Digital Commons Network^™

Inference For Time Series In Change Points And Statistical Learning, Jiaqi Li

Arts & Sciences Graduate Student Theses and Dissertations

This study aims to develop a comprehensive framework for inference theory in time series, with a focus on change-point detection and online learning. First, we introduce an $\ell^2$-based inference approach for multiple change-point detection in high-dimensional time series, which targets dense or spatially clustered signals by a novel Two-Way MOSUM (moving sum) test statistic. We derive the limiting distribution of this $\ell^2$-aggregated statistic by extending the high-dimensional Gaussian approximation to non-stationary spatial-temporal processes. Simulation exhibits promising performance of our test in detecting non-sparse weak signals, and the application to COVID-19 analysis shows the real-world relevance of our method. Next, we …

Emotions That Feel Bad Are Bad: An Investigation Into The Purportedly Positive Parts Of Negative Emotions, Christopher Colacchia

Arts & Sciences Graduate Student Theses and Dissertations

It has grown increasingly common to hold that some emotions that feel bad can be important to our well-being. This idea appears in “common sense” views, such as the view that it is important to feel grief after the loss of a loved one, as well as in sustained philosophical defenses, such as those written defending the value of anger for securing justice. I seek to push back on this idea. After preliminary clarifications, I defend the claim that an emotion’s feeling bad provides a prima facie reason to assign it a negative impact on our well-being on every plausible …

Dimerization Of The Fluoride Channel Fluc In Membranes, Melanie Ernst

Arts & Sciences Graduate Student Theses and Dissertations

Many ion channels are multi-subunit complexes where oligomerization is an obligatory requirement for function as the binding axis forms the charged permeation pathway. However, the mechanisms of assembly within the membrane are largely unknown. Are ion channel complexes thermodynamically stable, and do they participate in dynamic equilibrium oligomerization reactions in membranes? If so, what are the molecular factors governing these reactions? In this thesis, I present several key advances in the study of ion channel oligomerization in membranes through quantitative studies of the dimerization equilibrium reaction of the inverted topology, homodimeric fluoride channel Fluc in lipid bilayers. Chapter 1 provides …

Essays On Industrial Organization, Hayley Wabiszewski

Arts & Sciences Graduate Student Theses and Dissertations

Big pharma is increasingly using acquisitions to fill their R&D pipelines and the proliferation of the biotechnology industry has created a thick market of innovative target startups. This dissertation analyzes the dynamic equilibrium effects of biotech startup acquisitions by big pharma on drug innovation and entry. Using a novel dataset on 175 acquired startups from 2000 - 2018, I document several new facts regarding the R&D outcomes of acquired drug projects and entry behavior of startups in markets where acquisitions occur. Motivated by this evidence, I build a dynamic oligopoly model of the pharmaceutical industry featuring big firms and startups …

Women’S Participation In Kenya Dairy Cooperative Decision-Making Processes, Caroline Minoo Mukeku

Walden Dissertations and Doctoral Studies

Women contribute immensely to the dairy production workforce in Kenya, yet they lack access and control over production services and resources. They are also underrepresented in the decision-making processes of dairy cooperatives. Constraining women from reaching their maximum potential diminishes their ability to influence and participate in societal change. Although researchers have investigated this issue, few studies have focused on this topic. The purpose of this general qualitative study was to describe barriers that prevent women from participating in decision-making processes in Kenya’s dairy cooperatives. The research question was focused on factors that inhibit women’s participation in decision-making processes in …

Who Should You Learn From? Theory And Evidence From The Videogame Industry, Tatenda Marume Geofrey Pasipanodya

Olin Business School Graduate Student Theses and Dissertations

Knowledge spillovers can be a major driver of performance for those who successfully absorb them. This dissertation studies potential spillover recipients and characterizes how they may best benefit from the knowledge generated and possessed by their peers. Across three interconnected chapters, I examine whether the choice of peer whose spillovers a would-be recipient draws from affects the recipient’s outcomes. My pursuit is guided by the overarching question: who should knowledge seekers target as ideal sources of new knowledge? I focus my investigation on the extent of a source’s knowledge relative to the focal recipient – what I term knowledge distance …

