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Revealing The Role Of Serum Exosomal Novel Long Non-Coding Rna Nampt-As As A Promising Diagnostic/Prognostic Biomarker In Colorectal Cancer Patients, Nehal I. Rizk, Dina Kassem, Ahmed I. Abulsoud, Sherif Abdelhalim, Montasser Bellah Yasser, Mohamed M. Kamal, Nadia M. Hamdy Sep 2024

Revealing The Role Of Serum Exosomal Novel Long Non-Coding Rna Nampt-As As A Promising Diagnostic/Prognostic Biomarker In Colorectal Cancer Patients, Nehal I. Rizk, Dina Kassem, Ahmed I. Abulsoud, Sherif Abdelhalim, Montasser Bellah Yasser, Mohamed M. Kamal, Nadia M. Hamdy

Pharmacy

Aims

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Nicotinamide phosphoribosyl-transferase (NAMPT) was found to be over-expressed in several cancers including CRC. NAMPT-Antisense (NAMPT-AS) is a novel long non-coding RNA (lncRNA) recently reported to be associated with triple negative breast cancer. However, its role in CRC has not been investigated. This study was designed to explore the role of lncRNA NAMPT-AS in CRC, and to investigate its circulating serum exosomal levels in subjects with/without CRC.

Main methods

We analyzed CRC patients' data in The Cancer Genome Atlas (TCGA). LncRNA NAMPT-AS and NAMPT mRNA levels were …


K2-399 B Is Not A Planet, J. Lillo-Box, D. W. Latham, K. A. Collins, D. J. Armstrong, D. Gandolfi, Eric L.N. Jensen, A. Castro-González, O. Balsalobre-Ruza, B. Montesinos, S. G. Sousa, J. Aceituno, R. P. Schwarz, N. Narita, A. Fukui, J. Cabrera, A. Hadjigeorghiou, M. Kuzuhara, T. Hirano, M. Fridlund, A. P. Hatzes, O. Barragán, N. M. Batalha Sep 2024

K2-399 B Is Not A Planet, J. Lillo-Box, D. W. Latham, K. A. Collins, D. J. Armstrong, D. Gandolfi, Eric L.N. Jensen, A. Castro-González, O. Balsalobre-Ruza, B. Montesinos, S. G. Sousa, J. Aceituno, R. P. Schwarz, N. Narita, A. Fukui, J. Cabrera, A. Hadjigeorghiou, M. Kuzuhara, T. Hirano, M. Fridlund, A. P. Hatzes, O. Barragán, N. M. Batalha

Physics & Astronomy Faculty Works

Context. The transit technique has been very efficient over the past decades in detecting planet-candidate signals. The so-called statistical validation approach has become a popular way of verifying a candidate’s planetary nature. However, the incomplete consideration of false-positive scenarios and data quality can lead to misinterpretation of the results. Aims. In this work, we revise the planetary status of K2-399 b, a validated planet with an estimated false-positive probability of 0.078% located in the middle of the so-called Neptunian desert, and hence a potential key target for atmospheric prospects. Methods. We used radial velocity data from the …


Coal Ash Triggers An Elevated Temperature Landfill Development: Lessons From The Bristol Virginia Solid Waste Landfill Neighboring Community, Reagan Patton Witt, Marcelo I. Guzman Sep 2024

Coal Ash Triggers An Elevated Temperature Landfill Development: Lessons From The Bristol Virginia Solid Waste Landfill Neighboring Community, Reagan Patton Witt, Marcelo I. Guzman

UK CARES Faculty Publications

Landfills for disposing of solid waste are designed, located, managed, and monitored facili- ties expected to comply with government regulations to prevent contamination of the surrounding environment. After the average life expectancy of a typical landfill (30 to 50 years), a large investment in the construction, operation, final closure, and 30-year monitoring of a new site is needed. In this case study, we provide a holistic explanation of the unexpected development of elevated temperature landfills (ETLFs), such as that in the city of Bristol (United States) on the border of the states of Virginia and Tennessee, including the initial role …


