Digital Commons Network^™

The Role Of Group 2 Innate Lymphoid Cells In Restoring Lung Health And Chitinase Function After Epithelial Injury, Haerin Jung

Arts & Sciences Graduate Student Theses and Dissertations

Alveolar epithelial cells provide oxygen transport and act as a first line of defense against pathogens and environmental triggers that disturb tissue homeostasis. However, in the context of epithelial injury, fibrotic and inflammatory lung diseases develop where regenerative responses may become dysregulated or recurrently engaged. One cause of lung injury is infection with cytopathic respiratory viruses such as influenza and SARS-CoV-2 viruses, which induce lung inflammation, tissue damage, and epithelial cell injury and loss. Restoration of barrier integrity after lung injury is critical for re-establishing healthy lung function but the underlying mechanisms are unclear. In the steady state, lung epithelial …

Rapid Unleashing Macrophage Efferocytic Capacity By Transcriptional Pause Release, Turan Tufan

Arts & Sciences Graduate Student Theses and Dissertations

During development, inflammation or tissue injury, macrophages engulf multiple apoptotic cells via efferocytosis to maintain tissue homeostasis. The mechanism by which macrophages rapidly adapt their transcription for continuous corpse uptake is not well understood. Transcriptional pause/release is a conserved mechanism, in which RNA polymerase (Pol) II initiates transcription for 20-60 nucleotides, is paused for minutes to hours and is then released to the elongation phase. We show that macrophages quickly use Pol II pause/release upon encountering corpses to trigger a rapid transcriptional response. This mechanism is essential for continuous efferocytosis but does not affect other forms of phagocytosis. Genomic data …

Dean Melanie Leslie’S Office, Benjamin N. Cardozo School Of Law

2024 Event Invitations

Join Dean Leslie and Professor Zalman Rothschild for a discussion on the First Amendment, anti-discrimination law, and law and religion, as well as any questions raised by student attendees.

مدى مساهمة الهندسة البشرية الخضراء في خفض مستويات الاصابة بالأمراض المهنية: دراسة ميدانية في عدد من المصانع في محافظة نينوى, رياض جميل وهاب, عمر سعيد عبد الله

Muthanna Journal of Administrative and Economics Sciences

يسعى البحث الى قياس وتحديد مستوى مساهمة الهندسة البشرية الخضراء في خفض مستويات الاصابة بالأمراض المهنية وبالتالي انعكاس ذلك عل تحسين اداء العاملين وارتفاع الانتاجية ورفع الروح المعنوية للأفراد العاملين في بيئية العمل . يمكن تمثيل مشكلة البحث بانه ( بيئة العمل تعاني من ضعف الانتاجية نتيجة استخدام الوسائل والادوات التقليدية ذات الاثر السلبي على صحة وسلامة الافراد العاملين في الميدان المبحوث) ولغرض معالجة المشكلة المطروحة تم اختيار مدخل الهندسة البشرية الخضراء لتجاوز نقاط الضعف في المستلزمات المادية المستخدمة في بيئة العمل .وتم الاعتماد على الاستبانة كأداة رئيسية للحصول على البيانات من الميدان المبحوث ، تمثل عينة البحث بالأفراد العاملين …

Understanding Emotional Outbursts: A Cross-Cultural Study In Latin American Children With Autism Spectrum Disorder, Maria Cristina Triguero Veloz Teixeira, Rosane Lowenthal, Alexia Rattazzi, Sebastián Cukier, Daniel Valdez, Ricardo Garcia, Gabriela Garrido Candela, Analia Rosoli Murillo, Francislene Pereira Da Silva Leite, Cecilia Montiel-Nava

Psychological Science Faculty Publications

Objectives: One of the behavioral problems strongly associated with emotional dysregulation (ED) in ASD is emotional outbursts (EOs) characterized by a pattern of challenging behavior that varies across individuals and across time. Cultural factors can modulate the expression of EOs. This study aimed to characterize the profile of emotional outbursts (EOs) in children with autism spectrum disorder (ASD) across various countries in Latin America and to identify clinical, emotional, and contextual factors that contribute to the onset and frequency of EOs within this diverse sample. Methods: A cross-sectional and cross-cultural study was conducted between 2023 and 2024 comprising samples from …

Closed-Loop Adaptive Optics In The Presence Of Speckle And Weak Scintillation, Derek J. Burrell, Mark F. Spencer, Ronald G. Driggers

Faculty Publications

In this paper, we show that speckle averaging helps to improve adaptive-optics (AO) performance in closed loop as a result of reduced measurement error associated with a Shack–Hartmann wavefront sensor (SHWFS); however, this reduction is rendered ineffective with increasing beacon anisoplanatism. We do so operating in a weak-scintillation regime, where the SHWFS offers robust performance, and using in-plane translation of the illuminated rough surface to accomplish frame-to-frame speckle diversity. Understanding these trade-space limitations is critical when performing AO with non-cooperative, extended-source beacons.

