Digital Commons Network^™

Cytauxzoonosis In Indiana, Usa: A Case Series Of Cats Infected With Cytauxzoon Felis (2018-2022), Mason V. Reichard, Stacy R. Cotey, Sriveny Dangoudoubiyam, Pabasara Weerarathne, Kenneth Tussey, Rebecca P. Wilkes, Et. Al.

Michigan Tech Publications

CASE SERIES SUMMARY: This case series describes six cases involving seven cats naturally infected with Cytauxzoon felis in Indiana, USA. Medical records were retrospectively reviewed and all available information on signalment, history, clinical and diagnostic findings, treatment, outcome and pathology was reported. Cats infected with C felis were domestic shorthairs, were aged between 2 and 9 years and all but one of the cats were male. The seven infected cats originated from five counties in southwestern Indiana. Six of seven cats were found to have acute cytauxzoonosis based on clinical signs, gross pathologic lesions, observation of C felis in tissues …

The Holy Spirit As The Undiminished Giver In The Early Church, Kyle Weeks

Grapho : Concordia Seminary Student Journal

At one time or another, virtually every churchgoing Christian is bound to hear the moniker of “Sanctifier” applied to the Holy Spirit. In this role, the Spirit is often described as dwelling within believers to make them holy, so that they might produce the “fruit of the spirit” as they lead good and godly lives.2 To that end, the Spirit is said to effect a complete “regeneration and renewal” of the individual, empowering them with the strength, grace, virtues, and other “spiritual gifts” requisite for Christian life.3 In denominations such as Lutheranism, faith itself is proclaimed to be impossible without …

Virtual Reality In And For Creation, Jaron Melin

Grapho : Concordia Seminary Student Journal

Within the last few years, there has been growing excitement and concern in the rise of what is called the metaverse. How do various enthusiasts and observers characterize the metaverse? Bobrowsky on the Wall Street Journal reports the metaverse as “an extensive online world transcending individual tech platforms, where people exist in immersive, shared virtual spaces. Through avatars, people are able to try on items available in stores or attend concerts with friends, just as they would offline.”

Letter From The Chairman: Why We Are Not Our Own, Cody Macmillan

Grapho : Concordia Seminary Student Journal

In his book, You Are Not Your Own, author and professor Alan Noble argues that the fundamental lie of modernity is the one which says we belong to ourselves.1 He is concerned with our society's increased emphasis on individualism, and he asserts that it requires serious and intentional effort to remember how we belong to Christ. This truth, Noble says, is not just a doctrine to which we must subscribe but a reality which touches every part of our lives.2 It runs contrary to the narratives of self-discovery and self-ownership that we are surrounded by today, and it is the …

Bitterness And Anger In Ephesians, Archetypes, & The Bi-Hemispheric Structure Of The Brain: Comparing Paul, Jordan Peterson, And Iain Mcgilchrist, Joshua Armstrong

Grapho : Concordia Seminary Student Journal

Many people eager to confront falsehood and pursue justice or truth do so nourishing a vindictive, bitter, or resentful attitude. Nourishing anger, particularly resentment, is akin to stoking up the archetypal “Luciferian spirit,” according to clinical psychologist and author Jordan Peterson. This spirit presumes: “what I do is all there is to do, what I know is all there is to know.” It is symptomatic of attending to the world in a way overly reliant on a “left-hemisphere” approach, which leads to entrapment in a “self-reflexive virtual world” disconnected from real “other” things, and only really knowing itself, according to …

Christian Narrative Service: God’S Story Of Everything In Worship, Jaron Melin

Grapho : Concordia Seminary Student Journal

Christian Narrative Service: God’s Story of Everything in Worship

Grapho 2024, Cody Macmillan

Grapho : Concordia Seminary Student Journal

Grapho 2024

An Assessment Process And Guide For Intervention To Increase Procedural Fidelity, Silvia Cabal

