Digital Commons Network^™

Assessing The Usability Of Iprepared: An Application-Based, Non-Pharmacological Delirium Prevention Intervention, Luke S. Sztajnkrycer, Ian Ward Maia, Heidi Lindroth, Kayla P. Carpenter, Derek Vanmeter, Samantha Gracia, Grace Herbeck, Aidan Mullan, Molly M. Jeffery, Fernanda Bellolio

Journal of Geriatric Emergency Medicine

Introduction: Non-pharmacologic prevention measures reduce incident delirium by up to 30-40%% in inpatient and ED settings, but consistent application is often difficult. A mobile health application, titled iPREPARED (Improve Prevention and Recovery by Engaging Patients and FAmily-Caregivers to End Delirium) was co-developed with patients and their care partners to prepare them for delirium and empower them to use non-pharmacological prevention measures. This study assessed the feasibility, acceptability, and usability of iPREPARED in the emergency department (ED).

Methods: An IRB-approved prospective study enrolled a convenience sample of ED patients over age 60 and/or their care partners. Participants were provided a tablet …

Debtor's Plan Of Reorganization

Catholic Dioceses in Bankruptcy

No abstract provided.

Opinion And Order Denying Cna's Adversary

Catholic Dioceses in Bankruptcy

No abstract provided.

The Rider (2024-10-07), Natalie Lapsley

The Rider Archives

Vol.10 No.7

Genomics Of Natural Populations: Gene Conversion Events Reveal Selected Genes Within The Inversions Of Drosophila Pseudoobscura

Faculty, Staff and Students Publications

When adaptive phenotypic variation or quantitative trait loci map within an inverted segment of a chromosome, researchers often despair because the suppression of crossing over will prevent the discovery of selective target genes that established the rearrangement. If an inversion polymorphism is old enough, then the accumulation of gene conversion tracts offers the promise that quantitative trait loci or selected loci within inversions can be mapped. The inversion polymorphism of Drosophila pseudoobscura is a model system to show that gene conversion analysis is a useful tool for mapping selected loci within inversions. D. pseudoobscura has over 30 different chromosomal arrangements …

Implementation Study Of The Carra Uveitis Consensus Treatment Plans: Feasibility For Clinical Practice And Applicability For Research., Margaret H. Chang, Fatima Barbar-Smiley, Shoghik Akoghlanian, Joanne Drew, Sheila T. Angeles-Han, Megan Quinlan-Waters, John F. Bohnsack, Ashley M. Cooper, Barbara Edelheit, Jennifer Twachtman-Bassett, Melissa A. Lerman, Kabita Nanda, C Egla Rabinovich, Mindy S. Lo, Carra Uveitis Workgroup And The Carra Registry Investigators

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Chronic anterior uveitis (CAU) carries a significant risk for eye complications and vision loss. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) introduced consensus treatment plans (CTPs) to standardize treatment for CAU and facilitate future comparative effectiveness studies. Two CTPs were developed to address: 1) initiation of methotrexate (MTX) in patients with CAU naïve to steroid-sparing therapy, and 2) initiation of a TNF inhibitor (TNFi) in patients with severe uveitis or uveitis refractory to MTX. We evaluated implementation of the uveitis CTPs using existing CARRA Registry infrastructure and assessed feasibility of the CTPs for comparative effectiveness research.

METHODS: This …

Adolescents' Perceptions Of Food Outlets In The School Neighbourhood And Their Unhealthy Snacking Behaviour On The Way To And From School, Margaretha Liliana Situmorang, Sandra Mandic, Michael Keall, Melody Smith, Niamh Donnellan, Kirsten J. Coppell

Research outputs 2022 to 2026

Objective: To understand the relationship between adolescents' unhealthy snacking behaviour during their school journey and their perceived and objective measures of food outlet availability in the school neighbourhood. Design: A cross-sectional survey enquired about socio-demographic information, school transport modes, perceived presence of food outlets in the school neighbourhood and unhealthy food purchase and consumption on the school journey. A geographical information system analysis of the food outlets within 500 m and 1000 m school buffers was undertaken. Data were analysed using generalised linear mixed modelling. Setting: All twelve secondary schools in Dunedin, Aotearoa New Zealand, March 2020-June 2022. Participants: Adolescents …

The Fundamentals Of Antiseizure Medications: A Through Z, Kristen Park, David G Vossler, Archana A Patel, Alica Goldman

