Digital Commons Network^™

Phase 2 Study Of Neoadjuvant Enzalutamide And Paclitaxel For Luminal Androgen Receptor-Enriched Tnbc: Trial Results And Insights Into “Arness”, Bora Lim, Sahil Seth, Clinton Yam, Lei Huo, Takeo Fujii, Roland Bassett, Lisa Ravenberg, Jason White, Alyson Clayborn, Gil Guerra, Jennifer K Litton, Senthil Damodaran, Rachel Layman, Vicente Valero, Debasish Tripathy, Michael Lewis, Lacey E Dobrolecki, Jonathan Lei, Rosalind Candelaria, Banu Arun, Gaiane Rauch, Li Zhao, Jianhua Zhang, Qingqing Ding, W Fraser Symmans, Jeffrey T Chang, Alastair M Thompson, Stacy L Moulder, Naoto T Ueno

Faculty, Staff and Student Publications

Luminal androgen receptor (LAR)-enriched triple-negative breast cancer (TNBC) is a distinct subtype. The efficacy of AR inhibitors and the relevant biomarkers in neoadjuvant therapy (NAT) are yet to be determined. We tested the combination of the AR inhibitor enzalutamide (120 mg daily by mouth) and paclitaxel (80 mg/m2 weekly intravenously) (ZT) for 12 weeks as NAT for LAR-enriched TNBC. Eligibility criteria included a percentage of cells expressing nuclear AR by immunohistochemistry (iAR) of at least 10% and a reduction in sonographic volume of less than 70% after four cycles of doxorubicin and cyclophosphamide. Twenty-four patients were enrolled. Ten achieved a …

Targeting Mcl1-Driven Anti-Apoptotic Pathways Overcomes Blast Progression After Hypomethylating Agent Failure In Chronic Myelomonocytic Leukemia, Guillermo Montalban-Bravo, Natthakan Thongon, Juan Jose Rodriguez-Sevilla, Feiyang Ma, Irene Ganan-Gomez, Yi June Kim, Bethany Wildeman, Tomoyuki Tanaka, Faezeh Darbaniyan, Gheath Al-Atrash, Karen Dwyer, Sanam Loghavi, Rashmi Kanagal-Shamanna, Xingzhi Song, Jianhua Zhang, Koichi Takahashi, Hagop Kantarjian, Guillermo Garcia-Manero, Simona Colla

Faculty, Staff and Student Publications

RAS pathway mutations, which are present in 30% of patients with chronic myelomonocytic leukemia (CMML) at diagnosis, confer a high risk of resistance to and progression after hypomethylating agent (HMA) therapy, the current standard of care for the disease. Here, using single-cell, multi-omics technologies, we seek to dissect the biological mechanisms underlying the initiation and progression of RAS pathway-mutated CMML. We identify that RAS pathway mutations induce transcriptional reprogramming of hematopoietic stem and progenitor cells (HSPCs) and downstream monocytic populations in response to cell-intrinsic and -extrinsic inflammatory signaling that also impair the functions of immune cells. HSPCs expand at disease …

Repeat Controlled Human Plasmodium Falciparum Infections Delay Bloodstream Patency And Reduce Symptoms, Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, David M Rickert, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Faculty, Staff and Student Publications

Resistance to clinical malaria takes years to develop even in hyperendemic regions and sterilizing immunity has rarely been observed. To evaluate the maturation of the host response against controlled repeat exposures to P. falciparum (Pf) NF54 strain-infected mosquitoes, we systematically monitored malaria-naïve participants through an initial exposure to uninfected mosquitoes and 4 subsequent homologous exposures to Pf-infected mosquitoes over 21 months (n = 8 males) (ClinicalTrials.gov# NCT03014258). The primary outcome was to determine whether protective immunity against parasite infection develops following repeat CHMI and the secondary outcomes were to track the clinical signs and symptoms of malaria and anti-Pf antibody …

Fate-Mapping And Functional Dissection Reveal Perilous Influence Of Type I Interferon Signaling In Mouse Brain Aging, Wei Cao

Faculty, Staff and Student Publications

Background: Aging significantly elevates the risk of developing neurodegenerative diseases. Neuroinflammation is a universal hallmark of neurodegeneration as well as normal brain aging. Which branches of age-related neuroinflammation, and how they precondition the brain toward pathological progression, remain ill-understood. The presence of elevated type I interferon (IFN-I) has been documented in the aged brain, but its role in promoting degenerative processes, such as the loss of neurons in vulnerable regions, has not been studied in depth.

