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Obesity Promotes The Ceramide-Mediated Nadph Oxidase In Acute Myeloid Leukemia, Weiyuan Wang, Rachel Sabol, Alexus Day, Tamara Hathorn, Maria Clark, Sara Connell, Elana Mantis, Mariam Traore, Jacqueline Sicilano, Emma Arsenault, Noelle Labrecque, Emily Sullivan, Andrea Cote, Paul Toran, Brian Barth Apr 2024

Obesity Promotes The Ceramide-Mediated Nadph Oxidase In Acute Myeloid Leukemia, Weiyuan Wang, Rachel Sabol, Alexus Day, Tamara Hathorn, Maria Clark, Sara Connell, Elana Mantis, Mariam Traore, Jacqueline Sicilano, Emma Arsenault, Noelle Labrecque, Emily Sullivan, Andrea Cote, Paul Toran, Brian Barth

Faculty, Staff, and Students

Acute myeloid leukemia (AML) is a type of blood cancer of the myeloid cell lineage. Obesity is characterized by an increase in body weight that results in excessive fat accumulation. Obesity has been associated with an increased incidence of many cancers, including blood cancers. This study evaluated the role obesity in AML progression in a novel transgenic mouse model developed by crossing Flt3ITD mice with Lepob/ob mice. Leukemia burden was augmented in obese AML mice. In addition, it was determined that obesity upregulated the ceramide-mediated and ceramide-1-phosphate-mediated NADPH oxidase 2 (NOX2). Notably, increased oxidative pathways has been attributed to disease …


911-Never Forget, Karen Stepherson Apr 2024

911-Never Forget, Karen Stepherson

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No abstract provided.


A King's Resolution, Rachel Delight Walker Apr 2024

A King's Resolution, Rachel Delight Walker

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No abstract provided.


An Ode To The End Of The Line, Lauren Limburg Apr 2024

An Ode To The End Of The Line, Lauren Limburg

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No abstract provided.


2024 Forces, Collin College Apr 2024

2024 Forces, Collin College

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No abstract provided.


Aged Angles, Lisa K. Dorman Apr 2024

Aged Angles, Lisa K. Dorman

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No abstract provided.


Big Boy, Javier Gardia Apr 2024

Big Boy, Javier Gardia

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No abstract provided.


Bringing It, Anne Tilger Apr 2024

Bringing It, Anne Tilger

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No abstract provided.


Don't Panic, Emory Eagles Apr 2024

Don't Panic, Emory Eagles

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No abstract provided.


Enjoy Every Color Of Your Life, Kaci French Apr 2024

Enjoy Every Color Of Your Life, Kaci French

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No abstract provided.


Don't Push Me, A.J. Sanchez Apr 2024

Don't Push Me, A.J. Sanchez

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No abstract provided.


Flying High, Karen Stepherson Apr 2024

Flying High, Karen Stepherson

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No abstract provided.


Holiday Twilight, Ann Tilger Apr 2024

Holiday Twilight, Ann Tilger

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No abstract provided.


Happy Or Sad, Gilbert Hu Apr 2024

Happy Or Sad, Gilbert Hu

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No abstract provided.


Introduction, Scott Yarbrough Apr 2024

Introduction, Scott Yarbrough

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No abstract provided.


It's Jack Of Men, Peyton Penrose Apr 2024

It's Jack Of Men, Peyton Penrose

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No abstract provided.


Jeopardy And Peanuts, Matthew Ring Apr 2024

Jeopardy And Peanuts, Matthew Ring

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No abstract provided.


Hospital, Michael B. Duff Apr 2024

Hospital, Michael B. Duff

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No abstract provided.


Lisa Jo, Kimberly A. Catino Apr 2024

Lisa Jo, Kimberly A. Catino

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No abstract provided.


Jinx Fatasma Azul, Kaylee Chavers Apr 2024

Jinx Fatasma Azul, Kaylee Chavers

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No abstract provided.


Lost In The Passion Of Youth, Lori Hawk Fyfe Apr 2024

Lost In The Passion Of Youth, Lori Hawk Fyfe

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No abstract provided.


Little Miss Shorecrest, Annmarie Masters Apr 2024

Little Miss Shorecrest, Annmarie Masters

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No abstract provided.


Melted Dairy Treat, Caleb Lane Apr 2024

Melted Dairy Treat, Caleb Lane

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No abstract provided.


Morning Dew, Leon King Apr 2024

Morning Dew, Leon King

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No abstract provided.


My Junior High School: A Cozy Corner In The Highlands, Vietnam, Khanh Duy Tran Apr 2024

My Junior High School: A Cozy Corner In The Highlands, Vietnam, Khanh Duy Tran

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No abstract provided.


Mysterious Lady, Rachelle Raboy Apr 2024

Mysterious Lady, Rachelle Raboy

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No abstract provided.


Not Sure About That, Patricia Coble Apr 2024

Not Sure About That, Patricia Coble

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No abstract provided.


Orchid Forest Dream, Kaylee Chavers Apr 2024

Orchid Forest Dream, Kaylee Chavers

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No abstract provided.


Pavillion, Jessika Hughes Apr 2024

Pavillion, Jessika Hughes

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No abstract provided.


Perceptions, Reality, Illusions, The Optics, Cathy Donlad-Whitney Dr. Apr 2024

Perceptions, Reality, Illusions, The Optics, Cathy Donlad-Whitney Dr.

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No abstract provided.