Digital Commons Network^™

Using Rapid Protein Degradation To Determine The Effect Of Runx1 Loss-Of- Function On Dna Damage Accumulation And Repair., Jackriel Pina Morales

Theses and Dissertations

Germline mutations in RUNX1 are associated with familial platelet disorder with a predisposition to myeloid malignancy (RUNX1-FPDMM), in which patients present with low platelet counts,excessive bleeding and bruising, and an increased risk of Acute Myeloid Leukemia (AML)/Myelodysplastic Syndrome (MDS) development throughout their lifetime. To understand how these loss-of-function mutations in RUNX1 drive predispose to malignancy, it is important to develop a detailed understanding of the molecular basis of RUNX1 function. While RUNX1 is a transcription factor, preliminary data from our group and work from others suggests that RUNX1 also interacts with proteins that are critical for DNA damage …

Measuring Confidentiality With Multiple Observables, John J. Utley

Computer Science Senior Theses

Measuring the confidentiality of programs that need to interact with the outside world can prevent leakages and is important to protect against dangerous attacks. However, information propagation is difficult to follow through a large program with implicit information flow, tricky loops, and complicated instructions. Previous works have tackled this problem in several ways but often measure leakage a program has on average rather than the leakage produced by a set of particularly compromising interactions. We introduce new methods that target a specific set of observables revealed throughout execution to cut down on the resources needed for analysis. Our implementation examines …

Molecular Classification And Biomarkers Of Outcome With Immunotherapy In Extensive-Stage Small-Cell Lung Cancer: Analyses Of The Caspian Phase 3 Study, Mingchao Xie, Miljenka Vuko, Jaime Rodriguez-Canales, Johannes Zimmermann, Markus Schick, Cathy O'Brien, Luis Paz-Ares, Jonathan W Goldman, Marina Chiara Garassino, Carl M Gay, John V Heymach, Haiyi Jiang, J Carl Barrett, Ross A Stewart, Zhongwu Lai, Lauren A Byers, Charles M Rudin, Yashaswi Shrestha

Faculty, Staff and Student Publications

BACKGROUND: We explored potential predictive biomarkers of immunotherapy response in patients with extensive-stage small-cell lung cancer (ES-SCLC) treated with durvalumab (D) + tremelimumab (T) + etoposide-platinum (EP), D + EP, or EP in the randomized phase 3 CASPIAN trial.

METHODS: 805 treatment-naïve patients with ES-SCLC were randomized (1:1:1) to receive D + T + EP, D + EP, or EP. The primary endpoint was overall survival (OS). Patients were required to provide an archived tumor tissue block (or ≥ 15 newly cut unstained slides) at screening, if these samples existed. After assessment for programmed cell death ligand-1 expression and tissue …

Exploring The Tradeoff Between Data Privacy And Utility With A Clinical Data Analysis Use Case, Eunyoung Im, Hyeoneui Kim, Hyungbok Lee, Xiaoqian Jiang, Ju Han Kim

Faculty, Staff and Student Publications

BACKGROUND: Securing adequate data privacy is critical for the productive utilization of data. De-identification, involving masking or replacing specific values in a dataset, could damage the dataset's utility. However, finding a reasonable balance between data privacy and utility is not straightforward. Nonetheless, few studies investigated how data de-identification efforts affect data analysis results. This study aimed to demonstrate the effect of different de-identification methods on a dataset's utility with a clinical analytic use case and assess the feasibility of finding a workable tradeoff between data privacy and utility.

METHODS: Predictive modeling of emergency department length of stay was used as …

Risk Factors For Pediatric Ischemic Stroke And Intracranial Hemorrhage: A National Electronic Health Record Based Study, Stuart Fraser, Samantha M Levy, Amee Moreno, Gen Zhu, Sean Savitz, Alicia Zha, Hulin Wu

Faculty, Staff and Student Publications

BACKGROUND: Stroke is an important cause of morbidity in pediatrics. Large studies are needed to better understand the epidemiology, pathogenesis and risk factors associated with pediatric stroke. Large administrative datasets can provide information on risk factors in perinatal and childhood stroke at low cost. The aim of this hypothesis-generating study was to use a large administrative dataset to assess for prevalence and odds-ratios of rare exposures associated with pediatric stroke.

