Digital Commons Network^™

Psilocybin Utilization In Alcohol Use Disorder, Hannah Hall, Sarah Turske, Hannah Blake, Abigail Carter, Connor Dains, Haylee Whyde, Brianna Lu, Joshua Honaker, Lindsey Peters

Pharmacy and Wellness Review

Alcohol use disorder (AUD) is a medical condition that arises from the inability to control alcohol consumption regardless of negative consequences. Over 10% of the US population met the diagnostic criteria for having AUD in 2022.1 Each individual presents with symptoms of AUD differently and may therefore need more personalized treatment. Research has shown that using a combination of currently available pharmacological and non-pharmacological treatment options provides the best results for patients with AUD. However, there still remains a pressing need for the development of newer treatment options. Psilocybin, a naturally occurring psychedelic compound, is currently under investigation due to …

Lived Experience Of Burnout And Self-Efficacy In Intensive Care Unit Registered Nurses Caring For Covid-19 Patients In U.S. Hospitals, Trixie Alohilani Harris

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic has impacted the physical and mental health of intensive care unit registered nurses (ICU RNs). Burnout in ICU RNs existed long before the pandemic; however, the massive increase in critically ill patients and the scarcity of supplies and qualified staff to care for these patients put RNs in a dangerous situation. Research addressed this topic early in the pandemic but were primarily quantitative, with minimal qualitative studies appearing later. There remained a gap in examining ICU RNs in rural hospitals in the United States. The research question for this hermeneutic phenomenological study explored the interpretation of the …

Testing Whisper Ai As A Tool For Digital Library Workflows, Kenneth Cotich

Library Staff Publications and Research

This presentation was included as a part of town hall meeting for the librarians and employees of the Claremont Colleges Library. The content is focused around how recent advancements in Whisper AI allow for new directions in workflows involving oral histories and video production.

Integrative Molecular Analyses Of The Md Anderson Prostate Cancer Patient-Derived Xenograft (Mda Pca Pdx) Series, Nicolas Anselmino, Estefania Labanca, Peter D A Shepherd, Jiabin Dong, Jun Yang, Xiaofei Song, Subhiksha Nandakumar, Ritika Kundra, Cindy Lee, Nikolaus Schultz, Jianhua Zhang, John C Araujo, Ana M Aparicio, Sumit K Subudhi, Paul G Corn, Louis L Pisters, John F Ward, John W Davis, Elba S Vazquez, Geraldine Gueron, Christopher J Logothetis, Andrew Futreal, Patricia Troncoso, Yu Chen, Nora M Navone

Faculty, Staff and Student Publications

PURPOSE: Develop and deploy a robust discovery platform that encompasses heterogeneity, clinical annotation, and molecular characterization and overcomes the limited availability of prostate cancer models. This initiative builds on the rich MD Anderson (MDA) prostate cancer (PCa) patient-derived xenograft (PDX) resource to complement existing publicly available databases by addressing gaps in clinically annotated models reflecting the heterogeneity of potentially lethal and lethal prostate cancer.

EXPERIMENTAL DESIGN: We performed whole-genome, targeted, and RNA sequencing in representative samples of the same tumor from 44 PDXs derived from 38 patients linked to donor tumor metadata and corresponding organoids. The cohort includes models derived …

A Gold Standard-Derived Modular Barcoding Approach To Cancer Transcriptomics, Yan Zhu, Mohamad Karim I Koleilat, Jason Roszik, Man Kam Kwong, Zhonglin Wang, Dipen M Maru, Scott Kopetz, Lawrence N Kwong

Faculty, Staff and Student Publications

A challenge with studying cancer transcriptomes is in distilling the wealth of information down into manageable portions of information. In this resource, we develop an approach that creates and assembles cancer type-specific gene expression modules into flexible barcodes, allowing for adaptation to a wide variety of uses. Specifically, we propose that modules derived organically from high-quality gold standards such as The Cancer Genome Atlas (TCGA) can accurately capture and describe functionally related genes that are relevant to specific cancer types. We show that such modules can: (1) uncover novel gene relationships and nominate new functional memberships, (2) improve and speed …

Transcriptomic Profiling Of Plasma Extracellular Vesicles Enables Reliable Annotation Of The Cancer-Specific Transcriptome And Molecular Subtype, Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Scott Kopetz, Anirban Maitra, Paola A Guerrero