Thesis Projects

For applied behavior analytic (ABA) services to be effective and provide change, those providing services must be well trained. However, when low procedural fidelity is observed, whether it is due to a skill or performance deficit may be unknown. Assessments can help provide insight into whether low procedural fidelity by a Registered Behavior Technician (RBT) providing services is due to a skill or performance deficit. The intervention can then be tailored to the RBT's specific needs. This study evaluates this process by administering the Performance Diagnostic Checklist-Human Services (PDC-HS) to three RBTs and providing either a reinforcement intervention or behavioral …

The Grand Forks Business And Professional Women’S Club: A History Of Women’S Empowerment, Emily Bruer

History Student Publications

Members of the Grand Forks Business and Professional Women’s Club (GFBPWC) personified the intersection of consumer culture, Progressive reform, and the professionalization of women’s labor that occurred between 1890 and 1930. Their membership in the GFBPWC implied economic, political, and social empowerment and granted them an opportunity to actively participate in and transform their community. Not only were these professional women recognized as reputable, upstanding, and passionate members of their community, but they also saw themselves as agents of positive change and improvement within their own lives and for future generations. This study of the concurrent rise of consumer culture, …

Investigation Of Lignin Solubilization Using Quantum Chemical Calculations In Constrained Media, Leo Sanzone

Arts & Sciences Undergraduate Showcase

Lignin is a common, yet complex polymer found in a majority of vascular plants. The polymer can easily be functionalized, and it is a readily available and renewable source of carbon-based material without a petrol source. There are various methods to allow for the dissolution of lignin, one of which involves the use of H₂O and CO₂ in supercritical conditions. This particular solution bends the normal solvation rules and allows for multiple instances of H-bonding interactions.

By using Density Functional theory, this study aims to identify the molecular interactions of guaiacol (the most basic fragment of lignin) …

The Effect Of Diabetes Mellitus On Differentiation Of Mesenchymal Stem Cells Into Insulin-Producing Cells, Mohamed M. Kamal, Omar I. Badr, Shohda A. El-Maraghy, Heba R. Ghaiad

Pharmacy

Background

Diabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a metabolic disease associated with chronic hyperglycemia. Aside from conventional treatments, there is no clinically approved cure for DM up till now. Differentiating mesenchymal stem cells (MSCs) into insulin-producing cells (IPCs) is a promising approach for curing DM. Our study was conducted to investigate the effect of DM on MSCs differentiation into IPCs in vivo and in vitro.

Methods

We isolated adipose-derived mesenchymal stem cells (Ad-MSCs) from the epididymal fat of normal and STZ-induced diabetic Sprague–Dawley male rats. Afterwards, the in vitro differentiation of normal-Ad-MSCs (N-Ad-MSCs) and …

Outlining The Hidden Curriculum: Perspectives On Successfully Navigating Scientific Conferences, Eduardo J. Caro-Diaz, Marcy J. Balunas, Lesley Ann Giddings, Sandra Loesgen, Brian T. Murphy, C. Benjamin Naman, Christine E. Salomon, Kevin J. Tidgewell, Jaclyn M. Winter

Chemistry: Faculty Publications

Scientific conferences and meetings are valuable opportunities for researchers to network, communicate, and develop knowledge. For early career scientists, conferences can also be intimidating, confusing, and overwhelming, especially without having adequate preparation or experience. In this Perspective, we provide advice based on previous experiences navigating scientific meetings and conferences. These guidelines outline parts of the hidden curriculum around preparing for and attending meetings, navigating conference sessions, networking with other scientists, and participating in social activities while upholding a recommended code of conduct.

Using Genome And Transcriptome Data From African-Ancestry Female Participants To Identify Putative Breast Cancer Susceptibility Genes, Jie Ping, Guochong Jia, Qiuyin Cai, Xingyi Guo, Ran Tao, Christine Ambrosone, Dezheng Huo, Stefan Ambs, Mollie E Barnard, Yu Chen, Montserrat Garcia-Closas, Jian Gu, Jennifer J Hu, Esther M John, Christopher I Li, Katherine Nathanson, Barbara Nemesure, Olufunmilayo I Olopade, Tuya Pal, Michael F Press, Maureen Sanderson, Dale P Sandler, Toshio Yoshimatsu, Prisca O Adejumo, Thomas Ahearn, Abenaa M Brewster, Anselm J M Hennis, Timothy Makumbi, Paul Ndom, Katie M O'Brien, Andrew F Olshan, Mojisola M Oluwasanu, Sonya Reid, Song Yao, Ebonee N Butler, Maosheng Huang, Atara Ntekim, Bingshan Li, Melissa A Troester, Julie R Palmer, Christopher A Haiman, Jirong Long, Wei Zheng

