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Articles 360361 - 360390 of 5211500
Full-Text Articles in Entire DC Network
Association Between Psychological Distress And Diabetic Retinopathy Among U.S. Adults, Claret Ijeoma Onukogu
Association Between Psychological Distress And Diabetic Retinopathy Among U.S. Adults, Claret Ijeoma Onukogu
Walden Dissertations and Doctoral Studies
Diabetes can lead to diabetic retinopathy, an eye disease that causes damaged blood vessels and the growth of abnormal ones, leading to vision loss. The two stages of the disease are non-proliferative and proliferative diabetic retinopathy. In the non-proliferative stage, diabetics develop macular edema and ischemia with shortage of blood in the macula region of the eye, and the vision eventually becomes blurry. However, the proliferative stage is the advanced stage of the disease involves neovascularization and retinal detachment. The quantitative study employed the socioecological model as the theoretical framework to examine the relationship between psychological distress and diabetic retinopathy …
Cmsi Note #6: Sharpening The Sword: Chinese Navy Aircraft Carrier Battle Group Defense Zones, Daniel Clayton Rice
Cmsi Note #6: Sharpening The Sword: Chinese Navy Aircraft Carrier Battle Group Defense Zones, Daniel Clayton Rice
CMSI Notes
Perspectives and Key Takeaways:
- Chinese state media’s Channel 7 recently released a series of videos that described China’s aircraft carriers and the carrier battle groups, including their history, composition, and operational theory.
- The videos describe the carrier battle group (CVBG) “Outer Defense Zone” (外防区), also called the “Depth Defense Zone” (纵深防区), as 185 km to 400 km away from the aircraft carrier.
- The “Middle Defense Zone” (中防区), or the “Area Defense Zone” (区域防区) is described as 45 km to 185 km away from the aircraft carrier.
- The video details the “Inner Defense Zone” (内防区), otherwise called the “Point Defense Zone” …
The Influence Of Eyewitnesses And Police Tip Line Reports: An Exploratory Case Study Of A 2005 Homicide, Abigail Rose Torres
The Influence Of Eyewitnesses And Police Tip Line Reports: An Exploratory Case Study Of A 2005 Homicide, Abigail Rose Torres
Dissertations and Theses
Public tip lines provide the public to provide information [sic] to the police when there is an ongoing investigation. These public tip lines could increase investigations where the public is being made aware of the investigation, increasing the amount of information being brought forward. Research focuses on how tips reporting is similar to eyewitnesses in that individuals recall information. The literature illustrates how the media can influence the tips. The study is an exploratory content analysis looking at potential themes or patterns that emerged from analyzing the tips and patterns of the tip line and media files related to an …
Enhancing The Carbon Monoxide Oxidation Performance Through Surface Defect Enrichment Of Ceria-Based Supports For Platinum Catalyst, Shaohua Xie, Yue Lu, Kailong Ye, Wei Tan, Sufeng Cao, Daekun Kim, Jeremia Loukusa, Yaobin Li, Yan Zhang, Lu Ma, Steven N Ehrlich, Nebojsa S Marinkovic, Jiguang Deng, Maria Flytzani-Stephanopoulos, Fudong Liu
Enhancing The Carbon Monoxide Oxidation Performance Through Surface Defect Enrichment Of Ceria-Based Supports For Platinum Catalyst, Shaohua Xie, Yue Lu, Kailong Ye, Wei Tan, Sufeng Cao, Daekun Kim, Jeremia Loukusa, Yaobin Li, Yan Zhang, Lu Ma, Steven N Ehrlich, Nebojsa S Marinkovic, Jiguang Deng, Maria Flytzani-Stephanopoulos, Fudong Liu
Faculty, Staff and Student Publications