Faculty, Staff and Student Publications

Longitudinal monitoring of patients with advanced cancers is crucial to evaluate both disease burden and treatment response. Current liquid biopsy approaches mostly rely on the detection of DNA-based biomarkers. However, plasma RNA analysis can unleash tremendous opportunities for tumor state interrogation and molecular subtyping. Through the application of deep learning algorithms to the deconvolved transcriptomes of RNA within plasma extracellular vesicles (evRNA), we successfully predicted consensus molecular subtypes in patients with metastatic colorectal cancer. Analysis of plasma evRNA also enabled monitoring of changes in transcriptomic subtype under treatment selection pressure and identification of molecular pathways associated with recurrence. This approach …

The Calcineurin-Nfatc Pathway Modulates The Lipid Mediators In Bal Fluid Extracellular Vesicles, Thereby Regulating Microvascular Endothelial Cell Barrier Function, Manjula Karpurapu, Yunjuan Nie, Sangwoon Chung, Jiasheng Yan, Patrick Dougherty, Sonal Pannu, Jon Wisler, Ryan Harkless, Narasimham Parinandi, Evgeny Berdyshev, Dehua Pei, John W Christman

Faculty, Staff and Student Publications

Extracellular vesicles mediate intercellular communication by transporting biologically active macromolecules. Our prior studies have demonstrated that the nuclear factor of activated T cell cytoplasmic member 3 (NFATc3) is activated in mouse pulmonary macrophages in response to lipopolysaccharide (LPS). Inhibition of NFATc3 activation by a novel cell-permeable calcineurin peptide inhibitor CNI103 mitigated the development of acute lung injury (ALI) in LPS-treated mice. Although pro-inflammatory lipid mediators are known contributors to lung inflammation and injury, it remains unclear whether the calcineurin-NFATc pathway regulates extracellular vesicle (EV) lipid content and if this content contributes to ALI pathogenesis. In this study, EVs from mouse …

Oncology Patients’ Willingness To Report Their Medication Safety Concerns From Home: A Qualitative Study, Deema Bunni, Grace Walters, Misun Hwang, Katie Gahn, Heidi Mason, Milisa Manojlovich, Yang Gong, Yun Jiang

Faculty, Staff and Student Publications

Purpose: Oncology patients often struggle to manage their medications and related adverse events during transitions of care. They are expected to take an active role in self-monitoring and timely reporting of their medication safety events or concerns to clinicians. The purpose of this study was to explore the factors influencing oncology patients' willingness to report adverse events or concerns related to their medication after their transitions back home.

Methods: A qualitative interview study was conducted with adult patients with breast, prostate, lung, or colorectal cancer who experienced care transitions within the previous year. A semi-structured interview guide was developed to …

Ire1Α Determines Ferroptosis Sensitivity Through Regulation Of Glutathione Synthesis, Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan, Albert C Koong

Faculty, Staff and Student Publications

Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis. Cancer and normal cells depleted of IRE1α gain resistance to ferroptosis, while enhanced IRE1α expression promotes sensitivity to ferroptosis. Mechanistically, IRE1α's endoribonuclease activity cleaves and down-regulates the mRNA of key glutathione biosynthesis regulators glutamate-cysteine ligase catalytic subunit (GCLC) and solute carrier family 7 member 11 (SLC7A11). This activity of IRE1α is independent of its role in regulating the UPR and is …

Seasonality, Clinical Characteristics, And Outcomes Of Respiratory Syncytial Virus Disease By Subtype Among Children Aged <5 Years: New Vaccine Surveillance Network, United States, 2016-2020., Ariana P. Toepfer, Justin Z. Amarin, Andrew J. Spieker, Laura S. Stewart, Mary Allen Staat, Elizabeth P. Schlaudecker, Geoffrey A. Weinberg, Peter G. Szilagyi, Janet A. Englund, Eileen J. Klein, Marian G. Michaels, John V. Williams, Rangaraj Selvarangan, Christopher J. Harrison, Joana Y. Lively, Pedro A. Piedra, Vasanthi Avadhanula, Brian Rha, James Chappell, Meredith Mcmorrow, Heidi Moline, Natasha B. Halasa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory illnesses in children. RSV can be broadly categorized into 2 major subtypes: A and B. RSV subtypes have been known to cocirculate with variability in different regions of the world. Clinical associations with viral subtype have been studied among children with conflicting findings such that no conclusive relationships between RSV subtype and severity have been established.

METHODS: During 2016-2020, children aged/guardian interviews, chart reviews, and collection of midturbinate nasal plus/minus throat swabs for RSV (RSV-A, RSV-B, and untyped) using reverse transcription polymerase chain reaction.