Faculty, Staff and Students Publications

Since bromides were first used in 1857 to treat epilepsy, numerous antiseizure medications (ASM) have been developed. Many of these are available for the treatment of epilepsy and status epilepticus today. With so many ASM available, questions arise as to whether all of these medications are needed and when should they be used. As precision medicine begins to play a larger role in determining targeted treatments for specific types of epilepsy, a complete understanding of various medications is needed. Additionally, access to several of these medications can be limited in the United States and are especially limited globally. All these …

Rescue Of Scn5a Mis-Splicing Does Not Improve The Structural And Functional Heart Defects Of A Dm1 Heart Mouse Model, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic Dystrophy Type 1 (DM1) is an autosomal dominant multisystemic disorder for which cardiac features, including conduction delays and arrhythmias, are the second leading cause of disease mortality. DM1 is caused by expanded CTG repeats in the 3' untranslated region of the DMPK gene. Transcription of the expanded DMPK allele produces mRNAs containing long tracts of CUG repeats, which sequester the Muscleblind-Like family of RNA binding proteins, leading to their loss-of-function and the dysregulation of alternative splicing. A well-characterized mis-regulated splicing event in the DM1 heart is the increased inclusion of SCN5A exon 6A rather than the mutually exclusive exon …

An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, Mai T Dang, Et Al.

2020-Current year OA Pubs

We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis and immunosuppression in the tumor microenvironment and were conserved between mice and humans. iTAMs comprise two additional subsets based on gene expression profile and location-perivascular (pviTAM) and stromal (stiTAM). We identified the endothelin receptor type B (Ednrb) as a specific marker of iTAMs and found myeloid-specific deletion of Ednrb to reduce tumor growth and vascular density. Further studies identified the transcription factor Bach1 as a repressor of the iTAM transcriptional …

Law School News: The Powerful Combination Of Representation And Advocacy 10-7-2024, Danna Lorch

Life of the Law School (1993- )

No abstract provided.

Mmu: 10/07/24–10/13/24, Student Bar Association

Monday Morning Update

This Week @ NDLS

Mass Times

Commons Daily Menu

Saint of the Week

General Announcements

The Effect Of Small Class Size From Kindergarten Through Third Grade On Eighth-Grade Gender Reading Achievement, Christopher Harry

Seton Hall University Dissertations and Theses (ETDs)

This study examined the effect of small class size intervention on student outcomes using reading achievement scores as measured by the Comprehensive Test of Basic Skills (CTBS), a standardized, norm-referenced test, while controlling for independent variables inclusive of students' gender, race, socioeconomic status (SES), and environment. This study included students who participated in a randomized, long-term study, the Tennessee Student Teacher Achievement Ratio (STAR) experiment from 1985 through 1989. The STAR study took place in the Tennessee public school system, encompassing two groups of students: those who received treatment, small class intervention, 657 students, and students who did not, 5,689. …

Lanthorn, Vol. 59, No. 05, October 7, 2024, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Dna Methylation Near Mad1l1, Kdm2b, And Socs3 Mediates The Effect Of Socioeconomic Status On Elevated Body Mass Index In African American Adults, Brooke S Staley, Kendra Ferrier, Jan Bressler, Laura Loehr, Laura M Raffield, Mario Sims, Kari E North, Lindsay Fernández-Rhodes

Faculty, Staff and Student Publications

Obesity and poverty disproportionally affect African American persons. Epigenetic mechanisms could partially explain the association between socioeconomic disadvantage and body mass index (BMI). We examined the extent to which epigenetic mechanisms mediate the effect of socioeconomic status (SES) on BMI. Using data from African American adults from the Atherosclerosis Risk in Communities (ARIC) Study (n = 2664, mean age = 57 years), education, income, and occupation were used to create a composite SES score at visit 1 (1987-1989). We conducted two methylation-wide association analyses to identify associations between SES (visit 1), BMI and cytosine-phosphate-guanine (CpG) sites measured at a subsequent …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

October 7th - We Remember, Jewish Law Student Association (Jlsa)

2024–2025 Flyers

No abstract provided.