Permasalahan Guru Dalam Pembelajaran Keterampilan Seni Rupa Platform Digital Masa Pandemi Di Sekolah Menengah Pertama, Eka Kursita Manda Agustina, Iriaji Iriaji, Denik Ristya Rini

Journal of Innovation and Teacher Professionalism

The COVID-19 pandemic has changed the learning of skills, especially in Fine Arts subjects in Indonesia. The online learning process is applied as an alternative solution to create substitute learning for learning in schools. Digital platforms such as information and communication technology media are used as alternative media in online learning of Fine Arts. The existence of these alternative media creates new problems for Fine Arts teachers in online learning. This study aims to uncover various problems and solutions for teachers in learning Visual Arts skills on a digital platform during the pandemic at SMPN 2 Malang. This research method …

Implementasi Permainan Edukatif Pada Pendekatan Pembelajaran Teaching At The Right Level (Tarl) Di Kelas V Sekolah Dasar Negeri, Herlysa Saulina, Esti Untari

Journal of Innovation and Teacher Professionalism

The Teaching at the Right Level (TaRL) approach is a learning approach that can be applied to the National Curriculum. This Teaching at the Right Level (TaRL) approach will classify learners into proficient, intermediate, and non-proficient categories, so that learners' learning needs can be met. On the other hand, the TaRL approach has the disadvantage that it takes a long time. If learning takes too long, learning will be boring and learning objectives may not be achieved optimally. This study was conducted with the aim of seeing the effectiveness of the implementation of educational games in the Teaching at the …

Implementasi Pendekatan Culturally Responsive Teaching (Crt) Pada Pembelajaran Ipa Untuk Meningkatkan Motivasi Belajar Peserta Didik Di Smp, Ludfi Rachma Fadillah, Tomi Listiawan

Journal of Innovation and Teacher Professionalism

The purpose of this research was to overcome the low motivation to learn physics so that it was hoped that students' learning completeness can increase. This research was a collaborative classroom action research conducted in two cycles, while the stages of lesson study activities carried out are Plan (Planning), Do (Implementation) and See (observing and reflecting) and repeated until the second cycle and closed with conclusions during lesson study activities. Based on the results of the research that has been done, it can be seen that the motivation to learn science has increased significantly. In the initial observation results showed …

Pengembangan Learning Management Platform Berbasis Web Materi Tata Surya Kelas Vii Smp Sebagai Upaya Keberpihakan Pada Peserta Didik, Lady El Rida, Deny Setiawan

Journal of Innovation and Teacher Professionalism

The purpose of this research was to develop the final product of the Web-based Learning Management Platform for Solar System Materials for seventh grade students as an effort to favor learning to students by paying attention to students' learning styles. There were three sub topics, this product has a main page, main menu, apperception section, learning topics, integrated LKPD Live worksheets, teaching materials with media content such as images and videos, there were also interesting quizzes, reflection sheets, and contained creator information. Web-based Learning Management Platform for Solar System materials can be used online using any device and anywhere. The …

Profil Guru Pancasila Ditinjau Dari Filosofi Pendidikan Ki Hajar Dewantara, Ahmad Sofiuddin, Meidi Saputra

Journal of Innovation and Teacher Professionalism

The Merdeka Belajar curriculum advocates for the freedom of children or learners in the educational process. The objective of the Merdeka Belajar curriculum is translated into the Pancasila Student Profile, which consists of six dimensions. Besides the Pancasila Student Profile, there is also the Pancasila Teacher Profile, which shares the same six dimensions. The Pancasila Teacher Profile must be implemented by an educator within the Merdeka Belajar curriculum. The purpose of this research is to explore the Pancasila Teacher Profile from the perspective of education by Ki Hajar Dewantara. The method employed in this research is literature study. The research …

Estate Planning Toolkit - A Beginner's Guide To Estate Planning In Utah, Amanda Christensen, Melanie Jewkes, Andrea Schmutz, Kristilyn Wilkinson, Vincenza Vicari-Bentley, Jerevie Canlas, Alicia Nelson-Bell, Lisa Schainker, Melanie Dabb, Justin Baer, Jared Hawkins

