Digital Commons Network^™

The Prospector, October 8, 2024, Utep Student Publications

The Prospector

No abstract provided.

Whole Genomes Of Amazonian Uakari Monkeys Reveal Complex Connectivity And Fast Differentiation Driven By High Environmental Dynamism, Claudia Fontsere, Alejandro Valenzuela-Seba, Harvinder Pawar, Marta Gut, Joanna L Kelley, Sandra Ruibal-Puertas, Pol Alentorn-Moron, Armida Faella, Esther Lizano, Izeni Farias, Tomas Hrbek, Joao Valsecchi, Ivo G Gut, Jeffrey Rogers, Kyle Kai-How Farh, Lukas F K Kuderna, Tomas Marques-Bonet, Jean P Boubli

Faculty, Staff and Students Publications

Despite showing the greatest primate diversity on the planet, genomic studies on Amazonian primates show very little representation in the literature. With 48 geolocalized high coverage whole genomes from wild uakari monkeys, we present the first population-level study on platyrrhines using whole genome data. In a very restricted range of the Amazon rainforest, eight uakari species (Cacajao genus) have been described and categorized into the bald and black uakari groups, based on phenotypic and ecological differences. Despite a slight habitat overlap, we show that posterior to their split 0.92 Mya, bald and black uakaris have remained independent, without gene flow. …

Tca Metabolism Regulates Dna Hypermethylation In Lps And Mycobacterium Tuberculosis–Induced Immune Tolerance, Malik Ladki, Daanish Sheikh, Amera L Martinez, Emily M Mace, Sandra L Grimm, Thaleia Caldwell, Alexandra Portillo Varela, Rajagopal V Sekhar, Anna M Mandalakas, Mandla Mlotshwa, Sibuse Ginidza, Jeffrey D Cirillo, Robert S Wallis, Mihai G Netea, Reinout Van Crevel, Cristian Coarfa, Andrew R Dinardo

Faculty, Staff and Students Publications

Severe and chronic infections, including pneumonia, sepsis, and tuberculosis (TB), induce long-lasting epigenetic changes that are associated with an increase in all-cause postinfectious morbidity and mortality. Oncology studies identified metabolic drivers of the epigenetic landscape, with the tricarboxylic acid (TCA) cycle acting as a central hub. It is unknown if the TCA cycle also regulates epigenetics, specifically DNA methylation, after infection-induced immune tolerance. The following studies demonstrate that lipopolysaccharide and Mycobacterium tuberculosis induce changes in DNA methylation that are mediated by the TCA cycle. Infection-induced DNA hypermethylation is mitigated by inhibitors of cellular metabolism (rapamycin, everolimus, metformin) and the TCA …

Membrane Association And Polar Localization Of The Legionella Pneumophila T4ss Doto Atpase Mediated By Two Nonredundant Receptors, Sukhithasri Vijayrajratnam, Sonja Milek, Stefano Maggi, Kaleigh Ashen, Micah Ferrell, Ahmet Hasanovic, Agnieszka Holgerson, Shanmugapriya Kannaiah, Manpreet Singh, Debnath Ghosal, Grant J Jensen, Joseph P Vogel

2020-Current year OA Pubs

The

Impact Of Cancer Therapy On Clonal Hematopoiesis Mutations And Subsequent Clinical Outcomes, Kevin T Nead, Irenaeus C C Chan, Kelly L Bolton, Et Al.

2020-Current year OA Pubs

Exposure to cancer therapies is associated with an increased risk of clonal hematopoiesis (CH). The objective of our study was to investigate the genesis and evolution of CH after cancer therapy. In this prospective study, we undertook error-corrected duplex DNA sequencing in blood samples collected before and at 2 time points after chemoradiation in patients with esophageal or lung cancer recruited from 2013 to 2018. We applied a customized workflow to identify the earliest changes in CH mutation count and clone size and determine their association with clinical outcomes. Our study included 29 patients (87 samples). Their median age was …

Addressing Once More The (Im)Possibility Of Color Reconstruction In Underwater Images, Yuri Rzhanov, Kim Lowell

Center for Coastal and Ocean Mapping

Color is an important cue in object recognition and classification problems. In underwater imagery, colors undergo strong distortion due to light propagation through an absorbing and scattering medium. Distortions depend on a number of complex phenomena, the most important being wavelength-dependent absorption and the sensitivity of sensors in trichromatic cameras. It has been shown previously that unique reconstruction in this case is not possible—at least for a simplified image formation model. In this paper, the authors use numerical simulations to demonstrate that this statement also holds for the underwater image formation model that is currently the most sophisticated.