Challenges And Future Directions In Quantifying Terrestrial Evapotranspiration, Koong Yi, Gabriel B. Senay, Joshua B. Fisher, Lixin Wang, Kosana Suvočarev, Housen Chu, Georgianne W. Moore, Kimberly A. Novick, Mallory L. Barnes, Trevor F. Keenan, Kanishka Mallick, Xiangzhong Luo, Justine E. C. Missik, Kyle B. Delwiche, Jacob A. Nelson, Stephen P. Good, Xiangming Xiao, Steven A. Kannenberg, Arman Ahmadi, Tianxin Wang, Gil Bohrer, Marcy E. Litvak, David E. Reed, A. Christopher Oishi, Margaret S. Torn, Dennis Baldocchi

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Terrestrial evapotranspiration is the second-largest component of the land water cycle, linking the water, energy, and carbon cycles and influencing the productivity and health of ecosystems. The dynamics of ET across a spectrum of spatiotemporal scales and their controls remain an active focus of research across different science disciplines. Here, we provide an overview of the current state of ET science across in situ measurements, partitioning of ET, and remote sensing, and discuss how different approaches complement one another based on their advantages and shortcomings. We aim to facilitate collaboration among a cross-disciplinary group of ET scientists to overcome the …

2024 Annual Flu Shot And Covid-19 Vaccine Event, New York Law School

Miscellaneous Campus Flyers

October 8, 2024

October 16, 2024

Aspect-Ratio-Dependent Heat Transport By Baroclinic Acoustic Streaming, Jacques Abdul Massih, Remil Mushthaq, Guillaume Michel, Gregory P. Chini

Faculty Publications

Standing acoustic waves have been known to generate Eulerian time-mean ‘streaming’ flows at least since the seminal investigation of Lord Rayleigh in the 1880s. Nevertheless, a recent body of numerical and experimental evidence has shown that inhomogeneities in the ambient density distribution lead to much faster flows than arise in classical Rayleigh streaming. The emergence of these unusually strong flows creates new opportunities to enhance heat transfer in systems in which convective cooling cannot otherwise be easily achieved. To assess this possibility, a theoretical study of acoustic streaming in an ideal gas confined in a rectangular channel with top and …

Impact Of Cancer Therapy On Clonal Hematopoiesis Mutations And Subsequent Clinical Outcomes, Kevin T Nead, Taebeom Kim, Lijin Joo, Tina L Mcdowell, Justin W Wong, Elizabeth Brock, Ting Xu, Chad Tang, Chang-Lung Lee, Jun-Ichi Abe, Kelly L Bolton, Zhongxing Liao, Paul A Scheet, Steven H Lin

Faculty, Staff and Student Publications

Exposure to cancer therapies is associated with an increased risk of clonal hematopoiesis (CH). The objective of our study was to investigate the genesis and evolution of CH after cancer therapy. In this prospective study, we undertook error-corrected duplex DNA sequencing in blood samples collected before and at 2 time points after chemoradiation in patients with esophageal or lung cancer recruited from 2013 to 2018. We applied a customized workflow to identify the earliest changes in CH mutation count and clone size and determine their association with clinical outcomes. Our study included 29 patients (87 samples). Their median age was …

Fast, Variable Stiffness-Induced Braided Coiled Artificial Muscles, Xinghao Hu, Xiangyu Wang, Jian Wang, Guorong Zhang, Shaoli Fang, Ye Xiao, Ray H Baughman, Jianning Ding

