Nurse Anesthetists’ Perceptions And Experiences Of Managing Emergence Delirium: A Qualitative Study, Ya-Ling Yan, Shuo Wang, Guang-Ming Zhang, Rui Li

Faculty, Staff and Student Publications

BACKGROUND: This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium (ED), a common and complex postoperative complication in the post-anesthesia care unit. The role of nurses in managing ED is critical, yet research on their understanding and management strategies for ED is lacking.

AIM: To investigate anesthetic nurses' cognition and management experiences of ED in hopes of developing a standardized management protocol.

METHODS: This study employed a descriptive phenomenological approach from qualitative research methodologies. Purposeful sampling was utilized to select 12 anesthetic nurses from a tertiary hospital in Shanghai as research …

Effectiveness Of Implementing Evidence-Based Approaches To Promote Physical Activity In A Midwestern Micropolitan Area Using A Quasi-Experimental Hybrid Type I Study Design., Barbara Baquero, Nicole Novak, Daniel K. Sewell, Christine M Kava, Jason Daniel-Ulloa, Hanh Pham, Natoshia Askleson, Sato Ashida, Helena Laroche, Adriana Maldonado Gonzalez, Rebecca Bucklin, Heidi Haines, Edith A. Parker, Active Ottumwa Community Advisory Board

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Much evidence-based physical activity (PA) interventions have been tested and implemented in urban contexts. However, studies that adapt, implement, and evaluate the effectiveness of these interventions in micropolitan rural contexts are needed. The study aimed to evaluate the effectiveness of the Active Ottumwa intervention to promote PA in a micropolitan community.

METHODS: Between 2013 - 2019, we implemented Active Ottumwa in a micropolitan setting, and subsequently implemented and evaluated its effectiveness using a Hybrid Type I design. In this paper, we describe the intervention's effectiveness in promoting PA. We collected PA data over 24 months from a cohort of …

Examining Populist Political Parties In The Baltic States, Lilly Thompson

Honors College Theses

Globally, populist political parties and leaders have been making gains over the last decade. Many of these populist leaders have been using their power to erode democratic institutions and public trust. While the Baltic states of Lithuania, Latvia, and Estonia have long distinguished themselves from the other post-communist countries of Eastern Europe, they are no exception to the populist trend. Under what conditions are populist political parties in the Baltic states successful? In this paper, I analyze the distinctive variables present that can explain the popularity of populism in all three states. I argue that there is a positive correlation …

Resonance: A Methodology And Pedagogy For Socially Just Storytelling, Helen Plevka-Jones

Theses and Dissertations

Through a close analysis of Valeria Luiselli’s Lost Children Archive and a comparative analysis of the intertexts it references, this dissertation argues that literary scholars and literacy pedagogues can learn from sound studies and archival practices together to achieve more socially just reading, writing, and teaching. The novel narrates a family traveling across the United States, not only experiencing their own journey but also learning about past forced migrations upon the same land and present attempted migrations into the country. As they encounter and interact with different print, audio, and visual artifacts, the characters achieve a more inclusive and complex …

Sleep And Circadian Biomarkers Of Postoperative Delirium (Sleep-Pod): Protocol For A Prospective And Observational Cohort Study, Elizabeth Sugg, Elizabeth Gleeson, Sarah N Baker, Peng Li, Chenlu Gao, Ariel Mueller, Hao Deng, Shiqian Shen, Esteban Franco-Garcia, Richa Saxena, Erik S Musiek, Oluwaseun Akeju, Zhongcong Xie, Kun Hu, Lei Gao

2020-Current year OA Pubs

INTRODUCTION: Surgical patients over 70 experience postoperative delirium (POD) complications in up to 50% of procedures. Sleep/circadian disruption has emerged as a potential risk factor for POD in epidemiological studies. This protocol presents a single-site, prospective observational study designed to examine the relationship between sleep/circadian regulation and POD and how this association could be moderated or mediated by Alzheimer's disease (AD) pathology and genetic risk for AD.

METHODS AND ANALYSIS: Study staff members will screen for eligible patients (age ≥70) seeking joint replacement or spinal surgery at Massachusetts General Hospital (MGH). At the inclusion visit, patients will be asked a …

Ipsc-Based Modeling Of Preeclampsia Identifies Epigenetic Defects In Extravillous Trophoblast Differentiation, Robert Morey, Tony Bui, Virginia Chu Cheung, Chen Dong, Joseph E Zemke, Daniela Requena, Harneet Arora, Madeline G Jackson, Donald Pizzo, Thorold W Theunissen, Mariko Horii

2020-Current year OA Pubs

Preeclampsia (PE) is a hypertensive pregnancy disorder with increased risk of maternal and fetal morbidity and mortality. Abnormal extravillous trophoblast (EVT) development and function is considered to be the underlying cause of PE, but has not been previously modeled

User-Driven Data Privacy Protection In An Iot Environment, Nivetha B, Frank Michaud, Rahul Kata, Pranetha Priya R, Ganesh Paramasivan

Defensive Publications Series

Techniques are presented herein that enhance user data privacy in an Internet of things (IoT) environment. Aspects of the techniques introduce a third actor into such an environment – apart from a user and an IoT device – whose sole purpose is to empower a user to protect their own data. Such a data Custodian or Sanitizer may collect inputs from a user through a software as a service (SaaS) solution and then leverage the capabilities of the extended Berkeley Packet Filter (eBPF) to apply those inputs to an IoT device.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

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Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

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The Migrant - Tennessee Ornithological Society

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Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

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Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

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The Migrant - Tennessee Ornithological Society

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Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

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Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

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The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

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The Migrant - Tennessee Ornithological Society

No abstract provided.

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The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.

Full Issue, The Migrant

The Migrant - Tennessee Ornithological Society

No abstract provided.