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The Echo: April 15, 2024, Taylor University Apr 2024

The Echo: April 15, 2024, Taylor University

2023-2024 (Volume 111)

No abstract provided.


An Exploration Of Pediatric Occupational Therapist's Perspectives On Functional And Assistive Mobility, Jennifer Allison, Amy Lyons-Brown Apr 2024

An Exploration Of Pediatric Occupational Therapist's Perspectives On Functional And Assistive Mobility, Jennifer Allison, Amy Lyons-Brown

Spring 2024 Virtual OTD Capstone Symposium

Background: Occupational therapists (OTs) are highly skilled in assessing context, environment, and sensory-motor needs which are critical in addressing functional mobility and implementing assistive mobility devices. There is limited research on pediatric OT’s role in functional mobility. This study aims to explore pediatric OT's roles and perceptions of functional mobility and the implementation and use of assistive mobility devices.

Methods: Data was collected via an online survey with an option to participate in a follow-up interview. Descriptive statistics and thematic analysis were used to summarize trends and differences in the data.

Results: Twenty licensed OTs working in a variety of …


Wellness Research & Programming For Bodybuilders, Victoria Castillo, Karen Park, Kersten Laughlin Apr 2024

Wellness Research & Programming For Bodybuilders, Victoria Castillo, Karen Park, Kersten Laughlin

Spring 2024 Virtual OTD Capstone Symposium

This project explores the occupational impact on bodybuilders and wellness & program development for competitive bodybuilders. Phase one focuses on research to understand the occupational impact on bodybuilders during competition. Phase two, which focuses on program development, highlights the alignment to the objectives as they allow for the development of an educational program intended for bodybuilder coaches to help with health prevention and wellness with their bodybuilder clients.


The Mental Health And Wellness Of Young Adults With Down Syndrome, Annika Soderfelt, Susan Macdermott, Jazminne Orozco Arteaga Apr 2024

The Mental Health And Wellness Of Young Adults With Down Syndrome, Annika Soderfelt, Susan Macdermott, Jazminne Orozco Arteaga

Spring 2024 Virtual OTD Capstone Symposium

A poster presentation regarding the mental health and wellness of young adults with Down syndrome. This poster discusses how the mental health and wellness needs of individuals with Down syndrome are or are not currently being met and how resources and programming could be created, particularly by OTs, to better meet their need.


Acetaminophen Influences Musculoskeletal Signaling But Not Adaptations To Endurance Exercise Training, Brandon Roberts, Alyssa Geddis, Alexandra Ciuciu, Marinaliz Reynoso, Nikhil Mehta, Alyssa Varanoske, Alyssa Kelley, Raymond Walker, Rigoberto Munoz, Alexander Kolb, Jeffery Staab, Marshall Naimo, Ryan Tomlinson Apr 2024

Acetaminophen Influences Musculoskeletal Signaling But Not Adaptations To Endurance Exercise Training, Brandon Roberts, Alyssa Geddis, Alexandra Ciuciu, Marinaliz Reynoso, Nikhil Mehta, Alyssa Varanoske, Alyssa Kelley, Raymond Walker, Rigoberto Munoz, Alexander Kolb, Jeffery Staab, Marshall Naimo, Ryan Tomlinson

Department of Orthopaedic Surgery Faculty Papers

Acetaminophen (ACE) is a widely used analgesic and antipyretic drug with various applications, from pain relief to fever reduction. Recent studies have reported equivocal effects of habitual ACE intake on exercise performance, muscle growth, and risks to bone health. Thus, this study aimed to assess the impact of a 6-week, low-dose ACE regimen on muscle and bone adaptations in exercising and non-exercising rats. Nine-week-old Wistar rats (n = 40) were randomized to an exercise or control (no exercise) condition with ACE or without (placebo). For the exercise condition, rats ran 5 days per week for 6 weeks at a 5% …


Orchestra, April 15th, Arkansas State University Department Of Music Apr 2024

Orchestra, April 15th, Arkansas State University Department Of Music

Performance Programs

No abstract provided.