Faculty, Staff and Student Publications

African-ancestry (AA) participants are underrepresented in genetics research. Here, we conducted a transcriptome-wide association study (TWAS) in AA female participants to identify putative breast cancer susceptibility genes. We built genetic models to predict levels of gene expression, exon junction, and 3' UTR alternative polyadenylation using genomic and transcriptomic data generated in normal breast tissues from 150 AA participants and then used these models to perform association analyses using genomic data from 18,034 cases and 22,104 controls. At Bonferroni-corrected P < 0.05, we identified six genes associated with breast cancer risk, including four genes not previously reported (CTD-3080P12.3, EN1, LINC01956 and NUP210L). Most of these genes showed a stronger association with risk of estrogen-receptor (ER) negative or triple-negative than ER-positive breast cancer. We also replicated the associations with 29 genes reported in previous TWAS at P < 0.05 (one-sided), providing further support for an association of these genes with breast cancer risk. Our study sheds new light on the genetic basis of breast cancer and highlights the value of conducting research in AA populations.

Kras G12c Inhibitor Combination Therapies: Current Evidence And Challenge, Hirotaka Miyashita, Shumei Kato, David S Hong

Faculty, Staff and Student Publications

Although KRAS G12C inhibitors have proven that KRAS is a "druggable" target of cancer, KRAS G12C inhibitor monotherapies have demonstrated limited clinical efficacy due to primary and acquired resistance mechanisms. Multiple combinations of KRAS G12C inhibitors with other targeted therapies, such as RTK, SHP2, and MEK inhibitors, have been investigated in clinical trials to overcome the resistance. They have demonstrated promising efficacy especially by combining KRAS G12C and EGFR inhibitors for KRAS G12C-mutated colorectal cancer. Many clinical trials of combinations of KRAS G12C inhibitors with other targeted therapies, such as SOS1, ERK, CDK4/6, and wild-type RAS, are ongoing. Furthermore, preclinical …

De Novo Genome Assembly For The Coppery Titi Monkey (Plecturocebus Cupreus): An Emerging Nonhuman Primate Model For Behavioral Research, Susanne P Pfeifer, Alexander Baxter, Logan E Savidge, Fritz J Sedlazeck, Karen L Bales

Faculty, Staff and Students Publications

The coppery titi monkey (Plecturocebus cupreus) is an emerging nonhuman primate model system for behavioral and neurobiological research. At the same time, the almost entire absence of genomic resources for the species has hampered insights into the genetic underpinnings of the phenotypic traits of interest. To facilitate future genotype-to-phenotype studies, we here present a high-quality, fully annotated de novo genome assembly for the species with chromosome-length scaffolds spanning the autosomes and chromosome X (scaffold N50 = 130.8 Mb), constructed using data obtained from several orthologous short- and long-read sequencing and scaffolding techniques. With a base-level accuracy of ∼99.99% in chromosome-length …

Reduction Of Hospital-Acquired Pressure Injuries In The Acute Care Setting, Bailey Rasmussen, Taylor Bacon, Andrew Gross

Doctor of Nursing Practice Projects: College of Nursing

Background: Hospital-acquired pressure injuries (HAPIs) have been a longstanding problem in hospitals nationwide. HAPIs cause significant financial strain to a healthcare system and complications can be devastating to the patient.

Purpose: The purpose of this project was to implement the Standard Pressure Injury Prevention Protocol (SPIPP) 2.0 Checklist for patients in the Intensive Care Unit (ICU). The primary aim of this study was to determine if implementing the checklist would reduce the number of HAPIs.

Methods: This project took place over a four-week period at a Midwest hospital in the ICU. Data were collected via patient chart …

2024-05-02 Non-Tenure Track Faculty Concerns Committee Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Meeting minutes of the Non-Tenure Track Faculty Concerns Committee from May 2, 2024.

