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Attempts To Define The Concept Of ‘Dark Patterns’ In The Doctrine And Activities Of Authorities Of Eu Member States, Damian Kazimierski Sep 2024

Attempts To Define The Concept Of ‘Dark Patterns’ In The Doctrine And Activities Of Authorities Of Eu Member States, Damian Kazimierski

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The aim of the paper is to trace the different ways of defining the concept of ‘dark patterns’ in the doctrine and decisional practice of authorities operating within the territory of the European Union, with particular attention placed on the Polish perspective. The publication addresses the main elements of this notion, and indicates the premises that lack consensus in the academic community and in the decisional practices of the authorities. These include, first of all, the requirement of intentionality of the use of social engineering in order to induce the user of a website or application to take the expected …


Vol. 13(2) - Entire Issue Sep 2024

Vol. 13(2) - Entire Issue

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Entore issue 13(2)


‘Intentionality’ As A Feature Of The Subjective Side Of The Tort Of Allowing A Violation Of The Prohibition Of Agreements Restricting Competition, Marta Dobosz, Jarosław Szewczyk Sep 2024

‘Intentionality’ As A Feature Of The Subjective Side Of The Tort Of Allowing A Violation Of The Prohibition Of Agreements Restricting Competition, Marta Dobosz, Jarosław Szewczyk

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

In the event of finding that an entrepreneur has violated the prohibition specifi ed in Article 6(1) items 1–6 of the Polish Act on Competition and Consumer Protection or in Article 101(1) letter a–e of the TFEU, liability may also be borne by a manager who, in the performance of their function and within the duration of the established infringement, intentionally allowed such an infringement to occur through their action or omission (see Art. 6a of the Act of Competition and Consumer Protection). The purpose of assigning this liability is to demonstrate the individual features of the action in question. …


Termination Of Contracts Concluded By Entrepreneurs With Consumers For An Indefinite Period Of Time In The Light Of The Standpoint Of The President Of The Offi Ce Of Competition And Consumer Protection (Uokik) In The Amazon Case, Michał Kalinowski Sep 2024

Termination Of Contracts Concluded By Entrepreneurs With Consumers For An Indefinite Period Of Time In The Light Of The Standpoint Of The President Of The Offi Ce Of Competition And Consumer Protection (Uokik) In The Amazon Case, Michał Kalinowski

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

This article discusses the issue of permissibility of the termination of contracts concluded by entrepreneurs with consumers for an indefi nite period of time. The article presents the previous line of decisions of the President of the Offi ce of Competition and Consumer Protection (UOKiK) and the case-law of Polish courts concerning the so-called ‘valid reasons’ as a basis of such termination, both from the perspective of termination clauses and modifi cation clauses. This past practice is juxtaposed with the most recent position of the UOKiK President in the Amazon case, and the changes in the terms of service introduced …


Countering ‘Dark Patterns’ On The Example Of The Activities Of The President Of The Offi Ce Of Competition And Consumer Protection (Uokik) In Poland, Damian Kazimierski Sep 2024

Countering ‘Dark Patterns’ On The Example Of The Activities Of The President Of The Offi Ce Of Competition And Consumer Protection (Uokik) In Poland, Damian Kazimierski

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Online shopping is becoming an everyday occurrence for an increasing number of people, and many activities are moving online. With the spread of running day-to-day errands online, the knowledge of consumer behaviour on websites and mobile apps is also advancing. However, the experiences of cognitive psychologists and sociologists are becoming an incentive for website owners and graphic designers to use social engineering to get users to act in accordance with the will of the entrepreneur. The use of ‘dark patterns’ raises the need to counteract their effects on consumers. Several tools are available to supervisory authorities to counteract the use …


Improving Electronic Health Charting By Nurses In The Intensive Care Unit: An Evidence Informed Change Project, Dayananda Bittenahalli Omkarappa Sep 2024

Improving Electronic Health Charting By Nurses In The Intensive Care Unit: An Evidence Informed Change Project, Dayananda Bittenahalli Omkarappa

South West Clinical School Journal

#400WORDS: KNOWLEDGE + ACTION


Mapping Clinical Skills’ Inductions For Allied Health Professions Within An Integrated Care System: A Service Development Project, Sharn Hooper Sep 2024

Mapping Clinical Skills’ Inductions For Allied Health Professions Within An Integrated Care System: A Service Development Project, Sharn Hooper