Research On Cross-Domain Unmanned Swarm Cooperative Anti-Submarine Search Method, Ning Wang, Xiaolong Liang, Jiaqiang Zhang, Yueqi Hou, Aiwu Yang Apr 2024

Research On Cross-Domain Unmanned Swarm Cooperative Anti-Submarine Search Method, Ning Wang, Xiaolong Liang, Jiaqiang Zhang, Yueqi Hou, Aiwu Yang

Journal of System Simulation

Abstract: For the maritime ASW search, a cross-domain unmanned swarm cooperative search method is proposed in which USVs are used as the communication relay of UAVs. The digital grid map is used to characterize the mission area and the kinematic model of cross-domain platform is constructed. The cooperative method of cross-domain unmanned systems is proposed, and the distributed information fusion mechanism of unmanned systems is designed. The search objective function for heterogeneous platforms is designed to guide the unmanned systems to make real-time decisions in search task. The simulation results show that the proposed method can be effective to the …


Simulation Verification And Decision-Making Key Technologies Of Unmanned Swarm Game Confrontation: A Survey, Xiaolong Liang, Aiwu Yang, Jiaqiang Zhang, Yueqi Hou, Ning Wang, Xiao Huang, Junbin Gong Apr 2024

Simulation Verification And Decision-Making Key Technologies Of Unmanned Swarm Game Confrontation: A Survey, Xiaolong Liang, Aiwu Yang, Jiaqiang Zhang, Yueqi Hou, Ning Wang, Xiao Huang, Junbin Gong

Journal of System Simulation

Abstract: Unmanned swarm game confrontation is a new combat mode and plays a crucial role in intelligent warfare. Its core is the autonomous generation of a series of game confrontation decision sequences to "empower" the swarm. The progress of system simulation verification for the unmanned swarm game confrontation is analyzed. The key technologies of the autonomous decision-making are discussed from three aspects, technology based on expert systems and game theory, technology based on swarm intelligence and optimization theory, and technology based on neural networks and reinforcement learning. The key technology research conducted by the author's team on the autonomous decisionmaking …


Research On Integration Of Virtual-Real Hybrid Simulation Experiment Environment For Unmanned Swarm, Huijie Yang, Taoshun Xiao, Chen Wu, Lingfeng Guo Apr 2024

Research On Integration Of Virtual-Real Hybrid Simulation Experiment Environment For Unmanned Swarm, Huijie Yang, Taoshun Xiao, Chen Wu, Lingfeng Guo

Journal of System Simulation

Abstract: Constructing the experiment environment and researching the core technology, key equipment and operation theory is the key step for the development of unmanned swarm. Based on the requirement of hybrid simulation environment for unmanned swarm, the elements of the experiment environment are analyzed, and the architecture is proposed, which is composed of common infrastructure, general experiment services, special experiment tools, security and support tool. The key experiment environment integration technology is studied from the aspects of experiment network, model data and experiment application. The feasibility of the method to construct the virtual-real hybrid simulation environment is verified by an …


Mixed-Variable Particle Swarm Optimization Algorithm Based On Competitive Coevolution, Hu Zhang, Heng Zhang, Zilu Huang, Zhe Wang, Qingpo Fu, Jin Peng, Feng Wang Apr 2024

Mixed-Variable Particle Swarm Optimization Algorithm Based On Competitive Coevolution, Hu Zhang, Heng Zhang, Zilu Huang, Zhe Wang, Qingpo Fu, Jin Peng, Feng Wang

Journal of System Simulation

Abstract: For the current algorithm, it is difficult to obtain the available solution due to the irregularity of problem decision space caused by the numerous mixed variable optimization problems during real industrial applications. The coevolution strategy is introduced and a mixed variable particle swarm optimization algorithm(CCPSO) based on competitive coevolution is proposed. The search direction adjustment mechanism based on tolerance is designed to judge the evolution state of particles, adaptively adjust the search direction of particles, avoid falling into local optimum, and balance the convergence and diversity of the population. The learning object generation mechanism is adopted for each particle …