All Current Publications

Normalizing the estate planning conversation can help eliminate emotional distance or fear when discussing important life planning matters. Approaching discussions in a loving and calm manner can bring family closer together and minimize or avoid contention and resentment. Talking about estate planning doesn’t have to be uncomfortable and emotional. Where possible, start conversations early to have a more positive experience, rather than planning at the time of a life crisis. If you have children, start these conversations when they are young to help normalize the process. The Estate Planning Toolkit is a helpful preparation resource that covers wills, trusts, life …

The Differences In Maternal Clean And Healthy Living Behavior In The Incidence Of Stunting In Yogyakarta, Shafa Ramadhita, Anindhita Syahbi Syagata, Nor Eka Noviani

Indonesian Journal of Public Health Nutrition (IJPHN)

An indirect cause of stunting is maternal behavior. Moreover, good nutritional knowledge relates to good nutritional behaviors. Maternal clean and Healthy Living Behavior (PHBS) in daily life can reduce the risk of infectious diseases and be role models for children in implementing their future health behavior. The study aims to investigate the differences in PHBS of mothers in the incidence of stunting ages 24-59 months in the Minggir Primary Health Center working area. The cross-sectional approach of this research was conducted from March to April 2023. The subjects of this study were 69 respondents selected by cluster random sampling. The …

Factors Associated With Wasting In Toddlers Aged 6 – 59 Months At Cimpaeun Village, Depok City, West Java, Indonesia In 2023, Early Vici Azmia, Triyanti Triyanti

Indonesian Journal of Public Health Nutrition (IJPHN)

The prevalence of wasting under five in Indonesia in 2022 is 7.7%; according to WHO, this wasting problem is a serious public health problem. Wasting is a nutritional problem in toddlers that has an impact on morbidity and mortality. The research objective was to determine the factors associated with wasting in toddlers aged 6–59 months in Cimpaeun Village in 2023. The dependent variable is wasting, and the independent variables are birth weight, history of fever, diarrhea, acute respiratory infection, energy intake, carbohydrate intake, protein intake, fat intake, mother’s age, pregnancy, mother’s education level, mother’s nutritional knowledge, and family income. This …

Relationship Of Stress And Other Factors With Emotional Eating Among Adolescents In Depok, Muthia Syifa Rahmadina, Asih Setiarini

Indonesian Journal of Public Health Nutrition (IJPHN)

Emotional eating is an overeating behavior as a coping mechanism for negative emotions that emerges in adolescence. Emotional eating causes obesity, eating disorders, and non-communicable diseases. This study aims to determine the relationship between stress, body image, peer influence, parental rearing styles, social media use, sex, sleep quality, and emotion regulation with emotional eating among adolescents at senior high school in Depok. This cross-sectional quantitative study was conducted online in March 2022. The samples were grade X and XI students from senior high school in Depok who were chosen by using purposive sampling techniques (n=174). Chi X2 test and Mann …

The Relationship Of Energy And Nutrient Intake From Eating Out And Eating At Home On Blood Hemoglobin Levels In Adolescents, Adinda Aisyah Putri, Khoirul Anwar

Indonesian Journal of Public Health Nutrition (IJPHN)

Eating out of home is a common practice in adolescents. The high frequency of eating out of home characterized by higher intakes of energy, fats, sugar, and sodium. anemia, especially iron deficiency anemia which is characterized by blood hemoglobin levels, is still a nutritional problem in Indonesia in adolescents which can have an impact on adolescent health. The aim of this study was to determine the relationship between eating out and hemoglobin levels in adolescents in Jakarta. This research is an observational study with a cross sectional research design. The subjects of this research were female students aged 15-17 years. …

Determinant Factors Of The Incidence Of Low Birth Weight In Central Java Province: Analysis Of 2018 Basic Health Research Data, Desi Irawati, Ratu Ayu Dewi Sartika, Diah Mulyawati Utari, Fadila Wirawan

Indonesian Journal of Public Health Nutrition (IJPHN)

Low birth weight (LBW) is a global public health issue with significant short and long-term consequences for individuals and societies. This study aims to examine the most dominant risk and variations in the proportion of LBW based on fetal factors, maternal and obstetric factors, and sociodemographic factors among toddlers in Central Java Province, utilizing the 2018 Basic Health Research (RISKESDAS) data. The study used a cross-sectional study conducted on 4255 samples, utilizing univariate, bivariate (chi-square), and multivariate analysis (multiple logistic regression). Central Java has the 3rd highest number of LBW cases in Indonesia with a prevalence of 6.1%. However, univariate …