South West Clinical School Journal

#400WORDS: KNOWLEDGE + ACTION


Establishing A Community Of Practice For Nursing Associates Working In Mental Health, Learning Disabilities And Autism Care, Peter Watt Sep 2024

Establishing A Community Of Practice For Nursing Associates Working In Mental Health, Learning Disabilities And Autism Care, Peter Watt

South West Clinical School Journal

#400WORDS: RESEARCH + ACTION


An Analysis Of The Performance And Effectiveness Of Political Strategic Leadership In Indonesia, Arman Arman, Rini Indryati Patasaka Sep 2024

An Analysis Of The Performance And Effectiveness Of Political Strategic Leadership In Indonesia, Arman Arman, Rini Indryati Patasaka

Jurnal Wacana Politik

The purpose of this study is to analyze the performance and effectiveness of political policy strategies in Indonesia using a quantitative research method with a snowball sampling technique with a sample size of 1,200 respondents from 38 provinces. margin of error of approximately 5 percent at a 95 percent confidence level with descriptive statistical data techniques where the data used to describe or summarize the main characteristics of the analysis of performance and effectiveness of political strategy leadership in Indonesia, the data tool uses SPSS statistics version 26, with a time of 2 years, with the results of the analysis …


Satellite Observations Indicate That Chia Uses Less Water Than Other Crops In Warm Climates, Brian Kirsch, Joshua B. Fisher, Thomas Piechota, Mohammad Hassani, Diego C. Suardiaz, Radhika Puri, Joseph Cahill, Hagop S. Atamian Sep 2024

Satellite Observations Indicate That Chia Uses Less Water Than Other Crops In Warm Climates, Brian Kirsch, Joshua B. Fisher, Thomas Piechota, Mohammad Hassani, Diego C. Suardiaz, Radhika Puri, Joseph Cahill, Hagop S. Atamian

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Many parts of the world face severe and prolonged drought conditions, stressing the sustainability of water resources and agriculture. Transitioning to water-efficient crops is one strategy that can help adapt to water scarcity. An emerging drought-tolerant crop of interest is chia (Salvia hispanica). Yet, no study has compared its large-scale water use dynamics to those of widely established crops across the globe. Here, we use satellite data over multiple years to assess the water use efficiency of chia, alfalfa, corn, and soybean globally. Results show that chia consumed 13-38% less water than alfalfa, corn, and soy and assimilated …


A Review On Potential For Organic Farming In Pakistan, Amir Raza, Shahzada Asif Ali, Haroon Shahzad Sep 2024

A Review On Potential For Organic Farming In Pakistan, Amir Raza, Shahzada Asif Ali, Haroon Shahzad

Journal of Bioresource Management

Intensive use of agrochemicals (fertilizers and pesticides) has enhanced crop productivity in Pakistan. This rise in productivity has been achieved at the cost of degradation of natural resources (land and water), and environmental pollution. The current situation demands a gradual transformation towards eco-friendly farming practices like organic farming to ensure the sustainability of the agriculture sector. This article presents our viewpoint on the potential benefits of organic farming, its role in mitigating the impact of climate change and the potential for adoption and promotion of organic farming in Pakistan. Organic farming seems to offer promising opportunities on account of its …


Sarkopenia Sebagai Faktor Risiko Varises Esofagus Risiko Tinggi Berdasarkan Stratifikasi Child-Pugh Pasien Sirosis Hati, Iwandheny Sepmeitutu, Juferdy Kurniawan, Hasan Maulahela, Ikhwan Rinaldi, Hamzah Shatri, Triyanta Yuli Pramana, Dadang Makmun, Cosmas Rinaldi A Lesmana, Rudy Hidayat, Purwita Wijaya Laksmi, Diana Sunardi Sep 2024

Sarkopenia Sebagai Faktor Risiko Varises Esofagus Risiko Tinggi Berdasarkan Stratifikasi Child-Pugh Pasien Sirosis Hati, Iwandheny Sepmeitutu, Juferdy Kurniawan, Hasan Maulahela, Ikhwan Rinaldi, Hamzah Shatri, Triyanta Yuli Pramana, Dadang Makmun, Cosmas Rinaldi A Lesmana, Rudy Hidayat, Purwita Wijaya Laksmi, Diana Sunardi