Flagellar Motility Is Mutagenic, Souvik Bhattacharyya, Shelby Lopez, Abhyudai Singh, Rasika M Harshey

Faculty, Staff and Student Publications

Flagella are highly complex rotary molecular machines that enable bacteria to not only migrate to optimal environments but also to promote range expansion, competitiveness, virulence, and antibiotic survival. Flagellar motility is an energy-demanding process, where the sum of its production (biosynthesis) and operation (rotation) costs has been estimated to total ~10% of the entire energy budget of an

Advanced Air Mobility (Aam) Is Coming To A Town Near You...Are You Ready?, Sarah Nilsson

Publications

This briefing provides a high and low altitude view of what is coming in the way of Advanced Air Mobility (AAM) innovation. It is meant for county, town, or city officials; tribal governments; local businesspersons; airport, heliport, Fixed Base Operator (FBO), flight schools’ owners/operators; and other individuals; who wish to capitalize on, and prepare for, a US industry expected to hit around USD 68 Billion by 2032. Is your community or organization prepared for this new economy? Are your customers, or constituents accepting of these new technologies? Are you ready to capitalize on this AAM market and all the growth …

Perceptions Of Rural America: Exploring College Students' Views And Career Priorities Post-Graduation, Tom Hall

USF Tampa Graduate Theses and Dissertations

The problems facing rural America are wide ranging and multilayered. Perceptions can often be reality for those unfamiliar with rural life, which can pose a hurdle for businesses to overcome. With an in-depth literature review and research study, this dissertation aims to provide context and understanding to the problems and misconceptions of rural America. Without context, it is easy to interpret rural America as a dying, outdated part of the country, but the reality is far more complex. A research study was conducted that surveyed 400 actively enrolled college students from schools in 19 American states on three things: 1) …

Alliance A061202: Ixazomib, Pomalidomide, And Dexamethasone For Patients With Lenalidomide-Refractory Mm In First Relapse., Peter Voorhees, Vera Suman, Yvonne Efebera, Noopur Raje, Sascha Tuchman, Cesar Rodriguez, Jacob Laubach, Misty Bova-Solem, Destin Carlisle, Saad Usmani, Philip Mccarthy, Paul G Richardson

Oncology Articles

Optimal therapy for the growing number of patients with lenalidomide (LEN)-refractory multiple myeloma in their first relapse remains poorly defined. We therefore undertook a randomized phase 2 study to evaluate the efficacy and safety of combining the oral proteasome inhibitor ixazomib (IXA) with pomalidomide (POM) and dexamethasone (DEX) in this patient population. The overall response rate (ORR) for POM-DEX was 43.6%, and for IXA-POM-DEX, it was 63.2%. The depth of response, measured by the attainment of at least a very good partial response, favored triplet therapy over doublet therapy (28.9% vs 5.1%; P = .0063). A preplanned interim analysis after …

Portfolio Optimization Tools In Excel, Tom Arnold, Joseph Farizo, Terry D. Nixon

Finance Faculty Publications

The calculus and matrix algebra associated with finding the optimal portfolio weights for a set of securities is tedious. However, Excel tools make the computations simple, with minimal programming needed to arrive at optimal portfolio weights for securities in a portfolio. We provide this Excel template and techniques for acquiring optimal weights, which is useful for personal and institutional investors alike.