Handling Constrained Multi-Objective Optimization Problems Based On Relationship Between Pareto Fronts, Yubo Wang, Chengyu Hu, Wenyin Gong Apr 2024

Handling Constrained Multi-Objective Optimization Problems Based On Relationship Between Pareto Fronts, Yubo Wang, Chengyu Hu, Wenyin Gong

Journal of System Simulation

Abstract: To address the challenges of balancing the constraint satisfaction and objective function optimization, and dealing with the complex feasible regions in constrained multi-objective optimization problems(CMOPs), a classification-based search approach is proposed based on different Pareto front relationships. A dual-population dual-phase framework is proposed in which an auxiliary population Pa and a main population Pm are evolved and the evolution process is divided into a learning phase and a search phase. During the learning phase, Pa explores unconstrained Pareto front (UPF) and Pm explores constrained Pareto front(CPF), through which the relationship between UPF and CPF is determined. After completing the …


Element Grouping Faceted Fully Connected Network Based On Ris, Shunhu Hou, Shengliang Fang, Qingyao Zeng, Mengtao Wang Apr 2024

Element Grouping Faceted Fully Connected Network Based On Ris, Shunhu Hou, Shengliang Fang, Qingyao Zeng, Mengtao Wang

Journal of System Simulation

Abstract: In view of the over-fitting problem that caused by multiple parameters and high memory usage of the full connection layer of neural network in training, a RIS-based element grouping areal fully connected neural network (RGFCNN) is proposed for the first time based on the structural characteristics of reconfigurable intelligence surface (RIS). Based on the structural characteristics of RIS, the network is optimized on traditional FCNN. A novel transmission surface attention mechanism is designed for the effective feature extraction of data. Compared with the traditional FCNNs, the proposed network does not arrange the data in one-dimensional manner. Instead, a element …


In Support Of Industry-Conscious Disclosure Standards For Pharmaceutical And Biotechnology Patents, Mark T. Roundtree Apr 2024

In Support Of Industry-Conscious Disclosure Standards For Pharmaceutical And Biotechnology Patents, Mark T. Roundtree

Texas A&M Law Review

One of the fundamental requirements for a patent application is a disclosure of the invention via an accurate written description with sufficient detail to enable the recreation of the invention. The U.S. patent system has historically reviewed patent applications from various industries with a uniform set of requirements and standards. However, the biotechnology and pharmaceutical industries operate on notably extended product development timelines and face unique administrative pressures related to their products when compared with other industries. In response to these pressures, biotechnology and pharmaceutical companies have traditionally applied for patent protections through liberal use of genus claims and other …


Microcapsule Transport And Blockage In Rough-Walled Fractures, Brittney Diana Seaburn Apr 2024

Microcapsule Transport And Blockage In Rough-Walled Fractures, Brittney Diana Seaburn

Civil Engineering ETDs

Thermal short-circuiting is a potential problem for Enhanced Geothermal Systems (EGS). One solution to this problem is to reduce the permeability of very conductive fractures with thermally degradable microcapsules carrying porous polymers that bond to rock, reducing fluid flow without completely sealing the fracture. This concept requires microcapsules to principally travel in the larger, problematic fractures, minimizing entry into smaller fractures; consequently, understanding the transport and blockage of microcapsules is critical. Using a flow visualization configuration, this study involved quantifying the transport and blockage of microcapsules in transparent fracture replicas. Analyses determined most blockage occurred in regions with local apertures …


Can You Smell A Lawsuit Cooking? Possible Risks With The Rock’S Trademarks, Cameron Brody Apr 2024

Can You Smell A Lawsuit Cooking? Possible Risks With The Rock’S Trademarks, Cameron Brody

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

Dwayne Johnson is one of the most recognizable and successful working actors on the planet. For an entire generation, he is synonymous with smash-hit franchises such as Baywatch, Tooth Fairy, and Jungle Cruise. In fact, between 2019 and 2021, he was the highest-paid actor in Hollywood and raked in $270,000,000 in 2022 alone. Further, he is a co-founder of Teremana Tequila, which holds an estimated value of $3.5 billion, putting him on track alongside George Clooney and Ryan Reynolds as success stories in the celebrity alcohol market. His most recent endeavor, however, may put him on track towards a series …


