Digital Commons Network^™

Variant Surface Protein Gp60 Contributes To Host Infectivity Of Cryptosporidium Parvum, Muxiao Li, Fuxian Yang, Tianyi Hou, Xiaoqing Gong, Na Li, L David Sibley, Yaoyu Feng, Lihua Xiao, Yaqiong Guo

2020-Current year OA Pubs

Biological studies of the determinants of Cryptosporidium infectivity are lacking despite the fact that cryptosporidiosis is a major public health problem. Recently, the 60-kDa glycoprotein (GP60) has received attention because of its high sequence polymorphism and association with host infectivity of isolates and protection against reinfection. However, studies of GP60 function have been hampered by its heavy O-linked glycosylation. Here, we used advanced genetic tools to investigate the processing, fate, and function of GP60. Endogenous gene tagging showed that the GP60 cleavage products, GP40 and GP15, are both highly expressed on the surface of sporozoites, merozoites and male gametes. During …

Randomized Phase Iii Sierra Trial Of 131i-Apamistamab Before Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care For Relapsed/Refractory Aml, Boglarka Gyurkocza, Camille Abboud, Et Al.

2020-Current year OA Pubs

PURPOSE: Older patients with relapsed or refractory AML (RR AML) have dismal prognoses without allogeneic hematopoietic cell transplantation (alloHCT). SIERRA compared a targeted pretransplant regimen involving the anti-CD45 radioconjugate

METHODS: SIERRA (ClinicalTrials.gov identifier: NCT02665065) was a phase III open-label trial. Patients age ≥55 years with active RR AML were randomly assigned 1:1 to either an

RESULTS: The ITT population included 153 patients (

CONCLUSION: The

Cervantes Now, Instituto Cervantes Albuquerque, Latin American And Iberian Institute

LAII Events

Thursday, September 19, 2024 | 09:00 am - 09:00 pm

Instituto Cervantes, National Hispanic Cultural Center | 1701 4th Street SW

About:

Instituto Cervantes Albuquerque is organizing, together with the Cervantes Society of America (an academic society dedicated to the academic research of Cervantes' life and work) and the University of New Mexico, the Cervantes Now Conference.

The event, which will take place on September 19 and 20 at the Cervantes Albuquerque and UNM, will be attended by experts in Cervantes' work from all over the United States, who will offer interesting academic sessions and talks on the influence that …

Axatilimab In Recurrent Or Refractory Chronic Graft-Versus-Host Disease, Daniel Wolff, Iskra Pusic, Et Al.

2020-Current year OA Pubs

BACKGROUND: Colony-stimulating factor 1 receptor (CSF1R)-dependent monocytes and macrophages are key mediators of chronic graft-versus-host disease (GVHD), a major long-term complication of allogeneic hematopoietic stem-cell transplantation. The CSF1R-blocking antibody axatilimab has shown promising clinical activity in chronic GVHD.

METHODS: In this phase 2, multinational, pivotal, randomized study, we evaluated axatilimab at three different doses in patients with recurrent or refractory chronic GVHD. Patients were randomly assigned to receive axatilimab, administered intravenously, at a dose of 0.3 mg per kilogram of body weight every 2 weeks (0.3-mg dose group), at a dose of 1 mg per kilogram every 2 weeks (1-mg …

Air Quality And Mental Illness: Role Of Bioaerosols, Causal Mechanisms And Research Priorities, Kamaldeep Bhui, Marcella Ucci, Prashant Kumar, Simon K. Jackson, Corinne Whitby, Ian Colbeck, Christian Pfrang, Zaheer A. Nasir, Frederic Coulon

School of Biomedical Sciences

BACKGROUND: Poor air quality can both trigger and aggravate lung and heart conditions, as well as affecting child development. It can even lead to neurological and mental health problems. However, the precise mechanisms by which air pollution affect human health are not well understood.

AIMS: To promote interdisciplinary dialogue and better research based on a critical summary of evidence on air quality and health, with an emphasis on mental health, and to do so with a special focus on bioaerosols as a common but neglected air constituent.

METHOD: A rapid narrative review and interdisciplinary expert consultation, as is recommended for …

Target Consumers For Locally Grown Fruit In Utah, Kynda R. Curtis, Makaylie Langford, Tammy King

All Current Publications

This fact sheet describes target consumers for locally grown fruits and fruit products in Utah. The data examined here comes from an online survey (via Qualtrics) of Utah consumers conducted in 2023. Here, we compare consumers who are willing to pay a higher premium for local fruit products and those who are not, outlining the distinction between them in terms of their demographics, purchasing patterns and shopping habits, as well as their lifestyle and attitudes.

Target Consumers For Organically Grown Fruit In Utah, Kynda R. Curtis, Makaylie Langford, Tammy King

All Current Publications

This fact sheet provides an overview of target consumers for organically grown fruits and fruit products in Utah. The data examined here comes from an online survey (via Qualtrics) of Utah consumers conducted in 2023. Here, we compare those willing to pay premiums for organically grown fruit and those unwilling to do so, outlining the distinction between them in terms of their demographics, purchasing patterns and shopping habits, as well as their lifestyle and attitudes.