Integrated Transcriptomics And Histopathology Approach Identifies A Subset Of Rejected Donor Livers With Potential Suitability For Transplantation, Ankita Srivastava, Alexandra Manchel, John Waters, Manju Ambelil, Benjamin K. Barnhart, Jan B. Hoek, Ashesh P. Shah, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Liver transplantation is an effective treatment for liver failure. There is a large unmet demand, even as not all donated livers are transplanted. The clinical selection criteria for donor livers based on histopathological evaluation and liver function tests are variable. We integrated transcriptomics and histopathology to characterize donor liver biopsies obtained at the time of organ recovery. We performed RNA sequencing as well as manual and artificial intelligence-based histopathology (10 accepted and 21 rejected for transplantation).

RESULTS: We identified two transcriptomically distinct rejected subsets (termed rejected-1 and rejected-2), where rejected-2 exhibited a near-complete transcriptomic overlap with the accepted livers, …

Diet Quality As Assessed By The Healthy Eating Index-2020 Among Different Smoking Status: An Analysis Of National Health And Nutrition Examination Survey (Nhanes) Data From 2005 To 2018, Ting Luo, Tung Sung Tseng

School of Public Health Faculty Publications

Background: Combining smoking with poor eating habits significantly elevates the risk of chronic illnesses and early death. Understanding of how dietary quality shifts post-smoking cessation remains limited. The objective of this study is to examine dietary quality – using Healthy Eating Index (HEI – 2020) and its 13 components, among current, former, and never smokers, and particularly the impact of quitting and the duration of cessation on dietary habits. Methods: A cross-sectional analysis of 31,569 adults from the National Health and Nutrition Examination Survey (NHANES) 2005–2018 was conducted. Dietary quality was assessed using HEI-2020 scores, which were determined by NIH …

State Of Utah, Plaintiff/ Appellee, V. Thomas Jacob Walker, Defendant/ Appellant: Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

his is the reply brief of Appellant Walker to Appellee's brief of the bench trial conviction of Appellant on the charge of STALKING, Utah Code Annotated, Section 76-5- 106.5 (1953, as amended)

SAM WOODALL, Attorney for Plaintiff/Appellee

J. BRYAN JACKSON, P.C, Attorney for Defendant/ Appellant

The Role Of Acculturation In The Professional Identity Of Art Therapy And Counseling International Students, Ana Marcela Tobar Chavez

Art Therapy Counseling Final Research Projects

In a country of immigrants, the concept of acculturation needs to be familiar to almost any professional in the mental health field and it is a reality for immigrants and international students. As international and immigrant students continue to join the Art Therapy Counseling profession, it is important to understand how acculturation plays a role in the development of their counseling professional identity. Unlike most master’s students in the art therapy counseling profession, international and immigrant students go through unique experiences such as being born and raised in a different country with difference in cultures, languages, and immigration statuses that …

The Relationship Between Eating Disorders, Attachment Styles And The Uses Of Art Materials, Tsai-Yu Chen

Art Therapy Counseling Final Research Projects

Previous studies showed that both eating disorder (ED) behaviors and attachment styles (ASs) could reflect on individuals’ uses of art materials. This mixed methods study aimed to explore the correlation between ED diagnoses and ASs, investigate clients’ selection of and familiarity with art materials, as well as understand how clients’ self-reports of media interactions match clinical observations. Participants were adults receiving residential care in an ED facility in Midwestern United States. Data were collected through surveys, chart reviews, and discussions with the participants’ therapist. The results of this study found a high prevalence (85%) of insecure attachment in the population. …

Art Therapists’ Familiarity With And Beliefs About Twelve-Step Addiction Recovery Groups, David Brickhouse

Art Therapy Counseling Final Research Projects

This research proposed to study what art therapists know and believe about twelve-step addiction recovery groups such as Alcoholics Anonymous (AA), Narcotics Anonymous (NA), and Cocaine Anonymous (CA). The aim was to better understand the field’s familiarity with 12-step recovery, identify misconceptions about 12-step groups, and assess the comfortability of incorporating 12-step philosophy into clinical practice. Findings include that art therapists integrate 12-step into art making, are likely to refer clients to 12-step groups, and that higher familiarity with 12-step was associated with more positive perceptions and greater integration with clinical practice. The study participants also agreed that accessibility was …

