Digital Commons Network^™

Maximize Your Tools: Increasing User Engagement, Workflow Efficiency, And Ir Awareness With Springshare Products, Jennifer Deal

All Other Contributions

No abstract provided.

The Relationship Between Language Use And Conspiracy Beliefs, Isabelle Van Der Vegt, Bettina Rottweiler, Paul Gill

Reports, Projects, and Research

We know little about the individuals who share conspiracy beliefs online. By examining their language use, we can gain more insight into this population. We find that several language markers are associated with higher levels of conspiracy mentality, that is, a generic tendency to engage in conspiracy thinking. This has important implications for countering the impact of conspiracy theories and preventing support for election violence, a pathway we examine in a separate report.

One Year Later: The Impact Of The Oct. 7 Attack In The United States, Gina Scott Ligon, Mackenzie Harms, Erin Grace, Blake Ursch

Reports, Projects, and Research

NCITE products include analytical reports, white papers, reachback reports, and requests for information (RFIs) that provide in-depth, expert analysis of critical topics facing counterterrorism and homeland security. Our mission is to provide expert analysis on timely issues for stakeholders and the U.S. government.

This reachback report includes material from 27 experts in the NCITE network, writing from their professional perspectives on the impact in the U.S. of the Oct. 7, 2023, attack by Hamas on Israel and the ensuing war. This report was produced to address an important topic to homeland security: assessing the extremist threat landscape in the U.S. …

Digital Assessments For Children And Adolescents With Adhd: A Scoping Review, Franceli L. Cibrian, Elissa M. Monteiro, Kimberley D. Lakes

Engineering Faculty Articles and Research

Introduction: In spite of rapid advances in evidence-based treatments for attention deficit hyperactivity disorder (ADHD), community access to rigorous gold-standard diagnostic assessments has lagged far behind due to barriers such as the costs and limited availability of comprehensive diagnostic evaluations. Digital assessment of attention and behavior has the potential to lead to scalable approaches that could be used to screen large numbers of children and/or increase access to high-quality, scalable diagnostic evaluations, especially if designed using user-centered participatory and ability-based frameworks. Current research on assessment has begun to take a user-centered approach by actively involving participants to ensure the development …

An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, William A Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja, Irene S Molina, Hesham Mohei, Md Naushad Akhtar, Veena Kochat, Emre Arslan, Alexander J Lazar, Khalida Wani, William P Israel, Zhan Zhang, Venkata S Chaluvadi, Robert J Norgard, Ying Liu, Ashley M Fuller, Mai T Dang, Robert E Roses, Giorgos C Karakousis, John T Miura, Douglas L Fraker, T S Karin Eisinger-Mathason, M Celeste Simon, Kristy Weber, Kai Tan, Yi Fan, Kunal Rai, Malay Haldar

Faculty, Staff and Student Publications

We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis and immunosuppression in the tumor microenvironment and were conserved between mice and humans. iTAMs comprise two additional subsets based on gene expression profile and location-perivascular (pviTAM) and stromal (stiTAM). We identified the endothelin receptor type B (Ednrb) as a specific marker of iTAMs and found myeloid-specific deletion of Ednrb to reduce tumor growth and vascular density. Further studies identified the transcription factor Bach1 as a repressor of the iTAM transcriptional …

Author Correction: Longitudinal Single-Cell Profiling Reveals Molecular Heterogeneity And Tumor-Immune Evolution In Refractory Mantle Cell Lymphoma, Shaojun Zhang, Vivian Changying Jiang, Guangchun Han, Dapeng Hao, Junwei Lian, Qingsong Cai, Joseph Mcintosh, Ruiping Wang, Minghao Dang, Enyu Dai, Yuanxin Wang, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Jia Zhou, Rashmi Kanagal-Shamanna, Chi Young Ok, Hun Lee, Raphael E Steiner, Jianhua Zhang, Xingzhi Song, Ranjit Nair, Sairah Ahmed, Alma Rodriquez, Selvi Thirumurthi, Preetesh Jain, Nicolaus Wagner-Bartak, Holly Hill, Krystle Nomie, Christopher Flowers, Andrew Futreal, Linghua Wang, Michael Wang

Faculty, Staff and Student Publications

No abstract provided.