Faculty, Staff and Student Publications

Biomimetic actuation technologies with high muscle strokes, cycle rates, and work capacities are necessary for robotic systems. We present a muscle type that operates based on changes in muscle stiffness caused by volume expansion. This muscle is created by coiling a mechanically strong braid, in which an elastomer hollow tube is adhesively attached inside. We show that the muscle reversibly contracts by 47.3% when driven by an oscillating input air pressure of 120 kilopascals at 10 Hz. It generates a maximum power density of 3.0 W/g and demonstrates a mechanical contractile efficiency of 74%. The muscle's low-pressure operation allowed for …

Rapid Hyperspectral Photothermal Mid-Infrared Spectroscopic Imaging From Sparse Data For Gynecologic Cancer Tissue Subtyping, Reza Reihanisaransari, Chalapathi Charan Gajjela, Xinyu Wu, Ragib Ishrak, Sara Corvigno, Jinsong Liu, David Mayerich, Sebastian Berisha, Rohith Reddy

Faculty, Staff and Student Publications

Ovarian cancer detection has traditionally relied on a multistep process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from several drawbacks: it is qualitative, time-intensive, and heavily dependent on the quality of staining. Mid-infrared (MIR) hyperspectral photothermal imaging is a label-free, biochemically quantitative technology that, when combined with machine learning algorithms, can eliminate the need for staining and provide quantitative results comparable to traditional histology. However, this technology is slow. This work presents a novel approach to MIR photothermal imaging that enhances its speed by an order of magnitude. This …

Ct Strain Metrics Allow For Earlier Diagnosis Of Bronchiolitis Obliterans Syndrome After Hematopoietic Cell Transplant, Husham Sharifi, Christopher D Bertini, Mansour Alkhunaizi, Maria Hernandez, Zayan Musa, Ihsan Turk, Burton F Dickey, Guang-Shing Cheng, Gregory Yanik, Craig J Galban, Huawei Henry Guo, Myrna C B Godoy, Joseph M Reinhardt, Eric A Hoffman, Mario Castro, Gabriela Rondon, Amin M Alousi, Richard E Champlin, Elizabeth J Shpall, Ying Lu, Samuel Peterson, Keshav Datta, Mark R Nicolls, Joe Hsu, Ajay Sheshadri

Faculty, Staff and Student Publications

Bronchiolitis obliterans syndrome (BOS) after hematopoietic cell transplantation (HCT) is associated with substantial morbidity and mortality. Quantitative computed tomography (qCT) can help diagnose advanced BOS meeting National Institutes of Health (NIH) criteria (NIH-BOS) but has not been used to diagnose early, often asymptomatic BOS (early BOS), limiting the potential for early intervention and improved outcomes. Using pulmonary function tests (PFTs) to define NIH-BOS, early BOS, and mixed BOS (NIH-BOS with restrictive lung disease) in patients from 2 large cancer centers, we applied qCT to identify early BOS and distinguish between types of BOS. Patients with transient impairment or healthy lungs …

The Impact Of A Web-Based Prognostic Calculator On Prognostic Confidence In Outpatient Palliative Care, David Hui, John P Maxwell, Allison De La Rosa, Kristofer Jennings, Marieberta Vidal, Ahsan Azhar, Kimberson Tanco, Yvonne Heung, Marvin Delgado-Guay, Donna Zhukovsky, Joseph Arthur, Suresh Reddy, Sriram Yennu, Amy Ontai, Eduardo Bruera

Faculty, Staff and Student Publications

Purpose: Clinicians are often uncertain about their prognostic estimates, which may impede prognostic communication and clinical decision-making. We assessed the impact of a web-based prognostic calculator on physicians' prognostic confidence.

Methods: In this prospective study, palliative care physicians estimated the prognosis of patients with advanced cancer in an outpatient clinic using the temporal, surprise, and probabilistic approaches for 6 m, 3 m, 2 m, 1 m, 2 w, 1 w, and 3 d. They then reviewed information from www.predictsurvival.com , which calculated survival estimates from seven validated prognostic scores, including the Palliative Prognostic Score, Palliative Prognostic Index, and Palliative Performance …

Atr Inhibition Radiosensitizes Cells Through Augmented Dna Damage And G2 Cell Cycle Arrest Abrogation, Scott J Bright, Mandira Manandhar, David B Flint, Rishab Kolachina, Mariam Ben Kacem, Broderick X Turner, Conor H Mcfadden, Poliana C Marinello, Simona F Shaitelman, Gabriel O Sawakuchi