Analysis Of Data Containing Outliers, David L. Farnsworth Sep 2024

Analysis Of Data Containing Outliers, David L. Farnsworth

Articles

A strategy for accommodating outlying observations, as well as non-representative, suspect, missing, or otherwise troubling observations, is described. Each unusual observation is decomposed into the sum of two components. One component is the value implied by the trusted observations in the data set. The other component is the unusual part. In this way, the fitting of the data set can then proceed, and, additionally, a numerical value can be ascribed to the unusual part. The method offers not only an antidote for observations with irregular numerical values, which often have the power to contaminate and alter analyses, but also a …


Community Engagement Newsletter, September 2024, University Of Northern Iowa. Office Of Community Engagement. Sep 2024

Community Engagement Newsletter, September 2024, University Of Northern Iowa. Office Of Community Engagement.

Community Engagement Newsletter

Contents:

--- Panthers Give Back
--- Events
--- Engagement Opportunity
--- National Credential
--- Funding


Library News September 2024, Research Medical Library Sep 2024

Kentucky Surficial Geologic Map Compilation Database (Version 1), Matthew Massey Sep 2024

Kentucky Surficial Geologic Map Compilation Database (Version 1), Matthew Massey

Research Data--KGS

The Kentucky Geological Survey (KGS), a state-supported independent research center within the University of Kentucky, is committed to providing accurate and unbiased geologic information on natural resources, environmental issues, and natural hazards in Kentucky. While Kentucky boasts complete coverage by 1:24,000-scale geologic bedrock maps, surficial materials have been largely overlooked, except in regions with thick deposits obscuring the bedrock. Given the increasing trends in economic development and urbanization, detailed surficial geologic mapping has become crucial for supporting geotechnical planning, environmental management, and hazard assessment. In response, KGS has prioritized new, detailed surficial geologic mapping since 2004, specifically targeting areas anticipated …


A Systematic Unified Approach For Addressing Temporal Instability In Road Safety Analysis, Kazi Redwan Shabab, Tanmoy Bhowmik, Mohamed H. Zaki, Naveen Eluru Sep 2024

A Systematic Unified Approach For Addressing Temporal Instability In Road Safety Analysis, Kazi Redwan Shabab, Tanmoy Bhowmik, Mohamed H. Zaki, Naveen Eluru

Civil and Environmental Engineering Faculty Publications and Presentations

Multivariate models are widely employed for crash frequency analysis in traffic safety literature. In the context of analyzing data for multiple instances (such as years), it becomes essential to evaluate the stability of parameters over time. The current research proposes a novel approach, labelled the mixed spline indicator pooled model, that offers significant enhancement relative to current approaches employed for capturing temporal instability. The proposed approach entails carefully creating independent variables that allow us to measure parameter slope changes over time and can be easily integrated into existing methodological frameworks. The current research effort compares four multivariate model systems: year …


256-Level Honey Memristor-Based In-Memory Neuromorphic System, Harshvardhan Uppaluru, Zoe Templin, Mohammed Rafeeq Khan, Md Omar Faruque, Feng Zhao, Jinhui Wang Sep 2024

256-Level Honey Memristor-Based In-Memory Neuromorphic System, Harshvardhan Uppaluru, Zoe Templin, Mohammed Rafeeq Khan, Md Omar Faruque, Feng Zhao, Jinhui Wang

Electrical and Computer Engineering Faculty Research & Creative Works

Promising synaptic behavior has been exhibited by memristors based on natural organic materials. Such memristor-based neuromorphic systems offer notable benefits, including environmental sustainability, low production and disposal costs, non-volatile storage capability, and bio/Complementary Metal-Oxide-Semiconductor (CMOS) compatibility. Here, a 256-level honey memristor-based neuromorphic system is experimentally evaluated for image recognition. In detail, first, 256-level honey memristors are manufactured and tested based on in-house technology; next, the non-linear characteristics and inherent variation of honey memristor devices, which lead to imprecise weight updates and limit the inference accuracy, are investigated. Experimental results indicate that the inference accuracy of the 256-level honey memristor-based neuromorphic …


A New Air-Assisted Flare Tip Design For Managing Gas Flare Emissions (Cfd Analysis), Ahmed A. Maaroof, Joseph D. Smith, Mohammed H.S. Zangana Sep 2024

