Digital Commons Network^™

Tulips Decorate The Three-Dimensional Genome Of Pfa Ependymoma, Ana Nikolic, Elham Hasheminasabgorji, Audrey Baguette, Seungil Paik, Haifen Chen, Sachin Kumar, Carol C L Chen, Selin Jessa, Polina Balin, Vernon Fong, Melissa Zwaig, Kulandaimanuvel Antony Michealraj, Xun Chen, Yanlin Zhang, Srinidhi Varadharajan, Pierre Billon, Nikoleta Juretic, Craig Daniels, Amulya Nageswara Rao, Caterina Giannini, Eric M Thompson, Miklos Garami, Peter Hauser, Timea Pocza, Young Shin Ra, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji Yeoun Lee, Wieslawa Grajkowska, Marta Perek-Polnik, Sameer Agnihotri, Stephen Mack, Benjamin Ellezam, Alex Weil, Jeremy Rich, Guillaume Bourque, Jennifer A Chan, V Wee Yong, Mathieu Lupien, Jiannis Ragoussis, Claudia Kleinman, Jacek Majewski, Mathieu Blanchette, Nada Jabado, Michael D Taylor, Marco Gallo

Faculty, Staff and Students Publications

Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to search its 3D genome for characteristic features. Here, we reconstructed 3D genomes from diverse childhood tumor types and uncovered a global topology in PFA that is highly reminiscent of stem and progenitor cells in a variety of human tissues. A remarkable feature exclusively present in PFA are type B ultra long-range interactions in PFAs (TULIPs), regions separated by great distances along the linear genome that interact with each other in …

Data Study Group Final Report: Uk Centre For Ecology & Hydrology (Ukceh) - Advancing Insect Biodiversity Monitoring Through Automated Sensors, Deep Learning, And Citizen Science Data, Sonny Burniston, Matthew Faith, Vitalii Kriukov, Rachael J. Laidlaw, Mahsa P. Kalashami, Farzana Rahman, Arpita Saggar, Asger Svenning, Cameron Trotter, Kaiwen Zuo, Katriona Goldmann, David Roy

School of Biological and Marine Sciences

Executive Summary. The overarching goal in this Alan Turing Institute Data Study Group(DSG) was to advance understanding and support conservation efforts related to insect populations and biodiversity monitoring. This was achieved through the integration of reliable and trustworthy machine learning applications, with datasets provided by the UK Centre for Ecology & Hydrology (UKCEH).Our objectives were twofold:• Develop advanced analytical techniques for generating biodiversity metrics and interactive data visualisations. These tools aim to promote stakeholder engagement and interest in biodiversity monitoring.• Enhance the transparency of decision-making in machine learning models and increase the trustworthiness of subsequent biodiversity monitoring results. Our work …

Intra- And Inter-Host Evolution Of Human Norovirus In Healthy Adults, Frederick H Neill, Donna M Muzny, Harsha Doddapaneni, Vipin K Menon, Kristi L Hoffman, Matthew C Ross, Ginger Metcalf, Antone R Opekun, David Y Graham, Richard A Gibbs, Joseph F Petrosino, Mary K Estes, Robert L Atmar

Faculty, Staff and Students Publications

Background: Human noroviruses are a leading cause of acute and sporadic gastroenteritis worldwide. The evolution of human noroviruses in immunocompromised persons has been evaluated in many studies. Much less is known about the evolutionary dynamics of human norovirus in healthy adults.

Methods: We used sequential samples collected from a controlled human infection study with GI.1/Norwalk/US/68 virus to evaluate intra- and inter-host evolution of a human norovirus in healthy adults. Up to 12 samples from day 1 to day 56 post-challenge were sequenced using a norovirus-specific capture probe method.

