Digital Commons Network^™

The Urgency Of Administrative Reform In E-Government-Based Recruitment Of General Elections Commission Members In Bali Province, Ni Wayan Widhiasthini, Ni Kadek Winda Yanti, Nyoman Sri Subawa, Made Srinitha Millinia Utami

BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi

This study aims to explore the role of information technology, particularly the application of e-government, in the recruitment process for General Elections Commission (KPU) members, focusing on administrative reform in Bali. It emphasizes the optimization of administrative reform through an e-government-based recruitment system. Utilizing a qualitative research framework, this study employed a descriptive approach with a post-positivist perspective. Data were collected through interviews, observations, and document analysis, followed by systematic stages of data reduction, presentation, and conclusion drawing. Both qualitative and quantitative data were collected from primary and secondary sources and validated through source triangulation and determination. Informants were purposively …

Pan-Cancer Interrogation Of B7-H3 (Cd276) As An Actionable Therapeutic Target Across Human Malignancies, Garje Rohan, Bruno Bastos

All Publications

B7-H3 (CD276) is a transmembrane glycoprotein of the B7 immune checkpoint superfamily that has emerged as a promising therapeutic target. To better understand the applicability of B7-H3-directed therapies, we analyzed 156,791 samples comprising 50 cancer types to interrogate the clinical, genomic, transcriptomic, and immunologic correlates of B7-H3 mRNA expression. DNA (592-gene/whole-exome) and RNA (whole-transcriptome) sequencing was performed from samples submitted to Caris Life Sciences. B7-H3 high versus low expression was based on top and bottom quartiles for each cancer type. Patients' overall survival was determined from insurance claims data. Pathway analysis was performed using gene set enrichment analyses. Immune cell …

Tcaf1 Promotes Trpv2-Mediated Ca2+ Release In Response To Cytosolic Dna To Protect Stressed Replication Forks, Lingzhen Kong, Chen Cheng, Abigael Cheruiyot, Jiayi Yuan, Yichan Yang, Sydney Hwang, Daniel Foust, Ning Tsao, Emily Wilkerson, Nima Mosammaparast, Michael B Major, David W Piston, Shan Li, Zhongsheng You

2020-Current year OA Pubs

The protection of the replication fork structure under stress conditions is essential for genome maintenance and cancer prevention. A key signaling pathway for fork protection involves TRPV2-mediated Ca

Teachers' Experience Serving Students With Emotional And Behavioral Disorders In Distance Learning, Mireya Escalante Torres

Walden Dissertations and Doctoral Studies

During the COVID-19 pandemic, stay-at-home orders forced millions of students attending schools in the United States to shift to distance learning. As pandemic restrictions lifted and schools reopened, an emerging trend was observed: many parents of children with disabilities chose to continue distance learning. This decision gains significance in the context of students with emotional and behavioral disorders (EBDs) who are at a higher risk of disengagement from school. Educators need to understand how to address social, emotional, and behavioral needs within online learning frameworks. However, increasing engagement for students with EBDs in distance learning has not been well-researched. Drawing …

Secondary Mathematics Teachers’ Perceptions And Experiences With Implementing Collaboration In Us Classrooms, Scott Norman Cairney

Walden Dissertations and Doctoral Studies

Collaboration is an underused teaching strategy despite its benefits and the call for curriculums worldwide to increase its use. To aid in discovering why the strategy is underused, more information was needed about the implementation of collaboration in the mathematics classroom. The purpose of this study was to investigate mathematics teachers’ perceptions and experiences when implementing collaboration in their classrooms. The conceptual framework that grounded this study was Vygotsky’s social constructivism. Data for the basic qualitative study were collected through 12 interviews with mathematics teachers in California, Oregon, and Washington who have implemented collaboration. Through inductive analysis, seven themes emerged …

Workplace Climate And Culture Experiences Of Black Lgbtq Public School K-12 Educators, Sidney Gaskins

Walden Dissertations and Doctoral Studies

Recruiting and retaining Black educators is a problem in the United States. Research into specific subgroups within this population, such as Black LBGTQ educators, can help identify ways to address this problem. In this qualitative study, five individuals were recruited who self-identified as Black or African American, LGBTQ, hold a current teaching certificate, have taught more than three years, and were 30 years or older. Data were collected from participants through semistructured interviews, and those data were analyzed. Interpretative phenomenological analysis was used to allow for their voices, perspectives, and experiences to be heard directly. Findings revealed 11 themes associated …

Direct And Indirect Effects Of And Preference For Feedback During The Good Behavior Game In Elementary Classes, Jensen Chotto