METHODS: The data for patients aged 0-18 with a diagnosis of either ischemic stroke or intracranial hemorrhage were extracted from the Cerner Health Facts EMR Database from 2000 to 2018. …

Multiomics Analysis Of The Phlda Gene Family In Different Cancers And Their Clinical Prognostic Value, Safia Iqbal, Md Rezaul Karim, Shahnawaz Mohammad, Ramya Mathiyalagan, Md Niaj Morshed, Deok-Chun Yang, Hyocheol Bae, Esrat Jahan Rupa, Dong Uk Yang

Faculty, Staff and Student Publications

The PHLDA (pleckstrin homology-like domain family) gene family is popularly known as a potential biomarker for cancer identification, and members of the PHLDA family have become considered potentially viable targets for cancer treatments. The PHLDA gene family consists of PHLDA1, PHLDA2, and PHLDA3. The predictive significance of PHLDA genes in cancer remains unclear. To determine the role of pleckstrin as a prognostic biomarker in human cancers, we conducted a systematic multiomics investigation. Through various survival analyses, pleckstrin expression was evaluated, and their predictive significance in human tumors was discovered using a variety of online platforms. By analyzing the protein-protein interactions, …

Anion Binding And Sensing Using Cs124-Sensitized Luminescent Terbium Complexes, Alessandro Rizzi, Minhee Lee, Wade Grabow, Olivia Brooks, Helena Nguyen, Neal Yakelis, Clarisse Vanderfeltz

Honors Projects

Two terbium complexes with varying degrees of intramolecular coordination, Tb:DO2A-Cs124 and Tb:DOTA-Cs124, were prepared. Their capacity to detect biologically and environmentally relevant anions through their luminescence changes was investigated. Tb:DOTA-Cs124 demonstrated exceptional selectivity as a sensor for nitrite, while Tb:DO2A-Cs124 detects nitrite, phosphates, and a range of carboxylate-containing anions.

Kapadia '99 Honored With Ceps Distinguished Alumni Award, Hayley Barnhard

UNH Today Archive

No abstract provided.

Evaluating The Health Literacy Practices Of A Primary Care Health System Serving A Diabetic Population At High Risk For Low Health Literacy, Alana D. Norris-Bermudez

Dissertations

Health literacy (HL) is a powerful determinant of patient health outcomes, yet a minority of the U.S. population possesses proficient health literacy. Healthy People 2030 positions HL prominently among the new overarching goals as follows, "Eliminate health disparities, achieve health equity, and attain health literacy to improve the health and well-being of all" (The Office of Disease Prevention and Health Promotion, 2023). HL comprises two interlinked components: personal HL and organizational HL, (Office of Disease Prevention and Health Promotion, n.d.). Implementing HL practices within healthcare system facilities such as hospitals, FQHCs, and/or primary care practices to support universal HL precautions …

Um Scholarship Honors Oxford Chef, Edwin Smith

University of Mississippi News

OXFORD, Miss. – The University of Mississippi School of Applied Sciences is honoring chef and entrepreneur John Currence by creating a new scholarship in his name.

The Hidden Struggle: Challenges Older Women Face In Nevada, Annie Vong

Student Research

In 2020, almost one in five Nevadans was over the age of 65.[1] However, within this age group, women outnumber men due to longer life expectancies[2] and migration patterns. Women over 65 years of age make up an estimated 18.1% of the female population in Nevada.[3] Of the male population in Nevada, 15.1% are over 65 years of age.[4] Older women are less likely to be married, are less likely to have completed a bachelor’s degree, are more likely to drop out of the labor force, and are more likely to be living in poverty in …

Anonymity As Freedom: Drawing Critical Hope From Pandemic Pedagogy, Lucy Wenham

The Curriculum Studies Collaborative Journal

No abstract provided.

A Brief Introduction To General Topology, Richard P. Millspaugh

Open Educational Resources

The material in this text is intended to be accessible to undergraduates who have had an introduction to elementary set theory and proof techniques. It includes sufficient material from general topology to prove the two main topological results found in a standard first semester calculus course: the Intermediate Value Theorem and the Extreme Value Theorem. This material can be found in Chapters 2 through 6 and makes up the bulk of the text. Rather than approaching these topics through use of the standard euclidean metric, it defines the standard topology on R in terms of the usual order on R. …

A Review Of Image Sensors Used In Near-Infrared And Shortwave Infrared Fluorescence Imaging, Banghe Zhu, Henry Jonathan

The Brown Foundation: Institute of Molecular Medicine

To translate near-infrared (NIR) and shortwave infrared (SWIR) fluorescence imaging into the clinic, the paired imaging device needs to detect trace doses of fluorescent imaging agents. Except for the filtration scheme and excitation light source, the image sensor used will finally determine the detection limitations of NIR and SWIR fluorescence imaging systems. In this review, we investigate the current state-of-the-art image sensors used in NIR and SWIR fluorescence imaging systems and discuss the advantages and limitations of their characteristics, such as readout architecture and noise factors. Finally, the imaging performance of these image sensors is evaluated and compared.