Jurnal Penyakit Dalam Indonesia

Background The high prevalence of sarcopenia in chronic liver disease negatively impacts the quality of life and increases the risk of various complications of cirrhosis, one of which is the development of esophageal varices. The aim of this study was to determine the prevalence of sarcopenia in cirrhosis patients based on the severity of liver cirrhosis and to explore the association of sarcopenia with high-risk esophageal varices stratified by Child-Pugh. Methods This observational cross-sectional study involved patients with liver cirrhosis at Cipto Mangunkusumo Hospital between January and September 2023. Sarcopenia was defined as a reduction in muscle mass accompanied by …


Nilai Diagnostik Italian Score Untuk Memprediksi Infeksi Bakteri Extended Spectrum Beta-Lactamase (Esbl) Pada Pasien Sepsis Di Rsup Dr. M. Djamil Padang, Fadrian Fadrian, Armen Ahmad, Khairat Khairat Sep 2024

Nilai Diagnostik Italian Score Untuk Memprediksi Infeksi Bakteri Extended Spectrum Beta-Lactamase (Esbl) Pada Pasien Sepsis Di Rsup Dr. M. Djamil Padang, Fadrian Fadrian, Armen Ahmad, Khairat Khairat

Jurnal Penyakit Dalam Indonesia

Introduction. Infections caused by Extended-Spectrum Beta-Lactamase (ESBL) bacteria, especially in septic patients, require adequate management. Giving definitive antibiotics according to culture results takes a long time. Therefore, a clinical scoring system is needed to predict ESBL bacterial infection, one of which is the Italian score.

Methods. This research used a cross-sectional design and was conducted in the inpatient room of RSUP Dr. M. Djamil Padang for 6 months. The samples in this study were septic patients who underwent culture examination at RSUP Dr. M. Djamil Padang who met the research inclusion and exclusion criteria. Sampling was carried out …


Scoping The Literature On Professional Development For Educators And Educational Leaders In The Uae, Zeina Hojeij, Shayma Ali Alsuwaidi, Shanzila Ahmed Sep 2024

Scoping The Literature On Professional Development For Educators And Educational Leaders In The Uae, Zeina Hojeij, Shayma Ali Alsuwaidi, Shanzila Ahmed

All Works

This comprehensive scoping review aimed to identify and synthesize the existing research on professional development (PD) for educators and educational leaders in the United Arab Emirates (UAE) between 2018 and 2023. Fourteen scholarly articles covering a wide range of topics related to education in the UAE were collected and analyzed. The review revealed that PD initiatives in the UAE often focus on enhancing teacher effectiveness and leadership skills, particularly in the context of educational reforms and inclusive education practices. However, significant challenges were identified, including implementation gaps, cultural barriers, and resistance to centrally imposed PD programs. The findings suggest that …


Corporate Tax Disclosure In Indonesia: Trends, Content, And Determinants Based On Gri Standard 207, Sandra Aulia Sep 2024

Corporate Tax Disclosure In Indonesia: Trends, Content, And Determinants Based On Gri Standard 207, Sandra Aulia

BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi

This study analyzes the trends, content, and factors influencing corporate tax disclosure in Indonesia based on GRI Standard 207. Data were obtained from sustainability reports of companies listed on the Indonesia Stock Exchange for 2021–2023 and analyzed using content analysis, descriptive methods, and panel data regression. The findings show a significant increase in tax disclosure in line with GRI Standard 207 from 2021 to 2023. The financial and energy sectors had the highest disclosure rates, while the technology and property sectors had lower adoption. The "Approach to Tax" (207-1) element was most frequently disclosed, while technical elements like "Country-by-Country Reporting" …


Primary Intraocular Lymphoma: Rad-Path And Ophthalmologic Correlation, Denes Szekeres, Jonathan Parker, Evan Risch, Prasanna Vibhute, Girish Bathla, Shweta Agarwal, Amit Agarwal, Neetu Soni Sep 2024

Primary Intraocular Lymphoma: Rad-Path And Ophthalmologic Correlation, Denes Szekeres, Jonathan Parker, Evan Risch, Prasanna Vibhute, Girish Bathla, Shweta Agarwal, Amit Agarwal, Neetu Soni