A New Air-Assisted Flare Tip Design For Managing Gas Flare Emissions (Cfd Analysis), Ahmed A. Maaroof, Joseph D. Smith, Mohammed H.S. Zangana

Chemical and Biochemical Engineering Faculty Research & Creative Works

Recently, flares have been considered as a major source of air pollution from the petroleum refining industry. The United Nations has instigated an international effort related to the management of flare emissions to reduce the global warming impact related to flaring. Eliminating or removing the need for gas flares is difficult because these devices are generally used as safety devices to allow the combustion of flammable gases in a controlled fashion which supports safe operation. However, reducing flaring is generally possible using well-designed, efficiently operated flare equipment. In general, flare performance can be enhanced following the API-521 methodology and using …


Quantitative Assessment Of The Architect's Role Under Us Standard Construction Contracts: A Graph Theory Approach, Mariam Elazhary, Ahmed Shiha, Islam H. El-Adaway, Sammi Young Sep 2024

Quantitative Assessment Of The Architect's Role Under Us Standard Construction Contracts: A Graph Theory Approach, Mariam Elazhary, Ahmed Shiha, Islam H. El-Adaway, Sammi Young

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Evaluating the Architect's Role in Construction Contracts is Vital for Improving the Contractual Relationship and Preventing Disputes. Standard Contracts Define the Architect as an Owner's Agent And/or a Contract Administrator. Studies Often Use Qualitative and Subjective Evaluations to Analyze the Architect's Role. However, there is a Lack of Quantitative Measures that Objectively Evaluate the Architect's Capacities in Construction Contracts. This Paper Fills This Knowledge Gap. This Study Proposes a Quantitative Graph Theory-Based Approach to Analyze the Architect's Roles under Three Standard Forms of Construction Contracts in the US: (1) Extracting and Classifying Party Interactions; (2) Modeling the Interactions using Network …


Kuyper In A Postmodern World: Kuyper's Lectures On Calvinism And Postmodern Philosophy, Trygve Bulthuis Sep 2024

Kuyper In A Postmodern World: Kuyper's Lectures On Calvinism And Postmodern Philosophy, Trygve Bulthuis

Pro Rege

No abstract provided.


Criticism And Politics: A Polemical Introduction (Book Review), Shaun Stiemsma Sep 2024

Criticism And Politics: A Polemical Introduction (Book Review), Shaun Stiemsma

Pro Rege

Reviewed Title: Criticism and Politics: A Polemical Introduction by Bruce Robbins. Stanford University Press, 2022. 272 pp. ISBN: 9781503633209.


Reexamination Of Vacuum-Polarization Corrections To The Self-Energy In Muonic Bound Systems, B. Ohayon, Ulrich D. Jentschura Sep 2024

Reexamination Of Vacuum-Polarization Corrections To The Self-Energy In Muonic Bound Systems, B. Ohayon, Ulrich D. Jentschura

Physics Faculty Research & Creative Works

In muonic bound systems, the dominant radiative correction is due to vacuum polarization. Yet, for the interpretation of precision experiments, self-energy effects are also important. In turn, additional vacuum-polarization loops perturb the self-energy. Here we show that combined self-energy vacuum-polarization effects can perturb the bound-state self-energy at the percent level in one-muon bound systems with nuclear charges Z=1-6. We also update previous treatments of the corrections for muonic hydrogen, muonic deuterium, and muonic helium bound systems.


Relativistic And Recoil Corrections To Vacuum Polarization In Muonic Systems: Three-Photon Exchange, Gauge Invariance, And Numerical Values, Gregory S. Adkins, Ulrich D. Jentschura Sep 2024

Relativistic And Recoil Corrections To Vacuum Polarization In Muonic Systems: Three-Photon Exchange, Gauge Invariance, And Numerical Values, Gregory S. Adkins, Ulrich D. Jentschura