Takeaways:

• The calculus and matrix algebra associated with optimizing portfolio weights is tedious, but not necessary for finding optimal portfolio weights
• Based on the results of the associated mathematics for optimizing portfolio weights, a very accessible Excel template can …

Self-Management Systems For Patients And Clinicians In Parkinson's Disease Care: A Scoping Review, Selina Boege, Madison Milne-Ives, Ananya Ananthakrishnan, Camille Carroll, Edward Meinert

Peninsula Medical School

Background: Digital self-management tools including mobile apps and wearables can enhance personalized care in Parkinson's disease, and incorporating patient and clinician feedback into their evaluation can empower users and nurture patient-clinician relationships, necessitating a review to assess the state of the art and refine their use. Objective: This review aimed to summarize the state of the art of self-management systems used in Parkinson's disease management, detailing the application of self-management techniques and the integration of clinicians. It also aimed to provide a concise synthesis on the acceptance and usability of these systems from the clinicians' standpoint, reflecting both patient engagement …

Multidimensional Profiling Of Human T Cells Reveals High Cd38 Expression, Marking Recent Thymic Emigrants And Age-Related Naive T Cell Remodeling, Pavla Bohacova, Marina Terekhova, Riley Mullins, Kamila Husarcikova, Irina Shchukina, Alina Ulezko Antonova, Barbora Echalar, Jan Kossl, Adam Saidu, Chelsea Mannie, Laura Arthur, Daniel Kreisel, Philip A Mudd, Marina Cella, Sidharth V Puram, Pirooz Eghtesady, Maxim N Artyomov, Et Al.

2020-Current year OA Pubs

Thymic involution is a key factor in human immune aging, leading to reduced thymic output and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the precise definition of human RTEs and their corresponding cell surface markers lacks clarity. Analysis of single-cell RNA-seq/ATAC-seq data distinguished RTEs by the expression of SOX4, IKZF2, and TOX and CD38 protein, whereby surface CD38

People With Dyslexia Or Dyscalculia Are Less Biased: Results Of A Preregistered Study From Over 450,000 People On The Implicit Association Test, Liam Cross, Gray Atherton, Roderick Nicolson

School of Psychology

The implicit association test (IAT) provides a sensitive measure of attitudes to social dimensions such as race, gender or disability using a response speed procedure. The automatisation deficit account of dyslexia attributes the reading (and broader) difficulties of dyslexic people to reduced speed and strength of stimulus–response habit formation and, therefore, predicts reduced implicit bias for individuals with dyslexia. This novel prediction was tested using the ‘Project Implicit’ IAT database on attitudes to disability. Data from over 460,000 respondents was analysed, including 22,747 with physical disability (PD), 14,700 with dyslexia, and 1721 with dyscalculia. The dyslexia group did indeed show …

Estimates Of Actual And Potential Lives Saved In The United States From The Use Of Covid-19 Convalescent Plasma, Quigly Dragotakes, Jeffrey P Henderson, Et Al.

2020-Current year OA Pubs

In the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) to treat hospitalized patients. Over 500,000 patients were treated with CCP during the first year of the pandemic. In this study, we estimated the number of actual inpatient lives saved by CCP treatment in the United States of America based on CCP weekly use, weekly national mortality data, and CCP mortality reduction data from meta-analyses of randomized controlled trials and real-world data. We also estimate the potential number of lives saved if CCP had been deployed for 100% of hospitalized patients or used in …

Association Of Resilience-Related Life Experiences On Variability On Age Of Onset In Dominantly Inherited Alzheimer Disease, Hye Joo Son, Randall J. Bateman, Jorge J. Llibre-Guerra, Richard J. Perrin, John C. Morris, Carlos Cruchaga, Jason Hassenstab, Alisha Daniels, Et Al.

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: It remains unknown whether the associations between protective lifestyles and sporadic dementia risk reported in observational studies also affect age at symptom onset (AAO) in autosomal dominant Alzheimer disease (ADAD) with predominant genetic influences. We investigated the associations between resilience-related life experiences and interindividual AAO variability in ADAD.

METHODS: We performed a longitudinal and confirmatory analysis of the Dominantly Inherited Alzheimer Network prospective observational cohort (January 2009-June 2018, follow-up duration 2.13 ± 2.22 years), involving clinical, CSF, and lifestyle/behavioral assessments. We performed a 2-pronged comprehensive resilience assessment in each cohort. Cohort 1, incorporating the general resilience definition …

Informing Estimates Of Probability Of Clostridioides Difficile Infection For Testing And Treatment: Expert Consensus From A Modified-Delphi Procedure, Jonathan D Baghdadi, Erik R Dubberke, Michael Durkin, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

BACKGROUND:

METHODS: A panel of fifteen experts in infectious diseases participated in a modified UCLA/RAND Delphi study to estimate likelihood of CDI. Consensus, defined as agreement by >70% of panelists, was assessed via a REDCap survey. Items without consensus were discussed in a virtual meeting followed by a second survey.