Pathology Research and Scholarship

Primary intraocular lymphoma (PIOL) is a rare form of primary central nervous system lymphoma that poses diagnostic challenges due to its nonspecific clinical features and complex imaging characteristics. This paper presents a focus case and two companion cases, highlighting the complexities in identifying and treating PIOL. In the focus case, A 66-year-old male experienced gradual painless vision loss with choroidal thickening on funduscopic exam and subsequent follow-up MRI. Trans-vitreal biopsy confirmed PIOL, and the patient was treated with intravitreal steroids and systemic rituximab without recurrence. The companion case 1 involved a 66-year-old woman with vision changes and choroidal thickening with …


A Garch-Midas Approach To Modelling Stock Returns, Ezekiel N.N. Nortey, Ruben Agbeli, Godwin Debrah, Theophilus Ansah-Narh, Edmund F. Agyemang Sep 2024

A Garch-Midas Approach To Modelling Stock Returns, Ezekiel N.N. Nortey, Ruben Agbeli, Godwin Debrah, Theophilus Ansah-Narh, Edmund F. Agyemang

School of Mathematical & Statistical Sciences Faculty Publications

Measuring stock market volatility and its determinants is critical for stock market participants, as volatility spillover effects affect corporate performance. This study adopted a novel approach to analysing and implementing GARCH-MIDAS modelling methods. The classical GARCH as a benchmark and the univariate GARCH-MIDAS framework are the GARCH family models whose forecasting outcomes are examined. The outcome of GARCH-MIDAS analyses suggests that inflation, interest rate, exchange rate, and oil price are significant determinants of the volatility of the Johannesburg Stock Market All Share Index. While for Nigeria, the volatility reacts significantly to the exchange rate and oil price. Furthermore, inflation, exchange …


Predicting Students' Academic Performance Via Machine Learning Algorithms: An Empirical Review And Practical Application, Edmund F. Agyemang, Joseph A. Mensah, Obu-Amoah Ampomah, Louis Agyekum, Justice Akuoko-Frimpong, Amma Quansah, Oluwaferanmi M. Akinlosotu Sep 2024

Predicting Students' Academic Performance Via Machine Learning Algorithms: An Empirical Review And Practical Application, Edmund F. Agyemang, Joseph A. Mensah, Obu-Amoah Ampomah, Louis Agyekum, Justice Akuoko-Frimpong, Amma Quansah, Oluwaferanmi M. Akinlosotu

School of Mathematical & Statistical Sciences Faculty Publications

Predicting academic outcomes is complex and influenced by factors like socioeconomic background, motivation, and learning style. Machine Learning (ML) algorithms have become increasingly important due to their ability to analyze large data volumes and identify prediction patterns. Results show ML’s success in predicting academic performance, though effectiveness varies by dataset, algorithm choice, and training features. There is no consensus on the most effective ML method for predicting student performance with broad applicability. Among the five algorithms evaluated in this study, the Random Forest Classifier emerged as the best model, achieving the highest G-Mean and accuracy of 0.9243 and 85.42% respectively. …


Implementation Of A Split Flow (Quick Turn) Process To Improve Emergency Department Efficiency., Andrew C. Miller Do, David B. Burmeister Do, Facep, Cpe, Kimberly Reitz, Bryan G. Kane Md, Elizabeth Fuller, Joseph Walsh Do, Patrick Fagan, Chadd K. Kraus Do, Marna R. Greenberg Do, Mph, Facep, Kevin Weaver D.O.,Facoep Sep 2024

Implementation Of A Split Flow (Quick Turn) Process To Improve Emergency Department Efficiency., Andrew C. Miller Do, David B. Burmeister Do, Facep, Cpe, Kimberly Reitz, Bryan G. Kane Md, Elizabeth Fuller, Joseph Walsh Do, Patrick Fagan, Chadd K. Kraus Do, Marna R. Greenberg Do, Mph, Facep, Kevin Weaver D.O.,Facoep

Department of Emergency Medicine

No abstract provided.