RESULTS: Among 6398 RSV-positive …

Heterogeneous Profile Of Ror1 Protein Expression Across Tumor Types, Maria Gabriela Raso, Elizve Barrientos Toro, Kurt Evans, Yasmeen Rizvi, Rossana Lazcano, Argun Akcakanat, Patrizia Sini, Francesca Trapani, Eva Johanna Madlener, Lorenz Waldmeier, Alexander Lazar, Funda Meric-Bernstam

Faculty, Staff and Student Publications

The Wnt receptor ROR1 has generated increased interest as a cancer therapeutic target. Research on several therapeutic approaches involving this receptor is ongoing; however, ROR1 tissue expression remains understudied. We performed an immunohistochemistry analysis of ROR1 protein expression in a large cohort of multiple tumor and histologic types. We analyzed 12 anonymized multi-tumor tissue microarrays (TMAs), including mesothelioma, esophageal and upper gastrointestinal carcinomas, and uterine endometrioid carcinoma, among other tumor types. Additionally, we studied 5 different sarcoma types of TMAs and 6 patient-derived xenografts (PDX) TMAs developed from 19 different anatomic sites and tumor histologic types. A total of 1142 …

Era Of Confusion: The State Of Patent Eligibility Jurisprudence And The Need For Intervention, Alyssa Boggs

St. Mary's Law Journal

No abstract provided.

Data From: Interweaving Recurring Slope Lineae On Mars: Do They Support A Wet Hypothesis?, Daniel P. Mason, Louis A. Scuderi

Earth and Planetary Sciences Faculty and Staff Publications

This is a metadata only access point for the referenced dataset hosted in the Dryad data repository. The following abstract relates to the dataset that is available through Dryad.

Included in these supplementary materials is a manuscript citation and manuscript keywords for the manuscript “Interweaving Recurring Slope Lineae on Mars: Do They Support a Wet Hypothesis?”, as submitted to the scientific journal Icarus. Also included are two JP2 image files, a digital terrain model (DTM) file, two shapefiles, and forty-eight CSV files that all collectively detail data relating to channel counts and sinuosity measurements for Martian hillslope features known as …

Testing Hadronic-Model Predictions Of Depth Of Maximum Of Air-Shower Profiles And Ground-Particle Signals Using Hybrid Data Of The Pierre Auger Observatory, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, B. Fick, K. Nguyen, D. Nitz, Et Al.

Michigan Tech Publications

We test the predictions of hadronic interaction models regarding the depth of maximum of air-shower profiles, Xmax, and ground-particle signals in water-Cherenkov detectors at 1000 m from the shower core, S(1000), using the data from the fluorescence and surface detectors of the Pierre Auger Observatory. The test consists of fitting the measured two-dimensional (S(1000), Xmax) distributions using templates for simulated air showers produced with hadronic interaction models epos-lhc, qgsjet-ii-04, sibyll 2.3d and leaving the scales of predicted Xmax and the signals from hadronic component at ground as free-fit parameters. The method relies on the assumption that the mass composition remains …

Unseen Battles, Academic Frontlines: The Impact Of Military Experience On Student Veteran Persistence In Private Higher Education, Julius W. Moore Ii

Seton Hall University Dissertations and Theses (ETDs)

The purpose of this qualitative study was to understand how ten student veterans persist after entering private, 4-year institutions of higher education during or following their military service. The study’s conceptual framework, drawing from Vacchi’s Model of Student Veteran Support (2011, 2013), employs a narrative approach to spotlight the varied backgrounds and identities of the student veteran population. This research uncovers significant findings through the restorying of participants’ narratives and employing multiple rounds of coding—including deductive, open, in vivo, and process coding. These findings highlight the critical role of Adaptation to Academic Life, which emphasizes the veterans’ ability to adjust …

K(Now) W(Here), Yulin Yuan

Masters Theses, 2020-current

“How does one discover solace and belonging within these layered narratives?”

In mythology, narratives were once created to answer the incomprehensible questions of an era. These narratives unveil half-truths, customs, and convictions. K(now) W(here) is based on the experience of the artist who is Chinese and immigrated to South Africa at a young age; she elaborates the story about assimilation, authenticity, tales of her ancestral roots, and, most often, myths of identity.