RESULTS: All fifteen panelists completed both surveys (100% response rate). In the initial survey, consensus was present on 6 of 15 (40%) items related to risk of CDI. After panel discussion and clarification of questions, consensus (>70% agreement) was reached on all remaining items in the second survey. Antibiotics …

Enhanced Staphylococcus Aureus Protection By Uncoupling Of The Α-Toxin-Adam10 Interaction During Murine Neonatal Vaccination, Kelly L Tomaszewski, Meagan Blanchard, Reuben Olaniyi, Hannah R Brenton, Samantha Hayes, Farheen Fatma, Gaya K Amarasinghe, Byoung-Kyu Cho, Young Ah Goo, Andrea C Dedent, Stephanie A Fritz, Juliane Bubeck Wardenburg

2020-Current year OA Pubs

Staphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an essential virulence factor in disease, impairing the T cell response to infection. The anti-Hla antibody response is a correlate of human protective immunity. Here we observe that this response is limited early in human life and design a vaccine strategy to elicit immune protection against Hla in a neonatal mice. By targeted disruption of the interaction of Hla with its receptor ADAM10, we identify a vaccine antigen (Hla

Understanding Long Covid: Navigating The Journey To Recovery, Heather H. Kelley, Rachel Byers, Ty Aller, Timothy Keady

All Current Publications

This fact sheet provides very basic facts on what long COVID is and information on how to navigate the healthcare system and cope with long COVID.

Ballesteros-Gonzalez '25 Receives Lincoln Laureate Award, Jeffery Woodard

News and Events (Discontinued Series)

No abstract provided.

Genomic Analysis Of Virulence Loci That Enable Growth Of Plasmopara Viticola On Resistant Vitis Spp., Sarah Teeter

Theses

Plasmopara viticola is considered one of the most damaging grapevine pathogens, costing growers millions of dollars in losses. Despite the discovery of resistance to P. viticola (RPV) loci in grapevines to combat this pathogen, recent research shows that P. viticola can rapidly adapt virulence on some RPV loci, reducing their effectiveness. This thesis explored two strategies to understand how P. viticola adapted to two resistance loci of moderate strength, RPV3.1 and RPV10.3, by identification and characterization of P. viticola genomic regions showing a high selective sweep. Using sequenced natural infections from field samples, multiple tools and custom R scripts were …

Crazy Train: Managing An Ir During Transition, Lora Lennertz, Jessica Cabrera-Sarduy

University Libraries Faculty Publications and Presentations

Crazy, but that’s how it goes! The University of Arkansas’ organizational structure for the institutional repository and other publishing ventures underwent significant changes with the creation of a new department in July 2023, the resignation of the IR coordinator who had been the sole developer of the IR since its inception, the move of IR supervision to the department head in January 2024, and the hiring of a new IR coordinator in July 2024. We realized with the resignation of our coordinator that policy decisions, changes in template assignments, assigning metadata, and even the use of external forms and software …

Gender And Sexuality Awareness In Medical Education And Practice: Mixed Methods Study, Ruba Tuma, Hisham Atwan, Anna Siri, Manlio Converti, Francesco Chirico, Łukasz Szarpak, Carlo Biz, Raymond Farah, Nicola Bragazzi

Faculty, Staff and Students Publications

BACKGROUND: The integration of gender and sexuality awareness in health care is increasingly recognized as vital for patient outcomes. Despite this, there is a notable lack of comprehensive data on the current state of physicians' training and perceptions in these areas, leading to a gap in targeted educational interventions and optimal health care delivery.

OBJECTIVE: The study's aim was to explore the experiences and perceptions of attending and resident physicians regarding the inclusion of gender and sexuality content in medical school curricula and professional practice in Israel.