Predicting Mutation-Induced Allosteric Changes In Structures And Conformational Ensembles Of The Abl Kinase Using Alphafold2 Adaptations With Alanine Sequence Scanning, Nishank Raisinghani, Mohammed Alshahrani, Grace Gupta, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Despite the success of AlphaFold2 approaches in predicting single protein structures, these methods showed intrinsic limitations in predicting multiple functional conformations of allosteric proteins and have been challenged to accurately capture the effects of single point mutations that induced significant structural changes. We examined several implementations of AlphaFold2 methods to predict conformational ensembles for state-switching mutants of the ABL kinase. The results revealed that a combination of randomized alanine sequence masking with shallow multiple sequence alignment subsampling can significantly expand the conformational diversity of the predicted structural ensembles and capture shifts in populations of the active and inactive ABL states. …

Jovian Vortex Hunter: A Citizen Science Project To Study Jupiter’S Vortices, Ramanakumar Sankar, Shawn R. Brueshaber, Lucy Fortson, Candice Hansen-Koharcheck, Chris Lintott, Kameswara Mantha, Cooper Nesmith, Glenn S. Orton

Michigan Tech Publications

The Jovian atmosphere contains a wide diversity of vortices, which have a large range of sizes, colors, and forms in different dynamical regimes. The formation processes for these vortices are poorly understood, and aside from a few known, long-lived ovals, such as the Great Red Spot and Oval BA, vortex stability and their temporal evolution are currently largely unknown. In this study, we use JunoCam data and a citizen science project on Zooniverse to derive a catalog of vortices, some with repeated observations, from 2018 May to 2021 September, and we analyze their associated properties, such as size, location, and …

Diagnostic Error In Mental Health: A Review, Traber D Giardina, Hardeep Singh

Faculty, Staff and Students Publications

Diagnostic errors are associated with patient harm and suboptimal outcomes. Despite national scientific efforts to advance definition, measurement and interventions for diagnostic error, diagnosis in mental health is not well represented in this ongoing work. We aimed to summarise the current state of research on diagnostic errors in mental health and identify opportunities to align future research with the emerging science of diagnostic safety. We review conceptual considerations for defining and measuring diagnostic error, the application of these concepts to mental health settings, and the methods and subject matter focus of recent studies of diagnostic error in mental health. We …

Frequent Chd1 Deletions In Prostate Cancers Of African American Men Is Associated With Rapid Disease Progression, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A Sesterhenn, Joel T Moncur, Gregory T Chesnut, Gyorgy Petrovics, Gregory T Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D D'Andrea, Istvan Csabai, Shiv Srivastava, Matthew L Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi

Faculty, Staff and Students Publications

We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1 (CHD1) loss on prostate cancer tissue microarrays. We created CHD1-deficient prostate cancer cell lines for genomic, drug sensitivity and functional homologous recombination (HR) activity analysis. Subclonal deletion of CHD1 was nearly three times as frequent in prostate tumors of African American than in European American men and it associates with rapid disease progression. CHD1 deletion was not associated with HR deficiency associated mutational signatures or HR …

Zero Shot Health Trajectory Prediction Using Transformer, Jaroslaw Was, Quanzheng Li, David W Bates, Arkadiusz Sitek

Faculty, Staff and Students Publications

Integrating modern machine learning and clinical decision-making has great promise for mitigating healthcare's increasing cost and complexity. We introduce the Enhanced Transformer for Health Outcome Simulation (ETHOS), a novel application of the transformer deep-learning architecture for analyzing high-dimensional, heterogeneous, and episodic health data. ETHOS is trained using Patient Health Timelines (PHTs)-detailed, tokenized records of health events-to predict future health trajectories, leveraging a zero-shot learning approach. ETHOS represents a significant advancement in foundation model development for healthcare analytics, eliminating the need for labeled data and model fine-tuning. Its ability to simulate various treatment pathways and consider patient-specific factors positions ETHOS as …

Exploring The Complexity Of Systemic Sclerosis Etiology By Trio Whole Genome Sequencing, Elizabeth G Atkinson, Lindsay Burrage, Kim C Worley, Brian Christopher, Marka A Lyons, Shervin Assassi, Maureen D Mayes, Brendan Lee

Faculty, Staff and Students Publications

Systemic sclerosis (SSc) is a heterogeneous rare autoimmune fibrosing disorder affecting connective tissue. The etiology of systemic sclerosis is largely unknown and many genes have been suggested as susceptibility loci of modest impact by genome-wide association study (GWAS). Multiple factors can contribute to the pathological process of the disease, which makes it more difficult to identify possible disease-causing genetic alterations. In this study, we have applied whole genome sequencing (WGS) in 101 indexed family trios, supplemented with transcriptome sequencing on cultured fibroblast cells of four patients and five family controls where available. Single nucleotide variants (SNVs) and copy number variants …

Target Heart Rate Formulas For Exercise Stress Testing: What Is The Evidence?, Yochai Birnbaum