Effective synthesis and application of single-atom catalysts on supports lacking enough defects remain a significant challenge in environmental catalysis. Herein, we present a universal defect-enrichment strategy to increase the surface defects of CeO2-based supports through H2 reduction pretreatment. The Pt catalysts supported by defective CeO2-based supports, including CeO2, CeZrOx, and CeO2/Al2O3 (CA), exhibit much higher Pt dispersion and CO oxidation activity upon reduction activation compared to their counterpart catalysts without defect enrichment. Specifically, Pt is present as embedded single atoms on the CA support with enriched surface defects (CA-HD) based on which the highly active catalyst showing embedded …
Extracellular Vesicles, Circadian Rhythms, And Cancer: A Comprehensive Review With Emphasis On Hepatocellular Carcinoma, Baharan Fekry, Lierni Ugartemendia, Nestor F Esnaola, Laura Goetzl
Extracellular Vesicles, Circadian Rhythms, And Cancer: A Comprehensive Review With Emphasis On Hepatocellular Carcinoma, Baharan Fekry, Lierni Ugartemendia, Nestor F Esnaola, Laura Goetzl
Faculty, Staff and Student Publications
This review comprehensively explores the complex interplay between extracellular vesicles (ECVs)/exosomes and circadian rhythms, with a focus on the role of this interaction in hepatocellular carcinoma (HCC). Exosomes are nanovesicles derived from cells that facilitate intercellular communication by transporting bioactive molecules such as proteins, lipids, and RNA/DNA species. ECVs are implicated in a range of diseases, where they play crucial roles in signaling between cells and their surrounding environment. In the setting of cancer, ECVs are known to influence cancer initiation and progression. The scope of this review extends to all cancer types, synthesizing existing knowledge on the various roles …
Hiv/Aids-Associated Knowledge And Attitudes Towards Treating Disadvantaged Communities Among Pre-Community-Based Dental Education Dental Students In The Us, Aditi Tomar, Hannah Balcezak, Shirley Lewis Miranda, Marie C Latortue, Richa Chinchkhandi
Hiv/Aids-Associated Knowledge And Attitudes Towards Treating Disadvantaged Communities Among Pre-Community-Based Dental Education Dental Students In The Us, Aditi Tomar, Hannah Balcezak, Shirley Lewis Miranda, Marie C Latortue, Richa Chinchkhandi
Faculty, Staff and Student Publications
This study examines HIV/AIDS-associated knowledge and attitudes towards treating disadvantaged communities among predoctoral dental students in U.S. dental schools who have not yet commenced their Community-Based Dental Education (CBDE) training. It also compares the difference in the knowledge and attitudes between students with reported community engagement with PLWHA and those without. Our study comprised 89 predoctoral dental students within their D1-D3 years of dental school who had not yet initiated their Community-Based Dental Education (referred to as pre-CBDE dental students). Their responses were collected via an online survey. The participants were 68% females, 94% heterosexual, and with a mean age …
Biophysics Of Protein-Lipid Interactions, Paula A Bender, Vasanthi Jayaraman
Biophysics Of Protein-Lipid Interactions, Paula A Bender, Vasanthi Jayaraman
Faculty, Staff and Student Publications
The biological phenomenon of protein-lipid interactions in cell membranes underlies the diversity of peripheral membrane protein function and physical properties of the membrane. To summarize novel findings in the field, this research highlight focuses on recent publications in Biophysical Journal.
Clear Thrombectomy Score: An Index To Estimate The Probability Of Good Functional Outcome With Or Without Endovascular Treatment In The Late Window For Anterior Circulation Occlusion, Raul G Nogueira, Jelle Demeestere, Volker Puetz, Marc Ribo, Mohamad Abdalkader, João Pedro Marto, Alhamza R Al-Bayati, Hiroshi Yamagami, Diogo C Haussen, Marta Olive-Gadea, Simon Winzer, Mahmoud H Mohammaden, Robin Lemmens, Kanta Tanaka, Pekka Virtanen, Anne Dusart, Flavio Bellante, Daniel P O Kaiser, Francois Caparros, Hilde Henon, João Nuno Ramos, Santiago Ortega-Gutierrez, Sunil A Sheth, Stefania Nannoni, Lieselotte Vandewalle, Johannes Kaesmacher, Sergio Salazar-Marioni, Liisa Tomppo, Rita Ventura, Syed F Zaidi, Mouhammad Jumaa, Alicia C Castonguay, Milagros Galecio-Castillo, Ajit S Puri, Adnan Mujanovic, Piers Klein, Liqi Shu, Behzad Farzin, Hannah Moomey, Hesham E Masoud, Jessica Jesser, Markus A Möhlenbruch, Peter A Ringleb, Daniel Strbian, Osama O Zaidat, Shadi Yaghi, Davide Strambo, Patrik Michel, Daniel Roy, Shinichi Yoshimura, Kazutaka Uchida, Jean Raymond, Thanh N Nguyen