Community Policing And Meta-Stereotypes: Improving Citizenry-Police Relations In A Large, Multicultural Urban Area, Through A Participatory Action Research Community Safety Workshop, Cornelius Darnell Davis

College of Education Theses and Dissertations

The Term Policing and its surrounding themes are complex and deserve adequate attention. Since the early 1900’s, citizenry and police have had mistrustful relationships. Over the span of three eras, both positive and negative citizenry-police relations have been highlighted. In more recent years, the timely capturing of videos of over-policing and excessive use of deadly force incidents (mainly in BIPOC communities) have exacerbated negative citizenry-police relations, resulting in the lack of procedural justice and police legitimacy. Excessive policing and the seemingly constant deaths of unarmed African Americans undoubtedly contribute to the lack of confidence in police to effectively ensure all …

More Than Just A Paycheck: Campus Student Employment As High-Impact Practice, Katie Martin

College of Education Theses and Dissertations

Institutions of higher education have a unique opportunity to support their students’ holistic development by incorporating elements of high-impact practice into campus jobs. High-impact practices ask students to dedicate significant time and energy to meaningful work, which channels students’ efforts toward productive activities that deepen their learning and is correlated with higher levels of learning outcome achievement and persistence. According to the National Center for Education Statistics, nearly half of today’s college students are employed, which can distract from their ability to be successful in school. Using features of high-impact practice, universities can leverage campus jobs to offer students employment …

Factors Impacting Bsn Degrees In Community Colleges In Illinois And Exploring Community Colleges To Address Nursing Education Reform: A Mixed Methods Study, Lovelle Reynolds

College of Education Theses and Dissertations

This dissertation investigates the implementation of Bachelor of Science in Nursing (BSN) programs in Illinois community colleges, focusing on Associate Degree in Nursing (ADN) faculty perceptions. Utilizing an explanatory sequential mixed-methods design, the study first conducted a survey among full-time ADN faculty across Illinois community colleges to assess their support for BSN program offerings. An overwhelming 85% of respondents supported or strongly supported this offering, recognizing the potential benefits for meeting the complex demands of modern healthcare roles. Following the survey, in-depth interviews with volunteered faculty members provided deeper insight into the implementation challenges. These challenges included the need for …

A Phase-1 Trial Of Intensive Hybrid Stuttering Modification/Fluency Shaping Therapy, Jessica Smith

USF Tampa Graduate Theses and Dissertations

Purpose: The purpose of this study was to analyze changes in frequency stuttering behaviors, speech rate, and feelings/attitudes following the University of South Florida Program for Advanced Treatment of Stuttering (USF-PATS), a hybrid stuttering modification/fluency shaping program intended for teenagers and adults who stutter moderately to very severely.

Method: Baseline and post-treatment speech samples for participants (N = 3) were analyzed for speech rate and presence of stuttering behaviors (repeated movements, fixed postures, and superfluous behaviors) across conditions (monologue and reading). An abbreviated thematic analysis was completed to analyze feelings/attitudes post-treatment.

Results: Results revealed a decrease to zero and near-zero …

Modeling And Forecasting Cyanobacterial Harmful Algal Blooms (Cyanohabs) In Lake Pontchartrain, Shekhar Mahat

LSU Master's Theses

Harmful algal blooms (HABs) frequently occur in coastal waters worldwide, adversely affecting economies, human health, aquatic ecosystems, and recreational activities. Lake Pontchartrain, an oligohaline estuary, experienced frequent HABs from 2018 to 2023. While NOAA’s NCCOS and USEPA’s CyAN currently monitor cyanobacteria harmful algal blooms (CyanoHABs) in coastal, freshwater, and riverine systems, there is a notable lack of systems monitoring phycocyanin concentrations in the lake. This thesis utilizes satellite remote sensing environmental stressors to model and predict CyanoHABs in Lake Pontchartrain using machine learning techniques. A key focus of this study is assessing the forecasting capabilities of the random forest method …

Foam Fraction Flow: Using Mls-Mpm With Volume Fractions To Simulate Low-Density Dry Foam, Alexander Neville

Theses and Dissertations

Foaming bubbles are a common element seen throughout both nature and man-made civilization. All types of bubbles behave variably. For example, foams float in water, splash out from buckets, and are squeezed out of hand soap dispensers. Due to their complexity and variance in behavior, they can be expensive to simulate and difficult to portray realistically. When simulating dense concentrations of bubbles with little free-flowing water, such as soap films, three variables need to be accounted for: how the fluid will move, how the bubbles will be sized, and how the bubbles will behave when they come into contact with …

