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Spectrum, Volume 53, Issue 5, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Vice Presidential Candidates Debate Ahead of Nov. Election - SHU-Powered Poll Reveals Youth Climate Concerns - A Peek Into Family Weekend Campus - The Statues of Sacred Heart University - New Hub to Stream SHU Sports

Reacting To Criticism: What Motivates Top Leaders To Respond Substantively To Negative Social Performance Feedback?, Myrto Chliova, Gabriella Cacciotti, Teemu Kautonen, Ignacio Pavez

All Works

The responses of organizations in situations of negative feedback from stakeholders are attracting increasing scholarly and societal attention. The literature has so far largely focused on situational factors that direct such responses, while calling for a more acute examination of individual factors. Anchored in Stakeholder Theory and Trait Activation Theory, this study examines how and to what extent prosocial motivation (a normative-oriented trait) and fear of failure (an instrumental-oriented trait) determine organizational leaders’ substantive responses to negative social performance feedback. We test our predictions on two waves of original survey data, including a conjoint experiment, on a sample of leaders …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Monitoring Cow Behavior Based On Lying, Standing, Eating, And Ruminating Recognition Using Yolov8, Ali Saifudin, Sri Pantja Madyawati, Imam Yuadi, Rimayanti Rimayanti, Imam Mustofa, Riries Rulaningtyas, Teddy Surya Gunawan, Adnan Rahmat Anom Besari

Turkish Journal of Veterinary & Animal Sciences

Cow behavior is a crucial indicator for monitoring health, reproductive status, and welfare in livestock management. However, methods that rely on wearable devices often face significant challenges, including high costs, maintenance difficulties, and potential impacts on animal welfare. To address these limitations, this study explored the potential of using YOLOv8, a cutting-edge computer vision model, for non-invasive monitoring of cow behavior. The research methodology involved four key steps: data collection, preliminary data processing, model training, and validation. The findings revealed that YOLOv8 is capable of accurately detecting and localizing key cow behaviors—lying, standing, eating, and ruminating—achieving a mean average precision …

The Past, Present, And Future Of Long-Run Local Population Decline, Brian J. Asquith, Evan Mast

Upjohn Institute Policy and Research Briefs

No abstract provided.

A Government Of The People: Popular Engagement In U.S. Constitutional Democracy, Floersheimer Center For Constitutional Democracy, Wilfred U. Codrington Iii

2024 Event Invitations

Please join us for a fascinating discussion about the place and power of the people in constitutional practice and government design, including critical areas that feature prominently in today’s public conversation in light of recent Supreme Court terms and the upcoming election.

This event will feature three panelists—Alicia Bannon (Brennan Center for Justice at NYU School of Law), Corey Brettschneider (Brown University and Fordham Law School) and Joshua Douglas (University of Kentucky J. David Rosenberg College of Law), the latter two of whom have recently published books that center the people in core matters of political decision making—in conversation with …

Learn About Native American History At The Documentary Screening Of 'The Forgotten Creeks' And A Panel Discussion, Tehreem Khan

Browse All News

No abstract provided.

Uc Minutes 2024-10-09, Northern Illinois University

University Council Archives

No abstract provided.

Uc Agenda 2024-10-09, Northern Illinois University

University Council Archives

No abstract provided.

Palimbiosis, Leila Walker

Publications and Research

How does one begin to talk about the end? Contemporary artistic and literary responses to climate change frequently invoke Romantic traditions, in part because many theorists attribute our current crisis to historical developments in the Romantic period, but also as means of representing how climate change collapses the familiar orderliness of time. This essay is about the narrative forms that emerge when our place of safety is revealed to be as unstable as melting permafrost. It centers on Mary Shelley’s 1825 essay about a frozen Englishman reanimated during that especially warm summer. I read Shelley’s essay anachronistically alongside contemporary climate …

Nasoalveolar Molding In Lately Presented Moderate To Severe Unilateral Cleft Lip And Palate Infants: Does It Add?, Noha Ibrahim Abdelrahman Professor

Dentistry

Alignment of the alveolar segments with early nasal cartilage tackling is the foundation upon which excellent surgical results are dependent. The purpose is to evaluate the shortterm effect of triple combination of passive alveolar molding with early nasal molding augmented by controlled corrective power of lip tapping in lately presented moderate to severe unilateral complete cleft lip and palate infants. A prospective case series study was conducted in Plastic and Maxillofacial Surgery Department, Ain Shams University in collaboration with Orthodontics Department, from January 2021 till June 2023, 15 infants elder than 2 months till 6 months were enrolled in the …

Symposium: What Does The Microbiome Tell Us About Prevention And Treatment Of Ad/Adrd?, Joia K Capocchi, Claudia Figueroa-Romero, Sage J B Dunham, Gina Faraci, Jason A Rothman, Katrine L Whiteson, Dong-Oh Seo, David M Holtzman, Stefanie Grabrucker, Yvonne M Nolan, Rima Kaddurah-Daouk, David A Jett

2020-Current year OA Pubs

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota-gut-brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.

Activation Of Pkr By A Short-Hairpin Rna, Kyle A Cottrell, Sua Ryu, Helen Donelick, Hung Mai, Addison A Young, Jackson R Pierce, Brenda L Bass, Jason D Weber

2020-Current year OA Pubs

Recognition of viral infection often relies on the detection of double-stranded RNA (dsRNA), a process that is conserved in many different organisms. In mammals, proteins such as MDA5, RIG-I, OAS, and PKR detect viral dsRNA, but struggle to differentiate between viral and endogenous dsRNA. This study investigates an shRNA targeting DDX54's potential to activate PKR, a key player in the immune response to dsRNA. Knockdown of DDX54 by a specific shRNA induced robust PKR activation in human cells, even when DDX54 is overexpressed, suggesting an off-target mechanism. Activation of PKR by the shRNA was enhanced by knockdown of ADAR1, a …

Honey Targets Ribosome Biogenesis Components To Suppress The Growth Of Human Pancreatic Cancer Cells, Aun A. Bangash, Sahir S. Alvi, Muhammad Bangash, Haider Ahsan, Shiza Khan, Rida Shareef, Georgina Villanueva, Divyam Bansal, Mudassier Ahmad, Dae Joon Kim, Subhash Chauhan, Bilal B. Hafeez

School of Medicine Publications

Simple Summary

Pancreatic cancer (PanCa) is one of the deadliest forms of cancer with limited therapeutic options. The available conventional therapies are highly toxic and often show resistance. Accumulating evidence suggests that dysregulated ribosome biogenesis has been linked to the survival and aggressive phenotypes of many tumor types, including PanCa. Thus, targeting ribosome biogenesis could be a novel approach for suppressing the growth of PanCa. The current study aimed to investigate the anti-cancer efficacy and underlying molecular mechanisms of honey against PanCa. Our results demonstrated that honey induces apoptosis and inhibits the growth and invasive potential of PanCa cells by …

Data Quality Based Intelligent Instrument Selection With Security Integration, Sergei Chuprov, Raman Zatsarenko, Leon Reznik, Igor Khokhlov

Computer Science Faculty Publications

We propose a novel Data Quality with Security (DQS) integrated instrumentation selection approach that facilitates aggregation of multi-modal data from heterogeneous sources. As our major contribution, we develop a framework that incorporates multiple levels of integration in finding the best DQS-based instrument selection: data fusion from multi-modal sensors embedded into heterogeneous platforms, using multiple quality and security metrics and knowledge integration. Our design addresses the security aspect in the instrumentation design, which is commonly overlooked in real applications, by aggregating it with other metrics into an integral DQS calculus. We develop DQS calculus that formalizes the problem of finding the …

Nyls Blood Drive, New York Law School

Miscellaneous Campus Flyers

October 9, 2024

Brief Of 20 Professors Of Law And Public Knowledge As Amici Curiae In Support Of Affirmance, Charles Duan, Rachel Bamberger