Physics Faculty Research & Creative Works

For an accurate theoretical description of muonic bound systems, it is crucial to consistently treat relativistic and recoil corrections to vacuum polarization. The one-loop vacuum-polarization effect is by far the dominant quantum electrodynamic (QED) energy correction for bound muons, being of order α(Zα)2mr, where α is the fine-structure constant, Z is the nuclear charge number, and mr is the reduced mass. Gauge invariance of the relativistic and recoil corrections to vacuum polarization of order α(Zα)4mr is investigated with respect to nonretarded and standard, renormalized variants of Coulomb gauge. The invariance is shown after including three-photon exchange diagrams. Our derivation is …


Stability And Dynamics Of Nonlinear Excitations In A Two-Dimensional Droplet-Bearing Environment, G. Bougas, G. C. Katsimiga, P. G. Kevrekidis, S. I. Mistakidis Sep 2024

Stability And Dynamics Of Nonlinear Excitations In A Two-Dimensional Droplet-Bearing Environment, G. Bougas, G. C. Katsimiga, P. G. Kevrekidis, S. I. Mistakidis

Physics Faculty Research & Creative Works

We unravel stationary states in the form of dark soliton stripes, bubbles, and kinks embedded in a two-dimensional droplet-bearing setting emulated by an extended Gross-Pitaevskii approach. The existence of these configurations is corroborated through an effectively reduced potential picture demonstrating their concrete parametric regions of existence. The excitation spectra of such configurations are analyzed within the Bogoliubov-de Gennes framework exposing the destabilization of dark soliton stripes and bubbles, while confirming the stability of droplets, and importantly unveiling spectral stability of the kink against transverse excitations. Additionally, a variational approach is constructed providing access to the transverse stability analysis of the …


Separation Of Various Higher-Order Effects In The Ionization Of Helium By Proton Impact, S. Majumdar, S. Bastola, A. Hasan, R. Lomsadze, Michael Schulz Sep 2024

Separation Of Various Higher-Order Effects In The Ionization Of Helium By Proton Impact, S. Majumdar, S. Bastola, A. Hasan, R. Lomsadze, Michael Schulz

Physics Faculty Research & Creative Works

We have measured fully differential cross sections (FDCSs) for ionization of helium by 75 keV proton impact. Data were analyzed for electrons ejected into the scattering plane at projectile energy losses well below and above the matching velocity and for scattering angles ranging between 0.1 and 0.5 mrad. Earlier, we observed clear signatures of the post collision interaction (PCI) at the matching velocity; however, in the current data these signatures are completely absent at small energy losses and residues remain at large energy losses. At small energy losses the FDCSs are dominated by non-PCI higher-order effects.


A Robust Recurrent Neural Networks-Based Surrogate Model For Thermal History And Melt Pool Characteristics In Directed Energy Deposition, Sung Heng Wu, Usman Tariq, Ranjit Joy, Muhammad Arif Mahmood, Asad Waqar Malik, Frank Liou Sep 2024

A Robust Recurrent Neural Networks-Based Surrogate Model For Thermal History And Melt Pool Characteristics In Directed Energy Deposition, Sung Heng Wu, Usman Tariq, Ranjit Joy, Muhammad Arif Mahmood, Asad Waqar Malik, Frank Liou

Mechanical and Aerospace Engineering Faculty Research & Creative Works

In directed energy deposition (DED), accurately controlling and predicting melt pool characteristics is essential for ensuring desired material qualities and geometric accuracies. This paper introduces a robust surrogate model based on recurrent neural network (RNN) architectures—Long Short-Term Memory (LSTM), Bidirectional LSTM (Bi-LSTM), and Gated Recurrent Unit (GRU). Leveraging a time series dataset from multi-physics simulations and a three-factor, three-level experimental design, the model accurately predicts melt pool peak temperatures, lengths, widths, and depths under varying conditions. RNN algorithms, particularly Bi-LSTM, demonstrate high predictive accuracy, with an R-square of 0.983 for melt pool peak temperatures. For melt pool geometry, the GRU-based …


Ground Vacuum Facility To Simulate Low Earth Orbit Plasma Environment, Emmanuel Kofi Asuako Wie-Addo, Jacob Ortega, Daoru Han Sep 2024

Ground Vacuum Facility To Simulate Low Earth Orbit Plasma Environment, Emmanuel Kofi Asuako Wie-Addo, Jacob Ortega, Daoru Han