Shades Of Green: Navigating The Legality Of Environmental Marketing, David Zack Apr 2024

Shades Of Green: Navigating The Legality Of Environmental Marketing, David Zack

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

A majority of Americans are concerned about climate change.1 This fear seems to be a driver of consumer spending decisions. According to a study by PDI Technologies, 68% of Americans are willing to spend more on environmentally sustainable products than their competitors that are not sustainable.2 This number has steadily grown over the past two years.3 This figure is even greater for key marketing demographics. 77% of Gen Z, 72% of millennials, and 76% of parents would be willing to do so. Because of this, companies have increasingly sought to position and market themselves as green companies.

This post was …


Cas Connections- 2024 Spring Term - April, Dean's Office College Of Arts And Science Apr 2024

Cas Connections- 2024 Spring Term - April, Dean's Office College Of Arts And Science

CAS Connections

No abstract provided.


General Non-Destructive Evaluation For Friction Stir Welding, Johnathon Bryce Hunt Apr 2024

General Non-Destructive Evaluation For Friction Stir Welding, Johnathon Bryce Hunt

Theses and Dissertations

Friction stir welding (FSW) is an advantageous solid state joining method for many different engineering designs. It was invented in 1991 by TWI and since that time a tremendous amount of research has been executed to understand and implement FSW in a myriad of materials in numerous industries such as aerospace, ship building, train, automotive, energy, agriculture and others. Most industries have strict weld inspection processes to validate a weld before it is put into service. One of the main weld characteristics that is measured is the size of any subsurface volumetric voids. The current standard to test friction stir …


Application Of The Immobilized Low-Activity Waste Glass Corrosion Model To The Static Dissolution Of 24 Statistically-Designed Alkali-Borosilicate Waste Glasses, Sebastien N. Kerisit, James J. Neeway, Charmayne E. Lonergan, Benjamin Parruzot, Jarrod V. Crum, Richard C. Daniel, Gary L. Smith, R. Matthew Asmussen Apr 2024

Application Of The Immobilized Low-Activity Waste Glass Corrosion Model To The Static Dissolution Of 24 Statistically-Designed Alkali-Borosilicate Waste Glasses, Sebastien N. Kerisit, James J. Neeway, Charmayne E. Lonergan, Benjamin Parruzot, Jarrod V. Crum, Richard C. Daniel, Gary L. Smith, R. Matthew Asmussen

Materials Science and Engineering Faculty Research & Creative Works

Glass corrosion models that capture the complex mechanisms of the glass-water reaction enable the prediction of nuclear waste glass durability in disposal scenarios. Parameterization of such models is challenging because of the need to capture changes in corrosion behavior with time, reaction conditions, and glass composition. Here, we describe and employ the ILAW (immobilized low-activity waste) glass corrosion model (IGCM) in geochemical simulations of static dissolution tests, at two temperatures (40 °C and 90 °C), for a matrix of 24 enhanced low-activity waste (eLAW) glasses statistically designed to cover a processable composition space defined by 8 major glass components (Al …


Decoding Crystallization Behavior Of Aluminoborosilicate Glasses: From Structural Descriptors To Quantitative Structure – Property Relationship (Qspr) Based Predictive Models, Yingcheng Zhang, Marco Bertani, Alfonso Pedone, Randall E. Youngman, Gregory Tricot, Aditya Kumar, Ashutosh Goel Apr 2024

Decoding Crystallization Behavior Of Aluminoborosilicate Glasses: From Structural Descriptors To Quantitative Structure – Property Relationship (Qspr) Based Predictive Models, Yingcheng Zhang, Marco Bertani, Alfonso Pedone, Randall E. Youngman, Gregory Tricot, Aditya Kumar, Ashutosh Goel