LSU Doctoral Dissertations

The Good Behavior Game (GBG) is an effective procedure for reducing disruptive classroom behavior. In this study, students in 3 fifth grade classes selected the rules of the GBG and then experienced the GBG with different forms of feedback delivery for rule violations (vocal and visual, vocal only, visual only, no feedback) on disruptive classroom behavior in a multielement design. All versions of the GBG substantially reduced disruptive behavior below baseline levels. Additionally, in 1 of 3 classes, losing the GBG produced an increase in negative peer interactions immediately following the GBG. Subsequently, students selected which condition they previously experienced …

Evaluating The Relationship Between Parent-Adolescent Communication, Social Media Use, And Psychological Well-Being In Adolescents, Johannah Smith

LSU Doctoral Dissertations

Adolescents, particularly teenage girls, use social media substantially more than any other age group (Boneva et al., 2006; Gross, 2004; Padilla-Walker et al., 2020). Greater social media use has been linked to internalizing and externalizing problems; however, specific social media behavior and the relation to internalizing and externalizing problems is unknown. Additionally, how parent-adolescent communication impacts the relationships has not been explored. This is concerning as specific social media behavior, such as ruminating with peers and general social media addiction, has been linked to adolescents’ psychological well-being. (Sarmiento et al., 2020; Shensa et al., 2017; Nesi et al., 2020). The …

Final Report - A Field Deployable Wall-Climbing Robot For Bridge Inspection Using Vision And Impact Sounding Techniques, Jizhong Xiao, Ejup Hoxha, David Kirakosian

Project AS-6

This project developed two wall-climbing robots and two omni-directional ground robots for automated data collection on both horizontal and vertical surfaces of concrete structures. These robots are equipped with non-destructive evaluation (NDE) sensors, including ground penetrating radar (GPR), impact sounding (IS) and impact echo (IE) devices. Utilizing a vision-based positioning system powered by simultaneous localization and mapping (V-SLAM), the robots tag NDE data with real-time pose information, significantly accelerating the data collection process and enhancing the accuracy of defect mapping. While effective at detecting shallow defects, impact sounding is highly sensitive to ambient noise and unsuitable for identifying deeper flaws. …

The Effect Of A Dynamic Lighting Schedule On Neurobehavioral Performance During A 45-Day Simulated Space Mission, Leilah Grant, Brianne Kent, Shadab Rahman, Melissa St Hilaire, Crystal Kirkley, Kevin Gregory, Toni Clark, John Hanifin, Laura Barger, Charles Czeisler, George Brainard, Steven Lockley, Erin Flynn-Evans

Department of Neurology Faculty Papers

Study Objective: We previously reported that during a 45-day simulated space mission, a dynamic lighting schedule (DLS) improved circadian phase alignment and performance assessed once on selected days. This study aimed to evaluate how DLS affected performance on a 5-minute psychomotor vigilance task (PVT) administered multiple times per day on selected days.

Methods: Sixteen crewmembers (37.4 ± 6.7 years; 5F) underwent six cycles of 2 × 8-hour/night followed by 5 × 5-hour/night sleep opportunities. During the DLS (n = 8), daytime white light exposure was blue-enriched (∼6000 K; Level 1: 1079, Level 2: 76 melanopic equivalent daytime illuminance (melEDI) lux) …

Case-Based Learning In Undergraduate Orthodontic Education: A Cross Sectional Study, Asma Shafique, Asad Rehman, Shazia Ibnerasa, Rebecca Glanville, Professor Kamran Ali

Peninsula Dental School

Introduction Student centric learning approaches have been reported to be effective in introducing higher order cognitive skills required by the health professionals. However, learners’ perceptions must be constructively aligned with new learning interventions to achieve a positive impact on their learning. The aim of this study was to explore the learning experiences of undergraduate dental students with case-based learning in orthodontics. Methods A case-based learning model was introduced on orthodontic diagnosis and treatment planning for final year students on a Bachelor of Dentistry programme toward the end of their academic year. A survey was conducted to explore the perceptions and …

Spectator 2024-05-30, Editors Of The Spectator

The Spectator

No abstract provided.