Mechanical and Aerospace Engineering Faculty Research & Creative Works

This paper presents a large vacuum facility (6-ft-diameter, 10-ft-long chamber) equipped with a magnetic filter-type low Earth orbit plasma source. A recommended operating envelope for the plasma source was established through single-point measurements by varying the discharge currents of the plasma source and the gas flow rates. A three-axis translation stage was fabricated and tested with 2D and 3D scans of the simulated plasma environment. The measured plasma density during this study was between 1:63 x 1012 − 3:1 x 1012 m−3 for the electrons and 7:54 x 1012 − 1:82 x 1013 m−3 for the ions, whereas the electron …


The Role Of The Metaverse In Transforming The Management Skill Set Of Construction Practitioners, Ali M. Saad, Islam H. El-Adaway Sep 2024

The Role Of The Metaverse In Transforming The Management Skill Set Of Construction Practitioners, Ali M. Saad, Islam H. El-Adaway

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

No abstract provided.


Asphalt-Binder Mixtures Evaluated By T1 Nmr Relaxometry, Rebecca M. Herndon, Jay Balasubramanian, Magdy Abdelrahman, Klaus Woelk Sep 2024

Asphalt-Binder Mixtures Evaluated By T1 Nmr Relaxometry, Rebecca M. Herndon, Jay Balasubramanian, Magdy Abdelrahman, Klaus Woelk

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Asphalt pavements make up a majority of the essential transportation systems in the US. Asphalt mixtures age and degrade over time, reducing the pavement performance. Pavement performance critically depends on the aging of asphalt binder. The aging of asphalt binder during construction is traditionally modeled by rolling thin film oven (RTFO) testing, while aging during service life is modeled by pressure aging vessel (PAV) testing. Comparing these models to the aging of binders in actual pavements is limited because, to be used for current testing, binders must be separated from the pavement's aggregate by solvent extraction. Solvent extraction will, at …


Nuclear Magnetic Resonance (Nmr) Assessment Of Bio And Crude Oil-Based Rejuvenation, Rebecca M. Herndon, Jay Balasubramanian, Magdy Abdelrahman, Klaus Woelk Sep 2024

Nuclear Magnetic Resonance (Nmr) Assessment Of Bio And Crude Oil-Based Rejuvenation, Rebecca M. Herndon, Jay Balasubramanian, Magdy Abdelrahman, Klaus Woelk

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Asphalt binders in pavements lose their stability through aging and eventually fail in the field. Using nuclear magnetic resonance (NMR) to monitor the primary longitudinal relaxation time of asphalt samples and the ratio of material that carries this primary relaxation time has been shown to indicate the impact of ultraviolet (UV) radiation on the aging of asphalt pavements. Longitudinal NMR relaxation was used to investigate two types of proposed asphalt rejuvenators, a bio-oil-based rejuvenator and a crude-oil-based rejuvenator. Two different binders with the performance grades (PG) 64-22 and 76-22 were considered for their interactions with the rejuvenators. After 72 h …


Asphalt-Binder Mixtures Evaluated By T1 Nmr Relaxometry, Rebecca M. Herndon, Jay Balasubramanian, Magdy Abdelrahman, Klaus Woelk Sep 2024

Asphalt-Binder Mixtures Evaluated By T1 Nmr Relaxometry, Rebecca M. Herndon, Jay Balasubramanian, Magdy Abdelrahman, Klaus Woelk

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Asphalt pavements make up a majority of the essential transportation systems in the US. Asphalt mixtures age and degrade over time, reducing the pavement performance. Pavement performance critically depends on the aging of asphalt binder. the aging of asphalt binder during construction is traditionally modeled by rolling thin film oven (RTFO) testing, while aging during service life is modeled by pressure aging vessel (PAV) testing. Comparing these models to the aging of binders in actual pavements is limited because, to be used for current testing, binders must be separated from the pavement's aggregate by solvent extraction. Solvent extraction will, at …


Morning Thanks - Ed Kellogg, James C. Schaap, Edward Kellogg, David Platter Sep 2024

Morning Thanks - Ed Kellogg, James C. Schaap, Edward Kellogg, David Platter

Pro Rege

No abstract provided.


