Digital Commons Network^™

The Association Between Sampling And Survival In Patients With Pancreatic Ductal Adenocarcinoma Who Received Neoadjuvant Therapy And Pancreaticoduodenectomy, Mehran Taherian, Matthew H G Katz, Laura R Prakash, Dongguang Wei, Yi Tat Tong, Deyali Chatterjee, Michael Kim, Ching-Wei D Tzeng, Naruhiko Ikoma, Robert A Wolff, Dan Zhao, Eugene J Koay, Anirban Maitra, Huamin Wang

Faculty, Staff and Student Publications

Adequate sampling is essential to an accurate pathologic evaluation of pancreatectomy specimens resected for pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant therapy (NAT). However, limited data are available for the association between the sampling and survival in these patients. We examined the association of the entire submission of the tumor (ESOT) and the entire submission of the pancreas (ESOP) with disease-free survival (DFS) and overall survival (OS), as well as their correlations with clinicopathologic features, for 627 patients with PDAC who received NAT and pancreaticoduodenectomy. We demonstrated that both ESOT and ESOP were associated with lower ypT, less frequent perineural invasion, …

Spatial Organization Of Adenylyl Cyclase And Its Impact On Dopamine Signaling In Neurons

Faculty, Staff and Student Publications

The cAMP cascade is increasingly recognized to transduce physiological effects locally through spatially limited cAMP gradients. However, little is known about how adenylyl cyclase enzymes that initiate cAMP gradients are localized. Here we address this question in physiologically relevant striatal neurons and investigate how AC localization impacts downstream signaling function. We show that the major striatal AC isoforms are differentially sorted between ciliary and extraciliary domains of the plasma membrane, and that one isoform, AC9, is uniquely concentrated in endosomes. We identify key sorting determinants in the N-terminal cytoplasmic domain responsible for isoform-specific localization. We further show that AC9-containing endosomes …

Neuronal Alpha-Synuclein Disease Integrated Staging System Performance In Ppmi, Pasadena, And Spark Baseline Cohorts, Kathleen L Poston, Caroline M Tanner, Catherine M Kopil, Yuge Xiao, Sohini Chowdhury, Luis Concha-Marambio, Peter Dibiaso, Tatiana Foroud, Mark Frasier, Danna Jennings, Karl Kieburtz, Kalpana Merchant, Brit Mollenhauer, Thomas J Montine, Kelly Nudelman, John Seibyl, Todd Sherer, Andrew Singleton, Diane Stephenson, Matthew Stern, Claudio Soto, Eduardo Tolosa, Andrew Siderowf, Billy Dunn, Tanya Simuni, Kenneth Marek, Parkinson’S Progression Markers Initiative Collaborators

Faculty, Staff and Student Publications

The Neuronal alpha-Synuclein Disease (NSD) biological definition and Integrated Staging System (NSD-ISS) provide a research framework to identify individuals with Lewy body pathology and stage them based on underlying biology and increasing degree of functional impairment. Utilizing data from the PPMI, PASADENA, and SPARK studies, we developed and applied biologic and clinical data-informed definitions for the NSD-ISS across the disease continuum. Individuals enrolled as Parkinson's disease, Prodromal, or Healthy Controls were defined and staged based on biological, clinical, and functional anchors at baseline. Across the three studies 1741 participants had SAA data and of these 1030 (59%) were S+ consistent …

Strategic Deployment Of Service Vessels For Improved Offshore Wind Farm Maintenance And Availability, Chenyu Zhao, Adam Roberts, Ying Cui, Lars Johanning

School of Engineering, Computing and Mathematics

This research explores the optimization of Operations and Maintenance (O&M) strategies for offshore wind farms using a sophisticated O&M simulator built on the Markov Chain Monte Carlo method. By integrating real-world constraints such as vessel availability and weather conditions, the study assesses O&M logistics’ impacts on wind farm availability, energy production, and overall costs across different scenarios in the Celtic Sea. Through comparative analysis of eight case studies involving various combinations of Crew Transfer Vessels (CTV) and Service Operation Vessels (SOV), the research highlights the critical role of strategic vessel deployment and the potential of permanent SOV stationing to enhance …

The Association Of The Oral Microbiota With Cognitive Functioning In Adolescence, Elena L Grigorenko

Faculty, Staff and Students Publications

Background: A growing body of research supports the role of the microbial communities residing in the digestive system in the host's cognitive functioning. Most of these studies have been focused on the gut microbiome and its association with clinical phenotypes in middle-aged and older adults. There is an insufficiency of population-based research exploring the association of normative cognitive functioning with the microbiome particularly with the oral microbiota.