Materials Science and Engineering Faculty Research & Creative Works

Successful decoding of structural descriptors controlling the crystallization in multicomponent functional glasses can pave the way for the transition from the trial-and-error approach and empirical modeling for glass/glass-ceramic composition design toward more rational and scientifically rigorous Quantitative Structure-Property Relationship (QSPR) based models. However, due to the compositional and structural complexity of multicomponent glasses and the longer time and length scales associated with nucleation, the development and validation of QSPR models are still in it's infancy. The work presented in the article is an attempt to leap forward in this pursuit by combining the strengths of experimental and computational materials science …


448-452 W. 57 Assoc. Llc V. Ghali Apr 2024

448-452 W. 57 Assoc. Llc V. Ghali

All Decisions

The landlord sued the tenant for non-payment of rent, but the court dismissed the case because the landlord's demand for rent was based on an invalid lease agreement. The court ruled that a non-payment proceeding requires a valid agreement, express or implied, to pay the rent demanded and that the rent demand must specify the exact amount owed for each period.


The Study On Mechanical Model Considering Optimal Self-Adaption In The Bottleneck Area, Longcheng Yang, Huajun Wang, Jun Hu, Hongyu Pan, Juan Wei, Lei You, Hao Zhang, Junxi Wang Apr 2024

The Study On Mechanical Model Considering Optimal Self-Adaption In The Bottleneck Area, Longcheng Yang, Huajun Wang, Jun Hu, Hongyu Pan, Juan Wei, Lei You, Hao Zhang, Junxi Wang

Faculty, Staff and Student Publications

It aims to solve the problem that the evacuation state of pedestrians depicted by the traditional social force model in a crowded multiexit scenario has a relatively large difference with the actual state, especially the 'optimal path' considered by the self-driving force is the problem of shortest path, and the multiexit evacuation mode depicted by the 'herd behavior' is the local optimum problem. Through in-depth analysis of actual evacuation data of pedestrians and causes of problem, a new crowd evacuation optimization model is established in order to effectively improve the simulation accuracy of crowd evacuation in a multi-exit environment. The …


Multi-Omics Analysis Reveals Immune Features Associated With Immunotherapy Benefit In Patients With Squamous Cell Lung Cancer From Phase Iii Lung-Map S1400i Trial, Edwin Roger Parra, Jiexin Zhang, Dzifa Yawa Duose, Edgar Gonzalez-Kozlova, Mary W Redman, Hong Chen, Ganiraju C Manyam, Gayatri Kumar, Jianhua Zhang, Xingzhi Song, Rossana Lazcano, Mario L Marques-Piubelli, Caddie Laberiano-Fernandez, Frank Rojas, Baili Zhang, Len Taing, Aashna Jhaveri, Jacob Geisberg, Jennifer Altreuter, Franziska Michor, James Provencher, Joyce Yu, Ethan Cerami, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Hsin-Hui Huang, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, James Lindsay, Roshni Biswas, Stephen Van Nostrand, Seunghee Kim-Schulze, Jhanelle E Gray, Roy S Herbst, Ignacio I Wistuba, Scott Gettinger, Karen Kelly, Lyudmila Bazhenova, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Cara Haymaker Apr 2024

Multi-Omics Analysis Reveals Immune Features Associated With Immunotherapy Benefit In Patients With Squamous Cell Lung Cancer From Phase Iii Lung-Map S1400i Trial, Edwin Roger Parra, Jiexin Zhang, Dzifa Yawa Duose, Edgar Gonzalez-Kozlova, Mary W Redman, Hong Chen, Ganiraju C Manyam, Gayatri Kumar, Jianhua Zhang, Xingzhi Song, Rossana Lazcano, Mario L Marques-Piubelli, Caddie Laberiano-Fernandez, Frank Rojas, Baili Zhang, Len Taing, Aashna Jhaveri, Jacob Geisberg, Jennifer Altreuter, Franziska Michor, James Provencher, Joyce Yu, Ethan Cerami, Radim Moravec, Kasthuri Kannan, Rajyalakshmi Luthra, Gheath Alatrash, Hsin-Hui Huang, Hui Xie, Manishkumar Patel, Kai Nie, Jocelyn Harris, Kimberly Argueta, James Lindsay, Roshni Biswas, Stephen Van Nostrand, Seunghee Kim-Schulze, Jhanelle E Gray, Roy S Herbst, Ignacio I Wistuba, Scott Gettinger, Karen Kelly, Lyudmila Bazhenova, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Cara Haymaker