Stew News, Orientation Paddle 2024, University Of Dayton. Rivers Institute Sep 2024

Stew News, Orientation Paddle 2024, University Of Dayton. Rivers Institute

Stew News: The Newsletter of the University of Dayton River Stewards

No abstract provided.


Vulnerable Consumers Left Behind In The Overdraft Fee Saga, Mary Claire Griffith-Mccrery Sep 2024

Vulnerable Consumers Left Behind In The Overdraft Fee Saga, Mary Claire Griffith-Mccrery

Marquette Benefits and Social Welfare Law Review

Attention on the arguable pervasiveness of overdraft fees has

been increasing in recent years. Overdraft programs were originally

offered to banks’ trusted, high-dollar customers on a discretionary

basis. Technology brought about debit cards and electronic payment

methods along with direct deposit and enhanced the complexity of

processing transactions. Some practices increased the likelihood of

overdrafts. For example, reordering transactions such that they post

to the account from the largest to smallest dollar amount received

distinct scrutiny—and is discouraged by regulators. Today, the majority

of overdraft fees are paid by economically disadvantaged, vulnerable

consumers; more specifically, by Black and Hispanic consumers. …


Human Rights Cities: Realizing The Right To Housing At The Municipal Scale, Estair Van Wagner, Alexandra Flynn Sep 2024

Human Rights Cities: Realizing The Right To Housing At The Municipal Scale, Estair Van Wagner, Alexandra Flynn

UBC Law Review

No abstract provided.


Evaluating Efficacy Of Vedolizumab, Ustekinumab, And Golimumab In The Management Of Inflammatory Bowel Disease And The Combined Role Of Nutritional Therapy With Biologics: A Review, Shahed Kamal, Karan Varshney, Danielle Josefa F. Uayan, Fides Myles C. Caliwag Sep 2024

Evaluating Efficacy Of Vedolizumab, Ustekinumab, And Golimumab In The Management Of Inflammatory Bowel Disease And The Combined Role Of Nutritional Therapy With Biologics: A Review, Shahed Kamal, Karan Varshney, Danielle Josefa F. Uayan, Fides Myles C. Caliwag

Ateneo School of Medicine and Public Health Publications

Inflammatory bowel disease (IBD), which encompasses both ulcerative colitis (UC) and Crohn’s disease (CD), is a major health burden worldwide. There are increasing concerns surrounding the impacts of this disease due to significant rises in the prevalence rates of IBD across the world. In consideration of the complexities of managing IBD along with this marked rise in prevalence and incidence, developing new forms of treatment for this condition has become a major priority. In recent years, a potential new form of treatment for IBD has emerged in the form of biologic therapies. While there is a high level of optimism …


Investigating A Pollinator Curriculum (1-3 Grade), Divya Baranwal Sep 2024

Investigating A Pollinator Curriculum (1-3 Grade), Divya Baranwal

Multidisciplinary Studies Research

In this unit, elementary graders will identify and explain the pollen, flowering plants, and pollination process, and labelled various parts of a flower, pollinators. They will build the model of pollinators, initial models of the reproductive parts of plants. They will explore the 3D shapes, magnifying glasses, area and volume, modelling and explain low-high fidelity prototyping, engineering design process. The unit is designed by providing an abundance of practical ways to learn the significance of the pollination process and to get to know about pollinators and pollen in a place-based environment. Here, students will engage, explore, explain, elaborate and evaluate …


Political Freedom And Economic Constraints: The Political Setting For The Problem Of Twelve, John C. Coates Sep 2024

Political Freedom And Economic Constraints: The Political Setting For The Problem Of Twelve, John C. Coates

The University of Chicago Business Law Review

This essay outlines foundations of the current moment facing corporations and politics, which I have characterized as a new “problem of twelve”—that is, the concentration of power in the hands of a small number of index and private equity fund sponsors.1 Through the middle of the twentieth century, public companies dominated the U.S. economy and government. They owed their dominance to having been socially legitimated coming out of the Great Depression, a legitimation built on their affirmative war efforts and on the negative constraints of securities law, progressive taxation, labor unions, and operational regulation. From 1970 on, however, they changed …