Herniation Of The Right Colon, From The Cecum To The Hepatic Flexure, Through The Foramen Of Winslow: A Case Report, Austin M. Lundgren, Jordan Fader, Griffin A. Dufek, Ani G. Nathalang-Piñon

Student Publications

Herniation of bowel contents between the peritoneal cavity proper and the omental bursa, through the foramen of Winslow, can present diagnostic challenges that can potentially delay necessary surgical intervention. This case describes a 49-year-old female with a past medical history of hiatal hernia and biliary dyskinesia who presented to the emergency department with severe epigastric and right lower quadrant abdominal pain one day after a reported gastrointestinal illness of unknown etiology. Initial emergency department workup demonstrated an elevated white blood cell count without lactic acidosis. Computed tomography imaging was interpreted as gastric distension with volvulus around the mesentery and second …

The Debranching Enzyme Dbr1 Regulates Lariat Turnover And Intron Splicing, Luke Buerer, Brittany A Townley, Nima Mosammaparast, Et Al.

2020-Current year OA Pubs

The majority of genic transcription is intronic. Introns are removed by splicing as branched lariat RNAs which require rapid recycling. The branch site is recognized during splicing catalysis and later debranched by Dbr1 in the rate-limiting step of lariat turnover. Through generation of a viable DBR1 knockout cell line, we find the predominantly nuclear Dbr1 enzyme to encode the sole debranching activity in human cells. Dbr1 preferentially debranches substrates that contain canonical U2 binding motifs, suggesting that branchsites discovered through sequencing do not necessarily represent those favored by the spliceosome. We find that Dbr1 also exhibits specificity for particular 5' …

Variant-Specific Pathophysiological Mechanisms Of Aff3 Differently Influence Transcriptome Profiles, Sissy Bassani, Jacqueline Chrast, Giovanna Ambrosini, Norine Voisin, Frédéric Schütz, Alfredo Brusco, Fabio Sirchia, Lydia Turban, Susanna Schubert, Rami Abou Jamra, Jan-Ulrich Schlump, Desiree Demille, Pinar Bayrak-Toydemir, Gary Rex Nelson, Kristen Nicole Wong, Laura Duncan, Mackenzie Mosera, Christian Gilissen, Lisenka E L M Vissers, Rolph Pfundt, Rogier Kersseboom, Hilde Yttervik, Geir Åsmund Myge Hansen, Marie Falkenberg Smeland, Kameryn M Butler, Michael J Lyons, Claudia M B Carvalho, Chaofan Zhang, James R Lupski, Lorraine Potocki, Leticia Flores-Gallegos, Rodrigo Morales-Toquero, Florence Petit, Binnaz Yalcin, Annabelle Tuttle, Houda Zghal Elloumi, Lane Mccormick, Mary Kukolich, Oliver Klaas, Judit Horvath, Marcello Scala, Michele Iacomino, Francesca Operto, Federico Zara, Karin Writzl, Aleš Maver, Maria K Haanpää, Pia Pohjola, Harri Arikka, Anneke J A Kievit, Camilla Calandrini, Christian Iseli, Nicolas Guex, Alexandre Reymond

Faculty, Staff and Students Publications

BACKGROUND: We previously described the KINSSHIP syndrome, an autosomal dominant disorder associated with intellectual disability (ID), mesomelic dysplasia and horseshoe kidney, caused by de novo variants in the degron of AFF3. Mouse knock-ins and overexpression in zebrafish provided evidence for a dominant-negative mode of action, wherein an increased level of AFF3 resulted in pathological effects.

METHODS: Evolutionary constraints suggest that other modes-of-inheritance could be at play. We challenged this hypothesis by screening ID cohorts for individuals with predicted-to-be damaging variants in AFF3. We used both animal and cellular models to assess the deleteriousness of the identified variants.

RESULTS: We identified …

Strategies For Reducing Employee Turnover Costs, Karen Coates

Walden Dissertations and Doctoral Studies

High employee turnover costs are prevalent in academic healthcare centers. Healthcare center leaders who experience high employee turnover also experience high operational costs. Grounded in Blau's social exchange theory, the purpose of this qualitative multiple-case study was to explore strategies executive and senior healthcare leaders utilized to minimize employee turnover costs. Through interviews with four academic healthcare center leaders on the East Coast of the United States, using Ming-Shu Yuan's (2019) narrative analysis, four primary themes were identified: (a) strategies, (b) implementation, (c) measuring success, and (d) leadership support. One key recommendation is for academic medical center leaders to increase …

A Qualitative Exploration Of Well-Being In Cancer Survivorship: Implications For Counselors, Hallie M. Sylvestro, Lindsey K. Umstead, Heather Delgado, Christopher Lawrence, Keith Mobley, Kelly L. Wester, Andrew Wood

Adultspan Journal

Adult cancer survivors represent an important–and growing–population that could benefit from counseling services. This study employed consensual qualitative research to examine the well-being experiences of eight cancer survivors. Findings suggest a broad range of changes to individual well-being following cancer diagnosis and treatment, and indicate counseling can provide an ideal setting for processing such changes. Recommendations for counseling practice and future research are provided.