Jazz Ensemble Ii & Iii

Bailey School of Music Concert Programs

Jazz Ensemble II & III

From Sample To Population Generalization In Qualitative Research, Florentina Scârneci-Domnișoru

The Qualitative Report

The split of methodology into qualitative and quantitative had all sorts of negative consequences, including the neglecting of some important scientific goals, such as generalizing research results in qualitative studies. Even if they don’t talk about generalizations, many qualitative researchers illegitimately extend their research results to populations much wider than those investigated. The article shows that the generalization of research results (from sample to population) is possible in qualitative research but that it can only be achieved through a sampling procedure that complies with specific rules. The article describes this procedure of internal generalization of results through a logical or …

Evaluation Of Health Recommender Systems: A Scoping Review Protocol, Ananya Ananthakrishnan, Madison Milne-Ives, Rohit Shankar, Edward Meinert

Peninsula Medical School

Background People increasingly rely on online health information for their health-related decision-making. Given the overwhelming amount of information available, the risk of misinformation is high. Health recommender systems, which recommend personalised health-related information or interventions using intelligent algorithms, have the potential to address this issue. Many such systems have been developed and evaluated individually, but there is a need to synthesise the evaluation findings to identify gaps and ensure that future recommender systems are designed to have a positive impact on health or target behaviours.Objective The purpose of this review is to provide an overview of the state of the …

Primary Care Experiences Of Adults Reporting Learning Disability: A Probability Sample Survey, Rohit Shankar

Peninsula Medical School

BACKGROUND: Adults with learning disability face multiple adversities, but evidence on their needs and primary care experiences is limited.

AIM: To compare the characteristics and primary care experiences of adults reporting learning disability with those who did not.

DESIGN AND SETTING: This was an analysis of the 2022 General Practice Patient Survey, a national probability sample survey conducted in 2022 with people registered with NHS primary care in England.

METHOD: This analysis reports descriptive profiles, weighted and with 95% confidence intervals. Logistic regression models adjusting for gender, age, ethnicity, and area-level deprivation compared experiences of adults reporting learning disability with …

A Geospatial Approach To Landscape Gaze Using Social Media To Evaluate How People Value Landscapes In An Urban Context, Riley Bibaud, Eva Mcgrath, Zoe Sydenham, Richard Yarwood, Tom Mullier, Siân Rees

School of Biological and Marine Sciences

Urban park management generally prioritises green spaces and activities within park boundaries, rather than landscape interactions. Understanding how people experience and connect with broader landscapes is essential for improving societal environmental, economic and wellbeing outcomes. A geospatial and discourse analysis of three urban parks was conducted in Plymouth, UK. The predominant landscape gaze at each park revealed strong social ties to blue spaces–namely the coast and sea–indicating an interconnectedness between parks and coastal spaces beyond park boundaries. Textual analysis emphasised the beauty of nature, the expanse of the ocean, and the health and wellbeing benefits of blue and green spaces. …

Feature Boosting With Efficient Attention For Scene Parsing, Vivek Singh, Shailza Sharma, Fabio Cuzzolin

School of Engineering, Computing and Mathematics

The complexity of scene parsing grows with the number of object and scene classes, which is higher in unrestricted open scenes. The biggest challenge is to model the spatial relation between scene elements while succeeding in identifying objects at smaller scales. This paper presents a novel feature-boosting network that gathers spatial context from multiple levels of feature extraction and computes the attention weights for each level of representation to generate the final class labels. A novel ‘channel attention module’ is designed to compute the attention weights, ensuring that features from the relevant extraction stages are boosted while the others are …

Mixing Between Flavor Singlets In Lattice Gauge Theories Coupled To Matter Fields In Multiple Representations, Ed Bennett, Niccolò Forzano, Deog Ki Hong, Ho Hsiao, Jong Wan Lee, C. J.David Lin, Biagio Lucini, Maurizio Piai, Davide Vadacchino, Fabian Zierler

School of Engineering, Computing and Mathematics

We provide the first extensive, numerical study of the nontrivial problem of mixing between flavor-singlet composite states emerging in strongly coupled lattice field theories with matter field content consisting of fermions transforming in different representations of the gauge group. The theory of interest is the minimal candidate for a composite Higgs model that also accommodates a mechanism for top partial compositeness: the Sp(4) gauge theory coupled to two (Dirac) fermions transforming as the fundamental and three as the two-index antisymmetric representation of the gauge group, respectively. We apply an admixture of APE smearing and Wuppertal smearings, as well as the …

Human Epidemiology And Response To Sars-Cov-2 (Heros): Objectives, Design, And Enrollment Results Of A 12-City Remote Observational Surveillance Study Of Households With Children, Using Direct-To-Participant Methods, Patricia C Fulkerson, Katherine Rivera-Spoljaric, Et Al.