Immunologic Signatures Of Response And Resistance To Nivolumab With Ipilimumab In Advanced Metastatic Cancer, Apostolia M Tsimberidou, Farah A Alayli, Kwame Okrah, Alexandra Drakaki, Danny N Khalil, Saad A Khan, David Y Oh, Christopher R Cabanski, Shikha Gautam, Stefanie L Meier, Meelad Amouzgar, Shannon M Pfeiffer, Robin Kageyama, Enjun Yang, Marko Spasic, Michael T Tetzlaff, Wai Chin Foo, Travis J Hollmann, Yanyun Li, Matthew Adamow, Phillip Wong, Jonni S Moore, Sharlene Velichko, Richard O Chen, Dinesh Kumar, Samantha Bucktrout, Ramy Ibrahim, Ute Dugan, Lisa Salvador, Vanessa M Hubbard-Lucey, Jill O'Donnell-Tormey, Sandra Santulli-Marotto, Lisa H Butterfield, Diane M Da Silva, Justin Fairchild, Theresa M Lavallee, Lacey J Padrón, Padmanee Sharma

Faculty, Staff and Student Publications

Identifying pan-tumor biomarkers that predict responses to immune checkpoint inhibitors (ICI) is critically needed. In the AMADEUS clinical trial (NCT03651271), patients with various advanced solid tumors were assessed for changes in intratumoral CD8 percentages and their response to ICI. Patients were grouped based on tumoral CD8 levels: those with CD8 <15% (CD8-low) received nivolumab (anti-PD-1) plus ipilimumab (anti-CTLA4) and those with CD8 ≥15% (CD8-high) received nivolumab monotherapy. 79 patients (72 CD8-low and 7 CD8-high) were treated. The disease control rate was 25.0% (18/72; 95% CI: 15.8–35.2) in CD8-low and 14.3% (1/7; 95% CI: 1.1–43.8) in CD8-high. Tumors from 35.9% (14/39; 95% CI: 21.8–51.4) of patients converted from CD8 <15% pretreatment to ≥15% after treatment. Multiomic analyses showed that CD8-low responders had an inflammatory tumor microenvironment pretreatment, enhanced by an influx of CD8 T cells, CD4 T cells, B cells, and macrophages upon treatment. These findings reveal crucial pan-cancer immunological features for ICI response in patients with metastatic disease.

Longitudinal Single-Cell Profiling Reveals Molecular Heterogeneity And Tumor-Immune Evolution In Refractory Mantle Cell Lymphoma, Shaojun Zhang, Vivian Changying Jiang, Guangchun Han, Dapeng Hao, Junwei Lian, Qingsong Cai, Joseph Mcintosh, Ruiping Wang, Minghao Dang, Enyu Dai, Yuanxin Wang, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Jia Zhou, Rashmi Kanagal-Shamanna, Chi Young Ok, Hun Lee, Raphael E Steiner, Jianhua Zhang, Xingzhi Song, Ranjit Nair, Sairah Ahmed, Alma Rodriquez, Selvi Thirumurthi, Preetesh Jain, Nicolaus Wagner-Bartak, Holly Hill, Krystle Nomie, Christopher Flowers, Andrew Futreal, Linghua Wang, Michael Wang

Faculty, Staff and Student Publications

The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma (MCL) are incompletely understood. We characterize the cellular and molecular heterogeneity within and across patients and delineate the dynamic evolution of tumor and immune cell compartments at single cell resolution in longitudinal specimens from ibrutinib-sensitive patients and non-responders. Temporal activation of multiple cancer hallmark pathways and acquisition of 17q are observed in a refractory MCL. Multi-platform validation is performed at genomic and cellular levels in PDX models and larger patient cohorts. We demonstrate that due to 17q gain, BIRC5/survivin expression is upregulated in resistant MCL tumor cells and …

Hybrid Quantification Of Absolute Perfusion Requires Accurate Measurement Of Myocardial Mass

Faculty, Staff and Student Publications

No abstract provided.

Questionnaire-Based Subjective Evaluation And Analysis Of Factors Influencing The Effectiveness Of Treatment With The Vacuum Bell In Children With Pectus Excavatum: A Cross-Sectional Observational Study, Lihuan Zhou, Fang Deng, Yunfei Tian, Jiayi Lin, Guihong Yang, Yunfei Li, Jos M. Latour, Xicheng Deng

School of Nursing and Midwifery

Background: Vacuum bell (VB) is a technique to treat pectus excavatum in children. Its effectiveness and influencing factors, however, remain under investigated. The aim of this study was to examine the therapeutic effect and its influencing factors of VB in children with pectus excavatum. Methods: A cross-sectional observational study was conducted. Parents of children with pectus excavatum who underwent treatment with a VB between January 2018 and December 2019 were recruited. A survey was designed based on previously related studies and delivered to the parents in September–October 2021. The therapeutic effect was analyzed using subjective experiences by parents. Factors related …

White Nimbyism And Diversity Close To Home, Lucy Britt, Andreas Jozwiak

All Faculty Scholarship

Objective: We use a survey experiment to study what explains white “not in my backyard” opposition (NIMBYism) to dense and affordable housing—racial threat, material self-interest, or both. Methods: In a survey experiment on white U.S. respondents, we vary the presence of a racial prime about black and Latinx community organizations and the proximity of the housing development to the subject's home. We then measure levels of support for a proposed hypothetical housing development, willingness to take political action in support of or opposition to the development, and support for a number of housing-related and redistributive policies. Results: We find that …