The Management Variables And The Provision F Library Services To The University Undergraduates In South-East, Nigeria, Ngozi Immaculata Ike Dr.

Library Philosophy and Practice (e-journal)

This study investigated management variables and the provision of library services to the university undergraduates in federal universities across Southeast Nigeria. The research examined the relationship between planning and organizing, and the extent of library services provided. Three research questions and two hypotheses guided the study. A multiple correlational design was employed. Data collection utilized a 4-point modified Likert rating scale. The population of the study was 19390 comprising librarians and students. This is made up of 19188 students and 202 librarians. The population was made up of all university undergraduate registered library users and librarians within the period the …

Propofol Enhancement Of Slow Wave Sleep To Target The Nexus Of Geriatric Depression And Cognitive Dysfunction: Protocol For A Phase I Open Label Trial, Rachel Lynn Rios, Michael Green, S Kendall Smith, Mohammadmehdi Kafashan, Shinung Ching, Nuri B Farber, Nan Lin, Brendan P Lucey, Charles F Reynolds, Eric J Lenze, Ben Julian Agustin Palanca, Swiped Study Team

2020-Current year OA Pubs

INTRODUCTION: Late-life treatment-resistant depression (LL-TRD) is common and increases risk for accelerated ageing and cognitive decline. Impaired sleep is common in LL-TRD and is a risk factor for cognitive decline. Slow wave sleep (SWS) has been implicated in key processes including synaptic plasticity and memory. A deficiency in SWS may be a core component of depression pathophysiology. The anaesthetic propofol can induce electroencephalographic (EEG) slow waves that resemble SWS. Propofol may enhance SWS and oral antidepressant therapy, but relationships are unclear. We hypothesise that propofol infusions will enhance SWS and improve depression in older adults with LL-TRD. This hypothesis has …

Staff Education For Nurses On Patient Education About When To Call The Doctor, Branderly Maliwa

Walden Dissertations and Doctoral Studies

In 2010, nearly 1 in 5 visits to the emergency department (ED) were categorized as potentially avoidable, resulting in a significant $65 billion increase in health care expenditures and exacerbating ED overcrowding. This project addressed whether a staff education initiative focused on evidence-based patient teaching strategies can enhance nurses’ patient education skills regarding when patients should seek medical attention. Utilizing theories, such as the diffusion of innovation theory and transformational theory, a staff education program was developed in this project informed by evidence-based practice. Credible sources, including nursing databases and professional organizations, were used to identify the gap in nursing …

Management Strategies To Improve Employee Retention And Organizational Performance, Fay Etta Catlett

Walden Dissertations and Doctoral Studies

Employee turnover is a problem that is pervasive and negatively impacts the productivity of organizations. Business leaders who do not have strategies to combat employee turnover within organizations will incur unbudgeted costs of replacing employees who leave organizations, which affects organizational performance. Grounded in Vroom’s motivational theory, the purpose of this qualitative multiple-case study was to explore strategies business leaders use to retain experienced employees to improve organizational performance. The participants were 5 human resources and business leaders of various organizations who maximized employee retention and organizational performance. Data were collected using semistructured interviews and a review of publicly available …

Examining Barriers To Technology Integration Practices Of K-12 Teachers, Sherri N. Brackett

Walden Dissertations and Doctoral Studies

The problem this study addressed is that K-12 teachers inconsistently implement technology into classroom instructional practices. The use of technology influences every aspect of our daily life. In fact, schools now have a responsibility to integrate technology into teaching and learning. This qualitative study aimed to investigate how K-12 teachers’ perceptions of technology integration and barriers influence the integration of technology into their classroom practice. The technology acceptance model and the barrier to technology integration were the frameworks for this study. The research questions explored teachers’ perceptions and barriers that influence the integration of technology into classroom instructional practices. The …

Effective Sales Education Training Delivery Methods: A Pragmatic Inquiry, Eunice N. Onyelobi-Miller

Walden Dissertations and Doctoral Studies

Ineffective training delivery methods developed and delivered to Generation Z employees negatively impact a sales organization’s overall profitability, causing the risk of reduction in force or business closure. Grounded in content, instructional design, programmed learning, and recommendation (CIP-R) framework, and diversity, individualism and teamwork, technology, and organizational supports (DITTO) framework, the purpose of this qualitative pragmatic inquiry was to explore effective strategies sales managers used to develop and deliver sales training for Generation Z employees to increase sales organizations’ revenues. The participants were 10 sales managers in the United States who trained Generation Z employees and impacted revenues. Data were …