Faculty, Staff and Student Publications

PURPOSE: Identifying molecular and immune features to guide immune checkpoint inhibitor (ICI)-based regimens remains an unmet clinical need.

EXPERIMENTAL DESIGN: Tissue and longitudinal blood specimens from phase III trial S1400I in patients with metastatic squamous non-small cell carcinoma (SqNSCLC) treated with nivolumab monotherapy (nivo) or nivolumab plus ipilimumab (nivo+ipi) were subjected to multi-omics analyses including multiplex immunofluorescence (mIF), nCounter PanCancer Immune Profiling Panel, whole-exome sequencing, and Olink.

RESULTS: Higher immune scores from immune gene expression profiling or immune cell infiltration by mIF were associated with response to ICIs and improved survival, except regulatory T cells, which were associated with worse …


Safety Profile And Adverse Event Management For Futibatinib, An Irreversible Fgfr1-4 Inhibitor: Pooled Safety Analysis Of 469 Patients, Funda Meric-Bernstam, Antoine Hollebecque, Junji Furuse, Do-Youn Oh, John A Bridgewater, Masashi Shimura, Bailey Anderson, Nanae Hangai, Volker Wacheck, Lipika Goyal Apr 2024

Safety Profile And Adverse Event Management For Futibatinib, An Irreversible Fgfr1-4 Inhibitor: Pooled Safety Analysis Of 469 Patients, Funda Meric-Bernstam, Antoine Hollebecque, Junji Furuse, Do-Youn Oh, John A Bridgewater, Masashi Shimura, Bailey Anderson, Nanae Hangai, Volker Wacheck, Lipika Goyal

Faculty, Staff and Student Publications

PURPOSE: Futibatinib, a covalently-binding inhibitor of fibroblast growth factor receptor (FGFR)1-4 gained approval for the treatment of refractory, advanced intrahepatic cholangiocarcinoma (iCCA) harboring an FGFR2 fusion/other rearrangement. An integrated analysis was performed to evaluate safety and provide guidance on the management of futibatinib-associated adverse events (AEs) in patients with unresectable/metastatic tumors, including iCCA.

PATIENTS AND METHODS: Data from three global phase I or II studies of futibatinib (NCT02052778; JapicCTI-142552) were pooled. AEs were graded per NCI CTCAE v4.03, where applicable. Safety was analyzed for patients receiving any futibatinib starting dose (overall population) and in those receiving the approved starting dose …


Applying The Consumer Decision-Making Model To An On-Campus Coffee Shop, Madalynne Chapman Apr 2024

Applying The Consumer Decision-Making Model To An On-Campus Coffee Shop, Madalynne Chapman

Honors Projects

The purpose of this research was to use the consumer decision-making model as a framework to assess if there are factors that may prompt (or not prompt) an individual to make a purchase at Forhan’s Café, a small coffee shop located inside of the Maurer Center at Bowling Green State University. To answer this, both a personal interview with a BGSU Dining staff member and an online survey of campus consumers were conducted. The personal interview was conducted to understand their current marketing strategies for the café and to guide the survey design. The online survey consisted of 24 questions …


Clarice Lispector: From Brazil To The World, Earl Fitz Apr 2024

Clarice Lispector: From Brazil To The World, Earl Fitz

Purdue Studies in Romance Literatures

Clarice Lispector: From Brazil to the World explains why the Brazilian master was so transformative of modern Brazilian literature and why she has become such a celebrity in the world literature arena. This book also shows why Lispector is not one writer, as many think, but many writers. By offering close readings of her novels, stories, and nonfiction pieces, Earl E. Fitz shows the diverse sides of her literary world. Chapters cover Lispector’s devotion to language and its connection to identity; her political engagement; and her humor, eroticism, and struggle with the concept of God. The last chapter seeks to …