Faculty, Staff and Students Publications

Exercise stress testing (EST) is commonly used to evaluate chest pain, with some labs using 85% of age-predicted maximum heart rate (APMHR) as an endpoint for EST. The APMHR is often calculated using the formula 220-age. However, the accuracy of this formula and 85% APMHR as an endpoint may be questioned. Moreover, failing to reach 85% APMHR (known as chronotropic insufficiency) may also indicate poor cardiovascular prognosis, but measurements, such as percentage heart rate reserve (%HRR), maximum rate pressure product (MRPP), and the maximum metabolic equivalent of tasks (METs) reached during EST may provide better prediction of cardiovascular outcomes than …

Structural Changes Likely Cause Chemical Differences Between Empty And Full Aav Capsids, Caryn Heldt, Molly A. Skinner, Ganesh S. Anand

Michigan Tech Publications

Due to the success of adeno associated viruses (AAVs) in treating single-gene diseases, improved manufacturing technology is now needed to meet their demand. The largest challenge is creating a process to separate empty and full capsids. Patients received larger capsid doses than necessary due to the presence of empty capsids. By enabling the better separation of empty and full capsids, patients would receive the greatest therapeutic benefit with the least amount of virus capsids, thus limiting potential side effects from empty capsids. The two most common empty/full separation methods used in downstream processing are ultracentrifugation and anion exchange chromatography. Both …

Sequence-To-Expression Approach To Identify Etiological Non-Coding Dna Variations In P53 And Cmyc-Driven Diseases

Faculty, Staff and Student Publications

Disease risk prediction based on genomic sequence and transcriptional profile can improve disease screening and prevention. Despite identifying many disease-associated DNA variants, distinguishing deleterious non-coding DNA variations remains poor for most common diseases. In this study, we designed in vitro experiments to uncover the significance of occupancy and competitive binding between P53 and cMYC on common target genes. Analyzing publicly available ChIP-seq data for P53 and cMYC in embryonic stem cells showed that ~344-366 regions are co-occupied, and on average, two cis-overlapping motifs (CisOMs) per region were identified, suggesting that co-occupancy is evolutionarily conserved. Using U2OS and Raji cells untreated …

Exploring Social Networks: An Analysis Of Intra-Organizational Networks, Ximeng Chen, Yiding Cao, Jiachen Liu, Danushka Bandara, Hiroki Sayama

Northeast Journal of Complex Systems (NEJCS)

This research investigates intra-organizational social networks by employing network science methods, aiming to provide actionable insights for both managers and employees. Using datasets from the Colorado Index of Complex Networks (ICON), this study examines four intra-organizational networks from a consulting firm and a research team, focusing on advice requests and skill awareness. The analysis includes network topology, degree distribution, community detection, correlation between communities and node attributes, maximal clique detection, and multilayer network analysis. The findings reveal that intra-organizational networks are intricate and significantly impact organizational efficiency and individual career development. Key insights include the importance of mid-level employees in …

The Citizen's Industrial Insurance Company Letterhead

Eartha M. M. White Textual Material

Document: The Citizen's Industrial Insurance Company letterhead stationary. Undated.

List Of Names

Eartha M. M. White Textual Material

Document: Handwritten list of names and shares. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

List Of Names

Eartha M. M. White Textual Material

Notes: Handwritten list of names. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

Citizen's Industrial Insurance Company Meeting Minutes

Eartha M. M. White Textual Material

Document: Handwritten meeting minutes for the Citizen's Industrial Insurance Company. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

Citizen's Industrial Insurance Company Meeting Minutes

Eartha M. M. White Textual Material

Document: Handwritten meeting minutes for the Citizen's Industrial Insurance Company. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

Citizen's Industrial Insurance Company Meeting Minutes

Eartha M. M. White Textual Material

Document: Handwritten meeting minutes for the Citizen's Industrial Insurance Company. Minutes written on back of The Citizen's Industrial Insurance Company letterhead. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

List Of Names

Eartha M. M. White Textual Material

Document: Handwritten list of names and shares. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

Committee Recommendations

Eartha M. M. White Textual Material

Document: Handwritten list of recommendations from the Salaries Committee (Citizen's Industrial Insurance Company).Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

Citizen's Industrial Insurance Company Meeting Minutes

Eartha M. M. White Textual Material

Document: Handwritten meeting minutes for the Citizen's Industrial Insurance Company. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

List Of Sources And Money

Eartha M. M. White Textual Material

Notes: Handwritten list of funding sources and amounts of money. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

Notes Written On National Negro Welfare League Information Card

Eartha M. M. White Textual Material

Notes: Handwritten notes on National Negro Welfare League card regarding setting up a meeting. Also notes about employment and notes regarding a service. Part of assorted miscellaneous notes of meetings kept by Eartha White. Undated.

Interdenominational Ministers Alliance Meeting Notes

Eartha M. M. White Textual Material

Notes: Handwritten notes of meeting of Interdenominational Ministers Alliance. Part of assorted notes kept by Eartha White. Undated.

Letter From Florida Baptist College To The Public

Eartha M. M. White Textual Material

Correspondence: Letter from Florida Baptist College signed by James Weldon Johnson, Treasurer, Board of Trustees, and N.W. Collins, President. The letter certifies Eartha White to solicit funds and supplies for the college. Undated.