Blunt Cerebrovascular Injury (Bcvi): Universal Cta Neck Screening At Level 2 Trauma Center, Tamine Gogel

Doctor of Nursing Practice Projects

Blunt Cerebrovascular Injury (BCVI) refers to injuries to the vessels supplying blood to the brain, primarily carotid and vertebral arteries, and can result from trauma, resulting in stroke by vessel dissection, thrombus formation, embolization, and hemorrhage. Timely identification is crucial for effective intervention and improved outcomes. This doctoral project proposes the implementation of universal screening using Computed Tomography Angiography (CTA) of the neck during initial workup for blunt force trauma at a Level II ACS-verified trauma center. The primary objective is to mitigate potential delays in diagnosing and treating BCVI, thereby reducing the likelihood of complications. Patients ≥ 15 years …

Exploring Applications Of Ai In Developer-Side Web Accessibility Practices, Maria H. Cristoforo

Computer Science Senior Theses

No abstract provided.

Do Academic Advising And Levels Of Support Affect Nursing Students' Mental Health? A Cross-Sectional Study, Nashwa Ibrahim

Nursing

No abstract provided.

Umn Morris Welcomes Distinguished Visiting Professor Diane Negra, Communications And Marketing

Campus News Archive

No abstract provided.

Viability Of Elutriation For The Extraction Of Microplastics From Environmental Soil Samples, Kyle Forsythe, Mason Egermeier, Marcus Garcia, Rui Liu, Matthew Minghetti, Andrea Jilling Ph.D., Jorge Gonzalez-Estrella

Faculty Publications

In this study, we evaluated the suitability of elutriation, a method successfully employed in the extraction of microplastics from marine sediments, for the extraction of microplastics from freshwater and terrestrial soils. Five soils were sampled throughout Oklahoma, USA in order to capture a range of sand, silt, clay, and organic matter composition. Each soil was subjected to microplastic extraction with and without elutriation, followed by digestion in 7.5% NaOCl, and then flotation in 6 M ZnCl₂. The mass of each soil was measured after elutriation to determine sample mass reduction, and multiple methods including fluorescence imaging and automated …

Utilization Of Iron Fillings Solid Waste For Optimum Biodiesel Production, Fady Ihab Bayoumy Eng., Ahmed Osman Ahmed Dr., David W. Rooney Dr., Mai H. Roushdy

Chemical Engineering

This study explores the innovative application of iron filings solid waste, a byproduct from mechanical workshops, as a heterogeneous catalyst in the production of biodiesel from waste cooking oil. Focusing on sustainability and waste valorization, the research presents a dual-benefit approach: addressing the environmental issue of solid waste disposal while contributing to the renewable energy sector. Particle size distribution analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray fluorescence (XRF), Thermal analysis (TG-DTA), and FTIR analysis were used to characterize the iron filings. The response surface methodology (RSM) was used to guide a series of experiments that were conducted to …

Showcasing Faculty Projects: Beyond Traditional Types Of Publications, Ellen Neuhaus

Faculty Publications

There is value in collecting and preserving faculty projects which gives a broader perspective of faculty work than just the traditional publications (books and journal articles). The projects give a fuller picture of the faculty work at UNI than if just traditional publications were collected.

46 Walker Realty Llc V. Kuni Llc

All Decisions

The landlord commenced a holdover proceeding alleging the tenant's month-to-month tenancy expired. The tenant asserted the apartment was rent-stabilized under the Loft Law. The court found the landlord failed to establish the apartment was not subject to rent stabilization and granted the tenant's motion to dismiss the petition. The court determined the tenant was not collaterally estopped from challenging the regulatory status of the apartment based on a prior Loft Board order.

Investigation Of Piezocone Dissipation Test Interpretation In Clay Accounting For Vertical And Horizontal Porewater Pressure Dissipation With A Large Deformation Axisymmetric Penetration Model, Diane Moug, Andrew Huffman, Jason T. Dejong

Civil and Environmental Engineering Faculty Publications and Presentations

The piezocone (CPTu) dissipation test is used to characterize how the applied load from the penetrating cone is distributed between the soil and pore fluid during both penetrometer advancement and when penetration is paused. The coefficient of consolidation is often estimated from CPTu dissipation tests by interpreting the rate of excess porewater pressure (∆u) decay to static conditions during a pause in cone penetration. Most CPTu dissipation test interpretation methods are based on Terzaghi consolidation theory for ∆u dissipation at the cone shoulder (u₂ position) or cone face (u₁ position) and assume that radial ∆u dissipation dominates the …

Incoming President Chilton Aims To Promote A ‘Culture Of Belonging’, Keith Testa

UNH Today Archive

No abstract provided.