Results: Complete genomes were assembled, even in samples that were below the …

Hydroxychloroquine And A Low Antiresorptive Activity Bisphosphonate Conjugate Prevent And Reverse Ovariectomy-Induced Bone Loss In Mice Through Dual Antiresorptive And Anabolic Effects, Zhenqiang Yao, Akram Ayoub, Venkatesan Srinivasan, Jun Wu, Churou Tang, Rong Duan, Aleksa Milosavljevic, Lianping Xing, Frank H Ebetino, Alison J Frontier, Brendan F Boyce

Faculty, Staff and Students Publications

Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone formation, while the anabolic agent, teriparatide, does not inhibit bone resorption, and thus they have limited efficacy in preventing osteoporotic fractures and cause some side effects. Thus, there is an unmet need to develop dual antiresorptive and anabolic agents to prevent and treat osteoporosis. Hydroxychloroquine (HCQ), which is used to treat rheumatoid arthritis, prevents the lysosomal degradation of TNF receptor-associated factor 3 (TRAF3), an NF-κB adaptor protein that limits bone resorption and maintains bone formation. We attempted to covalently link HCQ to a hydroxyalklyl BP (HABP) …

Sengketa Pajak Atas Penugasan Pemerintah Pada Perusahaan Bumn (Studi Kasus Pertamina, Pos Indonesia Dan Reasuransi Indonesia Utama), Raja Darius Sutardjo Sinaga

Jurnal Hukum & Pembangunan

State-owned enterprises (BUMN) are legal entities which the government has more than 51% ownership. The purpose of BUMN being established is to carry out national development by seeking profits that can become income for the government as well as carrying out public activities through carrying out public services such as providing telecommunications, electricity, water, and construction of public facilities which cannot be fully fulfilled by the government. Therefore, the government hands over the completion of public services to BUMN to carry them out because of their expertise in their respective fields. In every business process carried out by a legal …

Racialization’S Influence On African American Male University Attrition: Is It Culture Shock Or Is There More To The Story, Joseph M. Butler

Dissertations

This dissertation investigates the influence of racialization on the attrition rates of African American male students in predominantly white institutions (PWIs). The study examines whether these students experience cultural shock or face more profound systemic challenges. The research explores how African American men navigate and perceive their college environments by employing Critical Race Theory and DuBois' double consciousness. The research utilizes a mixed-methods approach, combining qualitative interviews, demographic surveys, and document analysis to view these students' experiences comprehensively. The study focuses on four religiously affiliated universities, highlighting the intersection of race, identity, and institutional culture and revealing patterns of isolation, …

Navigating Culture And Family In Post-Secondary Education As Nigerian American College Students, Funmilayo Ojikutu

Dissertations

The purpose of this dissertation is to examine how Nigerian Americans and their families understand academic success, identity, and family influence. This research study aims to understand these three areas by examining the experiences of five Nigerian American undergraduate students and their respective families. The data for this study was collected through individual interviews, focus groups, and an artifact analysis. Through using the Multidimensional Model of Racial Identity framework, findings demonstrated the importance of balancing identities, community, legacy, and shifts in generational mindsets. The findings in this dissertation offer larger discussions related to differences within the Nigerian community, the impact …

Assessing The Role Of Psychological Self-Sufficiency And Organizational Factors In Achieving Economic Self-Sufficiency Among Low-Income Populations, Alanna Jeeyoung Shin

Dissertations

Low-income populations in the United States face complex challenges amid persistent high levels of poverty, income inequality, and child poverty (OECD, 2023; OECD, 2024; Smeeding & Thévenot, 2016; U.S. Bureau of Labor Statistics, 2023b). Influenced by neoclassical economic theory and human capital theory, work-first initiatives like Temporary Assistance for Needy Families (TANF) focus on fostering individual change by enhancing employable skills (Kim, 2010). These programs predominantly emphasize personal responsibility as a strategy for reducing poverty. However, multilayered barriers remain that hinder the achievement of economic self-sufficiency (Hong et al., 2014). To challenge the prevailing approach focusing on the individual level, …

Clinical Social Workers, Telemental Health And The Covid-19 Pandemic, Juli Chaffee