Clear Thrombectomy Score: An Index To Estimate The Probability Of Good Functional Outcome With Or Without Endovascular Treatment In The Late Window For Anterior Circulation Occlusion, Raul G Nogueira, Jelle Demeestere, Volker Puetz, Marc Ribo, Mohamad Abdalkader, João Pedro Marto, Alhamza R Al-Bayati, Hiroshi Yamagami, Diogo C Haussen, Marta Olive-Gadea, Simon Winzer, Mahmoud H Mohammaden, Robin Lemmens, Kanta Tanaka, Pekka Virtanen, Anne Dusart, Flavio Bellante, Daniel P O Kaiser, Francois Caparros, Hilde Henon, João Nuno Ramos, Santiago Ortega-Gutierrez, Sunil A Sheth, Stefania Nannoni, Lieselotte Vandewalle, Johannes Kaesmacher, Sergio Salazar-Marioni, Liisa Tomppo, Rita Ventura, Syed F Zaidi, Mouhammad Jumaa, Alicia C Castonguay, Milagros Galecio-Castillo, Ajit S Puri, Adnan Mujanovic, Piers Klein, Liqi Shu, Behzad Farzin, Hannah Moomey, Hesham E Masoud, Jessica Jesser, Markus A Möhlenbruch, Peter A Ringleb, Daniel Strbian, Osama O Zaidat, Shadi Yaghi, Davide Strambo, Patrik Michel, Daniel Roy, Shinichi Yoshimura, Kazutaka Uchida, Jean Raymond, Thanh N Nguyen
Faculty, Staff and Student Publications
Background: With the expanding eligibility for endovascular therapy (EVT) of patients presenting in the late window (6-24 hours after last known well), we aimed to derive a score to predict favorable outcomes associated with EVT versus best medical management.
Methods and results: A multinational observational cohort of patients from the CLEAR (Computed Tomography for Late Endovascular Reperfusion) study with proximal intracranial occlusion (2014-2022) was queried (n=58 sites). Logistic regression analyses were used to derive a 9-point score for predicting good functional outcome (modified Rankin Scale score 0-2 or return to premorbid modified Rankin Scale score) at 90 days, with sensitivity …
Cruising Speed: Our Journal's 10-Year Voyage, Dennis J. Baumgardner, Joe Grundle
Cruising Speed: Our Journal's 10-Year Voyage, Dennis J. Baumgardner, Joe Grundle
Journal of Patient-Centered Research and Reviews
In this invited editorial, two long-tenured editors for the Journal of Patient-Centered Research and Reviews recount the publication’s many impactful contributions to the medical literature over its first 10 years.
Central Nervous System Prophylaxis Utilization In Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma Within A Large Community Health System, Michael J. Williams, Sol D. Atienza, Renee H. Aranda, Kayleigh B. Flint, Sherjeel Sana, Stephen C. Medlin, Zartash Gul, Federico A. Sanchez, Michael A. Thompson
Central Nervous System Prophylaxis Utilization In Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma Within A Large Community Health System, Michael J. Williams, Sol D. Atienza, Renee H. Aranda, Kayleigh B. Flint, Sherjeel Sana, Stephen C. Medlin, Zartash Gul, Federico A. Sanchez, Michael A. Thompson
Journal of Patient-Centered Research and Reviews
Purpose: The impact of central nervous system (CNS) prophylaxis in diffuse large B-cell lymphoma (DLBCL) is contentious. The CNS International Prognostic Index (IPI) calculator offers prognostic guidance in identifying those patients who may be at highest risk of disease progression or relapse to the CNS. However, it is unclear whether this tool has guided clinician decision-making in a real-world setting. Studies have suggested that CNS prophylaxis may not offer clinically significant benefit in terms of preventing CNS disease progression. Given this, we investigated the utilization of CNS prophylaxis within our own population and documentation of the CNS-IPI score.