Methods: To comprehend the scope of IFN-I activity in the aging brain, we surveyed IFN-I-responsive reporter mice at multiple ages. We also examined 5- …

Student Academic Representation In The Uk: An Exploration Of Recruitment, Training, And Impacts, Jennie Winter, Rebecca Turner, Oliver Webb, Luciana Dalla Valle, Claire Benwell

Professional Services

Student academic representation is a staple feature in UK and international higher education. It provides a vital quality function whereby students, who are elected representatives of their programme, canvas the opinions of peers to inform quality assurance processes. In the UK, there is increasing regulatory pressure for universities and student unions to be dual owners of representation activity and much work has been done to enact this model. Nonetheless, little is known about the experiences of those serving as student representatives, despite this being a community of thousands of students across the UK, who hold an instrumental position in institutional …

Author Correction: Il-12 Reprograms Car-Expressing Natural Killer T Cells To Long-Lived Th1-Polarized Cells With Potent Antitumor Activity, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M Flick, Tracy A Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S Metelitsa, Gianpietro Dotti

Faculty, Staff and Students Publications

No abstract provided.

Remodeling Of Anti-Tumor Immunity With Antibodies Targeting A P53 Mutant, Jing-Ming Lim, Xu Wang, Praveen Neeli, Xinfang Yu, Ken H Young, Yong Li

Faculty, Staff and Students Publications

BACKGROUND: p53, the most frequently mutated gene in cancer, lacks effective targeted drugs.

METHODS: We developed monoclonal antibodies (mAbs) that target a p53 hotspot mutation E285K without cross-reactivity with wild-type p53. They were delivered using lipid nanoparticles (LNPs) that encapsulate DNA plasmids. Western blot, BLI, flow cytometry, single-cell sequencing (scRNA-seq), and other methods were employed to assess the function of mAbs in vitro and in vivo.

RESULTS: These LNP-pE285K-mAbs in the IgG1 format exhibited a robust anti-tumor effect, facilitating the infiltration of immune cells, including CD8+ T, B, and NK cells. scRNA-seq revealed that IgG1 reduces immune inhibitory signaling, increases …

Spatial Transcriptomics Analysis Identifies A Tumor-Promoting Function Of The Meningeal Stroma In Melanoma Leptomeningeal Disease., Hasan Alhaddad, Oscar E. Ospina, Mariam Lotfy Khaled, Yuan Ren, Ethan Vallebuona, Mohammad Baraa Boozo, Peter A. Forsyth, Yolanda Pina, Robert Macaulay, Vincent Law, Kenneth Y. Tsai, W Douglas Cress, Brooke L. Fridley, Inna Smalley

Manuscripts, Articles, Book Chapters and Other Papers

Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage melanoma patients. Here, we characterize the tumor microenvironment of LMD and patient-matched extra-cranial metastases using spatial transcriptomics in a small number of clinical specimens (nine tissues from two patients) with extensive in vitro and in vivo validation. The spatial landscape of melanoma LMD is characterized by a lack of immune infiltration and instead exhibits a higher level of stromal involvement. The tumor-stroma interactions at the leptomeninges activate tumor-promoting signaling, mediated through upregulation of SERPINA3. The meningeal stroma is required for melanoma cells to survive in the cerebrospinal fluid (CSF) and …

Real World Predictors Of Response And 24-Month Survival In High-Grade Tp53-Mutated Myeloid Neoplasms, Mariam T Nawas, Anand A Patel, Jay L Patel, Payal Sojitra, Barina Aqil, Madina Sukhanova, Megan E Mcnerney, Leo P Wu, Aibek Akmatbekov, Jeremy Segal, Melissa Y Tjota, Sandeep Gurbuxani, Jason X Cheng, Su-Yeon Yeon, Harini V Ravisankar, Carrie Fitzpatrick, Angela Lager, Michael W Drazer, Caner Saygin, Pankhuri Wanjari, Panagiotis Katsonis, Olivier Lichtarge, Jane E Churpek, Sharmila B Ghosh, Ami B Patel, Madhu P Menon, Daniel A Arber, Peng Wang, Girish Venkataraman