Methods: In this study, using metagenomics and metabolomics, we characterized the salivary microbiome diversity in a sample of 51 males of Hispanic and African American origin aged 12-18 years and explored …

The Integrated Violin-Box-Scatter (Vbs) Plot To Visualize The Distribution Of A Continuous Variable, David W. Gerbing

Business Faculty Publications and Presentations

The histogram remains a widely used tool for visualization of the distribution of a continuous variable, despite the disruption of binning the underlying continuity into somewhat arbitrarily sized discrete intervals imposed by the simplicity of its pre-computer origins. Alternatives include three visualizations, namely a smoothed density distribution such as a violin plot, a box plot, and the direct visualization of the individual data values as a one-dimensional scatter plot. To promote ease of use, the plotting function discussed in this work, Plot(x), automatically integrates these three visualizations of a continuous variable x into what is called a VBS plot here, …

Expanded Gene And Taxon Sampling Of Diplomonads Shows Multiple Switches To Parasitic And Free-Living Lifestyle, Monika Wiśniewska, Erik Salomaki, Jeffrey D. Silberman, Kristina Terpis, Eva Mazancová, Petr Táborský, Vasana Jinathama, Eleni Gentekaki, Ivan Čepička, Martin Kolisko

Biological Sciences Faculty Publications and Presentations

Background

Diplomonads are anaerobic flagellates classified within Metamonada. They contain both host-associated commensals and parasites that reside in the intestinal tracts of animals, including humans (e.g., Giardia intestinalis), as well as free-living representatives that inhabit freshwater and marine anoxic sediments (e.g., Hexamita inflata). The evolutionary trajectories within this group are particularly unusual as the free-living taxa appear to be nested within a clade of host-associated species, suggesting a reversal from host-dependence to a secondarily free-living lifestyle. This is thought to be an exceedingly rare event as parasites often lose genes for metabolic pathways that are essential to a …

Reliability And Application Of Data, Alex Brodersen, Katie Bass, Lina Traslaviña Stover, John Mccoy, Josie Gatti Schafer

CPAR Presents: A Data and Research Series for Community Impact

How Reliable Is Your Data? Ensuring Trustworthy Information for Economic and Community Growth To effectively utilize data for economic and community development, it must be reliable. Although data reliability is a statistical concept, it also includes building trust and understanding for data. This panel will delve into both the statistical and practical aspects of ensuring data reliability, featuring insights from experts in Nebraska. Attendees will gain valuable perspectives on how to verify and utilize data effectively in decision-making processes.

The "Pros" Of Probiotics: A Review Of Probiotics Place In Therapy, Kelley Maberry, Hanh Nguyen, Connor Quinter, Justine Magalona

Transformative Medicine

As different probiotic supplements become increasingly seen in the market, questions regarding their use for gut health from patients rises as well. Because these supplements do not require FDA approval, their safety and efficacy is often unknown and limited research available poses an even greater challenge for healthcare providers when prompted with questions regarding their use. This article summarizes evidence-based recommendations provided by the American Gastroenterological Association (AGA) and the World Gastroenterology Organization (WGO). Of the conditions discussed, supportive evidence on the use of probiotics is mostly seen in the prevention of C. diff associated diarrhea, prevention of antibiotic associated …

Which Endocrine Disorder Does This Ecg Suggest?, Muhammad Mohsin Zafar, Muhammad Asad Hanif

Transformative Medicine

No abstract provided.