2020-Current year OA Pubs

The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and allergic diseases, and to use the host nasal transcriptome sampled longitudinally to understand infection risk and sequelae at the molecular level. To overcome challenges of clinical study implementation due to the coronavirus pandemic, this surveillance study used direct-to-participant methods to remotely enroll and prospectively follow eligible children who are participants in other National Institutes of Health-funded pediatric …

Xenotransplanted Human Organoids Identify Transepithelial Zinc Transport As A Key Mediator Of Intestinal Adaptation, Maame Efua S Sampah, Vered Gazit, Deborah C Rubin, Et Al.

2020-Current year OA Pubs

Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is crucial in improving outcomes. To understand the human gene pathways associated with adaptation, we perform single-cell transcriptomic analysis of human small intestinal organoids explanted from mice with experimental SBS. We show that transmembrane ion pathways, specifically the transepithelial zinc transport pathway genes SLC39A4 and SLC39A5, are upregulated in SBS. This discovery is corroborated by an external dataset, bulk RT-qPCR, and Western blots. Oral zinc supplementation is shown to improve survival and weight gain of SBS mice and increase the proliferation of intestinal crypt cells in vitro. Finally, …

Understanding Students` Attitude And Intention Towards Vocational Education And Training (Vet) In The Sultanate Of Oman, Shweta Belwal, Fatma Rashid Al Moqbali, Rakesh Belwal

Plymouth Business School

The current study investigates the influence of attitudes, subjective norms (SN), and perceived behavioural control (PBC) in understanding the intentions of Grade 11 and Grade 12 (N = 376) students in Oman to join vocational education and training (VET) institutions. The study’s objectives were twofold: to assess secondary-school students’ attitudes toward vocational education and to investigate their intentions to join VET. A quantitative approach following the partial least square-based structural equation modelling was used. According to the findings, attitudes, PBC, and SNs, exhibit a significant favourable influence on students’ intention to join VET. However, some partial invariance to the relationship …

Performance Of A Bipolar Output Voltage Dc-Dc Converter For Voltage Regulation For Solar Pv System Application, Stampinus M. Stephano, Jackson. J. Justo, Bakari M. M. Mwinyiwiwa

Tanzania Journal of Science

A combined Single-Ended Primary-Inductor Converter (SEPIC) and Cuk DC-DC converter that provides a bipolar outputs voltage at the DC bus is widely used in applications especially solar photovoltaic (SPV) system. Maintaining constant output voltages at the DC bus under variable loads and input voltage from SPV is of great interest to many researchers. This paper presents a 400 W mathematical model of a combined SEPIC and Cuk DC-DC converter through state space averaging (SSA) in a continuous conduction mode (CCM). A nested voltage and current control loops are used to regulate voltage and increase the performance of the converter. These …

Trβ Activation Confers At2-To-At1 Cell Differentiation And Anti-Fibrosis During Lung Repair Via Klf2 And Cebpa, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O Rosas, Guoying Yu

Faculty, Staff and Students Publications

Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for lung regeneration. Moreover, thyroid hormone receptor α (TRα) promotes cell proliferation, while TRβ fuels cell maturation in lung regeneration. Using a specific TRβ agonist, sobetirome, we demonstrate that the anti-fibrotic effects of thyroid hormone mainly rely on TRβ in mice. Cellularly, TRβ activation enhances alveolar type-2 (AT2) cell differentiation into AT1 cell and constrains AT2 cell hyperplasia. Molecularly, TRβ activation directly regulates the …

Ndls Communicator: Week Of 10.07.24, Notre Dame Law School

NDLS Communicator

The Latest News

• Event Recap: American Democracy and the 2024 Election
• Anton Burri-Wenzel joins Notre Dame Law School as first postdoctoral fellow for the Program on Law & Economics
• Global Human Rights Clinic submits review of UN Bulletin on the Protection from Sexual Exploitation and Abuse
• In this episode of the DEI Podcast, Max Gaston talks with Jemar Tisby, New York Times bestselling author and Notre Dame alum, about his latest book, The Spirit of Justice: True Stories of Faith, Race, and Resistance.

Faculty News and Briefs

• Last week, Sam Bray spoke at a Festschrift honoring Profesor Douglas Laycock at …