Excellence Summit 2024, Office Of Research And Sponsored Projects Operations Apr 2024

Excellence Summit 2024, Office Of Research And Sponsored Projects Operations

Excellence Summit (Research Week) Archived Proceedings

In it's 17th year, the University of the Incarnate Word, welcome all to read and review the proceedings of the annual research week. The 2024 Excellence Summit highlighted academic excellence across all schools featuring topics from nutrition studies to soil amendments, artificial intelligence, medical case studies, and music composition studies. The rich mixture of humanities, health sciences, physical sciences, education, and business can be found in this booklet. We thank all that contributed to these works and hope the community enjoys learning from today's and tomorrow's leaders in research, inquiry, and scholarship.


Mcl-1 Mediates Intrinsic Resistance To Raf Inhibitors In Mutant Braf Papillary Thyroid Carcinoma, Maria Cavallo, Jacob Yo, Kayla Gallant, Camille Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa Sanders, Andrew Aplin, Edmund Pribitkin, Edward Hartsough Apr 2024

Mcl-1 Mediates Intrinsic Resistance To Raf Inhibitors In Mutant Braf Papillary Thyroid Carcinoma, Maria Cavallo, Jacob Yo, Kayla Gallant, Camille Cunanan, Amirali Amirfallah, Marzieh Daniali, Alyssa Sanders, Andrew Aplin, Edmund Pribitkin, Edward Hartsough

Kimmel Cancer Center Faculty Papers

Papillary thyroid carcinoma (PTC) is the most frequent form of thyroid cancer. PTC commonly presents with mutations of the serine/threonine kinase BRAF (BRAFV600E), which drive ERK1/2 pathway activation to support growth and suppress apoptosis. PTC patients often undergo surgical resection; however, since the average age of PTC patients is under 50, adverse effects associated with prolonged maintenance therapy following total thyroidectomy are a concern. The development of mutant-selective BRAF inhibitors (BRAFi), like vemurafenib, has been efficacious in patients with metastatic melanoma, but the response rate is low for mutant BRAF PTC patients. Here, we assay the therapeutic response …


On Learning Your Gender: A Comprehensive View, Audra M. Hazelwood Apr 2024

On Learning Your Gender: A Comprehensive View, Audra M. Hazelwood

Theses

This essay provides a metaphysical and epistemological account of gender. The metaphysics involves a ‘non-reductionist view of gender’, which is to say that gender cannot be reduced to a single factor. On this view gender begins with one’s innate gender inclinations (in the vein of Julia Serano). These inclinations pick out a specific range of gender possibilities from the gender spectrum that apply to a person. At the same time we live in communities and cultures with certain gender norms. This is where epistemology comes into play since our gender inclinations are filtered through gender norms and some people are …


Friction Stir Welding Of Tube-To-Tubesheet And Spot Joints For Virgin And Recycled Thermoplastic Materials., Syed Haris Iftikhar Apr 2024

Friction Stir Welding Of Tube-To-Tubesheet And Spot Joints For Virgin And Recycled Thermoplastic Materials., Syed Haris Iftikhar

Thesis/ Dissertation Defenses

Thermoplastic materials are becoming popular, due to their chemically inert and anti-fouling properties, for use in industrial heat exchanger applications involving heating/cooling of highly reactive fluids like acids. A novel nonconventional joining framework, based on the friction stir welding (FSW) technique, is developed to create high-quality thermoplastic tube-to-tubesheet joints (TTJs). The proposed technique has applications in the thermoplastic shell-andtube heat exchanger and piping industries (as flange-to-pipe joints). The primary objective is to study the feasibility of the FSW technique for developing thermoplastic TTJs, followed by optimization of the process parameters and detailed material characterizations. This work used workpieces (tube, tubesheet) …