An Unusual Presentation Of Erythrodermic Psoriasis, Eden L. Parks, Kojo-Frimpong B. Awuah Md, Caitlin D. Couper Md

Transformative Medicine

Introduction

Erythrodermic psoriasis is a rare form of psoriasis, occurring in less than 3% of patients with psoriasis. Limited information is known regarding diagnosis and treatment for this form of psoriasis, with most studies involving small groups or single patients. This unusual case of erythrodermic psoriasis outlines the presentation, diagnosis, and treatment that occurred in a 53-year-old patient who initially presented with dyspnea and a fever.

Case Presentation

The 53-year-old patient was originally admitted for dyspnea and a fever. A maculopapular rash developed diffusely on the upper extremities, lower extremities, trunk, and face. The rash then desquamated over several days, …

Management Strategies Of Cesarean Section Ectopic Pregnancy: A Case Report, Hannah E. Daley, Ava R. Hansen, Priyanka Raju Md, Jonathan Buerger Md

Transformative Medicine

Introduction:

Cesarean scar ectopic pregnancy is a rare form of pregnancy with potential life-threatening complications such as severe hemorrhage, uterine rupture, and emergency hysterectomy Currently, there is no consensus regarding a standardized treatment algorithm for this specific variant of ectopic pregnancies.

Case Description:

This case describes a 28-year-old female with history of two prior cesarean sections who was diagnosed with cesarean section scar ectopic pregnancy. Initial management with intramuscular methotrexate was unsuccessful in the setting of inadequate decrease in β-hCG level. The patient ultimately underwent surgical management with dilation and suction evacuation under ultrasound guidance for removal of the ectopic …

The Kent-Collins Protocol For Symptom Management In Post-Radiotherapy Eustachian Tube Dysfunction: A Case Report, Matthew E. Kent, Patrick J. Collins, Ayal A. Aizer

Transformative Medicine

Introduction: Eustachian tube dysfunction is a common side effect of radiotherapy for head and neck cancers or brain tumors, although few effective treatments exist. The Kent-Collins Protocol represents a novel therapeutic option for post-radiotherapy Eustachian tube dysfunction.

Case Description: The Kent-Collins Protocol was employed in one patient with Eustachian tube dysfunction following fractionated stereotactic radiotherapy for cerebral metastases from HER-2 positive breast cancer. The Kent-Collins Protocol provided relief of symptoms (conductive hearing loss, aural fullness, and otalgia) for a range of 5 to 45 minutes. The protocol could be repeated when symptoms returned to provide additional relief. The patient also …

Catastrophic Spontaneous Uterine And Bladder Rupture In An Unscarred Uterus, Nathanael N. Hoskins Do, Kathryn Brandt Do, Tory Peterson Md

Transformative Medicine

Introduction:

Uterine rupture during pregnancy is a rare event which can be life-threatening for both the patient and the fetus. This case report describes a rare complication of uterine rupture which ultimately required a hysterectomy and extensive urologic reconstruction.

Case Description:

A 36-year-old patient presented to the hospital after term pre-labor rupture of membranes. The patient underwent induction of labor which ultimately resulted in a uterine rupture in an unscarred uterus. The rupture extended into the posterior bladder wall, right ureter, urethra, and anterior vaginal wall, resulting in a vesicovaginal fistula. The patient required a cesarean hysterectomy due to the …

The Geography Of Demographic Change In Nebraska, Josie Gatti Schafer

CPAR Presents: A Data and Research Series for Community Impact

In this overview presentation of demographic and economic shifts in Nebraska, we utilize the most recent data available from the U.S. Census Bureau. Additionally, our analysis will explore key trends across various geographies, including places, counties, and regions, to examine how geography may contribute to explaining the demographic and economic changes. This approach offers valuable insights into the economic and community development imperatives for Nebraska.

Spontaneous Spinal Epidural Hematoma Presenting As A Stroke Alert: A Case Report, Christian Flores Do, Monisha Bindra Do, Mph, Adam Sigal Md, Michael Romeo Do

Transformative Medicine

Introduction

Spinal epidural hematoma (SEH) is a rare pathologic entity that accounts for less than 1% of all space-occupying spinal canal lesions [2,8]. Even more rare are spontaneous spinal epidural hematomas (SSEH), defined as a SEH without a known traumatic or inciting cause, with a reported incidence of 0.1 cases per 100,000 annually [1,2]. Currently, there is a paucity of literature regarding this topic [2,3]. SSEH can easily be missed or misdiagnosed if clinicians do not hold a high level of clinical suspicion.