Faculty, Staff and Students Publications

Current therapies for high-grade TP53-mutated myeloid neoplasms (≥10% blasts) do not offer a meaningful survival benefit except allogeneic stem cell transplantation in the minority who achieve a complete response to first line therapy (CR1). To identify reliable pre-therapy predictors of complete response to first-line therapy (CR1) and outcomes, we assembled a cohort of 242 individuals with TP53-mutated myeloid neoplasms and ≥10% blasts with well-annotated clinical, molecular and pathology data. Key outcomes examined were CR1 & 24-month survival (OS24). In this elderly cohort (median age 68.2 years) with 74.0% receiving frontline non-intensive regimens (hypomethylating agents +/- venetoclax), the overall cohort CR1 …

Evaluation Of Resistance Patterns And Bioremoval Efficiency Of Hydrocarbons And Heavy Metals By The Mycobiome Of Petroleum Refining Wastewater In Jazan With Assessment Of Molecular Typing And Cytotoxicity Of Scedosporium Apiospermum Jaz-20, Fuad Ameen, Mohammad J. Alsarraf, Tarad Abalkahail, Steven Lee Stephenson

Biological Sciences Faculty Publications and Presentations

Jazan Industrial Economic City (JIEC) is located on the Red Sea coast in the province of Jazan, southwest of Saudi Arabia anchors diverse heavy and secondary industries in the energy, water desalination, petroleum, aluminum, copper, refineries, pharmaceuticals and food manufacturing fields. These various industries generate a large quantity of industrial wastewaters containing various toxicants. The present work represents ecologically beneficial alternatives for the advancement of environmental biotechnology, which could help mitigate the adverse impacts of environmental pollution resulting from petroleum refining effluents. The mycobiome (32 fungal strains) isolated from the industrial wastewater of the refinery sector in Jazan were belonged …

Incidence And Risk Factors For New And Recurrent Infarcts In Adults With Sickle Cell Disease, Lori C Jordan, Allison A King, Andria L Ford, Taniya E Varughese, Lisa Garrett, Et Al.

2020-Current year OA Pubs

BACKGROUND: Most adults with sickle cell disease will experience a silent cerebral infarction (SCI) or overt stroke. Identifying patient subgroups with increased stroke incidence is important for future clinical trials focused on stroke prevention. Our 3-center prospective cohort study tested the primary hypothesis that adults with sickle cell disease and SCIs have a greater incidence of new stroke or SCI compared with those without SCI. A secondary aim focused on identifying additional risk factors for progressive infarcts, particularly traditional risk factors for stroke in adults.

METHODS AND RESULTS: This observational study included adults with sickle cell disease and no history …

Factors That Predict Online Health Seeking, Leorah Jones

Walden Dissertations and Doctoral Studies

As technology continues to advance, more people are using the internet to search for health information. This jump in online health information seeking has prompted researchers to examine different aspects of health information-seeking behavior because of the impact that online health information has on the patient and their overall health. There are very little data pertaining to specific factors that can predict online health-seeking behavior. This document examines predictive factors of online health-seeking behaviors, which are age, gender, education, income, overall health, and ethnicity, using a quantitative approach with a correlational design grounded in the theory of planned behavior. Data …

Amaia Salazar: Modern Detective, Fairy Tale Heroine, Ancestral Basque Woman, Agnieszka Gutthy

BOGA: Basque Studies Consortium Journal

Amaia Salazar is the protagonist of Dolores Redondo’s Baztán trilogy: El guardián invisible, 2012 (The Invisible Guardian), Legado en los huesos, 2013 (The Legacy of the Bones), Ofrenda a la tormenta, 2014 (Offering to the Storm. The novels are hybrid texts that weave in the detective story elements of Basque mythology, fairy tale, and the noir. It is in the character of the detective Amaia Salazar that all these elements converge. Dolores Redondo successfully created a character of a female detective who is not only bright, rational professional investigator relying on the most recent advance …

Effectual Entrepreneurship In Action: Twelve Men And The Rebirth Of Arctic Cat Snowmobiles, Tom Clement