The artist used narratives from Chinese mythology, collaged physically and metaphorically using tangible objects from other’s homes in combination with photography, digital media, and domestic items and assemblage …

Prediction Of Converter Gas Generation Based On Intermission Production Improved Elman, Jiajie Fei, Dinghui Wu, Junyan Fan, Jing Wang

Journal of System Simulation

Abstract: Aiming at large fluctuations of intermission and low prediction accuracy in iron and steel industry, based on the classification of intermission characteristics, a converter gas generation predicting model(CPSO-Elman) based on Elman neural network(ENN) optimized by chaotic PSO(CPSO) algorithm is proposed. The intermittent characteristics of converter gas generation time series are extracted and raw data is classified according to intermittent duration. The PSO algorithm improved by chaotic disturbance is introduced to optimize the initial weight and threshold of ENN and inertia weight of nonlinear updating is designed to balance global search ability and local search ability. Construct the combined prediction …

Dose-Dependent Effects Of Gamma Radiation Sterilization On The Collagen Matrix Of Human Cortical Bone Allograft And Its Influence On Fatigue Crack Propagation Resistance, Dylan B. Crocker, Thomas M. Hering, Ozan Akkus, Clare M. Rimnac

Student Scholarship

Fatigue crack propagation resistance and high-cycle S–N fatigue life of cortical bone allograft tissue are both negatively impacted in a radiation dose-dependent manner from 0 to 25 kGy. The standard radiation sterilization dose of 25–35 kGy has been shown to induce cleavage of collagen molecules into smaller peptides and accumulation of stable crosslinks within the collagen matrix, suggesting that these mechanisms may influence radiation-induced losses in cyclic fracture resistance. The objective of this study was to determine the radiation dose-dependency of collagen chain fragmentation and crosslink accumulation within the dose range of 0–25 kGy. Previously, cortical bone compact tension specimens …

Postnatal Brain Trajectories And Maternal Intelligence Predict Childhood Outcomes In Complex Chd, Vincent K Lee, Rafael Ceschin, William T Reynolds, Benjamin Meyers, Julia Wallace, Douglas Landsittel, Heather M Joseph, Daryaneh Badaly, J William Gaynor, Daniel Licht, Nathaniel H Greene, Ken M Brady, Jill V Hunter, Zili D Chu, Elisabeth A Wilde, R Blaine Easley, Dean Andropoulos, Ashok Panigrahy

Faculty, Staff and Student Publications

Objective: To determine whether early structural brain trajectories predict early childhood neurodevelopmental deficits in complex CHD patients and to assess relative cumulative risk profiles of clinical, genetic, and demographic risk factors across early development.

Study Design: Term neonates with complex CHDs were recruited at Texas Children’s Hospital from 2005–2011. Ninety-five participants underwent three structural MRI scans and three neurodevelopmental assessments. Brain region volumes and white matter tract fractional anisotropy and radial diffusivity were used to calculate trajectories: perioperative, postsurgical, and overall. Gross cognitive, language, and visuo-motor outcomes were assessed with the Bayley Scales of Infant and Toddler Development and …

Application Of Naoh Modified Micro-Polyethylene As Storage Material For H2, Tawanda Matamba, Hussein R. Abid, Masoumeh Zargar, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

H2 is increasingly regarded as a decarbonized solution for the increasing energy demand. However, due to its low density, H2 cannot be easily compressed, and there is a need for materials that can store large amounts of H2. Here we tested H2 adsorption capacity of micro-polyethylene (MicroPE) – a significant environmental pollutant - at 1–70 bar and 30 °C. H2 adsorption capacity increased with increasing the adsorption pressure (from 0.06 mol/kg at 17.21 bar to 0.20 mol/kg at 68.11 bar for raw MicroPE). MicroPE activated with aqueous NaOH significantly changed H2 adsorption under the same operating conditions. H2 adsorption increased …

Advective And Diffusive Gas Phase Transport In Vadose Zones: Importance For Defining Vapour Risks And Natural Source Zone Depletion Of Petroleum Hydrocarbons, Kaveh Sookhak Lari, Greg B. Davis, John L. Rayner, Trevor P. Bastow

Research outputs 2022 to 2026

Quantifying the interlinked behaviour of the soil microbiome, fluid flow, multi-component transport and partitioning, and biodegradation is key to characterising vapour risks and natural source zone depletion (NSZD) of light non-aqueous phase liquid (LNAPL) petroleum hydrocarbons. Critical to vapour transport and NSZD is transport of gases through the vadose zone (oxygen from the atmosphere, volatile organic compounds (VOCs), methane and carbon dioxide from the zone of LNAPL biodegradation). Volatilisation of VOCs from LNAPL, aerobic biodegradation, methanogenesis and heat production all generate gas pressure changes that may lead to enhanced gas fluxes apart from diffusion. Despite the importance of the gaseous …