A Study On Library Automation And Networking Status Among The Engineering College Libraries In Sri Venkateswara University Area, Dr.Thimapuram Raghunadha Reddy, V Pulla Reddy Proff

Library Philosophy and Practice (e-journal)

The aim of this study is to analyze the use of the Automation and networking among the faculty members and the students of engineering college libraries in Sri Venkateswara University Area. A well structured questionnaire was distributed among the 1314 faculty members and the students under study. The present study demonstrates and elaborates the various aspects of the Automation status, Categories of software used, Areas of Computerization, Source finance for their library automation work, automated services, topology of computer networking is used, to know the types of networks used, satisfaction with digital library services. It was found that the Automation …

Mir4435-2hg As A Possible Novel Predictive Biomarker Of Chemotherapy Response And Death In Pediatric B-Cell All, Yulieth Torres-Llanos, Jovanny Zabaleta, Nataly Cruz-Rodriguez, Sandra Quijano, Paula Carolina Guzmán, Iliana De Los Reyes, Nathaly Poveda-Garavito, Ana Infante, Liliana Lopez-Kleine, Alba Lucía Combita

School of Medicine Faculty Publications

Introduction: Although B-cell acute lymphoblastic leukemia (B-cell ALL) survival rates have improved in recent years, Hispanic children continue to have poorer survival rates. There are few tools available to identify at the time of diagnosis whether the patient will respond to induction therapy. Our goal was to identify predictive biomarkers of treatment response, which could also serve as prognostic biomarkers of death, by identifying methylated and differentially expressed genes between patients with positive minimal residual disease (MRD+) and negative minimal residual disease (MRD-). Methods: DNA and RNA were extracted from tumor blasts separated by immunomagnetic columns. Illumina MethlationEPIC and mRNA …

Sildenafil Versus Placebo For Early Pulmonary Vascular Disease In Scleroderma (Sepvadis): Protocol For A Randomized Controlled Trial, Matthew R. Lammi, Monica Mukherjee, Lesley Ann Saketkoo, Kyle Carey, Laura Hummers, Steven Hsu, Amita Krishnan, Marie Sandi, Ami A. Shah, Stefan L. Zimmerman, Paul M. Hassoun, Steven C. Mathai

School of Medicine Faculty Publications

BACKGROUND: Pulmonary hypertension (PH) is a leading cause of death in patients with systemic sclerosis (SSc). An important component of SSc patient management is early detection and treatment of PH. Recently the threshold for the diagnosis of PH has been lowered to a mean pulmonary artery pressure (mPAP) threshold of > 20 mmHg on right heart catheterization (RHC). However, it is unknown if PH-specific therapy is beneficial in SSc patients with mildly elevated pressure (SSc-MEP, mPAP 21-24 mmHg). METHODS: The SEPVADIS trial is a randomized, double-blind, placebo-controlled phase 2 trial of sildenafil in SSc-MEP patients with a target enrollment of 30 …

Examining Processes Of Change For Acceptance And Commitment Therapy And Cognitive Behavioral Therapy Self-Help Books With Depressed College Students, Carter H. Davis, Michael P. Twohig, Michael E. Levin

Psychology Faculty Publications

Given the prevalence of depression, it is worthwhile to consider a variety of treatment approaches to reach as many sufferers as possible, including highly accessible formats such as self-help books. Books based in acceptance and commitment therapy (ACT) and cognitive behavioral therapy (CBT) propose to treat depression through distinct processes of change, though the degree to which these treatments are distinguishable in this format is unclear. Furthermore, it is possible that some individuals may respond better to therapeutic processes from one approach over the other based on personal preferences. We tested the effects of ACT and CBT self-help books on …

Extracurricular Enterprise And Entrepreneurship Activities In Higher Education: Understanding Entrepreneurial Competencies And Capabilities, Sarah Preedy, Emily Beaumont

Plymouth Business School

This chapter examines the role extracurricular activities have in developing higher education (HE) student’s entrepreneurial competencies and capabilities. Specifically, this chapter examines: What type of students participate in extracurricular activities? Why do students choose to participate? and What activities offer for entrepreneurial competency and capability development. An electronic survey (e-survey) collected pre-and post-data from two groups: Group A – students participating in extracurricular enterprise and entrepreneurship (EEEx) activities (n = 119); and Group B – students engaged in non-enterprise-related extracurricular activities (n = 72). Findings indicated that students in both groups were motivated to engage in extracurricular activities to enhance …