Methods: We …
Factors Associated With Increased Health Care Utilization For Patients With Dementia With Lewy Bodies: A Narrative Review, Kathryn A. Wyman-Chick, Matthew J. Barrett, Michael J. Miller, Jennifer L. Kuntz, Ella A. Chrenka, Rebecca C. Rossom
Factors Associated With Increased Health Care Utilization For Patients With Dementia With Lewy Bodies: A Narrative Review, Kathryn A. Wyman-Chick, Matthew J. Barrett, Michael J. Miller, Jennifer L. Kuntz, Ella A. Chrenka, Rebecca C. Rossom
Journal of Patient-Centered Research and Reviews
Numerous studies have demonstrated that dementia is associated with increased utilization of health care services, which in turn results in increased costs of care. Dementia with Lewy bodies (DLB) is associated with greater costs of care relative to other forms of dementia due to higher rates of hospitalization and nursing home placement directly related to neuropsychiatric symptoms, parkinsonism, increased susceptibility to delirium, and elevated rates of caregiver burden. There is a critical need for researchers to identify potentially modifiable factors contributing to increased costs of care and poor clinical outcomes for patients with DLB, which may include comorbidities, polypharmacy/contraindicated medications, …
Bringing Virtual Reality To Mainstream Pediatric Care, Wayne Kuang, Eric J. Yang, Roland Truong, Benjamin K.P. Woo
Bringing Virtual Reality To Mainstream Pediatric Care, Wayne Kuang, Eric J. Yang, Roland Truong, Benjamin K.P. Woo
Journal of Patient-Centered Research and Reviews
Virtual reality (VR) stands as an innovative technology transforming our interactions with the digital world. Its integration into health care has proven advantageous for both patients and health care providers across multiple levels and modalities. Given that VR is becoming increasingly accessible and prevalent, health care providers should explore incorporating the technology into their practices, particularly within the pediatric population, which is becoming progressively more accustomed to the technology. This topic synopsis provides a broad discussion of the current literature, exploring current and probable future applications of VR in pediatric patient care, particularly in improving the hospital experience, facilitating education …
How The Cahps Clinician And Group Patient Experience Survey Data Have Been Used In Research: A Systematic Review, Denise D. Quigley, Marc N. Elliott, Nabeel Qureshi, Zachary Predmore, Ron D. Hays
How The Cahps Clinician And Group Patient Experience Survey Data Have Been Used In Research: A Systematic Review, Denise D. Quigley, Marc N. Elliott, Nabeel Qureshi, Zachary Predmore, Ron D. Hays
Journal of Patient-Centered Research and Reviews
Purpose: Patient experience is a key aspect of care quality. The Consumer Assessment of Healthcare Providers and Systems Clinician and Group (CG-CAHPS®) survey measures experiences with ambulatory care providers to inform public reporting, pay-for-performance initiatives, interventions, patient choice of physicians/practices, and quality improvement. Since the survey’s 2007 release, no systematic review of its use in research has been published.
Methods: We reviewed English-language, peer-reviewed articles published since 2008 using CG-CAHPS survey data in the U.S. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and used the Checklist for Analytical Cross-Sectional Studies.
Results: We examined 126 articles …
Abstracts From The 2024 Health Care Systems Research Network (Hcsrn) Annual Conference, Milwaukee, Wisconsin, Health Care Systems Research Network
Abstracts From The 2024 Health Care Systems Research Network (Hcsrn) Annual Conference, Milwaukee, Wisconsin, Health Care Systems Research Network
Journal of Patient-Centered Research and Reviews
The Health Care Systems Research Network (HCSRN) comprises 20 learning health systems with integrated care delivery and embedded research units. The network’s annual conference serves as a forum for research teams from member institutions to disseminate project findings, explore scientific collaborations, and share insights about population-based research practices that can measurably improve health and health care for all. The theme of this year’s conference was “Advancing high-quality, equitable research in the age of new health care technologies.” Abstracts presented at HCSRN 2024 are published in this issue supplement of the Journal of Patient-Centered Research and Reviews, the journal of record …
Noncontingent Reinforcement: A Functional Versus Nonfuctional Approach To Reducing Disruptive Behavior And Increasing Academic Engagement Across Socially Maintained Functions, Mariah Brooks
Theses and Dissertations
According to the School Survey on Crime and Safety (SSOCS; 2022) three notable discipline problems reported by public schools including acts of disrespect toward teachers, verbal abuse towards teachers, and widespread disorder in classrooms has been consistently increasing over the last decade (U.S. Department of Education, 2022). Noncontingent reinforcement (NCR), a function-based treatment, is a key focus of this study. NCR involves the systematic delivery of reinforcers, such as attention and escape, independent of the student's behavior. It has a long history of demonstrating statistically significant reductions in problem behaviors within multiple settings, including schools (Carr et al., 2009). The …