Collective Order And Group Structure Of Shoaling Fish Subject To Differing Risk-Level Treatments With A Sympatric Predator, Timothy M. Schaerf, Alexander D.M. Wilson, Mitchell Welch, Ashley J.W. Ward

School of Biological and Marine Sciences

It is imperative for individuals to exhibit flexible behaviour according to ecological context, such as available resources or predation threat. Manipulative studies on responses to threat often focus on behaviour in the presence of a single indicator for the potential of predation, whereas in the wild perception of threat will probably be more nuanced. Here, we examine the collective behaviour of eastern mosquitofish (Gambusia holbrooki) subject to five differing threat scenarios relating to the presence and hunger state of a jade perch (Scortum barcoo). Across threat scenarios, groups exhibit unique behavioural profiles that differ in the durations that particular collective …

Thinking About Cement, Luke Weinbaum

Sustainable Supply Chain Management

A discussion and analysis of contemporary cement production, environmental impact and industry innovations.

Introduction To The Special Issue Of The Journal Of Public And Professional Sociology: Teaching Sociology In Challenging Times, Linda A. Treiber

The Journal of Public and Professional Sociology

Introduction by Editor In Chief

"Even under ideal conditions, teaching sociology can be challenging; however, recent attacks on academic freedom involving core sociological tenets have brought a sense of urgency to the discipline..."

Controls On Distributions Of Aluminium, Manganese And Cobalt In The South Atlantic Ocean Along Geotraces Transect Ga10, Xue Gang Chen, Angela Milne, Jessica K. Klar, Martha Gledhill, Maeve C. Lohan, Yu Te Hsieh, Gideon M. Henderson, E. Malcolm S. Woodward, Eric P. Achterberg

School of Geography, Earth and Environmental Sciences

Trace metals (TMs) manganese (Mn), cobalt (Co), and aluminium (Al) have important geochemical and biological roles in the ocean. Here, we present full depth profiles of dissolved (d) and particulate Al, Mn, and Co along the latitude of 40 °S in the South Atlantic Ocean from the GEOTRACES GA10 cruises that operated in austral spring 2010 and summer 2011. The region is characterized by enhanced primary productivity and forms a key transition zone between the Southern Ocean and South Atlantic Subtropical Gyre. The mean concentrations of dAl, dCo, and dMn (±standard deviation) were 3.36 ± 2.65 nmol kg⁻¹, …

Improving 2–5 Qubit Quantum Phase Estimation Circuits Using Machine Learning, Charles Woodrum, Torrey J. Wagner, David E. Weeks

Faculty Publications

Quantum computing has the potential to solve problems that are currently intractable to classical computers with algorithms like Quantum Phase Estimation (QPE); however, noise significantly hinders the performance of today’s quantum computers. Machine learning has the potential to improve the performance of QPE algorithms, especially in the presence of noise. In this work, QPE circuits were simulated with varying levels of depolarizing noise to generate datasets of QPE output. In each case, the phase being estimated was generated with a phase gate, and each circuit modeled was defined by a randomly selected phase. The model accuracy, prediction speed, overfitting level …

Benefits And Advances Of Cone Beam Ct Use In Prostatic Artery Embolization: Review Of The Literature And Pictorial Essay, Nassir Rostambeigi, Daniel Crawford, Jafar Golzarian

2020-Current year OA Pubs

Prostatic artery embolization (PAE) has proven to be an efficacious treatment for urinary symptoms of benign prostatic hyperplasia. PAE is performed in a complex and challenging anatomical field which may pose difficulties from procedural standpoint. Cone beam computed tomography (CBCT) has been proposed as an invaluable tool during the PAE procedure. A review of different techniques and advancements, as well as demonstration of CBCT benefits via a pictorial overview of the salient examples is lacking. The techniques of CBCT are discussed herein and the virtual injection technology as an advancement in CBCT is discussed. To show the merits of CBCT …

2024-05-15 A Student Market And A Concert Makes For A Night Out At Radio Fest, Riley Zalbert

The Spectator Online

No abstract provided.

2024-05-15 Black Student Union On Overcoming Adversity To Provide A Space For Poc Students, Diego Gonzalez

The Spectator Online

No abstract provided.

2024-05-15 Chemistry Student Making An Impact, Abdullah El-Sherbeeny

The Spectator Online

No abstract provided.