Journal of Business & Entrepreneurship

In 1981, the largest snowmobile manufacturer, Arctic Enterprises, Inc., makers of Arctic Cat snowmobiles, declared bankruptcy and eventually ceased operations. This case tells the story of the rebirth of Arctic Cat snowmobiles when twelve former Arctic Enterprises founders, executives, and employees launched the startup Arctco Inc. in 1983. These twelve men relied heavily on the five principles of effectual entrepreneurship, which were first articulated 20 years after the failure of Arctic Enterprises. Students will learn the inside story of Arctco and retroactively apply the principles of effectual entrepreneurship to one of the rarest business scenarios: a publicly traded firm with …

War Relief In World War Ii: Women And The American Red Cross, Rebecca L. Trecek

Great Plains Graduate Review

This paper recognizes the growth of the American Red Cross (ARC) and the contributions women throughout the network of the ARC made to various goals during World War Two. This paper focuses on the work women completed particularly on the home front. While some aspects of the ARC are publicized, others, particularly on the home front, are less well-known. As the demands for women within multiple aspects of the American workforce grew, organizations like the American Red Cross contributed to bridging the gap between women in the workforce and home needs. ARC volunteers also took on the responsibility of recruiting …

Executive Summary, William T. Eliason

Joint Force Quarterly

JFQ is certainly the Chairman’s journal, but it exists solely to give voice to you and your ideas on the joint force, jointness in general, and how best to fight and win our Nation’s wars and secure the peace. For over 30 years, the best and brightest among us have sustained the dialogue within these pages, whether physical or virtual. Help us continue this great tradition by sending us your articles and adding to the growing body of knowledge that is Joint Force Quarterly.

Compact Compression Waterblock Lid With Die Inspection Opening For Die Failure Analysis, Thomas Chen, Danny H. Cheng, Galor Wenyi Zhang

Defensive Publications Series

A compact compression waterblock lid is provided with an integrated inspection cutout, designed for inspecting the die surface of chips. This solution enables active water cooling during failure analysis or operational testing while applying even distribution of the required force onto the chip in the socket. One of the benefits is that, by being in a socket, the chip does not need to be soldered to the board. The microchip is thereby allowed to function under typical or stress conditions while providing direct access to observe and analyze the chip's die for defects.

System And Methods For Reduced Energy Consumption And Sleep Functionality For Collaboration Resources, Eric Yarbrough, Jason Coleman, Steve Holl, Gonzalo A. Salgueiro, Jay Kuhne

Defensive Publications Series

A system and methods are provided to optimize the placement of calls on devices in such a way that certain devices can be put into a sleep, idle, or powered down state temporarily, to conserve energy when the device is not processing calls, but to still allow for that device to be 'woken up' in real-time to process a call when needed or presented through the device. This allows for the ability for service provider or enterprise to not sacrifice their device resiliency or service availability posture, but still optimize and conserve energy across a collaboration deployment.

Selected Essays On Family Law (Committee Of The Association Of American Law Schools, 1950), Karl Krastin

Florida Law Review

No abstract provided.

Destination Unknown (Walter Gordon Merritt, 1951), J. R. Richardson

Florida Law Review

No abstract provided.

Administrative Agencies And The Courts (Frank E. Cooper, 1951), Richard B. Stephens

Florida Law Review

No abstract provided.

Paving Pathways: Navigating The Intersection Of Ai And Student Support In Higher Education, Tracy M. Balduzzi, Lori Driscoll Edd, Sean Nufer, Amanda Major

FDLA Journal

Higher education is undergoing a major transformation influenced by globalization, technological advancements, and the recent challenges posed by global pandemics. In response to these disruptions, institutions are increasingly embracing innovative strategies to enhance student support, faculty development, and overall educational effectiveness. This article explores the intersection of artificial intelligence (AI), student support, and faculty development in higher education, highlighting key initiatives and strategies implemented by institutions across the United States.

The article examines the evolving role of educators with regard to AI, emphasizing the use of AI-powered tools to enhance teaching and learning experiences while addressing concerns about academic integrity …

Best Practices For Synchronous Online Teaching: A Framework To Support Engagement And Inclusion, Amy Sugar, Sue Bauer, Rohan Jowallah

FDLA Journal

The last two decades have seen an increasingly rapid advancement in the landscape of technology. While these advancements enhanced the quality of education, the COVID-19 pandemic forced institutions to rapidly transition to synchronous online teaching and learning. This transition was not often done within a sound pedagogical process. According to De Leon (2022), in many cases Covid negatively affected students’ development. The writer goes on to suggest that social, mental health, and instructional issues may have contributed to the deficit in learning currently being explored by many academics. Hence, we must create sound approaches for teaching and learning online. As …