METHODS: This cross-sectional survey targeted a diverse group of physicians across various specializations …

October 8, 2024, Nichole Mulvey

Minutes

Vol. 53, No. 4

Guest speaker: VPUA Mindy Spencer

Radiation Doses To Patients Undergoing Common X-Ray Examinations From Selected Hospitals In Dar Es Salaam And Zanzibar, Tanzania, Ali O. Masoud, Mwingereza J. Kumwenda, Salum K. Salum, Ahmad M. Jusabani

Tanzania Journal of Science

This study involved 300 patients, comprising 113 females and 187 males, from six X-ray units. The study focused on evaluating the patient dose for common X-ray examinations at selected hospitals in Dar es Salaam and Zanzibar, Tanzania. The achieved results were compared with previous studies and Diagnostic Reference Levels (DRLs). Entrance surface air kerma (ESAK) was calculated for chest posteroanterior (PA), cervical spine anteroposterior/lateral (AP/Lat), abdomen anteroposterior (AP), and lumbar spine anteroposterior/lateral (AP/LAT) examinations. The study results revealed the following average ESAK values: chest posteroanterior (PA), 0.34 mGy; abdomen anteroposterior (AP), 1.92 mGy; lumbar spine anteroposterior (AP), 2.78 mGy; and …

Transition Aged Youth Substance Use At Electric Dance Music Events In The Tampa Bay Area: A Qualitative Study Of Awareness And Prevention, Danielle Vinciguerra

USF Tampa Graduate Theses and Dissertations

The study investigates substance use among Transitional Aged Youth (TAY), particularly focusing on Electronic Dance Music (EDM) events in the Tampa Bay area. TAY, defined as individuals aged 18-29, experience significant psychological, biological, and developmental changes, which can lead to increased vulnerability to substance use. The study examines the prevalence and patterns of substance use, specifically ketamine and cocaine, among TAY at EDM events. Exploratory qualitative data collection method was utilized for the study. Applying Social Learning Theory as a framework, the research explores the beliefs, attitudes, experiences, and community influences that contribute to substance use within this demographic. Data …

Poor Representation Of Rural Counties Of The United States In Some Measures Of Consumer Broadband, Cari A. Bogulski, Mayssam Rabbani, Corey Hayes, Aysenur Betul Cengil, Catherine Shoults, Hari Eswaran

Industrial Engineering Faculty Publications and Presentations

Introduction:

Methods:

Book Review: A Call To Action: Lessons From Ukraine For The Future Force, John C. Erickson, Timothy S. Martin

Parameters Bookshelf – Online Book Reviews

Authors: John A. Nagl and Katie Crombe

Reviewed by John C. Erickson, senior engineer, Axiom Technologies, and Lieutenant Colonel Timothy S. Martin, director, Defense Strategy Course, US Army War College

John C. Erickson and Timothy S. Martin review one of the US Army War College Press’s most-downloaded publications, A Call to Action: Lessons from Ukraine for the Future Force, an integrated research project that covers the first year of the Russia-Ukraine War. Erickson and Martin provide a useful overview and analysis, highlighting 10 key themes, with a special focus on the “Clausewitzian triad” and “mission command,” and explaining why members …

Il-7rα On Cd4+ T Cells Is Required For Their Survival And The Pathogenesis Of Experimental Autoimmune Encephalomyelitis, Gholamreza Azizi, Bram Van Den Broek, Larissa Ishikawa, Hamed Naziri, Reza Yazdani, Guang-Xian Zhang, Bogoljub Ciric, Mohamad Rostami

Department of Neurology Faculty Papers

BACKGROUND: The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4+ T cells and their differentiation to effector/memory CD4+ T cells. Mice lacking IL-7Rα have severe lymphopenia and are resistant to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. However, it has been reported that IL-7Rα on peripheral CD4+ T cells is disposable for their maintenance and EAE pathogenesis, which does not align with the body of knowledge on the role of IL-7Rα in the biology of CD4+ T cells. Given that a definitive study …

Principal Perceptions Of The Challenges And Successes Experienced With Teacher Turnover, Elizabeth Anne Thomas

Walden Dissertations and Doctoral Studies

Despite interventions to decrease teacher turnover, there remains a 16-24% teacher turnover rate at one Southeastern School District (SSD) in the United States. There is a gap in practice related to the successes and challenges of retaining teachers in the local setting. The purpose of this basic qualitative study was to explore the teacher turnover rates in an SSD that are consistently higher than teacher turnover rates in other state schools and the nation. Lee and Mitchell’s unfolding model of voluntary employee turnover guided this study. Research questions addressed principals' perceptions of the successes and challenges related to the high …