Annual Progress In Global Carbon Capture, Utilization, And Storage In 2023, Siyuan Fang, Yun Hang Hu
Annual Progress In Global Carbon Capture, Utilization, And Storage In 2023, Siyuan Fang, Yun Hang Hu
Michigan Tech Publications
Since the industrial revolution, global anthropogenic CO2 emissions have surged dramatically to unsustainable levels, resulting in severe issues, such as global warming, extreme weather events, and species extinction. In response to this critical situation, extensive efforts have been undertaken across academia, industry, and policymaking sectors to deploy carbon capture, utilization, and storage (CCUS) technologies. Here, we present the annual summary of global CCUS for the year 2023. We begin by discussing the trends of anthropogenic CO2 emissions and atmospheric CO2 concentrations, and then offer an up-to-date summary of progress in academia, industry, and policy, respectively. In academia, we analyze the …
Mapping The Contribution Of The C-Linker Domain To Gating Polarity In Cnbd Channels, Jenna L Lin, Yongchang Chang, Debanjan Tewari, John Cowgill, Baron Chanda
Mapping The Contribution Of The C-Linker Domain To Gating Polarity In Cnbd Channels, Jenna L Lin, Yongchang Chang, Debanjan Tewari, John Cowgill, Baron Chanda
2020-Current year OA Pubs
Ion channels of the cyclic nucleotide-binding domain (CNBD) family play a crucial role in the regulation of key biological processes, such as photoreception and pacemaking activity in the heart. These channels exhibit high sequence and structural similarity but differ greatly in their functional responses to membrane potential. The CNBD family includes hyperpolarization-activated ion channels and depolarization-activated ether-à-go-go channels. Structural and functional studies show that the differences in the coupling interface between these two subfamilies' voltage-sensing domain and pore domain may underlie their differential response to membrane polarity. However, other structural components may also contribute to defining the polarity differences in …
Early Bolus Epinephrine Administration During Pediatric Cardiopulmonary Resuscitation For Bradycardia With Poor Perfusion: An Icu-Resuscitation Study, Amanda J O'Halloran, Stuart H Friess, Arushi Manga, Et Al.
Early Bolus Epinephrine Administration During Pediatric Cardiopulmonary Resuscitation For Bradycardia With Poor Perfusion: An Icu-Resuscitation Study, Amanda J O'Halloran, Stuart H Friess, Arushi Manga, Et Al.
2020-Current year OA Pubs
BACKGROUND: Half of pediatric in-hospital cardiopulmonary resuscitation (CPR) events have an initial rhythm of non-pulseless bradycardia with poor perfusion. Our study objectives were to leverage granular data from the ICU-RESUScitation (ICU-RESUS) trial to: (1) determine the association of early epinephrine administration with survival outcomes in children receiving CPR for bradycardia with poor perfusion; and (2) describe the incidence and time course of the development of pulselessness.
METHODS: Prespecified secondary analysis of ICU-RESUS, a multicenter cluster randomized trial of children (< 19 years) receiving CPR in 18 intensive care units in the United States. Index events (October 2016-March 2021) lasting ≥ 2 min with a documented initial rhythm of bradycardia with poor perfusion were included. Associations between early epinephrine (first 2 min of CPR) and outcomes were evaluated with Poisson multivariable regression controlling for a priori pre-arrest characteristics. Among patients with arterial lines, intra-arrest blood pressure waveforms were reviewed to determine presence of a pulse during CPR interruptions. The temporal nature of progression to pulselessness was described and outcomes were compared between patients according to subsequent pulselessness status.
RESULTS: Of 452 eligible subjects, 322 (71%) received early epinephrine. The early epinephrine group had higher pre-arrest severity of illness …
Exploring Lipin1 As A Promising Therapeutic Target For The Treatment Of Duchenne Muscular Dystrophy, Abdulrahman Jama, Abdullah A Alshudukhi, Steve Burke, Lixin Dong, John Karanja Kamau, Brooklyn Morris, Ibrahim A Alkhomsi, Brian N Finck, Andrew Alvin Voss, Hongmei Ren
Exploring Lipin1 As A Promising Therapeutic Target For The Treatment Of Duchenne Muscular Dystrophy, Abdulrahman Jama, Abdullah A Alshudukhi, Steve Burke, Lixin Dong, John Karanja Kamau, Brooklyn Morris, Ibrahim A Alkhomsi, Brian N Finck, Andrew Alvin Voss, Hongmei Ren
2020-Current year OA Pubs
BACKGROUND: Duchenne muscular dystrophy (DMD) is a progressive and devastating muscle disease, resulting from the absence of dystrophin. This leads to cell membrane instability, susceptibility to contraction-induced muscle damage, subsequent muscle degeneration, and eventually disability and early death of patients. Currently, there is no cure for DMD. Our recent studies identified that lipin1 plays a critical role in maintaining myofiber stability and integrity. However, lipin1 gene expression levels are dramatically reduced in the skeletal muscles of DMD patients and mdx mice.