The Efficacy Of High-Fidelity Simulation On Knowledge And Performance In Undergraduate Nursing Students: An Umbrella Review Of Systematic Reviews And Meta-Analysis, Celeste Marie Alfes

Faculty Scholarship

Objectives: This umbrella review aimed to consolidate the evidence base on the impact of high-fidelity simulation on knowledge and performance among undergraduate nursing students. Design: Umbrella review with meta-analyses of pooled effect sizes, followed by an additional meta-analysis of primary studies from the included systematic reviews, excluding overlapping results. Data sources: Systematic searches were performed up to August 2023 in PubMed, Embase, and Cochrane Library. We included reviews that compared high-fidelity simulation against other learning strategies. Review methods: The risk of bias was assessed for each included systematic review (ROBIS tool) and primary study (RoB 2 or ROBINS-I as appropriate). …

A Sublethal Concentration Of Chlorine Induces Antibiotic Resistance In Salmonella Via Production Of Reactive Oxygen Species, Mohammed Aljuwayd, Israa Abdullah Malli, Steven C. Ricke, Young Min Kwon

Poultry Science Faculty Publications and Presentations

Studies have shown that the production of reactive oxygen species (ROS) is triggered by bactericidal antibiotics, which contributes significantly to the killing of bacterial cells and increasing mutations in surviving cells. In this study, we hypothesized that exposure of Salmonella to sublethal concentrations of hypochlorite (NaOCl), a commonly used sanitizer in household and food industries increases mutation rates, leading to the development of antibiotic resistance. We found that a sublethal concentration (20 ppm) of NaOCl increased the mutation rates of S. typhimurium 14028s significantly (p < 0.05), which was prevented by the ROS scavenger thiourea, supporting that the increased mutation was due to NaOCl-triggered ROS production. We further found that the exposure of S. typhimurium 14028s to the same sublethal concentration of NaOCl increases resistance to kanamycin among the 3 antibiotics evaluated. The results of this study suggest that when NaOCl applied as a sanitizer fails to kill Salmonella due to diluted local concentrations or presence of organic materials, it can cause an adverse outcome of developing antibiotic resistance of the pathogen.

What Is The Additive Value Of Nutritional Deficiency To Va-Fi In The Risk Assessment For Heart Failure Patients?, Seulgi Erica Kim, Mehrnaz Azarian, Aanand D Naik, Catherine Park, Molly J Horstman, Salim S Virani, Orna Intrator, Christopher I Amos, Ariela Orkaby, Javad Razjouyan

Faculty, Staff and Student Publications

OBJECTIVES: to assess the impact of adding the Prognostic Nutritional Index (PNI) to the U.S. Veterans Health Administration frailty index (VA-FI) for the prediction of time-to-death and other clinical outcomes in Veterans hospitalized with Heart Failure.

METHODS: A retrospective cohort study of veterans hospitalized for heart failure (HF) from October 2015 to October 2018. Veterans ≥50 years with albumin and lymphocyte counts, needed to calculate the PNI, in the year prior to hospitalization were included. We defined malnutrition as PNI ≤43.6, based on the Youden index. VA-FI was calculated from the year prior to the hospitalization and identified three groups: …

Developing A Research Skilled Workforce Strategy, Carrie Biddle

South West Clinical School Journal

EDITORIAL: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

Capturing Current Research Engagement Across The South West Region: A Survey, Krithika Anil, Ralph Hammond, Rachel Knight Lozano, Susie Pearce

South West Clinical School Journal

EDITORIAL: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

Delegation And Caseload Management In Occupational Therapy: Team Perspectives From The Acute Wards At Royal Devon University Healthcare Nhs Foundation Trust Northern Services, Hannah Luggar, Christopher Lovegrove, Louise Bingham, Rebecca Fox

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

Primary Care Organisational Culture And Climate Impact Upon Paramedics, Steven Blakeway

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

Repeated Referrals In Community Rehabilitation: Prevalence And Reasons, Ria Dark, James Rodger

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION