Digital Commons Network^™

Rapid Hyperspectral Photothermal Mid-Infrared Spectroscopic Imaging From Sparse Data For Gynecologic Cancer Tissue Subtyping, Reza Reihanisaransari, Chalapathi Charan Gajjela, Xinyu Wu, Ragib Ishrak, Sara Corvigno, Jinsong Liu, David Mayerich, Sebastian Berisha, Rohith Reddy

Faculty, Staff and Student Publications

Ovarian cancer detection has traditionally relied on a multistep process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from several drawbacks: it is qualitative, time-intensive, and heavily dependent on the quality of staining. Mid-infrared (MIR) hyperspectral photothermal imaging is a label-free, biochemically quantitative technology that, when combined with machine learning algorithms, can eliminate the need for staining and provide quantitative results comparable to traditional histology. However, this technology is slow. This work presents a novel approach to MIR photothermal imaging that enhances its speed by an order of magnitude. This …

Ct Strain Metrics Allow For Earlier Diagnosis Of Bronchiolitis Obliterans Syndrome After Hematopoietic Cell Transplant, Husham Sharifi, Christopher D Bertini, Mansour Alkhunaizi, Maria Hernandez, Zayan Musa, Ihsan Turk, Burton F Dickey, Guang-Shing Cheng, Gregory Yanik, Craig J Galban, Huawei Henry Guo, Myrna C B Godoy, Joseph M Reinhardt, Eric A Hoffman, Mario Castro, Gabriela Rondon, Amin M Alousi, Richard E Champlin, Elizabeth J Shpall, Ying Lu, Samuel Peterson, Keshav Datta, Mark R Nicolls, Joe Hsu, Ajay Sheshadri

Faculty, Staff and Student Publications

Bronchiolitis obliterans syndrome (BOS) after hematopoietic cell transplantation (HCT) is associated with substantial morbidity and mortality. Quantitative computed tomography (qCT) can help diagnose advanced BOS meeting National Institutes of Health (NIH) criteria (NIH-BOS) but has not been used to diagnose early, often asymptomatic BOS (early BOS), limiting the potential for early intervention and improved outcomes. Using pulmonary function tests (PFTs) to define NIH-BOS, early BOS, and mixed BOS (NIH-BOS with restrictive lung disease) in patients from 2 large cancer centers, we applied qCT to identify early BOS and distinguish between types of BOS. Patients with transient impairment or healthy lungs …

The Impact Of A Web-Based Prognostic Calculator On Prognostic Confidence In Outpatient Palliative Care, David Hui, John P Maxwell, Allison De La Rosa, Kristofer Jennings, Marieberta Vidal, Ahsan Azhar, Kimberson Tanco, Yvonne Heung, Marvin Delgado-Guay, Donna Zhukovsky, Joseph Arthur, Suresh Reddy, Sriram Yennu, Amy Ontai, Eduardo Bruera

Faculty, Staff and Student Publications

Purpose: Clinicians are often uncertain about their prognostic estimates, which may impede prognostic communication and clinical decision-making. We assessed the impact of a web-based prognostic calculator on physicians' prognostic confidence.

Methods: In this prospective study, palliative care physicians estimated the prognosis of patients with advanced cancer in an outpatient clinic using the temporal, surprise, and probabilistic approaches for 6 m, 3 m, 2 m, 1 m, 2 w, 1 w, and 3 d. They then reviewed information from www.predictsurvival.com , which calculated survival estimates from seven validated prognostic scores, including the Palliative Prognostic Score, Palliative Prognostic Index, and Palliative Performance …

Atr Inhibition Radiosensitizes Cells Through Augmented Dna Damage And G2 Cell Cycle Arrest Abrogation, Scott J Bright, Mandira Manandhar, David B Flint, Rishab Kolachina, Mariam Ben Kacem, Broderick X Turner, Conor H Mcfadden, Poliana C Marinello, Simona F Shaitelman, Gabriel O Sawakuchi

Faculty, Staff and Student Publications

Ataxia telangiectasia and Rad3-related protein (ATR) is a key DNA damage response protein that facilitates DNA damage repair and regulates cell cycle progression. As such, ATR is an important component of the cellular response to radiation, particularly in cancer cells, which show altered DNA damage response and aberrant cell cycle checkpoints. Therefore, ATR's pharmacological inhibition could be an effective radiosensitization strategy to improve radiotherapy. We assessed the ability of an ATR inhibitor, AZD6738, to sensitize cancer cell lines of various histologic types to photon and proton radiotherapy. We found that radiosensitization took place through persistent DNA damage and abrogated G2 …

Development And Assessment Of A Point-Of-Care Application (Genomic Medicine Guidance) For Heritable Thoracic Aortic Disease

Faculty, Staff and Student Publications

Background: Genetic testing can determine familial and personal risks for heritable thoracic aortic aneurysms and dissections (TAD). The 2022 American College of Cardiology/American Heart Association guidelines for TAD recommend management decisions based on the specific gene mutation. However, many clinicians lack sufficient comfort or insight to integrate genetic information into clinical practice.

Objective: We therefore developed the Genomic Medicine Guidance (GMG) application, an interactive point-of-care tool to inform clinicians and patients about TAD diagnosis, treatment, and surveillance. GMG is a REDCap-based application that combines publicly available genetic data and clinical recommendations based on the TAD guidelines into one translational education …

Assessing Benthic Recovery Below The United Kingdom's First Large-Scale, Offshore, Longline Mussel Farm, Llucia Mascorda-Cabre, Philip Hosegood, Martin Attrill, Emma Sheehan

School of Biological and Marine Sciences

The recent expansion of the aquaculture industry into the offshore marine environment is perceived to have a comparatively low environmental impact coupled with a high growth potential as a sustainable, large-scale source of healthy protein. This study assessed changes in sediment characteristics and infauna assemblages following the development of the first large-scale offshore longline mussel farm in the United Kingdom. By evaluating the effects of the farm on the sediment ecosystem and by studying infaunal sediment environmental parameters along a distance gradient away from the farm, the first before-after control-impact (BACI) study of an offshore shellfish farm is presented. Sediment …

Under Pressure: Employee Work Stress, Supervisory Mentoring Support, And Employee Career Success, Berrin Erdogan, Selin Kudret, Emily D. Campion, Talya N. Bauer, Julie Mccarthy, Bonnie Hayden Cheng

Business Faculty Publications and Presentations

Despite consistent findings that stressed employees benefit from social support, these employees do not always have access to such support. We propose and test a conceptual model suggesting employee work stress will negatively affect supervisory career and psychosocial mentoring support. Drawing from social exchange theory, we predict this will indirectly affect employee career success (lower career satisfaction and promotability ratings, fewer promotions), and that the relationship between employee work stress and lower supervisory mentoring support can be explained by lower levels of work engagement experienced by, and attributed to, stressed employees. We tested our model across three studies. In Study …

Whole Genomes Of Amazonian Uakari Monkeys Reveal Complex Connectivity And Fast Differentiation Driven By High Environmental Dynamism, Claudia Fontsere, Alejandro Valenzuela-Seba, Harvinder Pawar, Marta Gut, Joanna L Kelley, Sandra Ruibal-Puertas, Pol Alentorn-Moron, Armida Faella, Esther Lizano, Izeni Farias, Tomas Hrbek, Joao Valsecchi, Ivo G Gut, Jeffrey Rogers, Kyle Kai-How Farh, Lukas F K Kuderna, Tomas Marques-Bonet, Jean P Boubli

Faculty, Staff and Students Publications

Despite showing the greatest primate diversity on the planet, genomic studies on Amazonian primates show very little representation in the literature. With 48 geolocalized high coverage whole genomes from wild uakari monkeys, we present the first population-level study on platyrrhines using whole genome data. In a very restricted range of the Amazon rainforest, eight uakari species (Cacajao genus) have been described and categorized into the bald and black uakari groups, based on phenotypic and ecological differences. Despite a slight habitat overlap, we show that posterior to their split 0.92 Mya, bald and black uakaris have remained independent, without gene flow. …

Tca Metabolism Regulates Dna Hypermethylation In Lps And Mycobacterium Tuberculosis–Induced Immune Tolerance, Malik Ladki, Daanish Sheikh, Amera L Martinez, Emily M Mace, Sandra L Grimm, Thaleia Caldwell, Alexandra Portillo Varela, Rajagopal V Sekhar, Anna M Mandalakas, Mandla Mlotshwa, Sibuse Ginidza, Jeffrey D Cirillo, Robert S Wallis, Mihai G Netea, Reinout Van Crevel, Cristian Coarfa, Andrew R Dinardo

Faculty, Staff and Students Publications

Severe and chronic infections, including pneumonia, sepsis, and tuberculosis (TB), induce long-lasting epigenetic changes that are associated with an increase in all-cause postinfectious morbidity and mortality. Oncology studies identified metabolic drivers of the epigenetic landscape, with the tricarboxylic acid (TCA) cycle acting as a central hub. It is unknown if the TCA cycle also regulates epigenetics, specifically DNA methylation, after infection-induced immune tolerance. The following studies demonstrate that lipopolysaccharide and Mycobacterium tuberculosis induce changes in DNA methylation that are mediated by the TCA cycle. Infection-induced DNA hypermethylation is mitigated by inhibitors of cellular metabolism (rapamycin, everolimus, metformin) and the TCA …

Gender And Sexuality Awareness In Medical Education And Practice: Mixed Methods Study, Ruba Tuma, Hisham Atwan, Anna Siri, Manlio Converti, Francesco Chirico, Łukasz Szarpak, Carlo Biz, Raymond Farah, Nicola Bragazzi

Faculty, Staff and Students Publications

BACKGROUND: The integration of gender and sexuality awareness in health care is increasingly recognized as vital for patient outcomes. Despite this, there is a notable lack of comprehensive data on the current state of physicians' training and perceptions in these areas, leading to a gap in targeted educational interventions and optimal health care delivery.

OBJECTIVE: The study's aim was to explore the experiences and perceptions of attending and resident physicians regarding the inclusion of gender and sexuality content in medical school curricula and professional practice in Israel.

METHODS: This cross-sectional survey targeted a diverse group of physicians across various specializations …

Estimates Of Actual And Potential Lives Saved In The United States From The Use Of Covid-19 Convalescent Plasma, Quigly Dragotakes, Jeffrey P Henderson, Et Al.

2020-Current year OA Pubs

In the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) to treat hospitalized patients. Over 500,000 patients were treated with CCP during the first year of the pandemic. In this study, we estimated the number of actual inpatient lives saved by CCP treatment in the United States of America based on CCP weekly use, weekly national mortality data, and CCP mortality reduction data from meta-analyses of randomized controlled trials and real-world data. We also estimate the potential number of lives saved if CCP had been deployed for 100% of hospitalized patients or used in …

Association Of Resilience-Related Life Experiences On Variability On Age Of Onset In Dominantly Inherited Alzheimer Disease, Hye Joo Son, Randall J. Bateman, Jorge J. Llibre-Guerra, Richard J. Perrin, John C. Morris, Carlos Cruchaga, Jason Hassenstab, Alisha Daniels, Et Al.

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: It remains unknown whether the associations between protective lifestyles and sporadic dementia risk reported in observational studies also affect age at symptom onset (AAO) in autosomal dominant Alzheimer disease (ADAD) with predominant genetic influences. We investigated the associations between resilience-related life experiences and interindividual AAO variability in ADAD.

METHODS: We performed a longitudinal and confirmatory analysis of the Dominantly Inherited Alzheimer Network prospective observational cohort (January 2009-June 2018, follow-up duration 2.13 ± 2.22 years), involving clinical, CSF, and lifestyle/behavioral assessments. We performed a 2-pronged comprehensive resilience assessment in each cohort. Cohort 1, incorporating the general resilience definition …

Informing Estimates Of Probability Of Clostridioides Difficile Infection For Testing And Treatment: Expert Consensus From A Modified-Delphi Procedure, Jonathan D Baghdadi, Erik R Dubberke, Michael Durkin, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

BACKGROUND:

METHODS: A panel of fifteen experts in infectious diseases participated in a modified UCLA/RAND Delphi study to estimate likelihood of CDI. Consensus, defined as agreement by >70% of panelists, was assessed via a REDCap survey. Items without consensus were discussed in a virtual meeting followed by a second survey.

RESULTS: All fifteen panelists completed both surveys (100% response rate). In the initial survey, consensus was present on 6 of 15 (40%) items related to risk of CDI. After panel discussion and clarification of questions, consensus (>70% agreement) was reached on all remaining items in the second survey. Antibiotics …

Membrane Association And Polar Localization Of The Legionella Pneumophila T4ss Doto Atpase Mediated By Two Nonredundant Receptors, Sukhithasri Vijayrajratnam, Sonja Milek, Stefano Maggi, Kaleigh Ashen, Micah Ferrell, Ahmet Hasanovic, Agnieszka Holgerson, Shanmugapriya Kannaiah, Manpreet Singh, Debnath Ghosal, Grant J Jensen, Joseph P Vogel

2020-Current year OA Pubs

The

Impact Of Cancer Therapy On Clonal Hematopoiesis Mutations And Subsequent Clinical Outcomes, Kevin T Nead, Irenaeus C C Chan, Kelly L Bolton, Et Al.

2020-Current year OA Pubs

Exposure to cancer therapies is associated with an increased risk of clonal hematopoiesis (CH). The objective of our study was to investigate the genesis and evolution of CH after cancer therapy. In this prospective study, we undertook error-corrected duplex DNA sequencing in blood samples collected before and at 2 time points after chemoradiation in patients with esophageal or lung cancer recruited from 2013 to 2018. We applied a customized workflow to identify the earliest changes in CH mutation count and clone size and determine their association with clinical outcomes. Our study included 29 patients (87 samples). Their median age was …

Multidimensional Profiling Of Human T Cells Reveals High Cd38 Expression, Marking Recent Thymic Emigrants And Age-Related Naive T Cell Remodeling, Pavla Bohacova, Marina Terekhova, Riley Mullins, Kamila Husarcikova, Irina Shchukina, Alina Ulezko Antonova, Barbora Echalar, Jan Kossl, Adam Saidu, Chelsea Mannie, Laura Arthur, Daniel Kreisel, Philip A Mudd, Marina Cella, Sidharth V Puram, Pirooz Eghtesady, Maxim N Artyomov, Et Al.

2020-Current year OA Pubs

Thymic involution is a key factor in human immune aging, leading to reduced thymic output and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the precise definition of human RTEs and their corresponding cell surface markers lacks clarity. Analysis of single-cell RNA-seq/ATAC-seq data distinguished RTEs by the expression of SOX4, IKZF2, and TOX and CD38 protein, whereby surface CD38

Genomic Analysis Of Virulence Loci That Enable Growth Of Plasmopara Viticola On Resistant Vitis Spp., Sarah Teeter

Theses

Plasmopara viticola is considered one of the most damaging grapevine pathogens, costing growers millions of dollars in losses. Despite the discovery of resistance to P. viticola (RPV) loci in grapevines to combat this pathogen, recent research shows that P. viticola can rapidly adapt virulence on some RPV loci, reducing their effectiveness. This thesis explored two strategies to understand how P. viticola adapted to two resistance loci of moderate strength, RPV3.1 and RPV10.3, by identification and characterization of P. viticola genomic regions showing a high selective sweep. Using sequenced natural infections from field samples, multiple tools and custom R scripts were …

Crazy Train: Managing An Ir During Transition, Lora Lennertz, Jessica Cabrera-Sarduy

University Libraries Faculty Publications and Presentations

Crazy, but that’s how it goes! The University of Arkansas’ organizational structure for the institutional repository and other publishing ventures underwent significant changes with the creation of a new department in July 2023, the resignation of the IR coordinator who had been the sole developer of the IR since its inception, the move of IR supervision to the department head in January 2024, and the hiring of a new IR coordinator in July 2024. We realized with the resignation of our coordinator that policy decisions, changes in template assignments, assigning metadata, and even the use of external forms and software …

Context-Preserving One-Click Task Creation Via Operating System Context Menu, Alexandra Hill

Defensive Publications Series

The process of adding tasks to a list in a task management application requires users to switch focus away from their current task and can require multiple clicks or actions. Managing and consolidating tasks across various productivity workflows can be overwhelming for users. Further, capturing the relevant context associated with a task can be challenging and time-consuming. This disclosure describes techniques that enable users to create tasks from any text on the screen of their device, such as a laptop, tablet, smartphone, etc. The techniques can be implemented as part of a device operating system and provide a seamless and …

A System And Method To Auto Generate Next Suspicious Purchase And Create Block Rule, Durga S. Kala, Varun Sharma, Chandan Das

Defensive Publications Series

The present disclosure provides a system and a method for generating an alert 106 for fraudulent transactions. The disclosure proposes a suspicious fraud purchase generator system 104 which receives streaming transaction flow from the transaction data 102, filters transactions from the streaming transaction flow, dispose the transactions into categories such as good, discard or fraud, the fraud transactions are processed with Gen AI algorithm, the Gen AI algorithm out generate an alert 106 for the fraudulent transactions.

Hybrid Cooling For Modular Electronic Systems, Karthik D Mayya, Jongsuk Hyun, Allen Siaotong, Tushara Ramesh, Mandy Lam

Defensive Publications Series

A hybrid cooling system for modular electronic systems is presented herein. The cooling system utilizes aluminum fins with coolant ducts retrofitted to the top and bottom enclosures of a chassis. During operation, the coolant can absorb heat from the electronic system environment and transfer the heat away from the electronic system.

A Review Of Slow Noodles: A Cambodian Memoir Of Love, Loss, And Family Recipes, Engheang Nol

Journal of Southeast Asian American Education and Advancement

"Slow Noodles: A Cambodian Memoir of Love, Loss, and Family Recipes" by Chantha Nguon, with assistance from Kim Green, is a poignant exploration of the author's journey from a Cambodian refugee to a beacon of empowerment in her homeland. This review delves into the book's narrative structure, which intertwines personal anecdotes with culinary reflections, offering a unique lens into the complexities of Chantha’s personal life. Through a detailed analysis of select chapters, including "Chicken-Lime Soup for the Village Soul" and "Instant Noodles," the review examines themes of resilience, identity, and especially societal expectations for what and how Cambodian women should …

Sisterhood And Authenticity: The Experiences Of Generation Z Sorority Women In National Panhellenic Council (Npc) Chapters, Pietro A. Sasso, Kim E. Bullington, Melissa Bidinger

New York Journal of Student Affairs

Generation Z (Gen Z) has entered higher education and is not the traditional undergraduate student (18-24) and are the contemporary members of sororities. Gen Z is different from their Millennial predecessors and requires a reexamination to meet the needs of college students today. This qualitative study examined how National Panhellenic Conference (NPC) sorority members who are in Gen Z described their connectedness through sense of belonging and their own generation. We identified two themes: (1) the importance of authenticity and deep connections and (2) emerging Gen Z group identity. Recommendations for practice include more interpersonal recruitment efforts and leadership development …

Operation And Management Of A Modern Park And Recreation System, Christopher Sullivan

Sustainability Seminar Series

The talk will focus on the various operational divisions which comprise most park and recreation agencies and how they work together to provide a modern park and recreation system to visitors, along with the common management challenges which face park and recreation agencies. On average, the Passaic County Department of Parks and Recreation employs 75 permanent employees and 113 seasonal. The department provides various recreation and environmental education activities throughout the year for all age levels, including a comprehensive K-5 elementary school based environmental education program which educates approximately 1,200 children per year and is available to all public and …

"The Heart To Friendship True" Poem

Asa Hoxey Family Papers

Two-page poem written for Sarah Ann Hoxey titled "The Heart to Friendship True."

Fall 2024 Full Issue, Undergraduate Research

PANDION: The Osprey Journal of Research and Ideas

No abstract provided.

Baby Boy, Elysa Adams

PANDION: The Osprey Journal of Research and Ideas

Artist Statement

Baby Boy is a tribute to friends lost in 2022 and 2023. he crown of flowers within the artwork serves as a metaphor, for the symbolic crucifixion of Black men. The piece reveals the harsh reality that numerous Black boys face challenges that prevent them from reaching adulthood. It emphasizes the lack of protection, highlighting a world that targets and jeopardizes their well-being. he narrative is represented through a woodcut of a young Black man.

My creative journey is inspired by the untold stories and vibrant spirits that permeate my community. I am motivated by a profound drive …

A Handful, Prathna Nirav Patel

PANDION: The Osprey Journal of Research and Ideas

Artist Statement

I created this drawing for my Drawing I class, where I was introduced to the cross-hatching method. Through this technique, I aimed to physicalize emotion through the beauty and expressiveness of the human hand. The title, A Handful, represents not only the literal handful of hands shown, but also the handful of emotions and experiences behind each one.

Fye Theater Showcase, Mindy Mclarty

PANDION: The Osprey Journal of Research and Ideas

Artist Statement

When I originally decided to make a poster to advertise our cohort’s final showcase, I knew I wanted it to be inspired by Nora’s character from A Doll’s House. Our class read this play, by Henrik Ibsen, which tells the story of Nora, and her stifling life married to her husband. Nora realizes her life and role as a mother is not what she thought it was. Her life is superficial, and this peripheral view that the audience has of the story made me start thinking about the character’s doll-like qualities. Between this and the play’s title, it …

Study Of A Lemon, Marcella Carson

PANDION: The Osprey Journal of Research and Ideas

No abstract provided.