Case Description

A 69-year-old female with no history of anticoagulation use or preceding trauma presented to the …

Same Or Different? Resolution Of Diagnostic Difficulty Of Two Mixed Cell-Type Tumors In Ovarian Pathology., Sarah Ingram, Priyanka Raju Md, Wei Shaw Do, Steve Sowers Pa, Kelly Brenan-Rothschild Md

Transformative Medicine

Introduction: When confronted by two disease processes, physicians in all disciplines are faced with the question: Are they manifestations of a common etiology, or distinct entities co-occurring? Inherent in this dilemma is whether an aberration from normal is even a disease process at all. Tissue pathology plays a key role in resolving this conundrum. Although diagnoses can be challenging, there are various methodologies used in the field of pathology to ascertain whether two tumors are of the same or different origins.

Case Description: This case report reviews two patients with large ovarian neoplasms and surgical pathology revealing histopathological features of …

Guardians Of The Genitals: The Dermatogynecologic Duo, Alexis Arza, Erin Stitzlein

Transformative Medicine

No abstract provided.

Research Integrity In The Academic Transformation Of A Community Hospital, Andrew Adorboe, Paul Hryvaniak, Carol Kriebel, Erica Klopp, Wei Du

Transformative Medicine

No abstract provided.

A Brief Review Of Zuranolone, Aubrey A. Jackson

Transformative Medicine

Zuranolone, a novel analog of allopregnanolone, has been approved by the U.S. Food and Drug Administration (FDA) as the first oral medication approved for the treatment of postpartum depression in adults. Developed by Sage Therapeutics under the brand name Zurzuvae, zuranolone was approved by the FDA on August 4^th, 2023.¹ Zuranolone is a modified version of brexanolone (sold under the brand name Zulpresso), an intravenously administered allopregnanolone formulation that was previously the only FDA-approved medication for postpartum depression. Zuranolone offers a more accessible treatment option for patients with efficacy established in clinical trials. Its approval expands the …

Updates On Data Products From The U.S. Census Bureau, Josie Gatti Schafer

CPAR Presents: A Data and Research Series for Community Impact

No abstract provided.

An Optimal Schedule Recovery Model For Transportation Carriers Under Uncertain Typhoon Disruption Periods, Yi-Chun Chen, Shangyao Yan

Journal of Marine Science and Technology–Taiwan

Due to the unsettled weather conditions caused by typhoons, it is not possible to forecast the time when a typhoon will arrive or depart accurately. The uncertainty regarding the duration of typhoon disruptions makes it challenging for transportation carriers to efficiently adjust their schedules. In this study, to deal with the problem of airline fleet rerouting, flight rescheduling, and passenger reassignment for uncertain disruption periods caused by a typhoon, we utilize network flow techniques with the concept of probability to construct a stochastic model for minimizing the total operating costs. A heuristic algorithm based on the divide-and-conquer technique is adopted …

واجب التسبيب كعنصر من عناصر الحق في الإدارة الجيدة "دراسة تحليلية في القانون الأمريكي والمقارن"

UAEU Law Journal

This study deals with the subject of the duty to reason as an element of good administration, and it analyzes the American experience in the field of duty to reason as the only model that was able to move the concept of reasoning administrative decisions from the proceduralist perspectives to the Rationalism perspectives. The Rationalism perspectives, in turn, is the focus and goal of good administration, which it is mainly focuses on controlling the exercise of the discretionary authority of administration and giving rationality to administrative action.

The study concluded that the American concept of the duty to reason is …

ماهية الملكة القانونية وتمييزها من غيرها وتقسيماتها

UAEU Law Journal

This study dealt with the legal apprehension, which is a thorny issue, as it is not based on legal rules and stable systematic results. The Legal Apprehension has multiple meanings and objectives for her association with all areas of legal creativity, in terms of legal opinions and proper judicial decisions, and the drafting of legislation that surrounds all legal aspects of community problems.