Small Business Leaders' Strategies To Improve Organizational Performance, Gregory Scott Wilson

Walden Dissertations and Doctoral Studies

Small business leaders are concerned with leadership that will improve their organizational performance because 20% of new small businesses fail within the first 2 years of operation. Grounded in the transformational leadership theory, the purpose of this qualitative pragmatic inquiry was to explore leadership strategies small business leaders use to improve organizational performance. The project participants were six small business leaders in the Central Illinois area of the United States who successfully used leadership strategies to improve organizational performance. Data were collected using semistructured interviews and reviewing financial and annual reports. Through thematic analysis, four themes were identified: (a) intellectual …

Successful Strategies Of Black Women Business Owners, Carolyn Bennett

Walden Dissertations and Doctoral Studies

Unsustainable business strategies have the potential to lead to adverse business outcomes when starting new business ventures. Business owners are concerned with having effective business strategies to sustain their businesses beyond 5 years. Grounded in the resource-based view theory, the purpose of this qualitative pragmatic inquiry was to explore successful strategies that were used by Black women business owners starting new business ventures to sustain their businesses for more than 5 years. Participants were seven Black women business owners who developed successful strategies to sustain their businesses. Data were collected using semi-structured interviews and a review of publicly available documents. …

Strategies For Nonprofit Organizations To Meet Performance Goals Through Employee, Allicia Graham

Walden Dissertations and Doctoral Studies

Dismal employee engagement can have an adverse effect on an organization’s productivity and profitability. Nonprofit organization leaders are concerned about employee engagement because the lack of it impedes meeting organizational performance goals. Grounded in engagement theory, the purpose of this qualitative pragmatic inquiry was to explore strategies that nonprofit organizational leaders used to increase employee engagement to meet organizational performance goals. The participants were six nonprofit industry leaders in the Northeast region of the U. S. who successfully implemented employee engagement strategies and met organizational performance goals. Data were collected through semi structured interviews and from publicly available data and …

Stress And Coping Experienced By Mothers With Autoimmune Diseases While Parenting Children With Autism, Christine Marie Dillon

Walden Dissertations and Doctoral Studies

The number of individuals diagnosed with autoimmune diseases (AD) continues to rise, with the majority being women of childbearing age. There has been a concurrent increase in the number of children diagnosed with autism spectrum disorder (ASD). Mothers of children with ASD are often the primary caretaker for their children, and report decreased quality of life and increased behavioral health concerns. AD and ASD have been studied separately through a quantitative lens, with findings demonstrating similarities between the two regarding potential etiology. Few qualitative studies have been conducted to understand the stress and coping experienced by mothers with AD parenting …

K-12 Teachers' Perceptions Of Culturally Relevant Pedagogy In Ontario, Canada, Heather Banks

Walden Dissertations and Doctoral Studies

Culturally relevant pedagogy (CRP) is an approach to teaching that emphasizes students’ cultural backgrounds in classroom learning to improve student success, cultural competence, and critical consciousness in culturally diverse learners. Research highlights that using CRP in multicultural classrooms supports the engagement, learning, and achievement of culturally diverse students around the world, but less is known about how K-12 teachers’ perceptions of CRP impact the usage of this practice in their classrooms. This basic qualitative study examined K-12 teachers’ perceptions of CRP in Ontario, Canada, to address this gap in practice and determine why educators are not widely using CRP in …

Presentation: Update For Spokane River - Expo H2o Symposium, 05/30/2024, Chad Pritchard , Ph.D, P.G.

EWU PFAS Research Collection

Presentation given May 30^th, 2024.

Management Overview Of The Lung Tuberculosis Control Program At The Dki Jakarta Provincial Health Office In 2023, Mutiara Kiranti, Helen Andriani

Journal of Indonesian Health Policy and Administration

Tuberculosis is one of the infectious diseases that is fatal if not cured immediately. In 2022, the success rate of tuberculosis treatment in DKI Jakarta Province is 81%, while the national target is 90%. In the field, the number of cadres to carry out contact investigations is still insufficient, so that in 2022 the coverage of contact investigations in DKI Jakarta Province will only reach 25%, while the national target is 90%. To increase the scope of successful treatment, the government should try to overcome tuberculosis, which is needed. Proper program management is required to run effectively and efficiently for …