Dissertations

As a result of the COVID-19 Pandemic, and due to the shelter in place order that most states required, licensed clinical social workers (CSW’s) were forced to switch from in person services to telemental health services almost overnight. Many did so without previous training, adequate technology, a confidential office, or professional support. While there is a growing body of research regarding the increased use of telemental health in the mental health field during COVID-19, there is minimal research which narrows in what it was like for the CSW’s who made this transition. The purpose of this study was to better …

Controlling The Skies: Leveraging Airspace As A Foreign Policy Tool, Samantha Costas

Dissertations

Open skies and deregulated airspace facilitate the seamless global transportation of people and property across borders. The closure of airspace to a particular country negatively impacts both the sender and target. The sender faces reduced revenue from loss of overflight fees and associated airline costs, while a target must reroute, increasing travel time and fuel requirements for the flight. Despite the substantial costs involved, airspace closures still occur. Using a three-case study analysis, this dissertation explores the factors that drive a country to close its airspace, as well as those that shape a target’s behavior when confronted with a closure. …

Using Airborne Edna To Assess Hemlock Woolly Adelgid (Adelges Tsugae) Infestations And Their Impact On Michigan Coastal Forests, Keely C. Dunham

Masters Theses

Invasive species colonization degrades ecosystem structure and function, creating a cascade of ecological consequences. Hemlock woolly adelgid (HWA, Adelges tsugae) is an invasive insect that has killed millions of eastern hemlocks (Tsuga canadensis), a foundation species in North America. HWA feed on eastern hemlocks, resulting in tree mortality within several years. In Michigan, land managers depend on early detection to contain infestations and respond through forest-level management. Environmental DNA (eDNA) applications have recently become a powerful biomonitoring tool for invasive species detection. This thesis had two main objectives: we investigated whether molecular analyses could assess HWA infestation level and we …

Pattern, Process And The Evolution Of Sexual Dimorphism In Three-Spine Stickleback Fish Gasterosteus Aculeatus From Vancouver Island, British Columbia, Katie Van Dame

Master's Theses

Males and females of a species often differ from one another in phenotype—a phenomenon known as sexual dimorphism. Sexual dimorphism is most often attributed to sexual selection. However, sexual dimorphism also derives from natural selection when resource competition generates disruptive selection favoring specialization on different resources, resulting in niche partitioning and the evolution of dimorphism in traits related to competition. Sexual dimorphism may be an important route to increased individual fitness (i.e., more resources, more survival). For example, ecologically driven divergent selection between sexes may derive from differences in their environments, resulting in the evolution of dimorphism in traits related …

Implementing A Pharmacogenomic-Driven Algorithm To Guide Antiplatelet Therapy Among Caribbean Hispanics: A Non-Randomised Clinical Trial, Dagmar Hernandez Suarez

All Publications

Objectives: To assess whether genotype-guided selection of oral antiplatelet drugs using a clinical decision support (CDS) algorithm reduces the rate of major adverse cardiovascular and cerebrovascular events (MACCEs) among Caribbean Hispanic patients, after 6 months.

Design: An open-label, multicentre, non-randomised clinical trial.

Setting: Eight secondary and tertiary care hospitals (public and private) in Puerto Rico.

Participants: 300 Caribbean Hispanic patients on clopidogrel, both genders, underwent percutaneous coronary intervention (PCI) for acute coronary syndromes, stable ischaemic heart disease and documented extracardiac vascular diseases.

Interventions: Patients were separated into standard-of-care (SoC) and genotype-guided (pharmacogenetic (PGx)-CDS) groups (150 each) and stratified by risk …

Structural And Functional Correlates Of The Sleep-Suicidal Ideation Association, Jolynn Jones

Theses and Dissertations

Each year, about 800,000 individuals die by suicide globally, affecting millions more. Mitigating suicide risks by targeting modifiable factors such as the sleep disturbances of insomnia and nightmares, which are prevalent and linked to suicidality is important. This study investigated the structural and functional brain differences related to sleep disturbances and suicidality, with the anterior cingulate (caudal and rostral), insula, middle frontal gyrus, posterior cingulate, thalamus, amygdala, and orbitofrontal cortex as seed regions. Participants had no history of suicidal ideation (NSI; n=43) or suicidal ideation within the past two weeks (SI; n=25). Measures for analyses included the Insomnia Severity Index …