Energy Service Security For Public Health Resilience: Perception And Concerns In Western Upper Peninsula Of Michigan☆, Shardul Tiwari, Zoē Ketola, Chelsea Schelly, Eric Boyer-Cole

Michigan Tech Publications

The Western Upper Peninsula of Michigan includes six rural counties and one Tribal Nation. The region is characterized by long winters, legacies of the extractive mining economy, and the infrastructural features of extreme rurality, including aging housing and low health service density. The region also faces exceptionally high electricity prices. There is limited research on the public health implications of energy service disruption in rural regions resulting from the increasing intensity and frequency of weather events caused by climate change. This article presents research findings examining the readiness of health facilities in this area to manage the rising intensity, severity, …

Understanding Students` Attitude And Intention Towards Vocational Education And Training (Vet) In The Sultanate Of Oman, Shweta Belwal, Fatma Rashid Al Moqbali, Rakesh Belwal

Plymouth Business School

The current study investigates the influence of attitudes, subjective norms (SN), and perceived behavioural control (PBC) in understanding the intentions of Grade 11 and Grade 12 (N = 376) students in Oman to join vocational education and training (VET) institutions. The study’s objectives were twofold: to assess secondary-school students’ attitudes toward vocational education and to investigate their intentions to join VET. A quantitative approach following the partial least square-based structural equation modelling was used. According to the findings, attitudes, PBC, and SNs, exhibit a significant favourable influence on students’ intention to join VET. However, some partial invariance to the relationship …

From Sample To Population Generalization In Qualitative Research, Florentina Scârneci-Domnișoru

The Qualitative Report

The split of methodology into qualitative and quantitative had all sorts of negative consequences, including the neglecting of some important scientific goals, such as generalizing research results in qualitative studies. Even if they don’t talk about generalizations, many qualitative researchers illegitimately extend their research results to populations much wider than those investigated. The article shows that the generalization of research results (from sample to population) is possible in qualitative research but that it can only be achieved through a sampling procedure that complies with specific rules. The article describes this procedure of internal generalization of results through a logical or …

Evaluation Of Health Recommender Systems: A Scoping Review Protocol, Ananya Ananthakrishnan, Madison Milne-Ives, Rohit Shankar, Edward Meinert

Peninsula Medical School

Background People increasingly rely on online health information for their health-related decision-making. Given the overwhelming amount of information available, the risk of misinformation is high. Health recommender systems, which recommend personalised health-related information or interventions using intelligent algorithms, have the potential to address this issue. Many such systems have been developed and evaluated individually, but there is a need to synthesise the evaluation findings to identify gaps and ensure that future recommender systems are designed to have a positive impact on health or target behaviours.Objective The purpose of this review is to provide an overview of the state of the …

Primary Care Experiences Of Adults Reporting Learning Disability: A Probability Sample Survey, Rohit Shankar

Peninsula Medical School

BACKGROUND: Adults with learning disability face multiple adversities, but evidence on their needs and primary care experiences is limited.

AIM: To compare the characteristics and primary care experiences of adults reporting learning disability with those who did not.

DESIGN AND SETTING: This was an analysis of the 2022 General Practice Patient Survey, a national probability sample survey conducted in 2022 with people registered with NHS primary care in England.

METHOD: This analysis reports descriptive profiles, weighted and with 95% confidence intervals. Logistic regression models adjusting for gender, age, ethnicity, and area-level deprivation compared experiences of adults reporting learning disability with …

A Geospatial Approach To Landscape Gaze Using Social Media To Evaluate How People Value Landscapes In An Urban Context, Riley Bibaud, Eva Mcgrath, Zoe Sydenham, Richard Yarwood, Tom Mullier, Siân Rees

School of Biological and Marine Sciences

Urban park management generally prioritises green spaces and activities within park boundaries, rather than landscape interactions. Understanding how people experience and connect with broader landscapes is essential for improving societal environmental, economic and wellbeing outcomes. A geospatial and discourse analysis of three urban parks was conducted in Plymouth, UK. The predominant landscape gaze at each park revealed strong social ties to blue spaces–namely the coast and sea–indicating an interconnectedness between parks and coastal spaces beyond park boundaries. Textual analysis emphasised the beauty of nature, the expanse of the ocean, and the health and wellbeing benefits of blue and green spaces. …

Feature Boosting With Efficient Attention For Scene Parsing, Vivek Singh, Shailza Sharma, Fabio Cuzzolin