METHODS: To identify whether increased lipin1 expression could prevent dystrophic pathology, we employed unique muscle-specific mdx:lipin1 transgenic (mdx:lipin1
RESULTS: …
Low Remnant Cholesterol And In-Hospital Bleeding Risk After Ischemic Stroke Or Transient Ischemic Attack, Zhiyuan Wu, Haiping Zhang, Yi Xu, Xia Li, Xingang Li, Lois Balmer, Xiuhua Guo, Qi Zhang, Xiang Han, Lixin Tao
Low Remnant Cholesterol And In-Hospital Bleeding Risk After Ischemic Stroke Or Transient Ischemic Attack, Zhiyuan Wu, Haiping Zhang, Yi Xu, Xia Li, Xingang Li, Lois Balmer, Xiuhua Guo, Qi Zhang, Xiang Han, Lixin Tao
Research outputs 2022 to 2026
BACKGROUND: Bleeding risk brought by intensive lipid-lowering therapy and low low-density lipoprotein cholesterol is concern-ing, while evidence regarding the relationship between remnant cholesterol and bleeding is frightening. This study aimed to investigate the association between remnant cholesterol at admission and an in-hospital bleeding event after acute ischemic stroke or transient ischemic attack (TIA). METHODS AND RESULTS: A total of 3222 eligible patients admitted to Shanghai Huashan Hospital between 2015 and 2021 with complete lipid data were analyzed. Patients were classified into low (<20.0 mg/dL), moderate (20.0–29.9 mg/dL), and high (≥30 mg/dL) groups by remnant cholesterol. The mean age of patients was 63.0± 13.1 years, including 2301 (71.4%) men and 651 (20.2%) with TIA. The median (interquartile range) of remnant cholesterol was 18.6 (13.5–25.9) mg/dL. After adjustment for confounding variables, patients with low remnant cholesterol had a higher risk of bleeding events (odds ratio, 2.56 [95% CI, 1.12–6.67]) than those with moderate remnant cholesterol. The high remnant cholesterol group was not significantly associated with bleeding risk. Combined assessment of low-density lipoprotein cholesterol and remnant cholesterol further identi-fied patients with the highest risk of bleeding events. CONCLUSIONS: Low remnant cholesterol levels were associated with bleeding events during the acute stage of ischemic stroke and TIA. The assessment of remnant cholesterol could inform the bleeding risk during hospitalization both for patients and physicians in clinical practice.
Chimeric Antigen Receptor-Induced Antigen Loss Protects Cd5cart Cells From Fratricide Without Compromising On-Target Cytotoxicity, Royce Ma, Mae Woods, Phillip Burkhardt, Noah Crooks, Dayenne G Van Leeuwen, Daniil Shmidt, Jacob Couturier, Alexandre Chaumette, Divya Popat, Laquisa C Hill, Rayne H Rouce, Sachin Thakkar, Aaron F Orozco, Alexandre F Carisey, Malcolm K Brenner, Maksim Mamonkin
Chimeric Antigen Receptor-Induced Antigen Loss Protects Cd5cart Cells From Fratricide Without Compromising On-Target Cytotoxicity, Royce Ma, Mae Woods, Phillip Burkhardt, Noah Crooks, Dayenne G Van Leeuwen, Daniil Shmidt, Jacob Couturier, Alexandre Chaumette, Divya Popat, Laquisa C Hill, Rayne H Rouce, Sachin Thakkar, Aaron F Orozco, Alexandre F Carisey, Malcolm K Brenner, Maksim Mamonkin
Center for Medical Ethics and Health Policy Staff Publications
Chimeric antigen receptor T cells (CART) targeting lymphocyte antigens can induce T cell fratricide and require additional engineering to mitigate self-damage. We demonstrate that the expression of a chimeric antigen receptor (CAR) targeting CD5, a prominent pan-T cell antigen, induces rapid internalization and complete loss of the CD5 protein on T cells, protecting them from self-targeting. Notably, exposure of healthy and malignant T cells to CD5.CART cells induces similar internalization of CD5 on target cells, transiently shielding them from cytotoxicity. However, this protection is short-lived, as sustained activity of CD5.CART cells in patients with T cell malignancies results in full …
Acceptability And Feasibility Of A Community Dementia Stigma Reduction Program In Kenya, Christine W. Musyimi, Levi A. Muyela, David M. Ndetei, Sara Evans-Lacko, Nicolas Farina
Acceptability And Feasibility Of A Community Dementia Stigma Reduction Program In Kenya, Christine W. Musyimi, Levi A. Muyela, David M. Ndetei, Sara Evans-Lacko, Nicolas Farina
Peninsula Medical School