Recurrent Adult Urinary Tract Infection Secondary To Unrecognized Ureterocele Urolithiasis, Katherine Wu, James Jing

Student Publications

Background: A ureterocele is a cystic dilation of the distal ureter, most commonly presenting as a congenital abnormality that may be associated with other renal anomalies. Ureteroceles present in a variety of manifestations in both children and adults, from asymptomatic to significant flank pain with urolithiasis or recurrent urinary tract infections (UTIs) that often mimic other more common renal pathologies, owing to its challenging clinical diagnosis.

Case Presentation: We report the case of a 78‐year‐old female patient who presented with recurrent UTIs and failure to thrive, complicated by a large stone that first presented in the bladder on computed tomography …

Patients Undergoing Revision Hip Arthroscopy With Labral Reconstruction Or Labral Repair And Patient-Reported Outcomes: A Systematic Review, Nancy Park, Trevan Klug, Seema Patel, Serkan Surucu, Michael S. Lee, Kian Kardestuncer, Mackenzie Norman, Justin Zhu, Nicholas Pettinelli, Maxwell Modrak, Andrew E. Jimenez

Student Publications

Background: Compromise of the acetabular labrum can lead to pain and loss of critical intra-articular fluid pressure. Revision labral preservation poses unique challenges due to adhesions and compromised tissue quality.

Purpose/Hypothesis: The purpose of the study was to evaluate patient-reported outcome (PRO) measures (PROMs) in patients undergoing revision hip arthroscopy with either labral reconstruction or labral repair after primary hip arthroscopy for labral tear. It was hypothesized that both procedures would lead to improved PROs.

Study Design: Systematic review; Level of evidence, 4.

Methods: A systematic review of the literature was conducted with the following keywords: (revision) AND (hip OR …

Substitution Of A Single Non-Coding Nucleotide Upstream Of Tmem216 Causes Non-Syndromic Retinitis Pigmentosa And Is Associated With Reduced Tmem216 Expression, Mukhtar Ullah, Aleksandr Jestin, Xiaodong Jiao, Mathieu Quinodoz, Lori Sullivan, Jessica C Gardner, Emily M Place, Michel Michaelides, Karolina Kaminska, Omar A Mahroo, Elena Schiff, Genevieve Wright, Francesca Cancellieri, Veronika Vaclavik, Cristina Santos, Atta Ur Rehman, Sudeep Mehrotra, Hafiz Muhammad Azhar Baig, Muhammad Ansar, Luisa Coutinho Santos, Ana Berta Sousa, Viet H Tran, Hiroko Matsui, Anjana Bhatia, Muhammad Asif Naeem, Shehla J Akram, Javed Akram, Sheikh Riazuddin, Carmen Ayuso, Eric A Pierce, Alison J Hardcastle, S Amer Riazuddin, Kelly A Frazer, J Fielding Hejtmancik, Carlo Rivolta, Kinga M Bujakowska, Gavin Arno, Andrew R Webster, Radha Ayyagari

Faculty, Staff and Student Publications

Genome analysis of individuals affected by retinitis pigmentosa (RP) identified two rare nucleotide substitutions at the same genomic location on chromosome 11 (g.61392563 [GRCh38]), 69 base pairs upstream of the start codon of the ciliopathy gene TMEM216 (c.-69G>A, c.-69G>T [GenBank: NM_001173991.3]), in individuals of South Asian and African ancestry, respectively. Genotypes included 71 homozygotes and 3 mixed heterozygotes in trans with a predicted loss-of-function allele. Haplotype analysis showed single-nucleotide variants (SNVs) common across families, suggesting ancestral alleles within the two distinct ethnic populations. Clinical phenotype analysis of 62 available individuals from 49 families indicated a similar clinical presentation …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Meta-Analysis Of Set-Based Multiple Phenotype Association Test Based On Gwas Summary Statistics From Different Cohorts, Lirong Zhu, Shuanglin Zhang, Qiuying Sha