Faculty, Staff and Student Publications

Ataxia telangiectasia and Rad3-related protein (ATR) is a key DNA damage response protein that facilitates DNA damage repair and regulates cell cycle progression. As such, ATR is an important component of the cellular response to radiation, particularly in cancer cells, which show altered DNA damage response and aberrant cell cycle checkpoints. Therefore, ATR's pharmacological inhibition could be an effective radiosensitization strategy to improve radiotherapy. We assessed the ability of an ATR inhibitor, AZD6738, to sensitize cancer cell lines of various histologic types to photon and proton radiotherapy. We found that radiosensitization took place through persistent DNA damage and abrogated G2 …

Development And Assessment Of A Point-Of-Care Application (Genomic Medicine Guidance) For Heritable Thoracic Aortic Disease

Faculty, Staff and Student Publications

Background: Genetic testing can determine familial and personal risks for heritable thoracic aortic aneurysms and dissections (TAD). The 2022 American College of Cardiology/American Heart Association guidelines for TAD recommend management decisions based on the specific gene mutation. However, many clinicians lack sufficient comfort or insight to integrate genetic information into clinical practice.

Objective: We therefore developed the Genomic Medicine Guidance (GMG) application, an interactive point-of-care tool to inform clinicians and patients about TAD diagnosis, treatment, and surveillance. GMG is a REDCap-based application that combines publicly available genetic data and clinical recommendations based on the TAD guidelines into one translational education …

Assessing Benthic Recovery Below The United Kingdom's First Large-Scale, Offshore, Longline Mussel Farm, Llucia Mascorda-Cabre, Philip Hosegood, Martin Attrill, Emma Sheehan

School of Biological and Marine Sciences

The recent expansion of the aquaculture industry into the offshore marine environment is perceived to have a comparatively low environmental impact coupled with a high growth potential as a sustainable, large-scale source of healthy protein. This study assessed changes in sediment characteristics and infauna assemblages following the development of the first large-scale offshore longline mussel farm in the United Kingdom. By evaluating the effects of the farm on the sediment ecosystem and by studying infaunal sediment environmental parameters along a distance gradient away from the farm, the first before-after control-impact (BACI) study of an offshore shellfish farm is presented. Sediment …

Under Pressure: Employee Work Stress, Supervisory Mentoring Support, And Employee Career Success, Berrin Erdogan, Selin Kudret, Emily D. Campion, Talya N. Bauer, Julie Mccarthy, Bonnie Hayden Cheng

Business Faculty Publications and Presentations

Despite consistent findings that stressed employees benefit from social support, these employees do not always have access to such support. We propose and test a conceptual model suggesting employee work stress will negatively affect supervisory career and psychosocial mentoring support. Drawing from social exchange theory, we predict this will indirectly affect employee career success (lower career satisfaction and promotability ratings, fewer promotions), and that the relationship between employee work stress and lower supervisory mentoring support can be explained by lower levels of work engagement experienced by, and attributed to, stressed employees. We tested our model across three studies. In Study …

Context-Preserving One-Click Task Creation Via Operating System Context Menu, Alexandra Hill

Defensive Publications Series

The process of adding tasks to a list in a task management application requires users to switch focus away from their current task and can require multiple clicks or actions. Managing and consolidating tasks across various productivity workflows can be overwhelming for users. Further, capturing the relevant context associated with a task can be challenging and time-consuming. This disclosure describes techniques that enable users to create tasks from any text on the screen of their device, such as a laptop, tablet, smartphone, etc. The techniques can be implemented as part of a device operating system and provide a seamless and …

A System And Method To Auto Generate Next Suspicious Purchase And Create Block Rule, Durga S. Kala, Varun Sharma, Chandan Das

Defensive Publications Series

The present disclosure provides a system and a method for generating an alert 106 for fraudulent transactions. The disclosure proposes a suspicious fraud purchase generator system 104 which receives streaming transaction flow from the transaction data 102, filters transactions from the streaming transaction flow, dispose the transactions into categories such as good, discard or fraud, the fraud transactions are processed with Gen AI algorithm, the Gen AI algorithm out generate an alert 106 for the fraudulent transactions.