دور روح دعابة القائد وسلوك المواطنة التنظيمية في التوجيه نحو الزبائن: دراسة استطلاعية لعينة من العاملين في بعض المصارف الحكومية والخاصة, عامر عبد الطيف كاظم, اريج كريم رحمان, كرار فاضل خلف Sep 2024

دور روح دعابة القائد وسلوك المواطنة التنظيمية في التوجيه نحو الزبائن: دراسة استطلاعية لعينة من العاملين في بعض المصارف الحكومية والخاصة, عامر عبد الطيف كاظم, اريج كريم رحمان, كرار فاضل خلف

Muthanna Journal of Administrative and Economics Sciences

يتناول هذا البحث دراسة العلاقة بين روح الدعابة لدى القيادة وسلوك المواطنة التنظيمية الموجه نحو الزبائن، وذلك من خلال إجراء دراسة استطلاعية لعينة من العاملين في المصارف في محافظة البصرة. تم استخدام استبيان لجمع البيانات من 200 موظف في مصرف في القطاع العام (الرشيد/ السيف ) ومصرف في القطاع الخاص( التنمية الدولي) ، وتم تحليل البيانات باستخدام برنامج [SPSS-Amos] لتحديد العلاقة بين روح الدعابة لدى القيادة وسلوك المواطنة التنظيمية الموجه نحو الزبائن. أظهرت النتائج أن روح الدعابة لدى القيادة لها علاقة ارتباط وتأثير إيجابي على سلوك المواطنة التنظيمية الموجه نحو الزبائن، وبالتالي يعد دعم روح الدعابة من القيادة أمرًا مهمًا …


Using Mlm, Nws And Lls To Estimate Of A Multivariate Regression Functions Based On The Skewed Heavy Tail Distribution Family, Sarmad Abdulkhaleq Saliha, Omar Ramzi Jasimb Sep 2024

Using Mlm, Nws And Lls To Estimate Of A Multivariate Regression Functions Based On The Skewed Heavy Tail Distribution Family, Sarmad Abdulkhaleq Saliha, Omar Ramzi Jasimb

Muthanna Journal of Administrative and Economics Sciences

The families of probability distributions with heavy tails are considered one of the most essential continuous distributions that have broad uses in various areas of life, especially in areas related to economics, which is concerned with the subject of oil prices and securities, so the research was estimated two types of regression functions, represented by the multivariable parametric, non-parametric regression function, depending on the Matrix-Variate Variance Gamma(M-VVG) distribution and Matrix-Variate Normal Inverse Gaussian(M-VNIG) distribution for the error of models. As the multivariate non-parametric regression model was converted into a linear model based on the local polynomial smoother and through the …


تشخيص الاداء المصرفي عبر نموذج Bankometer لعينة من المصارف العراقية الخاصة, سعد مجيد الجنابي Sep 2024

تشخيص الاداء المصرفي عبر نموذج Bankometer لعينة من المصارف العراقية الخاصة, سعد مجيد الجنابي

Muthanna Journal of Administrative and Economics Sciences

يهدف البحث الى استخدام نموذج Bankometer) ( لتشخيص وتقييم الاداء المصرفي الحالي والمستقبلي لعينة من المصارف العراقية الخاصة وقدرة هذا النموذج على اكتشاف مواطن الخلل والضعف لمعالجتها في الوقت المناسب قبل استفحالها وتحديد مواطن القوة لتعزيزها , والتعرف على مركزها المالي , اذ تتكون عينة البحث من خمس مصارف تجارية مدرجة في سوق العراق المالي للمدة من (2013 – 2022) , وأُستخدم هذا النموذج بوصفه احد النماذج الحديثة الذي قُدّم من قبل صندوق النقد الدولي سنة 2000, اذ يتميز هذا النموذج باحتواءه على ست نسب مالية ليكوَّن منها معـادلة خـطية ( S -Score ) يمكن من خلالها تقييم وتشخيص اداء …


Assessing The Response Results Of An Mhealth-Based Patient Experience Survey Among People Receiving Hiv Care In Lusaka, Zambia: Cohort Study, Jacob Mutale, Kombatende Sikombe, Boroma Mwale, Mwansa Lumpa, Sandra Simbeza, Chama Bukankala, Njekwa Mukamba, Aaloke Mody, Laura K Beres, Charles B Holmes, Carolyn Bolton Moore, Elvin H Geng, Izukanji Sikazwe, Jake M Pry Sep 2024

Assessing The Response Results Of An Mhealth-Based Patient Experience Survey Among People Receiving Hiv Care In Lusaka, Zambia: Cohort Study, Jacob Mutale, Kombatende Sikombe, Boroma Mwale, Mwansa Lumpa, Sandra Simbeza, Chama Bukankala, Njekwa Mukamba, Aaloke Mody, Laura K Beres, Charles B Holmes, Carolyn Bolton Moore, Elvin H Geng, Izukanji Sikazwe, Jake M Pry