Michigan Tech Publications

Genome-wide association studies (GWAS) have emerged as popular tools for identifying genetic variants that are associated with complex diseases. Standard analysis of a GWAS involves assessing the association between each variant and a disease. However, this approach suffers from limited reproducibility and difficulties in detecting multi-variant and pleiotropic effects. Although joint analysis of multiple phenotypes for GWAS can identify and interpret pleiotropic loci which are essential to understand pleiotropy in diseases and complex traits, most of the multiple phenotype association tests are designed for a single variant, resulting in much lower power, especially when their effect sizes are small and …

Educational Policies Committee Minutes September 5, 2024, Utah State University

Educational Policies Committee

• Approval of Minutes – April 4, 2024
• Subcommittee Reports
• Curriculum Subcommittee
• Program Proposals
• Academic Standards Committee
• General Education Subcommittee
• Other Business
• Adjourn: 3:35 pm

Adjunctive Intravenous Argatroban Or Eptifibatide For Ischemic Stroke, Opeolu Adeoye, Peter Panagos, Stephanie Pizzella, Et Al.

2020-Current year OA Pubs

BACKGROUND: Intravenous thrombolysis is a standard treatment of acute ischemic stroke. The efficacy and safety of combining intravenous thrombolysis with argatroban (an anticoagulant agent) or eptifibatide (an antiplatelet agent) are unclear.

METHODS: We conducted a phase 3, three-group, adaptive, single-blind, randomized, controlled clinical trial at 57 sites in the United States. Patients with acute ischemic stroke who had received intravenous thrombolysis within 3 hours after symptom onset were assigned to receive intravenous argatroban, eptifibatide, or placebo within 75 minutes after the initiation of thrombolysis. The primary efficacy outcome, the utility-weighted 90-day modified Rankin scale score (range, 0 to 10, with …

Enhancing Human Well-Being Through Cognitive And Affective Pathways Linking Landscape Sensation To Cultural Ecosystem Services, Yashi Wu, Lina Tang, Chang‑Bing Huang, Guofan Shao, Jundong Hou, Clive E. Sabel

School of Geography, Earth and Environmental Sciences

Context: Landscape sensation is essential for the delivery of cultural ecosystem services (CESs), yet the pathways through which these services are delivered remain inadequately understood. Exploring how people obtain CESs from landscapes facilitates better understanding of the tradeoffs and synergies between ecosystem services and landscape sustainability. Objectives: This study aimed to elucidate the sensory pathways that links landscape attributes to CESs, focusing on the roles of cognitive and affective experiences. Methods: We analyzed social media comments for the measurement scale of cognition. We employed partial least squares structural equation modeling to integrate sensation, cognition, affect, and satisfaction, using questionnaire data …

Palaeoenvironment And Bio-Events Of The Cretaceous Sediments Of The Cauvery Basin, India, R. Venkatachalapathy, L. Harini, M. B. Hart, Watkinson M. P.

School of Geography, Earth and Environmental Sciences

The Cauvery Basin is an important rift margin basin on the east coast of India. It's long research history began in the mid-nineteenth century with the pioneering work of H.F. Blanford. While much of the Cretaceous succession in the basin is fault-controlled, some of the recorded events represent global sea level changes, especially in the mid-Cretaceous. Macrofossils (ammonites, bivalves, etc.) and foraminifera are abundant throughout, and there is an important occurrence of fossil wood and ‘log-grounds’ in the Turonian-Coniacian. The basin is sub-divided into a series of sub-basins (known as depressions in the earlier literature) which - in places - …

A Systematic Review Of The Timing Of Therapeutic Anticoagulation In Adult Patients With Acute Traumatic Brain Injury: Narrative Synthesis Of Observational Studies, Sophie Samuel, Jennifer Cortes, Eugene Uh, Huimahn Alex Choi