Background: Dementia stigma has adverse effects on people with dementia and their carers. These effects can lead to poor quality of life among other negative impacts. Objective: The aim of this study is to develop and pilot a novel dementia stigma reduction intervention in rural Kenya, leveraging existing Community Health Workers (CHWs) for its delivery. Methods: The pre-post pilot study was conducted, utilizing a parallel mixed-methods design. Ten CHWs were trained to deliver a contextually developed dementia anti-stigma intervention. These CHWs delivered four workshops to 59 members of the general public in Makueni County, with each workshop lasting between 1.5 …
Chimeric Viruses Enable Study Of Antibody Responses To Human Rotaviruses In Mice, Sarah Woodyear, Tawny L Chandler, Takahiro Kawagishi, Tom M Lonergan, Vanshika A Patel, Caitlin A Williams, Sallie R Permar, Siyuan Ding, Sarah L Caddy
Chimeric Viruses Enable Study Of Antibody Responses To Human Rotaviruses In Mice, Sarah Woodyear, Tawny L Chandler, Takahiro Kawagishi, Tom M Lonergan, Vanshika A Patel, Caitlin A Williams, Sallie R Permar, Siyuan Ding, Sarah L Caddy
2020-Current year OA Pubs
The leading cause of gastroenteritis in children under the age of five is rotavirus infection, accounting for 37% of diarrhoeal deaths in infants and young children globally. Oral rotavirus vaccines have been widely incorporated into national immunisation programs, but whilst these vaccines have excellent efficacy in high-income countries, they protect less than 50% of vaccinated individuals in low- and middle-income countries. In order to facilitate the development of improved vaccine strategies, a greater understanding of the immune response to existing vaccines is urgently needed. However, the use of mouse models to study immune responses to human rotavirus strains is currently …
Social Vulnerability And Surgery Outcomes: A Cross-Sectional Analysis, Mohamed Abdelhack Washington University School Of Medicine In St. Louis, Sandhya Tripathi, Yixin Chen, Michael S Avidan, Christopher R King
Social Vulnerability And Surgery Outcomes: A Cross-Sectional Analysis, Mohamed Abdelhack Washington University School Of Medicine In St. Louis, Sandhya Tripathi, Yixin Chen, Michael S Avidan, Christopher R King
2020-Current year OA Pubs
BACKGROUND: Post-operative complications present a challenge to the healthcare system due to the high unpredictability of their incidence. Socioeconomic conditions have been established as social determinants of health. However, their contribution relating to postoperative complications is still unclear as it can be heterogeneous based on community, type of surgical services, and sex and gender. Uncovering these relations can enable improved public health policy to reduce such complications.
METHODS: In this study, we conducted a large population cross-sectional analysis of social vulnerability and the odds of various post-surgical complications. We collected electronic health records data from over 50,000 surgeries that happened …
Mate Selection And Current Trends In The Prevalence Of Autism, Elizabeth Forsen, Natasha Marrus, Jacqueline Joyce, Yi Zhang, John N Constantino
Mate Selection And Current Trends In The Prevalence Of Autism, Elizabeth Forsen, Natasha Marrus, Jacqueline Joyce, Yi Zhang, John N Constantino
2020-Current year OA Pubs
BACKGROUND: According to the most recent U.S. CDC surveillance data, the rise in prevalence of childhood autism spectrum disorder among minority children has begun to outpace that of non-Hispanic white children. Since prior research has identified possible differences in the extent of mate selection for autistic traits across families of different ethnicity, this study examined variation in autism related traits in contemporaneous, epidemiologically ascertained samples of spousal pairs representing Hispanic and non-Hispanic white populations. The purpose was to determine whether discrepancies by ethnicity could contribute to differential increases in prevalence in the current generation of young children.
METHODS: Birth records …
Papillary Tumor Of The Pineal Region: Analysis Of Dna Methylation Profiles And Clinical Outcomes In 76 Cases, Zhichao Wu, Sonika Dahiya, Et Al.