Amicus Briefs & Court Filings

In Carroll Shelby Licensing v. Halicki, the U.S. Court of Appeals considers whether a car in a film is a "character" for purposes of copyright law. Character copyright protection has proven to be an especially difficult area of the law, and courts and commentators have struggled with the proper boundaries of such protection and whether characters are independently protectable works at all. This brief presents a novel legal argument for resolving the scope of character copyright, at least in the context of inanimate objects in creative works such as cars. While the case law and commentary has to date focused …

Molecular And Clinical Features Of Pancreatic Acinar Cell Carcinoma: A Single-Institution Case Series, Ashwathy Balachandran Pillai, Mahmoud Yousef, Abdelrahman Yousef, Kristin D Alfaro-Munoz, Brandon G Smaglo, Robert A Wolff, Mark W Hurd, Anirban Maitra, Huamin Wang, Matthew Harold G Katz, Laura R Prakash, Ching-Wei D Tzeng, Rebecca Snyder, Luca F Castelnovo, Anthony Chen, Andrey Kravets, Kseniia Kudriavtseva, Artem Tarasov, Kirill Kryukov, Haoqiang Ying, John Paul Shen, Dan Zhao

Faculty, Staff and Student Publications

Objectives: Acinar cell carcinoma (ACC) accounts for about 1% of pancreatic cancers. The molecular and clinical features of ACC are less characterized than those of pancreatic ductal adenocarcinoma. Methods: We retrospectively evaluated the clinical and molecular features of ACC patients who underwent germline and/or somatic molecular testing at The University of Texas MD Anderson Cancer Center from 2008 to 2022 and two cases from 2023-2024 who underwent RNA and TME analysis by Boston Gene. Patient information was extracted from our institutional database with the approval of the Institutional Review Board. Results: We identified 16 patients with available molecular testing …

Phase I/Ii Study Of Bms-986156 With Ipilimumab Or Nivolumab With Or Without Stereotactic Ablative Radiotherapy In Patients With Advanced Solid Malignancies, Joe Y Chang, Xinyan Xu, Girish S Shroff, Nathan I Comeaux, Wei Li, Daniel D Karp, Vivek Verma, Aileen Chen, James Welsh, David S Hong

Faculty, Staff and Student Publications

Background: BMS-986156 is an agonist of the glucocorticoid-induced tumor necrosis factor receptor (TNFR)-related protein (GITR) and promotes increased effector T-cell activation. Combined anti-GITR, anti-programmed death-1, anti-cytotoxic T-lymphocyte-associated protein 4 antibodies and radiotherapy improve tumor control in preclinical studies. Herein we describe the results of the safety and efficacy of BMS-986156+ipilimumab or nivolumab with/without stereotactic ablative radiotherapy (SABR) in patients with advanced solid cancers (NCT04021043).

Methods: This open-label, multigroup, single-center phase I/II study enrolled patients with histologically-confirmed stage IV solid cancers resistant to standard treatments. Group 1 (G1, n=20) received four cycles of ipilimumab (3 mg/kg) plus BMS-986156 (30 …

Assessment Of Genetic Diversity By Phenological Traits, Field Performance, And Start Codon Targeted (Scot) Polymorphism Marker Of Seventeen Soybean Genotypes (Glycine Max L.), Mahmoud Abdel-Sattar, Ehab M. Zayed, Mohamed K. Abou-Shlell, Hail Z. Rihan, Ahmed A. Helal, Nabil E.G. Mekhaile, Ghada E. El-Badan

School of Biological and Marine Sciences

The Egyptian-farmed soybeans have a wide range of genetic diversity which is most important in plant improvement programs in order to develop new higher yielding soybean genotypes. The present study is designed to determine the genetic variability among seventeen genotypes of cultivated soybean (Glycine max L.) by examining the phenotypic level at the seedling stage, field performance over two years 2022/2023 and genetically using Start Codon Targeted (SCoT) markers. Results indicated that the SCoT markers, 100 seed weight, and tip angle (TA) traits were positively correlated with H2L12, DR 101, H15L5, and H117 genotypes. In addition, the number of branches …

2024-10-09 How I Got Roped Into Line Dancing, Tristan Scott

The Spectator Online

No abstract provided.