Hybrid Cooling For Modular Electronic Systems, Karthik D Mayya, Jongsuk Hyun, Allen Siaotong, Tushara Ramesh, Mandy Lam

Defensive Publications Series

A hybrid cooling system for modular electronic systems is presented herein. The cooling system utilizes aluminum fins with coolant ducts retrofitted to the top and bottom enclosures of a chassis. During operation, the coolant can absorb heat from the electronic system environment and transfer the heat away from the electronic system.

A Review Of Slow Noodles: A Cambodian Memoir Of Love, Loss, And Family Recipes, Engheang Nol

Journal of Southeast Asian American Education and Advancement

"Slow Noodles: A Cambodian Memoir of Love, Loss, and Family Recipes" by Chantha Nguon, with assistance from Kim Green, is a poignant exploration of the author's journey from a Cambodian refugee to a beacon of empowerment in her homeland. This review delves into the book's narrative structure, which intertwines personal anecdotes with culinary reflections, offering a unique lens into the complexities of Chantha’s personal life. Through a detailed analysis of select chapters, including "Chicken-Lime Soup for the Village Soul" and "Instant Noodles," the review examines themes of resilience, identity, and especially societal expectations for what and how Cambodian women should …

Sisterhood And Authenticity: The Experiences Of Generation Z Sorority Women In National Panhellenic Council (Npc) Chapters, Pietro A. Sasso, Kim E. Bullington, Melissa Bidinger

New York Journal of Student Affairs

Generation Z (Gen Z) has entered higher education and is not the traditional undergraduate student (18-24) and are the contemporary members of sororities. Gen Z is different from their Millennial predecessors and requires a reexamination to meet the needs of college students today. This qualitative study examined how National Panhellenic Conference (NPC) sorority members who are in Gen Z described their connectedness through sense of belonging and their own generation. We identified two themes: (1) the importance of authenticity and deep connections and (2) emerging Gen Z group identity. Recommendations for practice include more interpersonal recruitment efforts and leadership development …

Operation And Management Of A Modern Park And Recreation System, Christopher Sullivan

Sustainability Seminar Series

The talk will focus on the various operational divisions which comprise most park and recreation agencies and how they work together to provide a modern park and recreation system to visitors, along with the common management challenges which face park and recreation agencies. On average, the Passaic County Department of Parks and Recreation employs 75 permanent employees and 113 seasonal. The department provides various recreation and environmental education activities throughout the year for all age levels, including a comprehensive K-5 elementary school based environmental education program which educates approximately 1,200 children per year and is available to all public and …

"The Heart To Friendship True" Poem

Asa Hoxey Family Papers

Two-page poem written for Sarah Ann Hoxey titled "The Heart to Friendship True."

Fall 2024 Full Issue, Undergraduate Research

PANDION: The Osprey Journal of Research and Ideas

No abstract provided.

Baby Boy, Elysa Adams

PANDION: The Osprey Journal of Research and Ideas

Artist Statement

Baby Boy is a tribute to friends lost in 2022 and 2023. he crown of flowers within the artwork serves as a metaphor, for the symbolic crucifixion of Black men. The piece reveals the harsh reality that numerous Black boys face challenges that prevent them from reaching adulthood. It emphasizes the lack of protection, highlighting a world that targets and jeopardizes their well-being. he narrative is represented through a woodcut of a young Black man.

My creative journey is inspired by the untold stories and vibrant spirits that permeate my community. I am motivated by a profound drive …

A Handful, Prathna Nirav Patel

PANDION: The Osprey Journal of Research and Ideas

Artist Statement

I created this drawing for my Drawing I class, where I was introduced to the cross-hatching method. Through this technique, I aimed to physicalize emotion through the beauty and expressiveness of the human hand. The title, A Handful, represents not only the literal handful of hands shown, but also the handful of emotions and experiences behind each one.

Fye Theater Showcase, Mindy Mclarty

PANDION: The Osprey Journal of Research and Ideas

Artist Statement

When I originally decided to make a poster to advertise our cohort’s final showcase, I knew I wanted it to be inspired by Nora’s character from A Doll’s House. Our class read this play, by Henrik Ibsen, which tells the story of Nora, and her stifling life married to her husband. Nora realizes her life and role as a mother is not what she thought it was. Her life is superficial, and this peripheral view that the audience has of the story made me start thinking about the character’s doll-like qualities. Between this and the play’s title, it …

Study Of A Lemon, Marcella Carson

PANDION: The Osprey Journal of Research and Ideas

No abstract provided.