Given the Apprehension's legal connection to all different aspects of life, we have had to demonstrate its importance in enacting and interpreting legislation in line with the development of societies and the development of life that require …

ضوابط استخدام تقنية النانو في المجال الطبي: دراسة تأصيلية

UAEU Law Journal

The idea of this research is about the Nanotechnology's concept and applications in the Contemporary medical field, with presenting the benefits and the evils of this technology.

The research aimed at clarifying the legal rules of this issue citing evidence the legal evidence, the objectives of the Sharia, and the legitimacy rules.

In this research I've followed the inductive approach to collect the data and the information that is relevant to the topic, As well as the descriptive approach to illustrate the issue from the expert point of view, in addition the analytical approach to break the topic into issues …

الإطار القانوني للمعالجة الإلكترونية للبيانات الشخصية دراسة تحليلية مقارنة 2022

UAEU Law Journal

In order to ensure a high level of legal and technical protection for electronically processed personal data, legislation has established mechanisms to address the dangers resulting from the use of citizens’ personal data, and to legitimately combat the violation of their privacy and freedoms. As well as formulating obligations on the processor, the controller, and the data protection officer, and processing this data as they are among the active elements in the areas of dealing with personal data, whether by collecting, transferring, exchanging, storing, analyzing, or processing in any way.

Obliging institutions, entities and individuals that control and

process personal …

أركان القرار الإداري في عصر الذكاء الاصطناعي

UAEU Law Journal

This research deals with the extent to which the pillars of the administrative decision are available in the legal concept within the artificial intelligence system, through a review of the substantive and formal pillars, and an attempt to adapt them within the technical perception of them, to ensure their validity if those decisions are issued by artificial intelligence systems.

Where the formal pillars (represented in the corner of competence and the corner of form), as well as the substantive pillars (represented in the corner of the shop, the reason, the end) were presented to the general extent with

which it …

Retrieval-Augmented Generation (Rag) Classification And Access Control, Assaf Namer, Robert Lagerström, Gopinath Balakrishnan, Brandon Maltzman

Defensive Publications Series

Retrieval-augmented generation, a technique to improve the accuracy of responses of large language models (LLM), can result in an expanded attack surface for the LLM and an increased potential for exfiltration of sensitive data. This disclosure describes techniques to reduce the attack surface for LLMs that use retrieval-augmented generation. In a data upload phase, access permissions of data resources are recorded and quantified. Implicit permissions granted by the LLMs to different principals are assessed. If a data classification scheme is added to the data resources, a score can measure the risk of a prompt provided to the LLM, thus forestalling …

A Method To Secure A Mobile Payment Application Solution On A Cardholder-Owned Mobile Device, John Markh, Ian Javkin, Yeuxi Chen, Angelito Paca, Victor Tambunan, Marc Kekicheff, Sergey Smirnoff

Defensive Publications Series

Disclosed are methods for securing a mobile application on a cardholder-owned device, including defining principles and minimum security requirements for mobile applications that are designed to capture contactless payment instrument data and perform a cryptographic authentication of the contactless payment instrument. The present disclosure provides a solution that outlines minimum security requirements and evaluation guidance for mobile applications designed to capture data (e.g., a PAN, a cardholder’s name, an expiry data, an EMV cryptogram, etc.) of a contactless payment instrument using short-range communication, such as near-field communication (NFC), and further designed to perform a cryptographic authentication of the payment instrument.

Computationally Efficient Hdr Video Using A Packed Video Gain Map, Na

Defensive Publications Series

Gain map is a set of techniques that provide a consistent high dynamic range (HDR) appearance of visual content across devices based on an adaptation of the content to the capabilities of the display. When gain maps are applied to video, the reconstructed video frames require two decodes, one for the base frame and another for the gain-map frame, thereby doubling processing requirements. This disclosure describes techniques that reduce the number of decodes in gain-mapped video by scaling down the resolution of the gain-map frames and by packing them together into one frame. Gain map decodes that are conventionally performed …