Communication Beyond Words, Anna Brough

Art Therapy Counseling Final Research Projects

This research explores the definition and use of nonverbal communication within the therapeutic setting and the treatment of selective mutism by clinical providers. A phenomenological research method was used to interview three art therapists and two therapists without art therapy training. These interviews were used to explore their understanding and awareness of nonverbal communication within the context of providing treatment to clients with selective mutism. The analysis of participants’ discussions of their experiences of treating those with selective mutism revealed four major themes: Nonverbal Communication, Therapeutic Presence and Alliance, Art Materials and Interventions, and Culture and Society. Findings suggest no …

Understanding Clay And Its Media Properties Through The Expressive Therapies Continuum, Anne Geisz

Art Therapy Counseling Final Research Projects

For centuries, clay has been used by civilizations to hold food, memories, and records of history. To this day, it is used by engineers, hobbyists, artists, art therapists and many more. This art based, heuristic study explores clay through the researcher’s ongoing practice with the material, within the framework of the Expressive Therapies Continuum (ETC) and examines how its unique media properties make it such a versatile material for both ceramic artists and art therapists. Results exhibit these unique media properties and clay’s ability to reach all levels of the ETC through collected data of images, journals, critiques, and notes. …

Melting Premenstrual Dysphoric Disorder/ Premenstrual Exacerbation Symptoms With Metalsmithing: A Group Process, Maureen Bella Russo

Art Therapy Counseling Final Research Projects

People experiencing Premenstrual Dysphoric Disorder/Premenstrual Exacerbation, PMDD/PME, frequently live with debilitating symptoms that can arrest their daily life functions (Barker-Smith, 2020). Finding art to process and transform painful emotions that align with PMDD/PME hormonal depression/anxiety, may assist in supporting people to keep choosing life, especially when these art practices involve group settings and community artmaking (Phillips & Rosal, 1989; Robb, 2022). Metalsmithing requires significant cognitive awareness and promotes mind/body connections in its elemental art form (Carlson, 2015). This proposal outlines a group process involving 8-12 people who will receive a beginner’s metalsmithing, 12-week studio art program at Hyde Park Arts …

The Cowl - V. 88 N. 8 - May 2, 2024

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 8 - May 2, 2024. 28 pages.

Characterization Of The Potential Of Mouse Mammary Tumor Virus (Mmtv) To Disrupt Mammary Epithelial Cell Gene Expression And Its Consequences, Neena G. Panicker

Thesis/ Dissertation Defenses

The mouse mammary tumor virus (MMTV) is a betaretrovirus known to induce breast cancer in mice. Unlike most other tumorigenic retroviruses that target hematopoietic cells, MMTV primarily targets mammary epithelial cells for infection and transformation. This makes it a valuable model for studying human breast cancer, which also originates from mammary epithelial cells. MMTV is transmitted through milk, with the highest expression occurring in lactating mammary glands due to the mammary gland enhancer and hormone-responsive elements (HREs) in its promoter. However, not much is known about how MMTV affects these cells at the molecular level. Since elevated hormonal induction during …

Relationships Among Phonemic Awareness, Phonic Decoding, And Pseudo-And Sight-Word Reading: A Path Analysis With Second Grade Students, Nona Croom

Graduate Theses, Dissertations, and Capstones

This study examines the relationships between phonemic awareness, sight- and pseudoword reading, and phonic decoding in second-grade students. Previous research has shown that basic and advanced phonemic awareness, sight- and pseudoword reading, and phonic decoding impact reading fluency. Students were assessed in the middle of second grade using the Test of Word Reading Efficiency (TOWRE-2), Pseudo- and Sight-word reading subtests, the Developmental Spelling Assessment (DSA), and the Phonological Awareness Screening Test (PAST-S) to determine phonemic awareness, sight- and pseudo-word reading, and phonic decoding abilities. A path analysis using regression analysis was conducted to determine the significance of relationships among the …

The Colby Echo (2024-05-02), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.