Passing The Gen Z Vibe Check: A Values-Based Approach For Instructional Design, Charlotte A. Jones-Roberts, Rebecca Mcnulty

FDLA Journal

This paper emphasizes the significance of establishing a compelling digital course environment to meet the preferences of Generation Z (Gen Z) students, who prioritize multimedia content, personalization, and on-demand learning as key components to online learning. Educators seeking to enhance online pedagogy will need to consider these preferences in order to address the challenge of aligning instructional design with targeted learning experiences. To that end, this paper uses a literature review and analysis of values to explore the intersection between Gen Z values and preferences and to suggest pedagogical support for aligning online course content to corresponding values.

Lessons Learned: A Case Study On The Creation Of An Online Phd Program, Ashley H. Tharpe

FDLA Journal

This case study delves into the development of an online PhD program in Health Sciences at Liberty University, highlighting valuable lessons learned and offering insights for effective program creation and implementation. The study addresses the complexities of curriculum development, the importance of comprehensive communication, the role of faculty mentorship, and the significance of fostering a sense of community in online education. Drawing on the experiences of program developers, faculty members, and students, this research sheds light on strategies for aligning course content with program goals, embracing imperfection in program design, and cultivating a vibrant online learning community. Additionally, the study …

Discover The Power Of Social Health Data, Gmick Smith Dr.

FDLA Journal

In today's increasingly connected world, data plays a pivotal role in various fields, and healthcare is no exception. Social health data has emerged as a powerful tool to understand and improve public health outcomes. By harnessing the intelligence of this data, we are witnessing a transformative impact on healthcare, allowing for better insights, targeted interventions, and improved decision-making. This article explores the power of social health data and its potential in revolutionizing the healthcare landscape.

Bring Them Back To Campus: Optional Engaging Campus Activities For Online Classes With Livestreaming, Victoria Brown Ed. D., David Devraj Kumar

FDLA Journal

Ever since the pandemic, students have adapted to taking their classes online. However, coming to campus promotes a connection to the university through faculty and classmates. The event had a dual purpose in promoting the adoption of computational skills through robots in K-12 classrooms, which is the educational goal of the project. A carefully designed “Educational Robotics Day” event encourages students to return to campus through an engaging event while accommodating those students that are unable to come to the campus but still attend. The coordinators of the event also measured the effectiveness of the event through an exit survey …

Role Playing Job Scenarios In Online Discussions, Emily Franklin

FDLA Journal

This article focuses on the value and implementation of job scenario-based role plays in online discussions, which can apply to any field to engage online learners in their course community and subject matter. These role plays prepare students with on-the-job skills by providing safe practice of difficult problem-solving scenarios. This step-by-step guide reviews four components of designing, developing, implementing, and assessing job scenario-based role plays in an online course, noting both synchronous and asynchronous methods of delivery. Examples of how role plays were developed for an online English language skills course are discussed.

Blazing New Pathways For Digital Engagement In Mathematics Using Geogebra, Math Manipulatives, And Picture Books In A Stem World To Nurture Confident Young People In Mathematics, Joseph M. Furner

FDLA Journal

Using best practices for teaching mathematics like GeoGebra, math manipulatives, and children’s literature picture books can all be connected to each other and better help to prepare students for a STEM world to develop confident young people in doing mathematics in a world of AI and emerging technologies. This paper will highlight all the above best practiced and share how they can be connected and taught in a way that is make math meaningful and help students to be confident with technology and mathematics in a way that helps them see math in a hands-on, visual, and abstract way. Learners …

Evolution Of Global Anatomy Research Through Covid-19: A Post-Pandemic Evaluation, Harsh Chheda, Santanu De

FDLA Journal

The Coronavirus Infectious Disease 2019 (COVID-19) struck the world with a deep impact on many countries' healthcare systems. More specifically, anatomical research experienced a drastic setback due to the limitations and restrictions placed upon them by the medical community. This study aims to review how COVID-19 guidelines presented conflict regarding the retrieval and use of cadavers, as well as how anatomy research was modified on a global scale owing to the pandemic. The COVID-19 outbreak called for several changes upon each significant anatomical research technique, ranging from cadaver dissection to diagnostic imaging. Given the remarkable shift in medical research guidelines …