School of Engineering, Computing and Mathematics

The complexity of scene parsing grows with the number of object and scene classes, which is higher in unrestricted open scenes. The biggest challenge is to model the spatial relation between scene elements while succeeding in identifying objects at smaller scales. This paper presents a novel feature-boosting network that gathers spatial context from multiple levels of feature extraction and computes the attention weights for each level of representation to generate the final class labels. A novel ‘channel attention module’ is designed to compute the attention weights, ensuring that features from the relevant extraction stages are boosted while the others are …

Mixing Between Flavor Singlets In Lattice Gauge Theories Coupled To Matter Fields In Multiple Representations, Ed Bennett, Niccolò Forzano, Deog Ki Hong, Ho Hsiao, Jong Wan Lee, C. J.David Lin, Biagio Lucini, Maurizio Piai, Davide Vadacchino, Fabian Zierler

School of Engineering, Computing and Mathematics

We provide the first extensive, numerical study of the nontrivial problem of mixing between flavor-singlet composite states emerging in strongly coupled lattice field theories with matter field content consisting of fermions transforming in different representations of the gauge group. The theory of interest is the minimal candidate for a composite Higgs model that also accommodates a mechanism for top partial compositeness: the Sp(4) gauge theory coupled to two (Dirac) fermions transforming as the fundamental and three as the two-index antisymmetric representation of the gauge group, respectively. We apply an admixture of APE smearing and Wuppertal smearings, as well as the …

Human Epidemiology And Response To Sars-Cov-2 (Heros): Objectives, Design, And Enrollment Results Of A 12-City Remote Observational Surveillance Study Of Households With Children, Using Direct-To-Participant Methods, Patricia C Fulkerson, Katherine Rivera-Spoljaric, Et Al.

2020-Current year OA Pubs

The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and allergic diseases, and to use the host nasal transcriptome sampled longitudinally to understand infection risk and sequelae at the molecular level. To overcome challenges of clinical study implementation due to the coronavirus pandemic, this surveillance study used direct-to-participant methods to remotely enroll and prospectively follow eligible children who are participants in other National Institutes of Health-funded pediatric …

Xenotransplanted Human Organoids Identify Transepithelial Zinc Transport As A Key Mediator Of Intestinal Adaptation, Maame Efua S Sampah, Vered Gazit, Deborah C Rubin, Et Al.

2020-Current year OA Pubs

Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is crucial in improving outcomes. To understand the human gene pathways associated with adaptation, we perform single-cell transcriptomic analysis of human small intestinal organoids explanted from mice with experimental SBS. We show that transmembrane ion pathways, specifically the transepithelial zinc transport pathway genes SLC39A4 and SLC39A5, are upregulated in SBS. This discovery is corroborated by an external dataset, bulk RT-qPCR, and Western blots. Oral zinc supplementation is shown to improve survival and weight gain of SBS mice and increase the proliferation of intestinal crypt cells in vitro. Finally, …

Batching Of Communications Between A Phone And A Wearable Device, Sudeep Chauhan, Andy Killen, Eusebius Lai

Defensive Publications Series

A wearable computing device (e.g., a smartwatch, smart glasses, computerized ring, etc.) may utilize contextual signals to determine when to enable or disable batching of information (e.g., messages, notifications, system data, application data, etc.) between the wearable computing device and a companion device (e.g., a smartphone, portable computer, etc.). The contextual signals may include a state of the user (i.e., user scenarios), device configuration information, and context information such as location, time, user behavior history, calendar events, battery level information (e.g., amount of charge), and/or other relevant data. A user may not want, need, or access information sent to the …

Hacked! North Korea's Billion-Dollar Crypto Heisting Scheme, Kole Zellers

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Thinking Outside The Box: Matchmaking State Gambling Law Frameworks To International Approaches To Loot Box Regulation, Emerson B. Marles

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Protecting Students' Privacy: Expanding The Use Of Pseudonyms In Civil Litigation Concerning Sexual Assault At Colleges In The United States And Canada, Cassi Epstein

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

From Forced To Free Labor, Christopher M. Roberts

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

The New Age Of Mining: Isa's Vision Of The Deep Seabed Mining, Ganeswar Matcha

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Rethinking United States - Certain Measures On Steel And Aluminum Products: Rebalancing Should Be Allowed For The Section 232 Measures, Michiru Ishihara, Hiroaki Chiba-Okabe

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

The Digitization Of Trade And Artificial Intelligence: A Pandora's Box, Rafael Leal-Arcas, Lama Al Damer, Haya Al Hokail, Sultana Abdulhakim Al Saud, Salma Alshaikh, Sultana Faisal Al Saud, Sara Al Muhanna, Loulwa Faisal Al Saud, Nora Alaiban, Moudi Alsaud

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Foreword

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.