Papillary Tumor Of The Pineal Region: Analysis Of Dna Methylation Profiles And Clinical Outcomes In 76 Cases, Zhichao Wu, Sonika Dahiya, Et Al.
2020-Current year OA Pubs
Papillary tumor of the pineal region (PTPR) is an uncommon tumor of the pineal region with distinctive histopathologic and molecular characteristics. Experience is limited with respect to its molecular heterogeneity and clinical characteristics. Here, we describe 39 new cases and combine these with 37 previously published cases for a cohort of 76 PTPR's, all confirmed by methylation profiling. As previously reported, two main methylation groups were identified (PTPR-A and PTPR-B). In our analysis we extended the subtyping into three subtypes: PTPR-A, PTPR-B1 and PTPR-B2 supported by DNA methylation profile and genomic copy number variations. Frequent loss of chromosome 3 or …
The Influence Of System Optimization On Improving The Quality Of Administrative Services In The Ministry Of Education, Culture, Research And Technology, Mohammad Ridha, Dhini Novia Azaria
The Influence Of System Optimization On Improving The Quality Of Administrative Services In The Ministry Of Education, Culture, Research And Technology, Mohammad Ridha, Dhini Novia Azaria
Jurnal Administrasi Bisnis Terapan
ABSTRACT
Correspondence and record management are crucial components of a company or institute. Although often considered as things that do not require primary attention, these two components can have a very important role in the occurrence of an event. Along with the development of technology, the management of correspondence and archives is also growing. Generally, the development of this management is in the form of the emergence of an application that can accommodate the needs of correspondence and archives of a company or institute. In Ministry of Education, Culture, Research, and Technology, the application is called "Sistem Naskah Dinas Elektronik" …
Analysis Of The Potential For Enhancing The Efficiency Of A Floating Photovoltaic (Fpv) System, How-Ping Wu, Ching-Yi Tseng, Chuan-Chung Jen, Yuan-Ching Chiang, Sih-Li Chen
Analysis Of The Potential For Enhancing The Efficiency Of A Floating Photovoltaic (Fpv) System, How-Ping Wu, Ching-Yi Tseng, Chuan-Chung Jen, Yuan-Ching Chiang, Sih-Li Chen
Journal of Marine Science and Technology–Taiwan
This study examined the power generation capabilities of FPV systems and the advantages of employing active cooling on floating solar panels. Floating solar panels exhibit improved efficiency due to operating at lower temperatures facilitated by the cooling effect of water evaporation. Additionally, the high availability of water renders the application of the active cooling technique economically viable. This study developed a comprehensive simulation of a floating solar system, integrating a mathematical model to validate experimental findings and a temperature model derived from an energy equation specific to floating solar panels. This model calculates the heat transfer among the three different …
Sustaining America's Non-Jurisdictional Wetlands Post-Sackett Through Conservation, Shawna Bligh
Sustaining America's Non-Jurisdictional Wetlands Post-Sackett Through Conservation, Shawna Bligh
UMKC Law Review
Part I of this Article discusses the functional role of wetlands in meeting the intended purpose of the Clean Water Act (“CWA”). The intended purpose of the CWA is to "restore and maintain the chemical, physical and biological integrity of the Nation's waters." The Court's decision in Sackett undermines the intended purpose of the CWA. Wetlands play an essential role in meeting this objective. Wetlands are hydrologically connected to and an embedded part of the overall aquatic ecosystem. The Sackett decision leaves wetlands subject to further degradation.
Part II of this Article provides an overview of the CWA, how we …
Skills And Hills: Factors That Influence Women’S And Non-Binary College Students’ Decisions To Commute Via Bicycle, Emily Dzieniszewski, Ashley N. Myers, Lucas D. Elliott, Melissa Bopp
Skills And Hills: Factors That Influence Women’S And Non-Binary College Students’ Decisions To Commute Via Bicycle, Emily Dzieniszewski, Ashley N. Myers, Lucas D. Elliott, Melissa Bopp
International Journal of Exercise Science
International Journal of Exercise Science 17(8): 1003-1015, 2024. College students, who actively travel in the forms of walking and/or bicycling, have shown a wide range of physical and mental health benefits. Despite the known benefits of bicycling, participation is influenced by various demographics, including gender identity, sexual orientation, and race/ethnicity. Universities have the potential to promote active travel participation to all populations. The study aimed to understand the environmental and social factors influencing female students’ decision to commute via bicycle in a university setting. A volunteer sample of female college students (n=153) were surveyed to identify common themes from the …