Library Staff Publications

Traumatic brain injury (TBI) presents complex management scenarios, particularly in patients requiring anticoagulation for concurrent conditions such as venous thromboembolism (VTE) or atrial fibrillation (AF). A systematic search of PubMed/MEDLINE, Embase, and the Cochrane Library databases was conducted to identify relevant studies. Inclusion criteria encompassed studies assessing the effects of anticoagulation therapy on outcomes such as re-hemorrhage, hematoma expansion, thrombotic events, and hemorrhagic events in TBI patients with subdural hematomas (SDH). This systematic review critically addresses two key questions: the optimal timing for initiating anticoagulation therapy and the differential impact of this timing based on the type of intracranial bleed, …

A Panel Data Regression Model For Defense Merger And Acquisition Activity, Corey D. Mack, Clay Koschnick, Michael Brown, Jonathan D. Ritschel, Brandon M. Lucas

Faculty Publications

Excerpt: This paper examines the relationship between a prime contractor's financial health and its mergers and acquisitions (M&A) spending in the defense industry. It aims to provide models that give the United States Department of Defense (DoD) indications of future M&A activity, informing decision-makers and contributing to ensuring competitive markets that benefit the consumer.

The results show a significant relationship between efficiency and M&A spending, indicating that companies with lower efficiency tend to spend more on M&As. However, there was no significant relationship between M&A spending and a company's profitability or solvency. These results were consistent with previous research and …

Perilous Consequences Of Chemotherapy Induced Alopecia In Afflicted Cancer Survivors: A Comprehensive State Of The Art Review, Salma A. Fereig, Mona Gamal Arafa, Ghada Mamdouh Elzaafarany, Mona Mohamed Ahmed Abdelmottaleb, John Youshia

Pharmacy

Due to researchers’ great efforts during previous and current centuries to cure cancer, a remarkable increase in the number of cancer survivors has been observed. However, side effects of chemotherapeutic agents greatly affect the quality of life of cancer cases, usually referred to as cancer stigma, the most psychologically traumatizing of which is chemotherapy-induced alopecia (anagen effluvium). Unfortunately, there is no preventive protocol for chemotherapy-induced alopecia to date. The only suggested technique is vasoconstriction by scalp cooling during and after chemotherapy sessions to minimize the absorption of cytotoxic agents within the hair follicle area; a technique that is not very …

Musicology Colloquium: Musical Notation And The Mariachi Tradition: Approaches And Challenges, Dr. Adolfo Arias Estrada, Latin American And Iberian Institute

LAII Events

Thursday, September 05, 2024 | 02:00 pm - 03:30 pm

Latin American and Iberian Institute (Main Conference Room)

801 Yale Blvd NE (campus building #165)

About:

Traditionally, mariachi was predominantly an oral and aural tradition, but the genre has developed into a much larger ensemble with expanded instrumentation and more complex arrangements, making notation necessary. The transcription and notation of mariachi music present their own set of challenges, particularly in representing its defining complex musical characteristics.

Adolfo Estrada is an Inclusive Excellence Postdoctoral Research Fellow in the Department of Music at UNM. His research focuses on historical and contemporary mariachi …

2024-09-05 Power Point Presentation On The Real Effects Of The Provost's Proposed Constitutional Changes, Morehead State University. Faculty Senate., Annie Adams

Faculty Senate Records

A PowerPoint presentation titled, "Faculty Besieged: The Real Effect of the Provost's Proposed Constitutional Changes." Presented to the Faculty Senate by Annie Adams on September 5, 2024.

2024-09-05 Statement From Faculty Welfare & Concerns Committee Chair, Morehead State University. Faculty Senate.

Faculty Senate Records

A statement from the Chair of the Faculty Welfare and Concerns Committee presented to the Faculty Senate on September 5, 2024.

2024-09-05 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate newsletter from September 5, 2024.