2020-Current year OA Pubs

BACKGROUND: This pilot study evaluates the effectiveness of mobile talk-time incentives in maintaining participation in a longitudinal mobile health (mHealth) data collection program among people living with HIV in Lusaka, Zambia. While mHealth tools, such as mobile phone surveys, provide vital health feedback, optimal incentive strategies to ensure long-term engagement remain limited. This study explores how different incentive levels affect response rates in multiple survey rounds, providing insights into effective methods for encouraging ongoing participation, especially in the context of Zambia's prepaid mobile system and multi-SIM usage, a common practice in sub-Saharan Africa.

OBJECTIVE: This study aimed to assess the …


Continuous Adaptation Of Conversation Aids For Uterine Fibroids Treatment Options In A Four-Year Multi-Center Implementation Project, Danielle Schubbe, Tessa Madden, Et Al. Sep 2024

Continuous Adaptation Of Conversation Aids For Uterine Fibroids Treatment Options In A Four-Year Multi-Center Implementation Project, Danielle Schubbe, Tessa Madden, Et Al.

2020-Current year OA Pubs

BACKGROUND: Fibroids are non-cancerous uterine growths that can cause symptoms impacting quality of life. The breadth of treatment options allows for patient-centered preference. While conversation aids are known to facilitate shared decision making, the implementation of these aids for uterine fibroids treatments is limited. We aimed to develop two end-user-acceptable uterine fibroids conversation aids for an implementation project. Our second aim was to outline the adaptations that were made to the conversation aids as implementation occurred.

METHODS: We used a multi-phase user-centered participatory approach to develop a text-based and picture-enhanced conversation aid for uterine fibroids. We conducted a focus group …


Oaxaca Ingobernable: Relief Printmaking Workshop Series, Pavel Acevedo, Latin American And Iberian Institute Sep 2024

Oaxaca Ingobernable: Relief Printmaking Workshop Series, Pavel Acevedo, Latin American And Iberian Institute

LAII Events

Monday, September 30, 2024 | 04:00 pm - 05:00 pm

About:

The workshops below will take place at different units of UNM, with one of them offsite. They all feature guest artist Pavel Acevedo, who will introduce participants to the art of lino carving, lino printing, and silk screen printing.

Monday, September 30 | 4:00 - 8:00 PM

Location: UNM Department of Chicana/o Studies (1829 Sigma Rd NE)

Tuesday, October 1 | 3:00 - 7:00 PM

Location: UNM El Centro de la Raza (Mesa Vista Building 56)

Wednesday, October 2 | 3:00 - 7:00 PM

Location: UNM El Centro de …


Hormone Replacement Therapy And Risk Of Pancreatic Cancer In Postmenopausal Women: Evidence From The Us National Inpatient Sample 2008–2018, Lei Liu, Xinyu Wang, Dekai Guo, Ruirui Ma, Haibing Gong Sep 2024

Hormone Replacement Therapy And Risk Of Pancreatic Cancer In Postmenopausal Women: Evidence From The Us National Inpatient Sample 2008–2018, Lei Liu, Xinyu Wang, Dekai Guo, Ruirui Ma, Haibing Gong

Faculty, Staff and Student Publications

BACKGROUND: Pancreatic cancer is a serious, usually fatal disease and one of the most aggressive malignancies. Research into whether hormone replacement therapy (HRT) might protect against pancreatic cancer has yielded mixed results. This study aimed to investigate the potential association between HRT and the risk of pancreatic cancer in postmenopausal women.

METHODS: This population-based, retrospective study extracted data from the US National Inpatient Sample (NIS) 2008-2018. Hospitalized females aged ≥55 years were eligible for inclusion. Associations between HRT, other study variables, and pancreatic cancer diagnosis were determined using univariate and multivariable regression analyses.