2024-10-09 Mariners Are Done And So Are Fans, Danial Truog

The Spectator Online

No abstract provided.

2024-10-09 Seattle Storm Eyes Future After Promising Season Comes To An End, Kevin Ruiz

The Spectator Online

No abstract provided.

2024-10-09 Seattle University Swimming Kicks Off Their Final Wac Season, Diego Dumlao

The Spectator Online

No abstract provided.

2024-10-09 Smart Shopping And School Programs Help Fight Rising Grocery Prices, Danial Truog

The Spectator Online

No abstract provided.

Fathers At Work—Forfeits, Deficits And Disregarding Discourse, Jasmine Kelland, Andy Brown, Nicola Searle

Plymouth Business School

Existing research observes that fathers navigate the workplace through a complex network of mistreatment, adopting “ground breaker discourse” as a mechanism by which to maintain alignment with masculine norms to reduce mistreatment. Through analysis of online forum comments in response to a UK newspaper article exploring fathers and masculinity, this research investigates if “fatherhood forfeits” and the “patriarchal deficit” are evident in this context and how they are navigated. The research affirms the existence of “fatherhood forfeits” and the “patriarchal deficit,” uncovering an additional forfeit of “impeded attractiveness.” Additionally, it expands knowledge regarding the way in which fathers maintain hegemonic …

Winonan, Winona State University

The Winonan - 2020s

This issue of the Winonan, the Winona State University student newspaper, was published on October 9, 2024.

Pandemic Perspectives From Detained Youth During Covid-19: Bridging The Knowledge Gap For Future Safeguards., April Mcneill-Johnson, Zuri Hudson, Brittany Moore, Dumebi Okocha, Megha Ramaswamy, Kimberly Randell

Manuscripts, Articles, Book Chapters and Other Papers

Despite the worsening health disparities among youth in detention during the COVID-19 pandemic, there has been minimal exploration into the pandemic experiences of detained youth and opportunities for pandemic mitigation. This paper analyzes the perspectives of youth in detention on the pandemic, including the effect of the pandemic on their detention experience and their perceptions about COVID-19 vaccination. The study used purposive sampling to recruit 16 participants (aged 14-17 years) from two juvenile detention centers in the urban Midwest. We conducted semi-structured interviews and analyzed verbatim transcripts using a hybrid deductive-inductive approach and thematic analysis. Four themes emerged: 1) personal …

Forecasting The Effects Of Smoking Prevalence Scenarios On Years Of Life Lost And Life Expectancy From 2022 To 2050: A Systematic Analysis For The Global Burden Of Disease Study 2021

Faculty, Staff and Students Publications

BACKGROUND: Smoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although strategies have recently been proposed to achieve tobacco-free generations, none have been implemented to date. Assessing what could happen if current trends in smoking prevalence persist, and what could happen if additional smoking prevalence reductions occur, is important for communicating the effect of potential smoking policies.

METHODS: In this analysis, we use …

Single-Cell Somatic Copy Number Variants In Brain Using Different Amplification Methods And Reference Genomes, Ida Bomann, Sairam Behera, Caoimhe Morley, Sonja W Scholz, Zane Jaunmuktane, Jonas Demeulemeester, Fritz J Sedlazeck, Christos Proukakis

Faculty, Staff and Students Publications

The presence of somatic mutations, including copy number variants (CNVs), in the brain is well recognized. Comprehensive study requires single-cell whole genome amplification, with several methods available, prior to sequencing. Here we compare PicoPLEX with two recent adaptations of multiple displacement amplification (MDA): primary template-directed amplification (PTA) and droplet MDA, across 93 human brain cortical nuclei. We demonstrate different properties for each, with PTA providing the broadest amplification, PicoPLEX the most even, and distinct chimeric profiles. Furthermore, we perform CNV calling on two brains with multiple system atrophy and one control brain using different reference genomes. We find that 20.6% …