RESULTS: After 1:4 matching by age, data …


Reconstructing Oral Cavity Tumor Evolution Through Brush Biopsy, Evit John, Tom Lesluyes, Toby M Baker, Maxime Tarabichi, Ann Gillenwater, Peter Van Loo Sep 2024

Reconstructing Oral Cavity Tumor Evolution Through Brush Biopsy, Evit John, Tom Lesluyes, Toby M Baker, Maxime Tarabichi, Ann Gillenwater, Peter Van Loo

Faculty, Staff and Student Publications

Oral potentially malignant disorders (OPMDs) with genomic alterations have a heightened risk of evolving into oral squamous cell carcinoma (OSCC). Currently, genomic data are typically obtained through invasive tissue biopsy. However, brush biopsy is a non-invasive method that has been utilized for identifying dysplastic cells in OPMD but its effectiveness in reflecting the genomic landscape of OPMDs remains uncertain. This pilot study investigates the potential of brush biopsy samples in accurately reconstructing the genomic profile and tumor evolution in a patient with both OPMD and OSCC. We analyzed single nucleotide variants (SNVs), copy number aberrations (CNAs), and subclonal architectures in …


Single-Cell Transcriptomes And Chromatin Accessibility Of Endothelial Cells Unravel Transcription Factors Associated With Dysregulated Angiogenesis In Systemic Sclerosis, Mengqi Huang, Tracy Tabib, Dinesh Khanna, Shervin Assassi, Robyn Domsic Sep 2024

Single-Cell Transcriptomes And Chromatin Accessibility Of Endothelial Cells Unravel Transcription Factors Associated With Dysregulated Angiogenesis In Systemic Sclerosis, Mengqi Huang, Tracy Tabib, Dinesh Khanna, Shervin Assassi, Robyn Domsic

Faculty, Staff and Student Publications

Objectives: Vasculopathy emerges early in systemic sclerosis (SSc) and links to endothelial cell (EC) injury and angiogenesis. Understanding EC transcriptomes and epigenomes is crucial for unravelling the mechanisms involved.

Methods: Transcriptomes and chromatin accessibility were assessed by single-cell RNA sequencing and single-nucleus transposase-accessible chromatin sequencing. Immunofluorescent staining of skin and proteomics assay were employed to confirm the altered SSc EC phenotypes. Gain-of-function assay was used to evaluate the effects of ETS transcription factors on human dermal ECs (hDECs).

Results: Both control and SSc ECs shared transcriptomic signatures of vascular linages (arterial, capillary and venous ECs) and lymphatic ECs. Arterial ECs …


Barriers And Facilitators To Dental Care Services Utilization Among Children With Disabilities: A Systematic Review And Thematic Synthesis, Shiamaa Al-Mashhadani, Mona Nasser, Anas Alsalami, Lorna Burns, Martha Paisi Sep 2024

Barriers And Facilitators To Dental Care Services Utilization Among Children With Disabilities: A Systematic Review And Thematic Synthesis, Shiamaa Al-Mashhadani, Mona Nasser, Anas Alsalami, Lorna Burns, Martha Paisi

Peninsula Dental School

BACKGROUND: This systematic review investigates barriers and enablers to dental care utilization by disabled children. Given the high global prevalence of disabilities in children, coupled with poor oral hygiene and a 45% rate of dental caries in this group, developing inclusive oral health strategies is critical. The review aims to synthesize literature on factors affecting oral healthcare improvement for disabled children, identifying barriers, facilitators and knowledge gaps.

METHODS: The review was conducted following the Joanna Briggs Institute's methods and reported according to PRISMA guidelines. A comprehensive search spanned multiple databases, considering perspectives from carers, parents, dentists and health professionals. The …


The Location Of Cationic Substitutions In Carbonated Biomimetic Apatites Significantly Affects Crystal Nanomechanics, Stephanie Wong, Abigail Eaton, Cristina Krywka, Arun Nair, Alex Deymier Sep 2024

The Location Of Cationic Substitutions In Carbonated Biomimetic Apatites Significantly Affects Crystal Nanomechanics, Stephanie Wong, Abigail Eaton, Cristina Krywka, Arun Nair, Alex Deymier

Mechanical Engineering Faculty Publications and Presentations

Bone and teeth are comprised of carbonate-substituted apatites with cationic substitutions, like sodium and potassium. Cations substitute for calcium in the apatite lattice but it is unclear whether they substitute for Ca(1) or Ca(2). Additionally, although we know that anionic substitutions affect the mineral mechanics, it is unclear how cationic substitutions affect mineral stiffness. Here, a combined experimental and theoretical approach using in situ fluid-mediated hydrostatic loading with synchrotron Wide Angle X-ray Scattering (WAXS) and Density Functional Theory (DFT) is used to elucidate the role of CO32− and Na+ or K+ co-substitutions on the atomic structure …